Efflux pump proteins in antifungal resistance

scientific article published on 29 August 2014

Efflux pump proteins in antifungal resistance is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3389/FPHAR.2014.00202
P932PMC publication ID4148622
P698PubMed publication ID25221515
P5875ResearchGate publication ID265649147

P2093author name stringRajendra Prasad
Manpreet K Rawal
P2860cites workA human-curated annotation of the Candida albicans genomeQ21145286
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The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivoQ27931225
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A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiportQ28266457
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A mutation in intracellular loop 4 affects the drug-efflux activity of the yeast multidrug resistance ABC transporter Pdr5pQ28478735
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Disruption studies of a Candida albicans gene, ELF1: a member of the ATP-binding cassette familyQ32032209
Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter.Q32133639
MFS transportome of the human pathogenic yeast Candida albicansQ33389525
The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transportQ33560121
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Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance geneQ33752151
Chemical specificity of the PDR5 multidrug resistance gene product of Saccharomyces cerevisiae based on studies with tri-n-alkyltin chloridesQ33978498
Divergent signature motifs of nucleotide binding domains of ABC multidrug transporter, CaCdr1p of pathogenic Candida albicans, are functionally asymmetric and noninterchangeableQ34049370
Steroid binding protein(s) in yeastsQ68944603
Ketoconazole binds to the intracellular corticosteroid-binding protein in Candida albicansQ70183351
Efflux-mediated resistance to fluconazole could be modulated by sterol homeostasis in Saccharomyces cerevisiaeQ74138000
Expression of CDR1, a multidrug resistance gene of Candida albicans: transcriptional activation by heat shock, drugs and human steroid hormonesQ74416153
Identification of polymorphic mutant alleles of CaMDR1, a major facilitator of Candida albicans which confers multidrug resistance, and its in vitro transcriptional activationQ77323771
Complete inventory of ABC proteins in human pathogenic yeast, Candida albicansQ81411882
Alanine scanning of all cysteines and construction of a functional cysteine-less Cdr1p, a multidrug ABC transporter of Candida albicansQ82937705
Chimeras of the ABC drug transporter Cdr1p reveal functional indispensability of transmembrane domains and nucleotide-binding domains, but transmembrane segment 12 is replaceable with the corresponding homologous region of the non-drug transporter CQ83170269
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicansQ84804979
The signaling interface of the yeast multidrug transporter Pdr5 adopts a cis conformation, and there are functional overlap and equivalence of the deviant and canonical Q-loop residuesQ34196332
Intragenic Suppressing Mutations Correct the Folding and Intracellular Traffic of Misfolded Mutants of Yor1p, a Eukaryotic Drug TransporterQ34298963
Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitorQ34334444
The ATP switch model for ABC transportersQ34353789
Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene.Q34417276
Drug resistance in yeasts--an emerging scenarioQ34695128
The central cytoplasmic loop of the major facilitator superfamily of transport proteins governs efficient membrane insertionQ35191643
Functional characterization of Candida albicans ABC transporter Cdr1p.Q35697281
Multidrug resistance in yeast CandidaQ35983675
Changing patterns and trends in systemic fungal infectionsQ36239992
The transmission interface of the Saccharomyces cerevisiae multidrug transporter Pdr5: Val-656 located in intracellular loop 2 plays a major role in drug resistance.Q36558351
Proton-dependent multidrug efflux systemsQ36672016
Conserved Asp327 of walker B motif in the N-terminal nucleotide binding domain (NBD-1) of Cdr1p of Candida albicans has acquired a new role in ATP hydrolysisQ36853224
Sorting signals within the Saccharomyces cerevisiae sporulation-specific dityrosine transporter, Dtr1p, C terminus promote Golgi-to-prospore membrane transportQ36939035
Mutations define cross-talk between the N-terminal nucleotide-binding domain and transmembrane helix-2 of the yeast multidrug transporter Pdr5: possible conservation of a signaling interface for coupling ATP hydrolysis to drug transportQ37000251
Efflux-mediated antifungal drug resistance.Q37156645
Current perspectives on echinocandin class drugsQ37554055
The multidrug transporter Pdr5: a molecular diode?Q37824859
Yeast ATP-binding cassette transporters conferring multidrug resistanceQ38019037
Purification and characterization of the N-terminal nucleotide binding domain of an ABC drug transporter of Candida albicans: uncommon cysteine 193 of Walker A is critical for ATP hydrolysisQ38350658
The TetA(K) tetracycline/H(+) antiporter from Staphylococcus aureus: mutagenesis and functional analysis of motif C.Q39499430
Functional role of the intracellular loop linking transmembrane domains 6 and 7 of the human dipeptide transporter hPEPT1Q39628283
The Candida albicans CDR3 gene codes for an opaque-phase ABC transporterQ39848020
Functionally Relevant Residues of Cdr1p: A Multidrug ABC Transporter of Human Pathogenic Candida albicansQ40720740
Specificity of drug transport mediated by CaMDR1: a major facilitator of Candida albicansQ40778850
Cytoplasmic domains of the reduced folate carrier are essential for trafficking, but not functionQ41881973
Mapping of interdomain interfaces required for the functional architecture of Yor1p, a eukaryotic ATP-binding cassette (ABC) transporterQ41917414
Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains.Q42563449
Structure and function analysis of CaMdr1p, a major facilitator superfamily antifungal efflux transporter protein of Candida albicans: identification of amino acid residues critical for drug/H+ transportQ42912738
A key structural domain of the Candida albicans Mdr1 protein.Q43551296
The large cytoplasmic loop of the glucose transporter GLUT1 is an essential structural element for functionQ43840163
ABC transporters Cdr1p, Cdr2p and Cdr3p of a human pathogen Candida albicans are general phospholipid translocatorsQ43900293
ABC multidrug transporter Cdr1p of Candida albicans has divergent nucleotide-binding domains which display functional asymmetryQ45069193
Functional characterization of N-terminal nucleotide binding domain (NBD-1) of a major ABC drug transporter Cdr1p of Candida albicans: uncommon but conserved Trp326 of Walker B is important for ATP binding.Q46454431
Alanine scanning of transmembrane helix 11 of Cdr1p ABC antifungal efflux pump of Candida albicans: identification of amino acid residues critical for drug efflux.Q46529075
A novel catalytic mechanism for ATP hydrolysis employed by the N-terminal nucleotide-binding domain of Cdr1p, a multidrug ABC transporter of Candida albicansQ46579767
Characterization of Cdr1p, a major multidrug efflux protein of Candida albicans: purified protein is amenable to intrinsic fluorescence analysis.Q46942247
A Ste6p/P-glycoprotein homologue from the asexual yeast Candida albicans transports the a-factor mating pheromone in Saccharomyces cerevisiaeQ48039893
Functional analysis of a vacuolar ABC transporter in wild-type Candida albicans reveals its involvement in virulenceQ48310913
Characterisation of human steroid hormone transport mediated by Cdr1p, a multidrug transporter of Candida albicans, belonging to the ATP binding cassette super family.Q52528972
Topology, structure and evolution of two families of proteins involved in antibiotic and antiseptic resistance in eukaryotes and prokaryotes--an analysis.Q54247541
P304page(s)202
P577publication date2014-08-29
P1433published inFrontiers in PharmacologyQ2681208
P1476titleEfflux pump proteins in antifungal resistance
P478volume5

Reverse relations

cites work (P2860)
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