Liquid chromatography tandem mass spectrometry in the clinical laboratory.

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Liquid chromatography tandem mass spectrometry in the clinical laboratory. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1177/0004563214557678
P698PubMed publication ID25313226

P50authorJoanne AdawayQ64782271
P2093author name stringBrian G Keevil
Laura J Owen
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Validation and application of a method for the determination of nicotine and five major metabolites in smokers' urine by solid-phase extraction and liquid chromatography-tandem mass spectrometryQ33210890
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Screening of drugs and toxic compounds with liquid chromatography-linear ion trap tandem mass spectrometryQ33251285
A direct screening procedure for diuretics in human urine by liquid chromatography-tandem mass spectrometry with information dependent acquisitionQ33294599
Quantification of thyroglobulin, a low-abundance serum protein, by immunoaffinity peptide enrichment and tandem mass spectrometryQ33370510
High-throughput analysis of everolimus (RAD001) and cyclosporin A (CsA) in whole blood by liquid chromatography/mass spectrometry using a semi-automated 96-well solid-phase extraction systemQ33422532
Simultaneous determination of clozapine and its N-desmethyl and N-oxide metabolites in plasma by liquid chromatography/electrospray tandem mass spectrometry and its application to plasma level monitoring in schizophrenic patientsQ33423496
High-performance liquid chromatographic-tandem mass spectrometric evaluation and determination of stable isotope labeled analogs of rofecoxib in human plasma samples from oral bioavailability studiesQ33424866
Liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of estradiol and estrone in human plasmaQ33430674
Measurement of plasma free metanephrine and normetanephrine by liquid chromatography-tandem mass spectrometry for diagnosis of pheochromocytomaQ33430861
Simultaneous quantitative determination of cyclosporine A and its three main metabolites (AM1, AM4N and AM9) in human blood by liquid chromatography/mass spectrometry using a rapid sample processing methodQ33434762
Automated, fast and sensitive quantification of 17 alpha-hydroxy-progesterone, androstenedione and testosterone by tandem mass spectrometry with on-line extractionQ33435018
Hibernoma: a clinical model for exploring the role of brown adipose tissue in the regulation of body weight?Q47203521
Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.Q47636202
Cross-reactivities and structure-reactivity relationships of six benzodiazepines to EMIT(®) immunoassay.Q48452482
Simultaneous LC-MS/MS analysis of the biomarkers cAMP and cGMP in plasma, CSF and brain tissue.Q48838062
Investigation of the disposition of loxapine, amoxapine and their hydroxylated metabolites in different brain regions, CSF and plasma of rat by LC-MS/MS.Q48847148
Evaluation of matrix effects in analysis of estrogen using liquid chromatography-tandem mass spectrometry.Q49104142
LC-MS/MS quantitation of ribavirin in serum and identification of endogenous isobaric interferences.Q50555474
Evaluation of the MassTrak Immunosuppressant XE Kit for the determination of everolimus and cyclosporin A in human whole blood employing isotopically labeled internal standards.Q51021096
An automation-assisted generic approach for biological sample preparation and LC-MS/MS method validation.Q51533867
Identification of Biological Tissues by Rapid Evaporative Ionization Mass SpectrometryQ51673926
Simultaneous analysis of six amphetamines and analogues in hair, blood and urine by LC-ESI-MS/MS. Application to the determination of MDMA after low ecstasy intake.Q51746302
Dehydroepiandrostenedione sulphate interferes in many direct immunoassays for testosterone.Q51761394
Simultaneous determination of androstenedione and testosterone in human serum by liquid chromatography-tandem mass spectrometry.Q51768493
Simultaneous measurement of cyclosporin A and tacrolimus from dried blood spots by ultra high performance liquid chromatography tandem mass spectrometry.Q53085555
Standardization of LC-MS for therapeutic drug monitoring of tacrolimus.Q53105940
A novel mass spectrometry-based assay for the accurate measurement of thyroglobulin from patient samples containing antithyroglobulin autoantibodies.Q53109151
Amino acid analysis of dried blood spots for diagnosis of phenylketonuria using capillary electrophoresis-mass spectrometry equipped with a sheathless electrospray ionization interface.Q53329867
Liquid chromatography-isotope dilution-mass spectrometry as a new basis for the reference measurement procedure for hemoglobin A1c determination.Q53335123
Quantification of growth hormone in serum by isotope dilution mass spectrometry.Q53336347
Metabolomics takes its place as latest up-and-coming "omic" science.Q53342733
Molecular Beams of MacroionsQ54192453
Determination of urine caffeine and its metabolites by use of high-performance liquid chromatography-tandem mass spectrometry: estimating dietary caffeine exposure and metabolic phenotyping in population studies.Q54489147
Do deuterium labeled internal standards correct for matrix effects in LC-MS/MS assays? A case study using plasma free metanephrine and normetanephrine.Q54545152
Antibody-free LC-MS/MS quantification of rhTRAIL in human and mouse serum.Q54762590
Evaluation of a rapid micro-scale assay for tacrolimus by liquid chromatography-tandem mass spectrometryQ44134904
Simultaneous and rapid analysis of cyclosporin A and creatinine in finger prick blood samples using liquid chromatography tandem mass spectrometry and its application in C2 monitoringQ44228698
A rapid direct assay for the routine measurement of oestradiol and oestrone by liquid chromatography tandem mass spectrometryQ44372931
Simultaneous determination of clozapine, olanzapine, risperidone and quetiapine in plasma by high-performance liquid chromatography-electrospray ionization mass spectrometryQ44798091
Absolute quantification of the model biomarker prostate-specific antigen in serum by LC-Ms/MS using protein cleavage and isotope dilution mass spectrometryQ44978185
Rapid simultaneous quantification of immunosuppressants in transplant patients by turbulent flow chromatography combined with tandem mass spectrometryQ44980617
Simple extraction protocol for analysis of immunosuppressant drugs in whole bloodQ45016591
Deproteination of serum samples for LC-MS/MS analyses by applying magnetic micro-particlesQ45023762
Determination of bromazepam, clonazepam and metabolites after a single intake in urine and hair by LC-MS/MS. Application to forensic cases of drug facilitated crimesQ45080453
Simultaneous serum nicotine, cotinine, and trans-3'-hydroxycotinine quantitation with minimal sample volume for tobacco exposure status of solid organ transplant patientsQ45131427
Validation of an assay for voriconazole in serum samples using liquid chromatography-tandem mass spectrometryQ45166863
Fast, fully automated analysis of voriconazole from serum by LC-LC-ESI-MS-MS with parallel column-switching techniqueQ45216505
Comparison of serum cortisol measurement by immunoassay and liquid chromatography-tandem mass spectrometry in patients receiving the 11β-hydroxylase inhibitor metyraponeQ45244353
Measurement of cortisol, cortisone, prednisolone, dexamethasone and 11-deoxycortisol with ultra high performance liquid chromatography-tandem mass spectrometry: Application for plasma, plasma ultrafiltrate, urine and saliva in a routine laboratory.Q45585669
Design and validation of an immunoaffinity LC-MS/MS assay for the quantification of a collagen type II neoepitope peptide in human urine: application as a biomarker of osteoarthritisQ45897147
Therapeutic Drug Monitoring of the new targeted anticancer agents imatinib, nilotinib, dasatinib, sunitinib, sorafenib and lapatinib by LC tandem mass spectrometry.Q45977906
Therapeutic drug monitoring of clozapine and norclozapine in human serum using ultra-performance liquid chromatography- tandem mass spectrometry.Q45996148
New HPLC-MS method for the simultaneous quantification of the antileukemia drugs imatinib, dasatinib, and nilotinib in human plasma.Q46018727
Quantitative analysis of colistin A and colistin B in plasma and culture medium using a simple precipitation step followed by LC/MS/MS.Q46154490
Therapeutic drug monitoring of everolimus using the dried blood spot method in combination with liquid chromatography-mass spectrometryQ46156222
Liquid chromatography-mass spectrometry measurement of tacrolimus in finger-prick samples compared with venous whole blood samplesQ46158653
Analysis of second-generation antidepressant drug, sertraline and its active metabolite, N-desmethyl sertraline in human plasma by a sensitive and selective liquid chromatography-tandem mass spectrometry methodQ46183207
Interlaboratory variation in 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 is significantly improved if common calibration material is usedQ46222815
Challenges and developments in tandem mass spectrometry based clinical metabolomicsQ46247800
Improved tandem mass spectrometry (MS/MS) derivatized method for the detection of tyrosinemia type I, amino acids and acylcarnitine disorders using a single extraction processQ46314752
Measurement of urinary free cortisol using liquid chromatography-tandem mass spectrometry: comparison with the urine adapted ACS:180 serum cortisol chemiluminescent immunoassay and development of a new reference rangeQ46436689
Isopropanol protein precipitation for the analysis of plasma free metanephrines by liquid chromatography-tandem mass spectrometryQ46440186
A single fasting plasma 5-HIAA value correlates with 24-hour urinary 5-HIAA values and other biomarkers in midgut neuroendocrine tumors (NETs).Q46499182
Testosterone measurement by isotope-dilution liquid chromatography-tandem mass spectrometry: validation of a method for routine clinical practiceQ46551507
Routine isotope-dilution liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of the 25-hydroxy metabolites of vitamins D2 and D3.Q46601536
Cyclosporin A in the ocular fluids of uveitis patients following long-term systemic administrationQ46610416
Simultaneous liquid chromatography tandem mass spectrometric determination of urinary free metanephrines and catecholamines, with comparisons of free and deconjugated metabolitesQ46613736
Development and validation of a serum total testosterone liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay calibrated to NIST SRM 971.Q46624406
Simultaneous quantification of caffeine and its three primary metabolites in rat plasma by liquid chromatography-tandem mass spectrometryQ46634618
Modified HPLC-electrospray ionization/mass spectrometry method for HbA1c based on IFCC reference measurement procedureQ46651684
Simultaneous quantification of cyclosporine, tacrolimus, sirolimus and everolimus in whole blood by liquid chromatography-electrospray mass spectrometryQ46688638
Quantification of cyclosporine and tacrolimus in whole blood. Comparison of liquid chromatography-electrospray mass spectrometry with the enzyme multiplied immunoassay techniqueQ46688639
Screening method for benzodiazepines and hypnotics in hair at pg/mg level by liquid chromatography-mass spectrometry/mass spectrometryQ46696365
High-sensitivity tandem mass spectrometry assay for serum estrone and estradiolQ46699431
Quantification of imatinib in human plasma by high-performance liquid chromatography-tandem mass spectrometry.Q46713695
Naturally occurring isotopes of an analyte can interfere with doubly deuterated internal standard measurementQ46714946
Liquid chromatography-electrospray mass spectrometry determination of carbamazepine, oxcarbazepine and eight of their metabolites in human plasmaQ46734762
Simultaneous determination of norethindrone and ethinyl estradiol in human plasma by high performance liquid chromatography with tandem mass spectrometry--experiences on developing a highly selective method using derivatization reagent for enhancingQ46742675
Free thyroid hormones in serum by direct equilibrium dialysis and online solid-phase extraction--liquid chromatography/tandem mass spectrometryQ46765613
Fingerprick blood samples can be used to accurately measure tacrolimus levels by tandem mass spectrometryQ46790060
Simultaneous determination of erythromycin ethylsuccinate and its metabolite erythromycin in human plasma using liquid chromatography-electrospray ionization mass spectrometry for clinical studyQ46866731
Validated quantitation of angiotensin II receptor antagonists (ARA-II) in human plasma by liquid-chromatography-tandem mass spectrometry using minimum sample clean-up and investigation of ion suppressionQ46878747
High throughput quantification of cholesterol and cholesteryl ester by electrospray ionization tandem mass spectrometry (ESI-MS/MS).Q46928125
A simple, fast, and sensitive method for the measurement of serum nicotine, cotinine, and nornicotine by LC-MS/MS.Q46945983
High throughput therapeutic drug monitoring of clozapine and metabolites in serum by on-line coupling of solid phase extraction with liquid chromatography-mass spectrometryQ46983458
Measurement of 25-OH-vitamin D in human serum using liquid chromatography tandem-mass spectrometry with comparison to radioimmunoassay and automated immunoassayQ33445994
Serum steroid profiling by isotopic dilution-liquid chromatography-mass spectrometry: comparison with current immunoassays and reference intervals in healthy adultsQ33448761
Variability in the analysis of 25-hydroxyvitamin D by liquid chromatography-tandem mass spectrometry: the devil is in the detailQ33454206
Total 25-hydroxyvitamin D determination by an entry level triple quadrupole instrument: comparison between two commercial kitsQ33457581
Atmospheric pressure ionization (API) mass spectrometry. Solvent-mediated ionization of samples introduced in solution and in a liquid chromatograph effluent streamQ33474337
ESI-MS/MS library of 1,253 compounds for application in forensic and clinical toxicologyQ33504652
Selected reaction monitoring-mass spectrometric immunoassay responsive to parathyroid hormone and related variantsQ33519843
Measurement of thyroglobulin by liquid chromatography-tandem mass spectrometry in serum and plasma in the presence of antithyroglobulin autoantibodiesQ33594636
GC/MS-based metabolomics reveals fatty acid biosynthesis and cholesterol metabolism in cell lines infected with influenza A virusQ33733982
An overview of various validated HPLC and LC-MS/MS methods for quantitation of drugs in bile: challenges and considerationsQ33742355
Development and practical application of a library of CID accurate mass spectra of more than 2,500 toxic compounds for systematic toxicological analysis by LC-QTOF-MS with data-dependent acquisitionQ33762355
Validation of a bioanalytical method for the quantification of a therapeutic peptide, ramoplanin, in human dried blood spots using LC-MS/MS.Q33770850
Comparison of Bruker Biotyper matrix-assisted laser desorption ionization-time of flight mass spectrometer to BD Phoenix automated microbiology system for identification of gram-negative bacilliQ33786523
In situ, real-time identification of biological tissues by ultraviolet and infrared laser desorption ionization mass spectrometryQ33814674
Comparison of direct colony method versus extraction method for identification of gram-positive cocci by use of Bruker Biotyper matrix-assisted laser desorption ionization-time of flight mass spectrometryQ33912376
High-throughput, 384-well, LC-MS/MS CYP inhibition assay using automation, cassette-analysis technique, and streamlined data analysisQ34002793
Determination of thyroid hormones and their metabolites in tissue using SPE UPLC-tandem MS.Q34005717
Validation of an LC-MS/MS method to determine five immunosuppressants with deuterated internal standards including MPA.Q34124314
Measurement of quetiapine and four quetiapine metabolites in human plasma by LC-MS/MS.Q34126160
Ion suppression in mass spectrometryQ34207350
Multiplex ultra-performance liquid chromatography-tandem mass spectrometry method for simultaneous quantification in human plasma of fluconazole, itraconazole, hydroxyitraconazole, posaconazole, voriconazole, voriconazole-N-oxide, anidulafungin, andQ34309603
Intraoperative tissue identification using rapid evaporative ionization mass spectrometryQ34358096
Sensitive and rapid detection of viruses associated with hand foot and mouth disease using multiplexed MALDI-TOF analysisQ34495757
Isotopic pattern and accurate mass determination in urine drug screening by liquid chromatography/time-of-flight mass spectrometryQ34500109
Analysis of thyroid hormones in serum by liquid chromatography-tandem mass spectrometryQ34855743
Misleading measures in Vitamin D analysis: a novel LC-MS/MS assay to account for epimers and isobarsQ35044413
Targeted selected reaction monitoring mass spectrometric immunoassay for insulin-like growth factor 1Q35053898
Performance of Kiestra total laboratory automation combined with MS in clinical microbiology practiceQ35119444
Prenatal screening of sialic acid storage disease and confirmation in cultured fibroblasts by LC-MS/MS.Q35214546
Differential diagnosis in patients with suspected bile acid synthesis defects.Q35813202
Plasma methoxytyramine: a novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation statusQ36024376
Multi-analyte procedures for screening for and quantification of drugs in blood, plasma, or serum by liquid chromatography-single stage or tandem mass spectrometry (LC-MS or LC-MS/MS) relevant to clinical and forensic toxicologyQ36070734
Monitoring of cyclosporine levels in transplant recipients using self-administered fingerprick samplingQ36460876
Correlations of free thyroid hormones measured by tandem mass spectrometry and immunoassay with thyroid-stimulating hormone across 4 patient populationsQ36787933
Thyroid hormone testing by tandem mass spectrometryQ36789965
Multiplex liquid chromatography-tandem mass spectrometry assay for simultaneous therapeutic drug monitoring of ribavirin, boceprevir, and telaprevirQ36969893
Interlaboratory reproducibility of selective reaction monitoring assays using multiple upfront analyte enrichment strategiesQ37142875
Rapid development of sensitive, high-throughput, quantitative and highly selective mass spectrometric targeted immunoassays for clinically important proteins in human plasma and serumQ37187946
Amiodarone concentrations in plasma and fat tissue during chronic treatment and related toxicityQ37201673
Salivary testosterone measurement by liquid chromatography tandem mass spectrometry in adult males and females.Q37268778
Multisteroid LC-MS/MS assay for glucocorticoids and androgens, and its application in Addison's diseaseQ37354259
A stable isotope-labeled internal standard is essential for correcting for the interindividual variability in the recovery of lapatinib from cancer patient plasma in quantitative LC-MS/MS analysisQ37358418
Quantification of human plasma-busulfan concentration by liquid chromatography-tandem mass spectrometryQ37453495
Steroid measurement with LC-MS/MS. Application examples in pediatrics.Q37662971
A pilot study: subclinical hypothyroidism and free thyroid hormone measurement by immunoassay and mass spectrometryQ37677404
The analysis of dried blood spot samples using liquid chromatography tandem mass spectrometryQ37769817
Current status and future developments of LC-MS/MS in clinical chemistry for quantification of biogenic aminesQ37772253
Development and validation of a quantitative assay based on tandem mass spectrometryQ37838106
Therapeutic drug monitoring and LC-MS/MS.Q37944944
LC-MS/MS for protein and peptide quantification in clinical chemistryQ37946027
Critical overview of selected contemporary sample preparation techniquesQ37964132
Ultra high performance liquid chromatography tandem mass spectrometry determination and profiling of prohibited steroids in human biological matrices. A review.Q38073912
Steroid profiling for congenital adrenal hyperplasia by tandem mass spectrometry as a second-tier test reduces follow-up burdens in a tertiary care hospital: a retrospective and prospective evaluationQ38132578
The expanding role of tandem mass spectrometry in optimizing diagnosis and treatment of thyroid diseaseQ38135429
Novel liquid chromatography tandem mass spectrometry (LC-MS/MS) methods for measuring steroidsQ38149414
Critical evaluation of assays for vitamin D statusQ38150138
Isotope dilution mass spectrometry and the National Reference SystemQ38484237
Development of a high-performance liquid chromatographic-mass spectrometric method for the determination of cellular levels of the tyrosine kinase inhibitors lapatinib and dasatinibQ39783917
Streamlined pentafluorophenylpropyl column liquid chromatography-tandem quadrupole mass spectrometry and global (13)C-labeled internal standards improve performance for quantitative metabolomics in bacteriaQ39827234
Further studies on radioimmunoassay systems for plasma oestradiolQ40334652
Quantitation of azoles and echinocandins in compartments of peripheral blood by liquid chromatography-tandem mass spectrometryQ40337647
Protein identification from 2-DE gels by MALDI mass spectrometryQ41671192
Development, validation, and routine application of a high-performance liquid chromatography method coupled with a single mass detector for quantification of itraconazole, voriconazole, and posaconazole in human plasma.Q41916356
Analysis of cyclosporin A, tacrolimus, sirolimus, and everolimus in dried blood spot samples using liquid chromatography tandem mass spectrometryQ42716470
A rapid, simple and sensitive liquid chromatography-tandem mass spectrometry method for routine clinical monitoring of tacrolimus with the Waters Masstrak™ immmunosuppressant kit.Q42758768
A fast and simple assay for busulfan in serum or plasma by liquid chromatography-tandem mass spectrometry using turbulent flow online extraction technologyQ42844349
Liquid chromatography-tandem mass spectrometry assay for androstenedione, dehydroepiandrosterone, and testosterone with pediatric and adult reference intervalsQ43057883
A simplified liquid chromatography tandem mass spectrometry assay, using on-line solid-phase extraction, for the quantitation of cortisol in saliva and comparison with a routine DELFIA method.Q43164846
Quantification of levetiracetam in plasma of neonates by ultra performance liquid chromatography-tandem mass spectrometryQ43170278
Performance of plasma free metanephrines measured by liquid chromatography-tandem mass spectrometry in the diagnosis of pheochromocytomaQ43190918
Ultra fast liquid chromatography-tandem mass spectrometry routine method for simultaneous determination of cyclosporin A, tacrolimus, sirolimus, and everolimus in whole blood using deuterated internal standards for cyclosporin A and everolimusQ43221916
Simultaneous measurement of cortisol and cortisone in human saliva using liquid chromatography-tandem mass spectrometry: application in basal and stimulated conditionsQ43270748
Determination of imatinib plasma levels in patients with chronic myeloid leukemia by high performance liquid chromatography-ultraviolet detection and liquid chromatography-tandem mass spectrometry: methods' comparisonQ43278422
Simultaneous measurement of amiodarone and desethylamiodarone in human plasma and serum by stable isotope dilution liquid chromatography-tandem mass spectrometry assayQ43282948
LC-MS/MS coupled with immunoaffinity extraction for determination of estrone, 17beta-estradiol and estrone 3-sulfate in human plasmaQ43287651
Serum concentrations of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione and testosterone in children determined by TurboFlow-LC-MS/MS.Q43667637
Potential problems with using deuterated internal standards for liquid chromatography-tandem mass spectrometry.Q43954312
P433issuePt 1
P921main subjectliquid chromatography-tandem mass spectrometryQ117788892
P304page(s)18-38
P577publication date2014-10-13
P1433published inAnnals of Clinical BiochemistryQ15716536
P1476titleLiquid chromatography tandem mass spectrometry in the clinical laboratory
P478volume52

Reverse relations

cites work (P2860)
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Q52314908Serum Steroid Ratio Profiles in Prostate Cancer: A New Diagnostic Tool Toward a Personalized Medicine Approach.
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