Spinal cord injury and the neuron-intrinsic regeneration-associated gene program

scientific article published on October 2014

Spinal cord injury and the neuron-intrinsic regeneration-associated gene program is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1032364636
P356DOI10.1007/S12017-014-8329-3
P698PubMed publication ID25269879

P2093author name stringJoost Verhaagen
Jessica van Heest
Nitish D Fagoe
P2860cites workActions of neuropoietic cytokines and cyclic AMP in regenerative conditioning of rat primary sensory neuronsQ79368223
Combining an autologous peripheral nervous system "bridge" and matrix modification by chondroitinase allows robust, functional regeneration beyond a hemisection lesion of the adult rat spinal cordQ79892954
Activated CREB is sufficient to overcome inhibitors in myelin and promote spinal axon regeneration in vivoQ80996402
AAV vectors, insertional mutagenesis, and cancerQ81326066
Chondroitinase ABCI improves locomotion and bladder function following contusion injury of the rat spinal cordQ81411427
Chondroitinase ABC combined with neural stem/progenitor cell transplantation enhances graft cell migration and outgrowth of growth-associated protein-43-positive fibers after rat spinal cord injuryQ82036824
Chondroitinase ABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injuryQ83177422
Spinal cord injury facts and figures at a glanceQ86188869
Identification of the Nogo inhibitor of axon regeneration as a Reticulon proteinQ22253157
Steroids for acute spinal cord injuryQ24203854
Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathwaysQ24310693
PTEN deletion enhances the regenerative ability of adult corticospinal neuronsQ24625004
Identification of MoKA, a novel F-box protein that modulates Krüppel-like transcription factor 7 activityQ24629579
Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathwayQ24644113
Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injuryQ24794310
Dorsal horn-enriched genes identified by DNA microarray, in situ hybridization and immunohistochemistryQ24803220
Intrathecal long-term gene expression by self-complementary adeno-associated virus type 1 suitable for chronic pain studies in ratsQ25256466
HDAC signaling in neuronal development and axon regenerationQ27013969
Spinal cord injury: a review of current therapy, future treatments, and basic science frontiersQ27025166
The health and life priorities of individuals with spinal cord injury: a systematic reviewQ27026471
EphA4 blockers promote axonal regeneration and functional recovery following spinal cord injury in miceQ27320846
Cortical overexpression of neuronal calcium sensor-1 induces functional plasticity in spinal cord following unilateral pyramidal tract injury in ratQ27324189
Adenoviral and adeno-associated viral transfer of genes to the peripheral nervous systemQ28141743
Inhibitor of neurite outgrowth in humansQ28144415
Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1Q28144424
Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowthQ28204972
Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowthQ28211919
Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cordQ28305646
AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trialQ28307713
Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activationQ28566756
Disease gene candidates revealed by expression profiling of retinal ganglion cell developmentQ28576722
Identification of candidate transcriptional modulators involved in successful regeneration after nerve injuryQ28577382
Alpha9 integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon regenerationQ28581565
Regeneration-enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cordQ28584025
Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient miceQ28592877
The AP-1 transcription factor c-Jun is required for efficient axonal regenerationQ28594782
Chondroitinase ABC promotes functional recovery after spinal cord injuryQ29615017
Subcellular knockout of importin β1 perturbs axonal retrograde signalingQ30523785
Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain.Q31076606
Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectorsQ31148881
Gene profiling during development and after a peripheral nerve traumatism reveals genes specifically induced by injury in dorsal root gangliaQ33246545
Designer gene delivery vectors: molecular engineering and evolution of adeno-associated viral vectors for enhanced gene transferQ33296224
Anti-Nogo-A antibody treatment promotes recovery of manual dexterity after unilateral cervical lesion in adult primates--re-examination and extension of behavioral dataQ33418736
Molecular evolution of adeno-associated virus for enhanced glial gene deliveryQ33492733
Functional axonal regeneration through astrocytic scar genetically modified to digest chondroitin sulfate proteoglycansQ33767291
Comparison of AAV serotypes for gene delivery to dorsal root ganglion neuronsQ33822237
The zinc finger transcription factor Klf7 is required for TrkA gene expression and development of nociceptive sensory neuronsQ33841773
Ephrin-B3 is a myelin-based inhibitor of neurite outgrowthQ33897550
KLF family members regulate intrinsic axon regeneration ability.Q33899036
Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth.Q34114631
A pericyte origin of spinal cord scar tissueQ34198591
Chondroitinase and growth factors enhance activation and oligodendrocyte differentiation of endogenous neural precursor cells after spinal cord injuryQ34282030
Combined genetic attenuation of myelin and semaphorin-mediated growth inhibition is insufficient to promote serotonergic axon regenerationQ34282446
Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.Q34397099
Spinal-cord injuryQ34530651
A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cordQ34572480
Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trialQ34640765
ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regenerationQ34655825
Nontraumatic spinal cord injury: demographic characteristics and complicationsQ34721068
In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regenerationQ34794726
Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons.Q34977773
Hypothermic treatment for acute spinal cord injuryQ35006466
The tumor suppressor protein p53 is required for neurite outgrowth and axon regenerationQ35017906
Restoring function after spinal cord injuryQ35152019
Targeted disruption of the galanin gene reduces the number of sensory neurons and their regenerative capacityQ35320080
Multiple transcription factor families regulate axon growth and regenerationQ35539750
The transcription factor Sox11 promotes nerve regeneration through activation of the regeneration-associated gene Sprr1aQ35713028
Epigenetic regulation of axon and dendrite growthQ35791723
Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tractQ35982930
HDAC5 is a novel injury-regulated tubulin deacetylase controlling axon regenerationQ36103678
Molecular mechanisms in successful peripheral regenerationQ36155947
Regeneration of CNS axons back to their target following treatment of adult rat brain with chondroitinase ABC.Q38524950
Axonal growth-associated proteinsQ38613255
Chondroitinase ABC improves basic and skilled locomotion in spinal cord injured catsQ39225628
A gene network perspective on axonal regenerationQ39304438
A largely random AAV integration profile after LPLD gene therapyQ39401822
NFIL3 and cAMP response element-binding protein form a transcriptional feedforward loop that controls neuronal regeneration-associated gene expressionQ39763789
Sustained axon regeneration induced by co-deletion of PTEN and SOCS3Q39864495
Sox11 transcription factor modulates peripheral nerve regeneration in adult miceQ39897284
Glucocorticoid mechanisms in acute spinal cord injury: a review and therapeutic rationaleQ40348011
Signaling to transcription networks in the neuronal retrograde injury response.Q40449535
Injury-induced class 3 semaphorin expression in the rat spinal cordQ40640541
Factors affecting functional outcome in patients with nontraumatic spinal cord lesions after inpatient rehabilitation.Q40664199
Viral vectors, tools for gene transfer in the nervous systemQ40852313
Neuronal-specific and nerve growth factor-inducible expression directed by the preprotachykinin-A promoter delivered by an adeno-associated virus vectorQ40915172
SRY-box containing gene 11 (Sox11) transcription factor is required for neuron survival and neurite growth.Q41077931
Response of facial and rubrospinal neurons to axotomy: changes in mRNA expression for cytoskeletal proteins and GAP-43.Q41152749
Transcriptional profiling of intrinsic PNS factors in the postnatal mouse.Q41215506
High content screening of cortical neurons identifies novel regulators of axon growthQ41327476
Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal systemQ41340219
Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growthQ41440802
Correlation of axonal regeneration and slow component B in two branches of a single axonQ41542388
Experimental and clinical studies of the pathophysiology and management of acute spinal cord injuryQ41544726
Post-injury myelin-breakdown products inhibit axonal growth: an hypothesis to explain the failure of axonal regeneration in the mammalian central nervous systemQ41626271
Axotomy-induced Smad1 activation promotes axonal growth in adult sensory neurons.Q41767032
Ca2+, CREB and krüppel: a novel KLF7-binding element conserved in mouse and human TRKB promoters is required for CREB-dependent transcriptionQ41939307
Assessing spinal axon regeneration and sprouting in Nogo-, MAG-, and OMgp-deficient miceQ41970450
Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury.Q42140143
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brainQ42280576
Adenovirus-mediated gene therapy with sitimagene ceradenovec followed by intravenous ganciclovir for patients with operable high-grade glioma (ASPECT): a randomised, open-label, phase 3 trialQ42284125
Directed expression of the growth-associated protein B-50/GAP-43 to olfactory neurons in transgenic mice results in changes in axon morphology and extraglomerular fiber growthQ42516591
Axonal transcription factors signal retrogradely in lesioned peripheral nerveQ42554579
SOCS3 deletion promotes optic nerve regeneration in vivo.Q42949909
Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation.Q43294891
Comparison of deferoxamine and methylprednisolone: protective effect of pharmacological agents on lipid peroxidation in spinal cord injury in rats.Q43731542
An oligodendrocyte lineage-specific semaphorin, Sema5A, inhibits axon growth by retinal ganglion cells.Q43899178
Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cellsQ44019938
Adeno-associated virus and lentivirus vectors mediate efficient and sustained transduction of cultured mouse and human dorsal root ganglia sensory neurons.Q44073196
Generation of aberrant sprouting in the adult rat brain by GAP-43 somatic gene transferQ44235491
Efficiencies of transgene expression in nociceptive neurons through different routes of delivery of adeno-associated viral vectorsQ44492885
Corticospinal neurons up-regulate a range of growth-associated genes following intracortical, but not spinal, axotomyQ44553310
Novel changes in gene expression following axotomy of a sympathetic ganglion: a microarray analysisQ44845519
Lentiviral and adeno-associated vector-based therapy for motor neuron disease through RNAiQ44987905
Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous systemQ45007196
Negative impact of rAAV2 mediated expression of SOCS3 on the regeneration of adult retinal ganglion cell axonsQ45088606
Systemic hypothermia in acute cervical spinal cord injury: a case-controlled studyQ45401044
Cellular and molecular correlates of the regeneration of adult mammalian CNS axons into peripheral nerve graftsQ45856145
AAV vector integration sites in mouse hepatocellular carcinoma.Q45869780
Duration of lipid peroxidation after acute spinal cord injury in rats and the effect of methylprednisoloneQ46267446
Early changes in gene expression in the dorsal root ganglia after transection of the sciatic nerve; effects of amphiregulin and PAI-1 on regenerationQ46490091
Lack of the transcription factor C/EBPδ impairs the intrinsic capacity of peripheral neurons for regenerationQ46646908
Therapeutic time window for the application of chondroitinase ABC after spinal cord injuryQ46834058
Retinoic acid receptor beta2 promotes functional regeneration of sensory axons in the spinal cordQ46875564
In vitro and in vivo characterization of a novel semaphorin 3A inhibitor, SM-216289 or xanthofulvin.Q47670405
Increased activation of nuclear factor kappa B in rat lumbar dorsal root ganglion neurons following partial sciatic nerve injuriesQ47836336
Bovine CNS myelin contains neurite growth-inhibitory activity associated with chondroitin sulfate proteoglycansQ48093854
Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matterQ48105976
Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesionsQ48242887
Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but not neonatal CNS.Q48245393
Evidence for a role of the chemorepellent semaphorin III and its receptor neuropilin-1 in the regeneration of primary olfactory axons.Q48346569
Adeno-associated viral vector (AAV)-mediated gene transfer in the red nucleus of the adult rat brain: comparative analysis of the transduction properties of seven AAV serotypes and lentiviral vectorsQ48427069
Transcriptional upregulation of SCG10 and CAP-23 is correlated with regeneration of the axons of peripheral and central neurons in vivoQ48492910
Kindlin-1 enhances axon growth on inhibitory chondroitin sulfate proteoglycans and promotes sensory axon regeneration.Q48496050
Targeted overexpression of the neurite growth-associated protein B-50/GAP-43 in cerebellar Purkinje cells induces sprouting after axotomy but not axon regeneration into growth-permissive transplantsQ48604374
Adenoviral vector-mediated expression of B-50/GAP-43 induces alterations in the membrane organization of olfactory axon terminals in vivo.Q48633464
The transcription factor ATF-3 promotes neurite outgrowthQ48696691
Transplantation and repair: combined cell implantation and chondroitinase delivery prevents deterioration of bladder function in rats with complete spinal cord injuryQ48718495
Inhibition of neurite outgrowth on astroglial scars in vitroQ48867392
A transcriptional role for C/EBP beta in the neuronal response to axonal injuryQ48868508
Peripheral nerve autografts to the rat spinal cord: Studies with axonal tracing methodsQ48956342
Delayed anti-nogo-a antibody application after spinal cord injury shows progressive loss of responsivenessQ48963873
Spinal axon regeneration evoked by replacing two growth cone proteins in adult neuronsQ49120968
The histone acetyltransferase p300 promotes intrinsic axonal regenerationQ49124872
Chondroitinase combined with rehabilitation promotes recovery of forelimb function in rats with chronic spinal cord injury.Q49138132
Axonal Elongation into Peripheral Nervous System "Bridges" After Central Nervous System Injury in Adult RatsQ49156758
Combination treatment with anti-Nogo-A and chondroitinase ABC is more effective than single treatments at enhancing functional recovery after spinal cord injury.Q50888613
Overexpression of GAP-43 in thalamic projection neurons of transgenic mice does not enable them to regenerate axons through peripheral nerve grafts.Q52165692
Intrinsic versus extrinsic factors in determining the regeneration of the central processes of rat dorsal root ganglion neurons: the influence of a peripheral nerve graft.Q52201038
Time-dependent differences in the increase in GAP-43 expression in dorsal root ganglion cells after peripheral axotomyQ52238817
PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system.Q54363458
The transmembrane semaphorin Sema4D/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesionQ56914645
Synergistic Effects of Transplanted Adult Neural Stem/Progenitor Cells, Chondroitinase, and Growth Factors Promote Functional Repair and Plasticity of the Chronically Injured Spinal CordQ57839425
Neuronal plasticity after spinal cord injury: identification of a gene cluster driving neurite outgrowthQ58443743
Peripheral injury enhances central regeneration of primary sensory neuronesQ59080085
Nogo-A antibody improves regeneration and locomotion of spinal cord-injured ratsQ60223474
Nogo-A–specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primatesQ61960342
Activation of NF-κB in the mouse spinal cord following sciatic nerve transectionQ62907120
Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytesQ67703308
Axonal regeneration in dorsal spinal roots is accelerated by peripheral axonal transectionQ68998720
A novel role for myelin-associated glycoprotein as an inhibitor of axonal regenerationQ71647850
Rehabilitation of patients with spinal cord lesions in The Netherlands: an epidemiological studyQ71779538
Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic miceQ71806446
Axonal regeneration in bifurcating axons of rat dorsal root ganglion cellsQ72641232
Specific changes in rapidly transported proteins during regeneration of the goldfish optic nerveQ72641780
The effectiveness of surgery on the treatment of acute spinal cord injury and its relation to pharmacological treatmentQ72829288
Effects of intravenous methylprednisolone on spinal cord lipid peroxidation and Na+ + K+)-ATPase activity. Dose-response analysis during 1st hour after contusion injury in the catQ72933111
Influence of the axotomy to cell body distance in rat rubrospinal and spinal motoneurons: differential regulation of GAP-43, tubulins, and neurofilament-MQ73107528
Impaired axonal regeneration in alpha7 integrin-deficient miceQ73469663
c-Jun expression in adult rat dorsal root ganglion neurons: differential response after central or peripheral axotomyQ73940780
Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cordQ78003481
The influence of spinal canal narrowing and timing of decompression on neurologic recovery after spinal cord contusion in a rat modelQ78204355
Axonally transported proteins associated with axon growth in rabbit central and peripheral nervous systemsQ36204698
Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreadingQ36218407
Functional switch between motor tracts in the presence of the mAb IN-1 in the adult rat.Q36243160
Regeneration of descending axon tracts after spinal cord injuryQ36306812
Genetic dissection of axon regeneration via in vivo electroporation of adult mouse sensory neuronsQ36457585
Methylprednisolone treatment in acute spinal cord injury: the myth challenged through a structured analysis of published literatureQ36465108
The timing of surgical intervention in the treatment of spinal cord injury: a systematic review of recent clinical evidenceQ36473728
Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3.Q36501925
The making of successful axonal regeneration: genes, molecules and signal transduction pathwaysQ36641659
Intraspinal microinjection of chondroitinase ABC following injury promotes axonal regeneration out of a peripheral nerve graft bridgeQ36710287
Regulation of intrinsic neuronal properties for axon growth and regenerationQ36711818
Acute delivery of EphA4-Fc improves functional recovery after contusive spinal cord injury in ratsQ36947648
Perivascular fibroblasts form the fibrotic scar after contusive spinal cord injuryQ37128159
Nerve injury signalingQ37226963
STAT3 promotes corticospinal remodelling and functional recovery after spinal cord injuryQ37252437
NFAT-3 is a transcriptional repressor of the growth-associated protein 43 during neuronal maturationQ37254018
Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of deliveryQ37355740
Epigenetic regulation of sensory axon regeneration after spinal cord injuryQ37381853
Retrograde signaling in axonal regenerationQ37584415
Incidence of spinal cord injury worldwide: a systematic reviewQ37686999
Injury-induced HDAC5 nuclear export is essential for axon regeneration.Q37704511
Guidance molecules in axon regenerationQ37762337
Gene therapy for the peripheral nervous system: a strategy to repair the injured nerve?Q37835297
Training and anti-CSPG combination therapy for spinal cord injuryQ37938543
Epidemiology of traumatic spinal cord injury: trends and future implicationsQ37978133
Psychosocial issues in spinal cord injury: a reviewQ37978134
The role of Nogo-A in axonal plasticity, regrowth and repairQ38010337
Waking up the sleepers: shared transcriptional pathways in axonal regeneration and neurogenesis.Q38035203
Defeating inhibition of regeneration by scar and myelin componentsQ38055565
Molecular target discovery for neural repair in the functional genomics era.Q38055572
Combination treatment with chondroitinase ABC in spinal cord injury--breaking the barrierQ38120433
Epigenetic regulation of axon outgrowth and regeneration in CNS injury: the first steps forward.Q38123724
Spinal cord injury: debating the efficacy of methylprednisoloneQ38230512
Identification of genes regulated by transcription factor KLF7 in differentiating olfactory sensory neuronsQ38307380
Genome-wide gene expression and promoter binding analysis identifies NFIL3 as a repressor of C/EBP target genes in neuronal outgrowthQ38339038
P433issue4
P304page(s)799-813
P577publication date2014-10-01
P1433published inNeuroMolecular MedicineQ15716731
P1476titleSpinal cord injury and the neuron-intrinsic regeneration-associated gene program
P478volume16

Reverse relations

cites work (P2860)
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