The cognitive burden in Huntington's disease: pathology, phenotype, and mechanisms of compensation

scientific article published on April 2014

The cognitive burden in Huntington's disease: pathology, phenotype, and mechanisms of compensation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/MDS.25864
P698PubMed publication ID24757115
P5875ResearchGate publication ID261771028

P50authorIzelle LabuschagneQ56936053
Marina PapoutsiQ59036432
Sarah J. TabriziQ24039464
Julie C. StoutQ45290281
P2860cites workOutcomes of a computer-based cognitive rehabilitation program on Alzheimer's disease patients compared with those on patients affected by mild cognitive impairment.Q50772194
Participation in cognitively stimulating activities and risk of incident Alzheimer disease.Q52014336
Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Treatment of Parkinson's DiseaseQ57743474
Task-Set Switching Deficits in Early-Stage Huntington's Disease: Implications for Basal Ganglia FunctionQ57913121
Long-term effects of cognitive training on everyday functional outcomes in older adultsQ24602305
Memory enhancement in healthy older adults using a brain plasticity-based training program: a randomized, controlled study.Q24684349
Can noninvasive brain stimulation enhance cognition in neuropsychiatric disorders?Q26824270
Practice effects in healthy adults: a longitudinal study on frequent repetitive cognitive testingQ30496995
Cognitive reserve and brain reserve in prodromal Huntington's diseaseQ30541757
Video game training enhances cognitive control in older adultsQ30575914
Concurrent activation of striatal direct and indirect pathways during action initiation.Q30579307
Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational dataQ30624346
Functional and connectivity changes during working memory in Huntington's disease: 18 month longitudinal data from the IMAGE-HD study.Q30661116
Multi-modal neuroimaging in premanifest and early Huntington's disease: 18 month longitudinal data from the IMAGE-HD study.Q30670030
Functional changes during working memory in Huntington's disease: 30-month longitudinal data from the IMAGE-HD study.Q30696281
Change in MRI striatal volumes as a biomarker in preclinical Huntington's diseaseQ31105242
Applications of real-time fMRI.Q31172605
The role of the basal ganglia in learning and memory: neuropsychological studiesQ33390025
Functional imaging in Huntington's diseaseQ33403110
Cognitive reserveQ33452282
Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline dataQ33489152
Differential loss of striatal projection neurons in Huntington diseaseQ33637273
Huntington's disease: from molecular pathogenesis to clinical treatmentQ33773061
Real-time fMRI: a tool for local brain regulationQ33926401
Exercise: a behavioral intervention to enhance brain health and plasticityQ33959877
Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism.Q33976362
An active and socially integrated lifestyle in late life might protect against dementiaQ33978519
Real-time fMRI and its application to neurofeedbackQ34054595
Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational dataQ34089875
What is the impact of education on Huntington's disease?Q34172955
Cerebral cortex structure in prodromal Huntington diseaseQ34204077
The organization of the human striatum estimated by intrinsic functional connectivityQ34290294
Tapping linked to function and structure in premanifest and symptomatic Huntington diseaseQ34455567
Neurocognitive signs in prodromal Huntington diseaseQ34474382
Technology insight: noninvasive brain stimulation in neurology-perspectives on the therapeutic potential of rTMS and tDCS.Q34646129
Thalamic metabolism and symptom onset in preclinical Huntington's diseaseQ34692568
Goal-directed and habitual control in the basal ganglia: implications for Parkinson's diseaseQ35072636
A tale of two factors: what determines the rate of progression in Huntington's disease? A longitudinal MRI studyQ35162891
Striatal volume contributes to the prediction of onset of Huntington disease in incident casesQ35612769
An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrusQ35720477
Altered brain mechanisms of emotion processing in pre-manifest Huntington's disease.Q35888638
Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease.Q36011977
Cognitive training in Alzheimer's disease: a meta-analysis of the literatureQ36534246
Measuring executive dysfunction longitudinally and in relation to genetic burden, brain volumetrics, and depression in prodromal Huntington diseaseQ36603018
Cognitive impairment in Huntington disease: diagnosis and treatmentQ36773397
Preclinical Huntington's disease: compensatory brain responses during learningQ36846810
Detection of Huntington's disease decades before diagnosis: the Predict-HD studyQ36941187
Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onsetQ37073913
Brain reserve and the prevention of dementiaQ37125840
An event-based model for disease progression and its application in familial Alzheimer's disease and Huntington's diseaseQ45306122
Dorsolateral prefrontal cortex dysfunction in presymptomatic Huntington's disease: evidence from event-related fMRI.Q45306386
Evidence for a preferential loss of enkephalin immunoreactivity in the external globus pallidus in low grade Huntington's disease using high resolution image analysisQ45307235
Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's diseaseQ45307289
Gene-environment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington's disease transgenic mice.Q45307374
Evidence for segregated and integrative connectivity patterns in the human Basal GangliaQ45716308
Lifetime antecedents of cognitive reserveQ47819027
Huntington diseaseQ48465200
Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneityQ37132239
Functional compensation of motor function in pre-symptomatic Huntington's diseaseQ37201396
Cognitive decline in prodromal Huntington Disease: implications for clinical trialsQ37227655
Cognitive domains that predict time to diagnosis in prodromal Huntington diseaseQ37267442
The cognitive functions of the caudate nucleusQ37281865
Can cognitive exercise prevent the onset of dementia? Systematic review of randomized clinical trials with longitudinal follow-upQ37395637
Interregional compensatory mechanisms of motor functioning in progressing preclinical neurodegenerationQ37505020
The neurobiology of brain and cognitive reserve: mental and physical activity as modulators of brain disordersQ37612436
Dopamine and glutamate in Huntington's disease: A balancing act.Q37734563
Mechanisms mediating brain and cognitive reserve: experience-dependent neuroprotection and functional compensation in animal models of neurodegenerative diseases.Q37812899
Cognitive functions and corticostriatal circuits: insights from Huntington's disease.Q37827939
Emotion recognition in Huntington's disease: a systematic reviewQ37893737
Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function.Q37930190
A review of cognition in Huntington's diseaseQ38070573
The basal ganglia and rule-governed language use: evidence from vascular and degenerative conditions.Q38417649
Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysisQ39809906
In vivo evidence for the selective subcortical degeneration in Huntington's disease.Q39991119
Pallidal neuronal discharge in Huntington's disease: support for selective loss of striatal cells originating the indirect pathwayQ41563648
Effects of low versus high frequencies of repetitive transcranial magnetic stimulation on cognitive function and cortical excitability in Alzheimer's dementiaQ44045758
Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic miceQ44842418
Brain activation and functional connectivity in premanifest Huntington's disease during states of intrinsic and phasic alertnessQ45289548
Emotion recognition in Huntington's disease and frontotemporal dementiaQ45289760
Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's diseaseQ45290217
Prefrontal activity in Huntington's disease reflects cognitive and neuropsychiatric disturbances: the IMAGE-HD study.Q45290568
Altered frontostriatal coupling in pre-manifest Huntington's disease: effects of increasing cognitive load.Q45290709
Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's diseaseQ45291252
Sensorimotor mapping affects movement correction deficits in early Huntington's diseaseQ45296775
A retrospective study of the impact of lifestyle on age at onset of Huntington disease.Q45298844
Delaying the onset of Huntington's in miceQ45300228
Visuomotor integration deficits precede clinical onset in Huntington's diseaseQ45300601
Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice.Q45301264
Early changes in white matter pathways of the sensorimotor cortex in premanifest Huntington's diseaseQ45301408
"Brain training" improves cognitive performance and survival in a transgenic mouse model of Huntington's diseaseQ45301758
Connectivity-based segmentation of the striatum in Huntington's disease: vulnerability of motor pathwaysQ45301952
The impairment of emotion recognition in Huntington's disease extends to positive emotionsQ45302113
Clinical markers of early disease in persons near onset of Huntington's disease.Q45303704
Motor timing variability increases in preclinical Huntington's disease patients as estimated onset of motor symptoms approachesQ45304893
Environmental enrichment slows disease progression in R6/2 Huntington's disease miceQ45305273
Beyond disgust: impaired recognition of negative emotions prior to diagnosis in Huntington's diseaseQ45305470
fMRI detection of early neural dysfunction in preclinical Huntington's diseaseQ45305904
Psychomotor, executive, and memory function in preclinical Huntington's diseaseQ45305988
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectphenotypeQ104053
Huntington's diseaseQ190564
pathologyQ7208
P304page(s)673-683
P577publication date2014-04-01
P1433published inMovement DisordersQ1486418
P1476titleThe cognitive burden in Huntington's disease: pathology, phenotype, and mechanisms of compensation
P478volume29

Reverse relations

cites work (P2860)
Q55161995A Data-Driven Method for Generating Robust Symptom Onset Indicators in Huntington's Disease Registry Data.
Q92956179A probabilistic disease progression modeling approach and its application to integrated Huntington's disease observational data
Q41031227A stop-signal task for sheep: introduction and validation of a direct measure for the stop-signal reaction time.
Q38599326A systematic linguistic profile of spontaneous narrative speech in pre-symptomatic and early stage Huntington's disease
Q35787704Abnormal Electrophysiological Motor Responses in Huntington's Disease: Evidence of Premanifest Compensation
Q41518825Abnormal cerebellar volume and corticocerebellar dysfunction in early manifest Huntington's disease.
Q89605499Accuracy of automated amygdala MRI segmentation approaches in Huntington's disease in the IMAGE-HD cohort
Q64067597Amelioration of Huntington's disease phenotype in astrocytes derived from iPSC-derived neural progenitor cells of Huntington's disease monkeys
Q89733981Apathy predicts rate of cognitive decline over 24 months in premanifest Huntington's disease
Q37382878Assistive Technology for Cognition and Health-related Quality of Life in Huntington's Disease.
Q30862037Attempted and successful compensation in preclinical and early manifest neurodegeneration - a review of task FMRI studies
Q57489816Cognitive Performance After a One-Year Multidisciplinary Intensive Rehabilitation Program for Huntington's Disease: An Observational Study
Q38928777Cognitive dysfunction in Huntington's disease: mechanisms and therapeutic strategies beyond BDNF.
Q38430852Cognitive interventions to enhance neural compensation in Huntington's disease
Q28393234Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study
Q37019338Compensatory activation in fronto-parietal cortices among HIV-infected persons during a monetary decision-making task
Q45294951Compromised Dopaminergic Encoding of Reward Accompanying Suppressed Willingness to Overcome High Effort Costs Is a Prominent Prodromal Characteristic of the Q175 Mouse Model of Huntington's Disease
Q104617061Dissociable Motivational Deficits in Pre-manifest Huntington's Disease
Q48112823Early Detection of Apathetic Phenotypes in Huntington's Disease Knock-in Mice Using Open Source Tools.
Q45721188Families Affected by Huntington's Disease Report Difficulties in Communication, Emotional Involvement, and Problem Solving.
Q64958688G-Computation and Hierarchical Models for Estimating Multiple Causal Effects From Observational Disease Registries With Irregular Visits.
Q38884150Health Care Delivery Practices in Huntington's Disease Specialty Clinics: An International Survey.
Q56083219Huntington disease
Q36090810Huntington disease iPSCs show early molecular changes in intracellular signaling, the expression of oxidative stress proteins and the p53 pathway
Q92106147International Guidelines for the Treatment of Huntington's Disease
Q42110375Introduction: the importance of cognition in movement disorders
Q36379175Measuring compensation in neurodegeneration using MRI.
Q100462515Montreal Cognitive Assessment for evaluating cognitive impairment in Huntington's disease: a systematic review
Q45302525Myelin breakdown in human Huntington's disease: Multi-modal evidence from diffusion MRI and quantitative magnetization transfer.
Q40058208Normalization of timed neuropsychological tests with the PATA rate and nine-hole pegboard tests
Q37739897Operationalizing compensation over time in neurodegenerative disease
Q38680458PIN1 Modulates Huntingtin Levels and Aggregate Accumulation: An In vitro Model
Q43182909Preserving cortico-striatal function: deep brain stimulation in Huntington's disease
Q37284640Problem solving, impulse control and planning in patients with early- and late-stage Huntington's disease
Q55010368Reduced amygdala volumes are related to motor and cognitive signs in Huntington's disease: The IMAGE-HD study.
Q36206024Selective vulnerability of Rich Club brain regions is an organizational principle of structural connectivity loss in Huntington's disease
Q55159264Sexual behavior and testis morphology in the BACHD rat model.
Q37514484Striatal morphology correlates with frontostriatal electrophysiological motor processing in Huntington's disease: an IMAGE-HD study.
Q92812803The Expanding Therapeutic Potential of Neuronal KCC2
Q45304583The Neuropsychology of Huntington's Disease
Q42327973Theory of Mind Is Impaired in Mild to Moderate Huntington's Disease Independently from Global Cognitive Functioning.

Search more.