Dynamics of the ClpP serine protease: a model for self-compartmentalized proteases

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Dynamics of the ClpP serine protease: a model for self-compartmentalized proteases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3109/10409238.2014.925421
P698PubMed publication ID24915503

P2093author name stringWalid A Houry
Kaiyin Liu
Adedeji Ologbenla
P2860cites workInsights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1Q27643627
The structural basis for the activation and peptide recognition of bacterial ClpPQ27650574
Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanismQ27660298
Dynamic regulation of archaeal proteasome gate opening as studied by TROSY NMRQ27660397
Structural and theoretical studies indicate that the cylindrical protease ClpP samples extended and compact conformationsQ27663549
Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP.Q27664573
The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparumQ27664851
A conformational switch underlies ClpP protease functionQ27667731
Structural Switching of Staphylococcus aureus Clp Protease: A KEY TO UNDERSTANDING PROTEASE DYNAMICSQ27673403
Structural insights into the conformational diversity of ClpP from Bacillus subtilisQ27675546
Insights into Structural Network Responsible for Oligomerization and Activity of Bacterial Virulence Regulator Caseinolytic Protease P (ClpP) ProteinQ27676956
Helix Unfolding/Refolding Characterizes the Functional Dynamics of Staphylococcus aureus Clp ProteaseQ27677829
Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triadQ27678774
Molecular architecture and assembly of the eukaryotic proteasomeQ27693890
Crystal structure of heat shock locus V (HslV) from Escherichia coliQ27738799
The structure of ClpP at 2.3 A resolution suggests a model for ATP-dependent proteolysisQ27748258
Proteasomes and their kin: proteases in the machine ageQ29614359
Activities at the Universal Protein Resource (UniProt)Q29617787
ClpP hydrolyzes a protein substrate processively in the absence of the ClpA ATPase: mechanistic studies of ATP-independent proteolysisQ30848480
STRAP: editor for STRuctural Alignments of ProteinsQ30986215
Molecular determinants of complex formation between Clp/Hsp100 ATPases and the ClpP peptidase.Q32063825
Proteasomes and other self-compartmentalizing proteases in prokaryotesQ33542295
Binding of the ClpA unfoldase opens the axial gate of ClpP peptidaseQ33824950
Local and global mobility in the ClpA AAA+ chaperone detected by cryo-electron microscopy: functional connotationsQ33853445
The ClpP N-terminus coordinates substrate access with protease active site reactivityQ34061068
Quantitative NMR spectroscopy of supramolecular complexes: dynamic side pores in ClpP are important for product releaseQ34133375
ClpXP, an ATP-powered unfolding and protein-degradation machineQ34198403
Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP.Q34364492
Paradigms of protein degradation by the proteasomeQ34410240
Dysregulation of bacterial proteolytic machinery by a new class of antibioticsQ34456129
Sequence analysis of four new heat-shock genes constituting the hslTS/ibpAB and hslVU operons in Escherichia coli.Q34728633
Six-fold rotational symmetry of ClpQ, the E. coli homolog of the 20S proteasome, and its ATP-dependent activator, ClpY.Q34737150
The asymmetry in the mature amino-terminus of ClpP facilitates a local symmetry match in ClpAP and ClpXP complexesQ35226259
Prokaryotic proteasomes: nanocompartments of degradationQ37606186
Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ proteaseQ40002824
The ClpP double ring tetradecameric protease exhibits plastic ring-ring interactions, and the N termini of its subunits form flexible loops that are essential for ClpXP and ClpAP complex formationQ45258108
Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP proteaseQ47579181
ClpA and ClpX ATPases bind simultaneously to opposite ends of ClpP peptidase to form active hybrid complexesQ47904809
Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organismsQ48036866
Crystal structure at 1.9A of E. coli ClpP with a peptide covalently bound at the active site.Q53623920
Quantitative dynamics and binding studies of the 20S proteasome by NMRQ59082478
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)400-412
P577publication date2014-06-10
P1433published inCritical Reviews in Biochemistry and Molecular BiologyQ5186661
P1476titleDynamics of the ClpP serine protease: a model for self-compartmentalized proteases
P478volume49

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cites work (P2860)
Q92513029A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery
Q34463606AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control
Q47221701Activation of a Cell Surface Signaling Pathway in Pseudomonas aeruginosa Requires ClpP Protease and New Sigma Factor Synthesis.
Q40776051Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease
Q92578193Akt phosphorylation of mitochondrial Lonp1 protease enables oxidative metabolism and advanced tumor traits
Q89983079An allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR
Q64955662ClpP Protease, a Promising Antimicrobial Target.
Q91388634ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores
Q93067396Consequences of the loss of catalytic triads in chloroplast CLPPR protease core complexes in vivo
Q48126792Discovery of a Unique Clp Component, ClpF, in Chloroplasts: A Proposed Binary ClpF-ClpS1 Adaptor Complex Functions in Substrate Recognition and Delivery
Q36221405Enzyme Tunnels and Gates As Relevant Targets in Drug Design.
Q100512225Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy
Q91619725Molecular and structural insights into an asymmetric proteolytic complex (ClpP1P2) from Mycobacterium smegmatis
Q57751886Reversible inhibition of the ClpP protease via an N-terminal conformational switch
Q48194392Structures, Functions, and Interactions of ClpT1 and ClpT2 in the Clp Protease System of Arabidopsis Chloroplasts.
Q36070569The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis.

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