Modulation of nitric oxide by flavonoids.

scientific article

Modulation of nitric oxide by flavonoids. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1039/C4FO00144C
P698PubMed publication ID24901042
P5875ResearchGate publication ID262885470

P50authorFrancisco Pérez-VizcaínoQ42880787
Juan DuarteQ43018338
P2093author name stringV Francisco
P2860cites work(-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humansQ24536110
Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1Q24649505
MicroRNA signatures in human cancersQ27860962
In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) productionQ28209052
Nitric oxide synthases: regulation and functionQ28247092
Endothelial nitric oxide synthase in vascular disease: from marvel to menaceQ28305279
Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive ratsQ28363825
Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivoQ28565952
Peroxynitrite: biochemistry, pathophysiology and development of therapeuticsQ29615424
Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shockQ29619768
Identification and in vitro biological activities of hop proanthocyanidins: inhibition of nNOS activity and scavenging of reactive nitrogen speciesQ30694951
Green tea polyphenol epigallocatechin gallate reduces endothelin-1 expression and secretion in vascular endothelial cells: roles for AMP-activated protein kinase, Akt, and FOXO1Q33577496
Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels.Q33978871
Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neuronsQ34088466
Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155.Q34122788
Cellular mechanisms of nonspecific immunity to intracellular infection: cytokine-induced synthesis of toxic nitrogen oxides from L-arginine by macrophages and hepatocytesQ34160690
Increased microparticle production and impaired microvascular endothelial function in aldosterone-salt-treated rats: protective effects of polyphenols.Q34341545
Flavonoid intake and risk of CVD: a systematic review and meta-analysis of prospective cohort studiesQ34364706
Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction.Q34616080
Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity.Q34620508
Neuroprotective role of nanoencapsulated quercetin in combating ischemia-reperfusion induced neuronal damage in young and aged ratsQ34688621
Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly StudyQ34726987
(-)-Epicatechin induces calcium and translocation independent eNOS activation in arterial endothelial cellsQ34782177
DNA deaminating ability and genotoxicity of nitric oxide and its progenitorsQ34983829
Blocking NO synthesis: how, where and why?Q35013972
Involvement of thromboxane A2 in the endothelium-dependent contractions induced by myricetin in rat isolated aortaQ35029144
The intestinal anti-inflammatory effect of quercitrin is associated with an inhibition in iNOS expression.Q35048387
Endothelial dysfunction: a marker of atherosclerotic riskQ35067247
Kaempferol acts through mitogen-activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cellsQ35376097
Study of the mechanisms involved in the vasorelaxation induced by (-)-epigallocatechin-3-gallate in rat aortaQ35545232
Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanismsQ35684610
Inhibition of nitric oxide in LPS-stimulated macrophages of young and senescent mice by δ-tocotrienol and quercetinQ35704170
Hydrogen peroxide regulation of endothelial function: origins, mechanisms, and consequencesQ36189782
Inhibiting inducible nitric oxide synthase with rutin reduces renal ischemia/reperfusion injuryQ36601599
Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenolsQ36610393
Role of nitric oxide synthesis in macrophage antimicrobial activityQ36656920
The role of microRNAs in cholesterol efflux and hepatic lipid metabolism.Q36728983
Anticarcinogenesis by dietary phytochemicals: cytoprotection by Nrf2 in normal cells and cytotoxicity by modulation of transcription factors NF-kappa B and AP-1 in abnormal cancer cellsQ36976619
Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-κB signallingQ37053805
Peroxynitrite, a stealthy biological oxidantQ37168344
microRNAs and the immune responseQ37178538
Red wine polyphenols prevent metabolic and cardiovascular alterations associated with obesity in Zucker fatty rats (Fa/Fa).Q37184694
Inducible nitric-oxide synthase expression is regulated by mitogen-activated protein kinase phosphatase-1.Q37447921
Polyphenols in the prevention and treatment of sepsis syndromes: rationale and pre-clinical evidenceQ37510239
A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disordersQ37607440
Nitric oxide and neuronal deathQ37765041
Flavonols and cardiovascular diseaseQ37788333
Neuroinflammation: modulation by flavonoids and mechanisms of actionQ37959586
Antioxidant effects of resveratrol and other stilbene derivatives on oxidative stress and *NO bioavailability: Potential benefits to cardiovascular diseasesQ37963610
Epicatechin: endothelial function and blood pressure.Q37996119
Relative impact of flavonoid composition, dose and structure on vascular function: a systematic review of randomised controlled trials of flavonoid-rich food productsQ38045237
Oxidative stress in vascular disease and its pharmacological prevention.Q38100879
Quercetin inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-κB pathway and activating the Nrf2-dependent HO-1 pathwayQ38446572
Quercetin glucuronide prevents VSMC hypertrophy by angiotensin II via the inhibition of JNK and AP-1 signaling pathwayQ38522640
Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigeninQ39051816
Enhanced activation of NAD(P)H: quinone oxidoreductase 1 attenuates spontaneous hypertension by improvement of endothelial nitric oxide synthase coupling via tumor suppressor kinase liver kinase B1/adenosine 5'-monophosphate-activated protein kinaseQ39062339
Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cellsQ39144033
Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary arteryQ39253159
Inhibitory effect of astragalin on expression of lipopolysaccharide-induced inflammatory mediators through NF-κB in macrophagesQ39419360
Effects of luteolin on the release of nitric oxide and interleukin-6 by macrophages stimulated with lipopolysaccharide from Prevotella intermediaQ39594689
Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged miceQ39671307
Immunoregulatory effects of the flavonol quercetin in vitro and in vivo.Q39676934
Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-kappaB signaling pathwayQ39697354
Inhibition of nitric oxide production by quercetin in endotoxin/cytokine-stimulated microgliaQ39754125
Lack of beneficial metabolic effects of quercetin in adult spontaneously hypertensive rats.Q39776704
Some phenolic compounds increase the nitric oxide level in endothelial cells in vitroQ39805515
Flavonoids with iNOS inhibitory activity from Pogonatherum crinitumQ39986758
Baicalin inhibits macrophage activation by lipopolysaccharide and protects mice from endotoxin shockQ40025758
Apigenin inhibits the production of NO and PGE2 in microglia and inhibits neuronal cell death in a middle cerebral artery occlusion-induced focal ischemia mice modelQ40044970
Lycopene, quercetin and tyrosol prevent macrophage activation induced by gliadin and IFN-gammaQ40137486
Quercetin exhibits a specific fluorescence in cellular milieu: a valuable tool for the study of its intracellular distributionQ40154175
The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cellsQ40191280
Luteolin inhibits LPS-stimulated inducible nitric oxide synthase expression in BV-2 microglial cellsQ40322458
Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia.Q40371518
Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophagesQ40378838
Flavonoids differentially modulate nitric oxide production pathways in lipopolysaccharide-activated RAW264.7 cellsQ40434732
Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264.7 cellsQ40492021
(-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injuryQ40505291
Inhibition of nitric oxide production from lipopolysaccharide-treated RAW 264.7 cells by synthetic flavones: structure-activity relationship and action mechanismQ40506345
Wine polyphenols and ethanol do not significantly scavenge superoxide nor affect endothelial nitric oxide productionQ40541247
Quercetin suppresses proinflammatory cytokines production through MAP kinases andNF-kappaB pathway in lipopolysaccharide-stimulated macrophageQ40666301
(-)-epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide, and related signaling pathwaysQ40676666
Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expressions by rutin, quercetin, and quercetin pentaacetate in RAW 264.7 macrophagesQ40786648
Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179).Q40799734
Protection against nitric oxide toxicity by tea.Q40841000
Evidence for the stimulatory effect of resveratrol on Ca(2+)-activated K+ current in vascular endothelial cellsQ40892208
Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationshipsQ40935078
Molecular biology of nitric oxide synthasesQ41739514
Increased expression of neutrophil gelatinase-associated lipocalin receptor by interleukin-1β in human mesangial cells via MAPK/ERK activationQ42483732
Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: a critical role for heme oxygenase-1.Q42709532
Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity.Q42944533
Quercetin metabolites and protection against peroxynitrite-induced oxidative hepatic injury in ratsQ43294351
Antihypertensive effect of a polyphenol-rich cocoa powder industrially processed to preserve the original flavonoids of the cocoa beans.Q43538334
Inhibition of angiotensin converting enzyme activity by flavanol-rich foodsQ43566082
Human metabolic transformation of quercetin blocks its capacity to decrease endothelial nitric oxide synthase (eNOS) expression and endothelin-1 secretion by human endothelial cellsQ43575487
Vasorelaxant effects of the bioflavonoid chrysin in isolated rat aortaQ43710463
Acute effect of black and green tea on aortic stiffness and wave reflectionsQ44005150
Green tea polyphenols down-regulate caveolin-1 expression via ERK1/2 and p38MAPK in endothelial cellsQ44017863
Endothelium-independent vasodilator effects of the flavonoid quercetin and its methylated metabolites in rat conductance and resistance arteriesQ44028860
Blood pressure-lowering effect of dietary (-)-epicatechin administration in L-NAME-treated rats is associated with restored nitric oxide levelsQ44037935
Protective effects of the flavonoid quercetin in chronic nitric oxide deficient rats.Q44113836
Nitric oxide formation and corresponding relaxation of porcine coronary arteries induced by plant phenols: essential structural featuresQ44200614
Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta.Q44208895
Red wine polyphenols do not lower peripheral or central blood pressure in high normal blood pressure and hypertensionQ44354826
Abarema cochliacarpos reduces LPS-induced inflammatory response in murine peritoneal macrophages regulating ROS-MAPK signal pathway.Q44598188
Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aortaQ44658927
Green tea inhibits human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1alpha activationQ44727254
Nitric oxide (NO) scavenging and NO protecting effects of quercetin and their biological significance in vascular smooth muscle.Q44814781
Effects of quercetin treatment on vascular function in deoxycorticosterone acetate-salt hypertensive rats. Comparative study with verapamil.Q44850078
Dietary compounds prevent oxidative damage and nitric oxide production by cells involved in demyelinating disease.Q44855757
Endothelial dysfunctionQ45000505
Luteolin suppresses the differentiation of THP-1 cells through the Inhibition of NOX2 mRNA expression and the membrane translocation of p47phoxQ45396192
Baicalein inhibits nuclear factor-κB and apoptosis via c-FLIP and MAPK in D-GalN/LPS induced acute liver failure in murine models.Q45591342
Protective effects of flavanol-rich dark chocolate on endothelial function and wave reflection during acute hyperglycemia.Q45762818
Modulation of endothelial nitric oxide by plant-derived products.Q45982392
Effects of quercetin on gene and protein expression of NOX and NOS after myocardial ischemia and reperfusion in rabbitQ46126477
Epicatechin attenuates doxorubicin-induced brain toxicity: critical role of TNF-α, iNOS and NF-κB.Q46191896
Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activationQ46295708
Effects of chronic quercetin treatment in experimental renovascular hypertensionQ46405592
Quercetin-induced induction of the NO/cGMP pathway depends on Ca2+-activated K+ channel-induced hyperpolarization-mediated Ca2+-entry into cultured human endothelial cellsQ46560803
Glucuronidated metabolites of the flavonoid quercetin do not auto-oxidise, do not generate free radicals and do not decrease nitric oxide bioavailability.Q46592338
Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC.Q46627334
A comparison of the effects of kaempferol and quercetin on cytokine-induced pro-inflammatory status of cultured human endothelial cellsQ46660209
Isovitexin suppresses lipopolysaccharide-mediated inducible nitric oxide synthase through inhibition of NF-kappa B in mouse macrophagesQ46687240
Red wine acutely induces favorable effects on wave reflections and central pressures in coronary artery disease patientsQ46718857
Wine polyphenols improve endothelial function in large vessels of female spontaneously hypertensive ratsQ46765368
Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive ratsQ46838045
(-)-Epicatechin reduces blood pressure and improves vasorelaxation in spontaneously hypertensive rats by NO-mediated mechanism.Q46971267
Role of neuronal nitric oxide synthase in the antiallodynic effects of intrathecal EGCG in a neuropathic pain rat model.Q50504270
Epigallocatechin gallate elicits contractions of the isolated aorta of the aged spontaneously hypertensive rat.Q50526981
Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: role of NADPH oxidase.Q50551325
Polyphenols restore endothelial function in DOCA-salt hypertension: role of endothelin-1 and NADPH oxidase.Q50689589
Possible nitric oxide modulation in the protective effects of rutin against experimental head trauma-induced cognitive deficits: behavioral, biochemical, and molecular correlates.Q50691875
Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn.Q50693400
Tea flavanols inhibit angiotensin-converting enzyme activity and increase nitric oxide production in human endothelial cells.Q50721327
Combined acute effects of red wine consumption and cigarette smoking on haemodynamics of young smokers.Q50730841
Antioxidant effect of quercetin against acute spinal cord injury in rats and its correlation with the p38MAPK/iNOS signaling pathway.Q50978825
Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages.Q53418310
Apigenin inhibits the TNFα-induced expression of eNOS and MMP-9 via modulating Akt signalling through oestrogen receptor engagement.Q54490286
Chronic (-)-epicatechin improves vascular oxidative and inflammatory status but not hypertension in chronic nitric oxide-deficient rats.Q54561347
The reaction of flavonoid metabolites with peroxynitriteQ57931903
Flavonoid-rich apples and nitrate-rich spinach augment nitric oxide status and improve endothelial function in healthy men and women: a randomized controlled trialQ58418624
Effect of a cocoa polyphenol extract in spontaneously hypertensive ratsQ58817354
P433issue8
P304page(s)1653-1668
P577publication date2014-08-01
P1433published inFood & FunctionQ3076426
P1476titleModulation of nitric oxide by flavonoids
P478volume5

Reverse relations

cites work (P2860)
Q36244324An Integrated View of the Effects of Wine Polyphenols and Their Relevant Metabolites on Gut and Host Health.
Q55385184Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats.
Q99548839Characterization of Rat Cardiovascular System by Anacrotic/Dicrotic Notches in the Condition of Increase/Decrease of NO Bioavailability
Q96228623Consumption of flavonoid-rich fruits and risk of coronary heart disease: a prospective cohort study
Q47705838Evaluation of the free-radical scavenging and antioxidant activities of Chilauni, Schima wallichii Korth in vitro
Q39364420Flavanone Intake Is Inversely Associated with Risk of Incident Ischemic Stroke in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study
Q39033673Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans: a randomised, controlled, double-masked, cross-over intervention study
Q41131961Flavonoid glucosylation by non-Leloir glycosyltransferases: formation of multiple derivatives of 3,5,7,3',4'-pentahydroxyflavane stereoisomers
Q55236619Mangifera indica L. Leaf Extract in Combination With Luteolin or Quercetin Enhances VO2peak and Peak Power Output, and Preserves Skeletal Muscle Function During Ischemia-Reperfusion in Humans.
Q51820527Mechanisms of Endothelial Protection by Natural Bioactive Compounds from Fruit and Vegetables.
Q57169099Moderate Effect of Flavonoids on Vascular and Renal Function in Spontaneously Hypertensive Rats
Q47811794Modulation of inducible nitric oxide synthase (iNOS) expression and cardiovascular responses during static exercise following iNOS antagonism within the ventrolateral medulla
Q36989431Molecular mechanisms of flavonoids in melanin synthesis and the potential for the prevention and treatment of melanoma
Q92209460Potent Vasodilator and Cellular Antioxidant Activity of Endemic Patagonian Calafate Berries (Berberis microphylla) with Nutraceutical Potential
Q64250714Protective Effects of Extract against Cardiac Ischemia/Reperfusion Injury in Spontaneously Hypertensive Rats
Q48132314Protective vascular effects of quercitrin in acute TNBS-colitis in rats: the role of nitric oxide
Q46273415Semisynthesis, an Anti-Inflammatory Effect of Derivatives of 1β-Hydroxy Alantolactone from Inula britannica
Q89910570The Effects and Mechanism of Quercetin Dietary Supplementation in Streptozotocin-Induced Hyperglycemic Arbor Acre Broilers
Q37678782Vlasouliolides A-D, four rare C17/C15 sesquiterpene lactone dimers with potential anti-inflammatory activity from Vladimiria souliei

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