| scholarly article | Q13442814 |
| review article | Q7318358 |
| P356 | DOI | 10.1002/EJI.201344428 |
| P698 | PubMed publication ID | 25251823 |
| P50 | author | Navin Kumar Verma | Q47982046 |
| P2093 | author name string | Dermot Kelleher | |
| P2860 | cites work | Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling | Q22254087 |
| Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation | Q24294733 | ||
| Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration | Q24295854 | ||
| Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes | Q24300891 | ||
| A new group of conserved coactivators that increase the specificity of AP-1 transcription factors | Q24310680 | ||
| Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation | Q24313377 | ||
| Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation | Q24313629 | ||
| A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits | Q24322085 | ||
| Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation | Q24522552 | ||
| Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase | Q24530620 | ||
| SH3P7 is a cytoskeleton adapter protein and is coupled to signal transduction from lymphocyte antigen receptors | Q24530648 | ||
| An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R | Q24646010 | ||
| The PH domain and the polybasic c domain of cytohesin-1 cooperate specifically in plasma membrane association and cellular function | Q24647179 | ||
| Cytohesin-1 regulates beta-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1 | Q24685452 | ||
| p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils | Q27308144 | ||
| Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule | Q28115147 | ||
| Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1 | Q28138425 | ||
| JAB1 interacts with both the progesterone receptor and SRC-1 | Q28139007 | ||
| Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1 | Q28139243 | ||
| Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity | Q28141877 | ||
| Association of immature hypophosphorylated protein kinase cepsilon with an anchoring protein CG-NAP | Q28143906 | ||
| Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus | Q28198531 | ||
| Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton | Q28202663 | ||
| Actin cytoskeletal association of cytohesin-1 is regulated by specific phosphorylation of its carboxyl-terminal polybasic domain | Q28204714 | ||
| Jab1 interacts directly with HIF-1alpha and regulates its stability | Q28205085 | ||
| Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells | Q28207240 | ||
| Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling | Q28208944 | ||
| DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines | Q28209633 | ||
| Of mice and not men: differences between mouse and human immunology | Q28246229 | ||
| LFA-1 as a key regulator of immune function: approaches toward the development of LFA-1-based therapeutics | Q28258646 | ||
| Integrins take partners: cross-talk between integrins and other membrane receptors | Q28286693 | ||
| Cytohesin-1 is a dynamic regulator of distinct LFA-1 functions in leukocyte arrest and transmigration triggered by chemokines | Q43826432 | ||
| Progressive multifocal leukoencephalopathy associated with efalizumab use in psoriasis patients | Q44264602 | ||
| Membrane cholesterol regulates LFA-1 function and lipid raft heterogeneity | Q44361995 | ||
| Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2. | Q44470191 | ||
| Lymphocyte function-associated antigen-1-mediated T cell adhesion is impaired by low molecular weight phosphotyrosine phosphatase-dependent inhibition of FAK activity | Q44483366 | ||
| Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1. | Q44607809 | ||
| Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX. | Q44840871 | ||
| A role of STAT3 in Rho GTPase-regulated cell migration and proliferation | Q45261051 | ||
| Distinct roles of talin and kindlin in regulating integrin α5β1 function and trafficking. | Q45928438 | ||
| The integrin coactivator Kindlin-3 is not required for lymphocyte diapedesis | Q47692376 | ||
| Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of development. | Q48750414 | ||
| Talin at a glance. | Q50335781 | ||
| Endothelial adapter proteins in leukocyte transmigration. | Q51732048 | ||
| Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells. | Q51734747 | ||
| Analysis of dynamic tyrosine phosphoproteome in LFA-1 triggered migrating T-cells. | Q54643161 | ||
| Elucidation of the integrin LFA-1-mediated signaling pathway of actin polarization in natural killer cells. | Q54674163 | ||
| Src homology 2-domain containing leukocyte-specific phosphoprotein of 76 kDa is mandatory for TCR-mediated inside-out signaling, but dispensable for CXCR4-mediated LFA-1 activation, adhesion, and migration of T cells. | Q54716456 | ||
| Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor | Q57185397 | ||
| The Integrins α3β1and α6β1 Physically and Functionally Associate with CD36 in Human Melanoma Cells | Q57371907 | ||
| 14-3-3 Proteins Bind Both Filamin and Lbeta2 Integrin in Activated T Cells | Q58199167 | ||
| The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes | Q61053444 | ||
| The STAT3-Binding Long Noncoding RNA lnc-DC Controls Human Dendritic Cell Differentiation | Q61645724 | ||
| Leukocyte function-associated antigen 1 (LFA-1) and CD44 are signalling molecules for cytoskeleton-dependent morphological changes in activated T cells | Q71831053 | ||
| LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment | Q73508884 | ||
| Neutrophil-induced changes in the biomechanical properties of endothelial cells: roles of ICAM-1 and reactive oxygen species | Q73869204 | ||
| A novel targeted T-cell modulator, efalizumab, for plaque psoriasis | Q79308555 | ||
| Talin1 regulates TCR-mediated LFA-1 function | Q79370181 | ||
| Efalizumab | Q80235396 | ||
| LFA-1 (CD11a) as a therapeutic target | Q82357911 | ||
| L-plastin regulates polarization and migration in chemokine-stimulated human T lymphocytes | Q84121464 | ||
| Therapy: Targeted but not trouble-free: efalizumab and PML | Q84335968 | ||
| Cofilin: a redox sensitive mediator of actin dynamics during T-cell activation and migration | Q38151845 | ||
| Imaging early signaling events in T lymphocytes with fluorescent biosensors | Q38156116 | ||
| PAG--a multipurpose transmembrane adaptor protein. | Q38161403 | ||
| The interaction of activated integrin lymphocyte function-associated antigen 1 with ligand intercellular adhesion molecule 1 induces activation and redistribution of focal adhesion kinase and proline-rich tyrosine kinase 2 in T lymphocytes. | Q38611804 | ||
| The kindlin 3 pleckstrin homology domain has an essential role in lymphocyte function-associated antigen 1 (LFA-1) integrin-mediated B cell adhesion and migration | Q39164311 | ||
| Nanobody-induced perturbation of LFA-1/L-plastin phosphorylation impairs MTOC docking, immune synapse formation and T cell activation | Q39273543 | ||
| Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-C kinase 1 (RACK1). | Q39396524 | ||
| Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion | Q39567890 | ||
| STAT3-stathmin interactions control microtubule dynamics in migrating T-cells | Q39878474 | ||
| WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse. | Q40115442 | ||
| Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2. | Q40290179 | ||
| The scaffolding protein CG-NAP/AKAP450 is a critical integrating component of the LFA-1-induced signaling complex in migratory T cells | Q40341610 | ||
| Crucial importance of PKC-beta(I) in LFA-1-mediated locomotion of activated T cells. | Q40803098 | ||
| Functional complementation of BLNK by SLP-76 and LAT linker proteins | Q40863036 | ||
| Divalent cation regulation of the function of the leukocyte integrin LFA-1 | Q41650080 | ||
| Leukocyte function-associated antigen 1 (LFA-1) is a signaling molecule for cytoskeletal changes in a human T cell line | Q41719053 | ||
| Measuring the proximity of T-lymphocyte CXCR4 and TCR by fluorescence resonance energy transfer (FRET). | Q42240154 | ||
| A Pak- and Pix-dependent branch of the SDF-1alpha signalling pathway mediates T cell chemotaxis across restrictive barriers | Q42407859 | ||
| Signaling through the leukocyte integrin LFA-1 in T cells induces a transient activation of Rac-1 that is regulated by Vav and PI3K/Akt-1. | Q42457125 | ||
| ICAM-1 cross-linking stimulates endothelial glutathione synthesis. | Q42504387 | ||
| The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation | Q42698606 | ||
| The hepatitis C envelope 2 protein inhibits LFA-1-transduced protein kinase C signaling for T-lymphocyte migration | Q42998181 | ||
| Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins | Q43590665 | ||
| Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation | Q43619602 | ||
| Rho and Rho-associated kinase modulate the tyrosine kinase PYK2 in T-cells through regulation of the activity of the integrin LFA-1. | Q43698972 | ||
| Coupling of the TCR to integrin activation by Slap-130/Fyb. | Q43744923 | ||
| Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes | Q43793517 | ||
| A novel leukocyte adhesion deficiency III variant: kindlin-3 deficiency results in integrin- and nonintegrin-related defects in different steps of leukocyte adhesion | Q28307986 | ||
| The adaptor protein EBP50 is important for localization of the protein kinase A-Ezrin complex in T-cells and the immunomodulating effect of cAMP | Q28505451 | ||
| Kindlin-2 controls bidirectional signaling of integrins | Q28507652 | ||
| Integrin leukocyte function-associated antigen-1-mediated cell binding can be activated by clustering of membrane rafts | Q28509937 | ||
| ADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugation | Q28771478 | ||
| Stretching single talin rod molecules activates vinculin binding | Q29617762 | ||
| Crk family adaptors-signalling complex formation and biological roles | Q30167857 | ||
| p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells | Q30176832 | ||
| Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell | Q30480879 | ||
| SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility | Q30488841 | ||
| The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells | Q30490766 | ||
| Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation | Q30514206 | ||
| Phosphorylation of Rab5a protein by protein kinase Cϵ is crucial for T-cell migration. | Q30583489 | ||
| Role of STAT3 in cancer metastasis and translational advances | Q31142794 | ||
| Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts | Q31672539 | ||
| RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1. | Q33292490 | ||
| T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells | Q33543765 | ||
| T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade | Q33785785 | ||
| Roles of STAT3 defined by tissue-specific gene targeting | Q33941404 | ||
| The centrosome in vertebrates: more than a microtubule-organizing center | Q33954846 | ||
| Talins and kindlins: partners in integrin-mediated adhesion. | Q33978054 | ||
| The final steps of integrin activation: the end game | Q34106011 | ||
| Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency III patient reveal distinct effects on leukocyte function in vitro | Q34107741 | ||
| Dynamic partitioning into lipid rafts controls the endo-exocytic cycle of the alphaL/beta2 integrin, LFA-1, during leukocyte chemotaxis | Q34148232 | ||
| Kindlin-3 is required for the stabilization of TCR-stimulated LFA-1:ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells. | Q34181908 | ||
| JAB1/CSN5: a new player in cell cycle control and cancer | Q34292695 | ||
| COP9 signalosome component JAB1/CSN5 is necessary for T cell signaling through LFA-1 and HIV-1 replication | Q34388158 | ||
| Vav proteins, adaptors and cell signaling. | Q34405552 | ||
| Adapter protein NRBP associates with Jab1 and negatively regulates AP-1 activity | Q34575365 | ||
| What does Stat3 do? | Q34627068 | ||
| Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase. | Q34659377 | ||
| Biochemical and structural properties of the integrin-associated cytoskeletal protein talin | Q34979246 | ||
| Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions | Q34992989 | ||
| Targeting ICAM-1/LFA-1 interaction for controlling autoimmune diseases: designing peptide and small molecule inhibitors | Q35121998 | ||
| T-cell integrins: more than just sticking points | Q35576652 | ||
| Contact-dependent T cell activation and T cell stopping require talin1 | Q35612842 | ||
| The nuclear pore complex: a jack of all trades? | Q35744893 | ||
| Adaptors and linkers in T and B cells | Q35768882 | ||
| The role of adaptor proteins in lymphocyte activation | Q35818851 | ||
| Transmembrane adaptor proteins: organizers of immunoreceptor signalling | Q35852278 | ||
| The genetics of Pak. | Q35872596 | ||
| Paxillin: adapting to change | Q35895201 | ||
| Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling | Q36137526 | ||
| T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2 | Q36228047 | ||
| A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes. | Q36320696 | ||
| The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2. | Q36322824 | ||
| ILK, PINCH and parvin: the tIPP of integrin signalling | Q36403372 | ||
| Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins | Q36508910 | ||
| Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells | Q36714858 | ||
| Regulation of T-cell activation by the cytoskeleton | Q36720943 | ||
| Integrin regulation of lymphocyte trafficking: lessons from structural and signaling studies | Q36769474 | ||
| The role of the integrin LFA-1 in T-lymphocyte migration | Q36877329 | ||
| Leukocyte function antigen-1, kindlin-3, and calcium flux orchestrate neutrophil recruitment during inflammation | Q37045308 | ||
| A new twist to adaptor proteins contributes to regulation of lymphocyte cell signaling | Q37206781 | ||
| Integrins in immunity | Q37360858 | ||
| Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics | Q37368752 | ||
| The ins and outs of leukocyte integrin signaling | Q37419383 | ||
| AKAP signaling complexes: pointing towards the next generation of therapeutic targets? | Q37427846 | ||
| The tail of integrins, talin, and kindlins | Q37483142 | ||
| The mechanism of kindlin-mediated activation of integrin αIIbβ3. | Q37552184 | ||
| Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project | Q37568787 | ||
| Mediation of T-cell activation by actin meshworks | Q37779419 | ||
| The insider's guide to leukocyte integrin signalling and function | Q37877543 | ||
| T cell receptor signalling networks: branched, diversified and bounded | Q38092568 | ||
| Defects of leukocyte migration in primary immunodeficiencies | Q38102968 | ||
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | immunotherapy | Q1427096 |
| P304 | page(s) | 3484-3499 | |
| P577 | publication date | 2014-10-30 | |
| P1433 | published in | European Journal of Immunology | Q5412727 |
| P1476 | title | Adaptor regulation of LFA-1 signaling in T lymphocyte migration: Potential druggable targets for immunotherapies? | |
| P478 | volume | 44 |
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| Q64940056 | Crk adaptor proteins mediate actin-dependent T cell migration and mechanosensing induced by the integrin LFA-1. |
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