SUMOylation of the polycomb group protein L3MBTL2 facilitates repression of its target genes.

scientific article published on 24 December 2013

SUMOylation of the polycomb group protein L3MBTL2 facilitates repression of its target genes. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKT1317
P932PMC publication ID3950706
P698PubMed publication ID24369422
P5875ResearchGate publication ID259468311

P50authorGuntram SuskeQ42324955
P2093author name stringMaren Scharfe
Florian Finkernagel
Michael Jarek
Bastian Stielow
Christina Stielow
P2860cites workDetection of protein SUMOylation in vivoQ60304832
Model-based analysis of ChIP-Seq (MACS)Q21183902
The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)Q24294810
Regulation of cell cycle progression and gene expression by H2A deubiquitinationQ24296401
A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cellsQ24297079
Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motifQ24297572
Histone deacetylase 3 is selectively involved in L3MBTL2-mediated transcriptional repressionQ24306470
L3MBTL1, a histone-methylation-dependent chromatin lockQ24307503
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUBQ24309403
Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2Q24313233
Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbtQ24316968
A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulationQ24337802
Transcription factor Sp3 is silenced through SUMO modification by PIAS1Q24534887
PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic treesQ24595315
PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexesQ24625878
The landscape of histone modifications across 1% of the human genome in five human cell linesQ24673723
Structural and functional analyses of methyl-lysine binding by the malignant brain tumour repeat protein Sex comb on midlegQ27648759
L3MBTL1 recognition of mono- and dimethylated histonesQ27649109
Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD FingerQ27649150
The malignant brain tumor repeats of human SCML2 bind to peptides containing monomethylated lysineQ27651638
System-wide changes to SUMO modifications in response to heat shockQ27865236
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognitionQ27865256
Comparative proteomic analysis identifies a role for SUMO in protein quality controlQ27865258
The nucleoporin RanBP2 has SUMO1 E3 ligase activityQ28115025
The polycomb protein Pc2 is a SUMO E3Q28115324
ENCODE data in the UCSC Genome Browser: year 5 updateQ28280234
Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motifQ28508128
The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early developmentQ28594836
A chromatin landmark and transcription initiation at most promoters in human cellsQ29547180
The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domainsQ29614228
SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targetingQ29619527
SUMO--nonclassical ubiquitinQ29620234
Multiple activities contribute to Pc2 E3 functionQ30435381
Histone H2A monoubiquitination and Polycomb repression: the missing pieces of the puzzleQ33354010
Epigenetic silencing of spermatocyte-specific and neuronal genes by SUMO modification of the transcription factor Sp3.Q33750227
MEME-ChIP: motif analysis of large DNA datasetsQ35019674
L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structureQ35124384
Inferring direct DNA binding from ChIP-seqQ36280574
SUMO: a multifaceted modifier of chromatin structure and functionQ36564384
MBT domain proteins in development and diseaseQ37169605
SUMO-modified Sp3 represses transcription by provoking local heterochromatic gene silencingQ39962765
Polycomb protein Cbx4 promotes SUMO modification of de novo DNA methyltransferase Dnmt3aQ42155935
Genome-wide localization and expression profiling establish Sp2 as a sequence-specific transcription factor regulating vitally important genesQ42324809
A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activitiesQ42424377
The CTCF insulator protein is posttranslationally modified by SUMO.Q43194304
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectprotein sumoylationQ3503705
P304page(s)3044-3058
P577publication date2013-12-24
P1433published inNucleic Acids ResearchQ135122
P1476titleSUMOylation of the polycomb group protein L3MBTL2 facilitates repression of its target genes
P478volume42

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cites work (P2860)
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Q64389662L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage
Q48141997MGA, L3MBTL2 and E2F6 determine genomic binding of the non-canonical Polycomb repressive complex PRC1.6.
Q38262063Methionine adenosyltransferase α2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells
Q50296457PIAS1 SUMOylates L3MBTL2 with SUMO2
Q57459357PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex
Q50062727SUMOylation regulates cytochrome P450 2E1 expression and activity in alcoholic liver disease.
Q48808965Sumoylation of FOXP2 Regulates Motor Function and Vocal Communication Through Purkinje Cell Development
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