Mucus layers in inflammatory bowel disease

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Mucus layers in inflammatory bowel disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1097/MIB.0000000000000117
P698PubMed publication ID25025717

P2093author name stringMalin E V Johansson
P2860cites workGenomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteinsQ22008050
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel diseaseQ22252318
Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in miceQ24295254
Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp proteinQ24309654
The protein disulfide isomerase AGR2 is essential for production of intestinal mucusQ24314611
Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitisQ24537963
Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestineQ24609125
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Stem cells, self-renewal, and differentiation in the intestinal epitheliumQ28294807
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitisQ28472412
Autophagy proteins control goblet cell function by potentiating reactive oxygen species productionQ28507855
Colorectal cancer in mice genetically deficient in the mucin Muc2Q28588769
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteriaQ28594441
Unravelling the pathogenesis of inflammatory bowel diseaseQ29547551
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cellsQ29614565
Inflammatory bowel diseaseQ29616286
Glycan foraging in vivo by an intestine-adapted bacterial symbiontQ29617848
Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protectionQ29618129
Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype.Q30522343
Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patchesQ30544011
The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment.Q30861929
Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel diseaseQ33300519
Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosaQ33582232
Sulfation of colonic mucins by N-acetylglucosamine 6-O-sulfotransferase-2 and its protective function in experimental colitis in miceQ33673855
IFN-γ-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia.Q33702103
Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation.Q33811085
Immune adaptations that maintain homeostasis with the intestinal microbiotaQ34100501
The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestineQ34224134
The gastrointestinal mucus system in health and diseaseQ34332180
Fast renewal of the distal colonic mucus layers by the surface goblet cells as measured by in vivo labeling of mucin glycoproteinsQ34345531
Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distributionQ34801672
Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient miceQ35026610
Sulphation and secretion of the predominant secretory human colonic mucin MUC2 in ulcerative colitisQ35354507
Importance and regulation of the colonic mucus barrier in a mouse model of colitisQ35825870
Calcium and pH-dependent packing and release of the gel-forming MUC2 mucinQ35889379
Immune-mediated alteration in gut physiology and its role in host defence in nematode infectionQ36023644
Gel-forming mucins appeared early in metazoan evolution.Q36092589
Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycansQ36229430
Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection.Q36303831
Negative feedback by IRE1β optimizes mucin production in goblet cellsQ36637632
Colonic gene expression profile in NHE3-deficient mice: evidence for spontaneous distal colitis.Q36807774
Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB).Q36850408
Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitisQ37086842
IL-10R polymorphisms are associated with very-early-onset ulcerative colitisQ37096891
Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteinsQ37142603
Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammationQ37234762
Inflammatory bowel disease and mutations affecting the interleukin-10 receptorQ37454505
Inflammatory bowel disease: pathogenesisQ37454586
RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tractQ37535131
ER stress and the unfolded protein response in intestinal inflammation.Q37719188
Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signalsQ37734574
Inflamed gut mucosa: downstream of interleukin-10.Q37883443
Mucins in inflammatory bowel diseases and colorectal cancerQ37931346
Transepithelial antigen delivery in the small intestine: different paths, different outcomesQ38079085
Increased understanding of the biochemistry and biosynthesis of MUC2 and other gel-forming mucins through the recombinant expression of their protein domainsQ39202871
Unifying hypothesis for inflammatory bowel disease and associated colon cancer: sticking the pieces together with sugarQ40928931
Dimerization of the human MUC2 mucin in the endoplasmic reticulum is followed by a N-glycosylation-dependent transfer of the mono- and dimers to the Golgi apparatusQ41024598
NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expressionQ41917631
Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse.Q43595015
IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells.Q43796791
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibilityQ44808056
ZG16p, an animal homolog of β-prism fold plant lectins, interacts with heparan sulfate proteoglycans in pancreatic zymogen granulesQ44909903
A complex, but uniform O-glycosylation of the human MUC2 mucin from colonic biopsies analyzed by nanoLC/MSn.Q46074774
Ischaemia-induced mucus barrier loss and bacterial penetration are rapidly counteracted by increased goblet cell secretory activity in human and rat colonQ46393924
Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factorQ48059051
Viscosity gradient within the mucus layer determines the mucosal barrier function and the spatial organization of the intestinal microbiotaQ48693252
A solvent-based fixative for electron microscopy to improve retention and visualization of the intestinal mucus blanket for probiotics studies.Q50530170
Defective IL10 signaling defining a subgroup of patients with inflammatory bowel disease.Q54376104
P433issue11
P921main subjectinflammationQ101991
inflammatory bowel diseasesQ917447
P304page(s)2124-2131
P577publication date2014-11-01
P1433published inInflammatory Bowel DiseasesQ15749161
P1476titleMucus layers in inflammatory bowel disease
P478volume20

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