Targeted radiotherapy with gold nanoparticles: current status and future perspectives

scientific article published on May 2014

Targeted radiotherapy with gold nanoparticles: current status and future perspectives is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2217/NNM.14.55
P932PMC publication ID4143893
P698PubMed publication ID24978464

P2093author name stringRajiv Kumar
G Mike Makrigiorgos
Wilfred Ngwa
Piotr Zygmanski
Srinivas Sridhar
Ross Berbeco
Robert A Cormack
Houari Korideck
P2860cites workIn vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tagsQ40031376
Nanomedicine: nanocarriers shape up for long lifeQ40066554
Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes.Q40139914
Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjectsQ40293849
Antiangiogenic properties of gold nanoparticlesQ40427876
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.Q40479307
The use of gold nanoparticles to enhance radiotherapy in miceQ40499366
Intravenous transferrin, RGD peptide and dual-targeted nanoparticles enhance anti-VEGF intraceptor gene delivery to laser-induced CNV.Q41442716
The Role of Surface Functionality on Acute Cytotoxicity, ROS Generation and DNA Damage by Cationic Gold NanoparticlesQ41642723
Third generation gold nanoplatform optimized for radiation therapyQ41829461
In vitro radiosensitization by gold nanoparticles during continuous low-dose-rate gamma irradiation with I-125 brachytherapy seeds.Q41829627
Patient-reported quality of life after salvage brachytherapy for radio-recurrent prostate cancer: A prospective Phase II studyQ41848137
DNA damage enhancement from gold nanoparticles for clinical MV photon beamsQ42011166
Intravenously administered gold nanoparticles pass through the blood-retinal barrier depending on the particle size, and induce no retinal toxicityQ43239219
Flurbiprofen-loaded stealth liposomes: studies on the development, characterization, pharmacokinetics, and biodistributionQ43246889
Cellular radiation dosimetry and its implications for estimation of radiation risks. Illustrative results with technetium 99m-labeled microspheres and macroaggregatesQ43957801
Nanoscience and nanotechnology: evolving definitions and growing footprint on the scientific landscapeQ44262085
Long-term failure patterns and survival in a randomized dose-escalation trial for prostate cancer. Who dies of disease?Q44772974
Applying gold nanoparticles as tumor-vascular disrupting agents during brachytherapy: estimation of endothelial dose enhancementQ44786631
Impact of beam quality on megavoltage radiotherapy treatment techniques utilizing gold nanoparticles for dose enhancement.Q44900411
The management of respiratory motion in radiation oncology report of AAPM Task Group 76.Q44924583
Enhanced macromolecule diffusion deep in tumors after enzymatic digestion of extracellular matrix collagen and its associated proteoglycan decorinQ44989902
Kilovoltage stereotactic radiosurgery for age-related macular degeneration: assessment of optic nerve dose and patient effective doseQ45173238
Gold nanoparticles enhance the radiation therapy of a murine squamous cell carcinomaQ45213619
An eight-year experience of HDR brachytherapy boost for localized prostate cancer: biopsy and PSA outcome.Q45248416
CCR3 is a target for age-related macular degeneration diagnosis and therapyQ24338258
The dosimetric feasibility of gold nanoparticle-aided radiation therapy (GNRT) via brachytherapy using low-energy gamma-/x-ray sourcesQ24632315
Global data on visual impairment in the year 2002Q24650312
Gold nanoparticles as novel agents for cancer therapyQ27008020
Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilitiesQ27011598
A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancsQ28285226
Radiotherapy enhancement with gold nanoparticlesQ28288052
Utilizing targeted gene therapy with nanoparticles binding alpha v beta 3 for imaging and treating choroidal neovascularizationQ28740612
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapyQ29547379
Determining the size and shape dependence of gold nanoparticle uptake into mammalian cellsQ29615461
Ranibizumab for neovascular age-related macular degenerationQ29617549
Designer nanoparticles: incorporating size, shape and triggered release into nanoscale drug carriers.Q30476027
Acute and late complications after radiotherapy for prostate cancer: results of a multicenter randomized trial comparing 68 Gy to 78 Gy.Q31151905
Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes.Q32107154
Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overviewQ33226381
Update of Dutch multicenter dose-escalation trial of radiotherapy for localized prostate cancerQ33336936
Intravascular delivery of particulate systems: does geometry really matter?Q33361339
Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted miceQ33398443
Nuclear targeting of gold nanoparticles in cancer cells induces DNA damage, causing cytokinesis arrest and apoptosisQ33525128
Dose escalation and quality of life in patients with localized prostate cancer treated with radiotherapy: long-term results of the Dutch randomized dose-escalation trial (CKTO 96-10 trial).Q33565184
Near infrared light-triggered drug generation and release from gold nanoparticle carriers for photodynamic therapyQ33578775
Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticlesQ33666994
Estimation of microscopic dose enhancement factor around gold nanoparticles by Monte Carlo calculationsQ33689742
Intratumoral delivery of beta-lapachone via polymer implants for prostate cancer therapyQ33753357
16-Gy low-voltage x-ray irradiation followed by as-needed ranibizumab therapy for AMD: 6-month outcomes of a "radiation-first" strategyQ33989238
16-Gy low-voltage x-ray irradiation with ranibizumab therapy for AMD: 6-month safety and functional outcomesQ33989248
Locally recurrent prostate cancer after external beam radiation therapy: diagnostic performance of 1.5-T endorectal MR imaging and MR spectroscopic imaging for detectionQ34017719
24-Gy low-voltage x-ray irradiation with ranibizumab therapy for neovascular AMD: 6-month safety and functional outcomes.Q34129730
The potential of nanomedicine therapies to treat neovascular disease in the retina.Q34220590
Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncologyQ34328650
Assessment of targeting accuracy of a low-energy stereotactic radiosurgery treatment for age-related macular degenerationQ34402842
Targeting angiogenesis, the underlying disorder in neovascular age-related macular degenerationQ34425420
Cell-specific targeting of nanoparticles by multivalent attachment of small moleculesQ34462201
Cell-Specific Radiosensitization by Gold Nanoparticles at Megavoltage Radiation EnergiesQ34462887
Radiation therapy for neovascular age-related macular degenerationQ34548686
Multistage nanoparticle delivery system for deep penetration into tumor tissueQ34572820
Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicityQ34595551
Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration: year 1 results of the FOCUS Study.Q34653066
Selective targeting of brain tumors with gold nanoparticle-induced radiosensitizationQ34701455
Delivering nanomedicine to solid tumorsQ34726981
A perspective on vascular disrupting agents that interact with tubulin: preclinical tumor imaging and biological assessmentQ34765364
Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomyQ34794205
Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR studyQ34913612
Targeting the tumor blood vessel network to enhance the efficacy of radiation therapyQ35042096
Infrared-transparent gold nanoparticles converted by tumors to infrared absorbers cure tumors in mice by photothermal therapyQ35092823
Brachytherapy for recurrent prostate cancer after radiation therapyQ35120294
Photodynamic therapy for age-related macular degeneration in a clinical setting: visual results and angiographic patternsQ35666861
Salvage brachytherapy after external-beam irradiation for prostate cancer.Q35685340
Making polymeric micro- and nanoparticles of complex shapesQ35901299
Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivoQ36017657
Endothelial cell proliferation as a novel approach to targeting tumour therapyQ36046291
Role of salvage radical prostatectomy for recurrent prostate cancer after radiation therapyQ36309694
pHLIP peptide targets nanogold particles to tumorsQ36535248
Nanoparticle location and material dependent dose enhancement in X-ray radiation therapyQ36584987
The effect of flattening filter free delivery on endothelial dose enhancement with gold nanoparticlesQ36648953
Drug insight: vascular disrupting agents and angiogenesis--novel approaches for drug deliveryQ36670473
Intensity modulating and other radiation therapy devices for dose paintingQ36756945
Particle shape: a new design parameter for micro- and nanoscale drug delivery carriersQ36838213
Gold nanoparticle imaging and radiotherapy of brain tumors in miceQ36853281
Management of prostate cancer recurrences after radiation therapy-brachytherapy as a salvage optionQ36904756
Patient selection, cancer control, and complications after salvage local therapy for postradiation prostate-specific antigen failure: a systematic review of the literatureQ36908600
Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotypeQ37162103
Multifunctional magnetic nanoparticles for targeted imaging and therapyQ37174947
Triple therapy for neovascular age-related macular degeneration using single-session photodynamic therapy combined with intravitreal bevacizumab and triamcinoloneQ37186846
Shape effects of filaments versus spherical particles in flow and drug deliveryQ37338776
Strategies for biologic image-guided dose escalation: a reviewQ37392536
Targeted gold nanoparticles enable molecular CT imaging of cancerQ37409530
Vascular disrupting agents: a novel mechanism of action in the battle against non-small cell lung cancerQ37497826
Gold-loaded polymeric micelles for computed tomography-guided radiation therapy treatment and radiosensitizationQ37532295
Antiangiogenic approaches to age-related macular degeneration todayQ37607658
Nanoparticles for improved therapeutics and imaging in cancer therapy.Q37771341
Intracellular uptake, transport, and processing of gold nanostructures.Q37798554
Strategies to improve radiotherapy with targeted drugsQ37856721
Biogenic gold nanoparticles: As a potential candidate for brain tumor directed drug deliveryQ38192664
Enhanced relative biological effectiveness of proton radiotherapy in tumor cells with internalized gold nanoparticlesQ38366112
Gold nanoparticle-aided brachytherapy with vascular dose painting: estimation of dose enhancement to the tumor endothelial cell nucleusQ38435105
Radiosensitizer-eluting nanocoatings on gold fiducials for biologicalin-situimage-guided radio therapy (BIS-IGRT)Q38442840
Biological in situ dose painting for image-guided radiation therapy using drug-loaded implantable devicesQ38448133
Drug-loaded gold plasmonic nanoparticles for treatment of multidrug resistance in cancer.Q39042860
Photoactivation of gold nanoparticles for glioma treatmentQ39156510
Enhanced proton treatment in mouse tumors through proton irradiated nanoradiator effects on metallic nanoparticlesQ39234538
Dependence of Monte Carlo microdosimetric computations on the simulation geometry of gold nanoparticles.Q39324477
Biogenic gold nanoparticles as fotillas to fire berberine hydrochloride using folic acid as molecular road map.Q39336184
Targeted gold nanoparticles enable molecular CT imaging of cancer: an in vivo studyQ39395788
The influence of size, shape and vessel geometry on nanoparticle distributionQ39428932
Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapyQ39684409
Preferential tumour accumulation of gold nanoparticles, visualised by Magnetic Resonance Imaging: radiosensitisation studies in vivo and in vitro.Q39687243
The pattern of prostate cancer local recurrence after radiation and salvage cryoablationQ39718325
Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatinQ39728421
Enhancement of cell radiation sensitivity by pegylated gold nanoparticles.Q39749727
Gold nanoparticle sensitize radiotherapy of prostate cancer cells by regulation of the cell cycleQ39808184
Mediating tumor targeting efficiency of nanoparticles through designQ39864411
Enhancement of radiation cytotoxicity in breast-cancer cells by localized attachment of gold nanoparticlesQ39949337
Importance of the liposomal cationic lipid content and type in tumor vascular targeting: physicochemical characterization and in vitro studies using human primary and transformed endothelial cellsQ39956311
Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy.Q39975675
Parameters governing gold nanoparticle X-ray radiosensitization of DNA in solutionQ39982631
Imaging epidermal growth factor receptor expression in vivo: pharmacokinetic and biodistribution characterization of a bioconjugated quantum dot nanoprobeQ40017269
Gold nanoparticles of diameter 1.4 nm trigger necrosis by oxidative stress and mitochondrial damage.Q45916200
Bioaccumulation and toxicity of gold nanoparticles after repeated administration in miceQ46535897
Gold nanoparticles: a new X-ray contrast agentQ46960636
Size-dependent radiosensitization of PEG-coated gold nanoparticles for cancer radiation therapy.Q47304949
Implications on clinical scenario of gold nanoparticle radiosensitization in regards to photon energy, nanoparticle size, concentration and locationQ47367623
Assessing the effect of surface chemistry on gold nanorod uptake, toxicity, and gene expression in mammalian cellsQ48025543
Dosimetric consequences of intrafraction prostate motionQ48891096
Influence of intrafraction motion on margins for prostate radiotherapyQ48936951
Effects of the vascular disrupting agent ZD6126 on interstitial fluid pressure and cell survival in tumorsQ50116234
Fabrication and characterization of controlled release poly(D,L-lactide-co-glycolide) millirods.Q50506105
Stereotactic low-voltage x-ray irradiation for age-related macular degeneration.Q50695186
The calculation of dose enhancement close to platinum implants for skull radiography.Q50915263
The adhesive strength of non-spherical particles mediated by specific interactions.Q51174053
Localized dose enhancement to tumor blood vessel endothelial cells via megavoltage X-rays and targeted gold nanoparticles: new potential for external beam radiotherapy.Q51624320
Potential improvements in the therapeutic ratio of prostate cancer irradiation: dose escalation of pathologically identified tumour nodules using intensity modulated radiotherapy.Q52044715
Gold nanoparticle enhancement of stereotactic radiosurgery for neovascular age-related macular degeneration.Q53140889
Stereotactic radiosurgery for AMD: a Monte Carlo-based assessment of patient-specific tissue doses.Q53260326
Long-term results of conformal radiotherapy for prostate cancer: impact of dose escalation on biochemical tumor control and distant metastases-free survival outcomes.Q53549211
Sphingosine-1-phosphate protects proliferating endothelial cells from ceramide-induced apoptosis but not from DNA damage-induced mitotic death.Q53570400
Treatment failure after primary and salvage therapy for prostate cancer: likelihood, patterns of care, and outcomes.Q54290701
Radiation oncology: a century of achievements.Q55038981
Monte Carlo simulation of microbeam radiation therapy with an interlaced irradiation geometry and an Au contrast agent in a realistic head phantomQ56933336
Gold Nanoparticles as Radiation Sensitizers in Cancer TherapyQ59382376
Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degenerationQ61865891
Irradiation of gold nanoparticles by x-rays: Monte Carlo simulation of dose enhancements and the spatial properties of the secondary electrons productionQ61902152
Radiosensitization of DNA by gold nanoparticles irradiated with high-energy electronsQ64387707
The presence of a concomitant bulky tumor can decrease the uptake and therapeutic efficacy of radiolabeled antibodies in small tumorsQ68135095
Inhomogeneous deposition of radiopharmaceuticals at the cellular level: experimental evidence and dosimetric implicationsQ68884404
Vascular Endothelium as the Vulnerable Element in TumoursQ72749467
Gold microspheres: a selective technique for producing biologically effective dose enhancementQ73139073
Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticlesQ73344148
Tumor response to radiotherapy regulated by endothelial cell apoptosisQ73401346
It is not time to abandon radiotherapy for neovascular age-related macular degenerationQ73437491
Role of extracellular matrix assembly in interstitial transport in solid tumorsQ73793048
Prostate cancer radiotherapy dose response: an update of the fox chase experienceQ75435977
Locally advanced prostatic cancer: long-term toxicity outcome after three-dimensional conformal radiation therapy--a dose-escalation studyQ77401846
Increased apoptotic potential and dose-enhancing effect of gold nanoparticles in combination with single-dose clinical electron beams on tumor-bearing miceQ81078170
Characterization of the theorectical radiation dose enhancement from nanoparticlesQ81314428
Long-term outcome and toxicity of salvage brachytherapy for local failure after initial radiotherapy for prostate cancerQ82814129
Promise of new vascular-disrupting agents balanced with cardiac toxicity: is it time for oncologists to get to know their cardiologists?Q83019266
Significant reduction of normal tissue dose by proton radiotherapy compared with three-dimensional conformal or intensity-modulated radiation therapy in Stage I or Stage III non-small-cell lung cancerQ83304061
Generation of reactive oxygen species induced by gold nanoparticles under x-ray and UV IrradiationsQ83443712
Quantifying tumor-selective radiation dose enhancements using gold nanoparticles: a monte carlo simulation studyQ83693929
A Monte Carlo study on tissue dose enhancement in brachytherapy: a comparison between gadolinium and gold nanoparticlesQ84381453
Contrast-enhanced radiotherapy: feasibility and characteristics of the physical absorbed dose distribution for deep-seated tumorsQ84452155
Beam energy considerations for gold nano-particle enhanced radiation treatmentQ84611761
An x-ray fluorescence imaging system for gold nanoparticle detectionQ86564184
P433issue7
P921main subjectadaptive radiation therapyQ180507
nanoparticleQ61231
P304page(s)1063-1082
P577publication date2014-05-01
P1433published inNanomedicineQ15817508
P1476titleTargeted radiotherapy with gold nanoparticles: current status and future perspectives
P478volume9

Reverse relations

cites work (P2860)
Q50922065A Monte Carlo study of I-125 prostate brachytherapy with gold nanoparticles: dose enhancement with simultaneous rectal dose sparing via radiation shielding.
Q35686257A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy
Q38406535A Software App for Radiotherapy with In-situ Dose-painting using high Z nanoparticles
Q38837229AGuIX nanoparticles as a promising platform for image-guided radiation therapy
Q92136656Anti-cancer effects of chemotherapeutic agent; 17-AAG, in combined with gold nanoparticles and irradiation in human colorectal cancer cells
Q58231809Bulbous gold–carbon nanodot hybrid nanoclusters for cancer therapy
Q38742241Cellular Uptake of Gold Nanoparticles and Their Behavior as Labels for Localization Microscopy.
Q64275109Challenges and Contradictions of Metal Nano-Particle Applications for Radio-Sensitivity Enhancement in Cancer Therapy
Q39191184Challenges and Prospects for Providing Radiation Oncology Services in Africa
Q92444845Delivery of Nanoparticle-Based Radiosensitizers for Radiotherapy Applications
Q57492232Determination of dose enhancement caused by AuNPs with Xoft Axxent Electronic (eBx™) and conventional brachytherapy: in vitro study
Q48218239Dose enhancement effects of gold nanoparticles specifically targeting RNA in breast cancer cells
Q92864492Dosimetry and Radioenhancement Comparison of Gold Nanoparticles in Kilovoltage and Megavoltage Radiotherapy using MAGAT Polymer Gel Dosimeter
Q39393466Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy.
Q89005900Energy optimization in gold nanoparticle enhanced radiation therapy
Q38727923Enhancing radiotherapy for lung cancer using immunoadjuvants delivered in situ from new design radiotherapy biomaterials: a preclinical study.
Q50524925Evaluation of spectral photon counting computed tomography K-edge imaging for determination of gold nanoparticle biodistribution in vivo.
Q64251956Femtosecond Spectroscopy of Au Hot-Electron Injection into TiO₂: Evidence for Au/TiO₂ Plasmon Photocatalysis by Bactericidal Au Ions and Related Phenomena
Q33602008Functional Gene Analysis Reveals Cell Cycle Changes and Inflammation in Endothelial Cells Irradiated with a Single X-ray Dose
Q59128247Gold Nanoparticle Mediated Phototherapy for Cancer
Q41475959Gold nanoparticles enhance anti-tumor effect of radiotherapy to hypoxic tumor.
Q90002752In vivo evaluation of safety, biodistribution and pharmacokinetics of laser-synthesized gold nanoparticles
Q36803774Kilovoltage radiosurgery with gold nanoparticles for neovascular age-related macular degeneration (AMD): a Monte Carlo evaluation.
Q51031719Low-Dose Prostate Cancer Brachytherapy with Radioactive Palladium-Gold Nanoparticles.
Q53113375Multiphoton Microscopy of Nonfluorescent Nanoparticles In Vitro and In Vivo.
Q42156032Nanoparticle Drones to Target Lung Cancer with Radiosensitizers and Cannabinoids
Q38831572Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy
Q42212265Nanoparticle-aided external beam radiotherapy leveraging the Čerenkov effect.
Q38661115Nanoscale radiation transport and clinical beam modeling for gold nanoparticle dose enhanced radiotherapy (GNPT) using X-rays
Q55346844Octaarginine-modified gold nanoparticles enhance the radiosensitivity of human colorectal cancer cell line LS180 to megavoltage radiation.
Q89818181Optimizing a Novel Au-Grafted Lipid Nanoparticle Through Chelation Chemistry for High Photothermal Biologic Activity
Q36003550Photo-thermal effect enhances the efficiency of radiotherapy using Arg-Gly-Asp peptides-conjugated gold nanorods that target αvβ3 in melanoma cancer cells
Q37098720Potential for enhancing external beam radiotherapy for lung cancer using high-Z nanoparticles administered via inhalation
Q37108646Potential of using cerium oxide nanoparticles for protecting healthy tissue during accelerated partial breast irradiation (APBI).
Q92906894Radiation as an In Situ Auto-Vaccination: Current Perspectives and Challenges
Q47714803Signal enhancement due to high-Z nanofilm electrodes in parallel plate ionization chambers with variable microgaps
Q39105322Smart Radiation Therapy Biomaterials
Q90254050Systemic immune effects boost radiotherapy
Q37097954Targeted radiotherapy enhancement during electronic brachytherapy of accelerated partial breast irradiation (APBI) using controlled release of gold nanoparticles
Q28610710Technology for Innovation in Radiation Oncology
Q89550903TiO2 Nanomaterials Non-Controlled Contamination Could Be Hazardous for Normal Cells Located in the Field of Radiotherapy
Q38759409Titanium peroxide nanoparticles enhanced cytotoxic effects of X-ray irradiation against pancreatic cancer model through reactive oxygen species generation in vitro and in vivo.
Q49958115Using immunotherapy to boost the abscopal effect

Search more.