Pathogenesis and management of the diabetogenic effect of statins: a role for adiponectin and coenzyme Q10?

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Pathogenesis and management of the diabetogenic effect of statins: a role for adiponectin and coenzyme Q10? is …
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scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1036702127
P356DOI10.1007/S11883-014-0472-7
P698PubMed publication ID25398645

P50authorGerald WattsQ71943021
Jing PangQ51018104
Dick ChanQ58842465
P2093author name stringJing Pang
Dick C Chan
P2860cites workMuscle mitochondrial metabolism and calcium signaling impairment in patients treated with statinsQ83305399
Effects of pravastatin and rosuvastatin on the generation of adiponectin in the visceral adipose tissue in patients with coronary artery diseaseQ84537980
The effect of statins on the development of new-onset type 2 diabetes: a meta-analysis of randomized controlled trialsQ94695308
Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humansQ73366753
Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11pQ77829278
Can correction of sub-optimal coenzyme Q status improve beta-cell function in type II diabetics?Q78030738
Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired glucose tolerance and coronary artery diseaseQ79368237
Statin therapy induces ultrastructural damage in skeletal muscle in patients without myalgiaQ79788074
Meta-analysis of cardiovascular outcomes trials comparing intensive versus moderate statin therapyQ80020360
Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alphaQ80175296
Efficacy of atorvastatin therapy in ischaemic heart disease - effects on oxidized low-density lipoprotein and adiponectinQ80793732
The effect of fluvastatin on plasma adiponectin levels in dyslipidaemiaQ83225668
Pitavastatin in cardiometabolic disease: therapeutic profileQ21246037
Are statins diabetogenic?Q24630205
MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trialQ28214393
2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice GuidelinesQ28301815
Standards of medical care in diabetes--2014Q28304435
Nitric oxide induces apoptosis via Ca2+-dependent processes in the pancreatic beta-cell line MIN6Q28372031
Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery diseaseQ28373513
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesityQ28506782
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30Q28511676
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive proteinQ29547752
Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trialQ29617817
Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trialsQ29617910
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndromeQ29619211
Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol LevelsQ29620696
Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trialsQ29622947
Pravastatin and the development of diabetes mellitus: evidence for a protective treatment effect in the West of Scotland Coronary Prevention StudyQ31829404
Comparison of effects of pitavastatin and atorvastatin on glucose metabolism in type 2 diabetic patients with hypercholesterolemiaQ33588898
Higher potency statins and the risk of new diabetes: multicentre, observational study of administrative databases.Q33685412
Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemiaQ33946056
MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trialQ33966645
Coenzyme Q10 and statins: biochemical and clinical implicationsQ34003990
Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysisQ34027392
Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 randomized controlled trials involving 65,229 participantsQ34123160
Simvastatin improves flow-mediated dilation but reduces adiponectin levels and insulin sensitivity in hypercholesterolemic patientsQ34177113
Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre raQ34189543
ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS).Q34196167
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individualsQ34221038
Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretionQ34231901
Adiponectin and Metabolic SyndromeQ34269072
Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trialQ34293369
ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collabQ34368081
Association of adiponectin and resistin with adipose tissue compartments, insulin resistance and dyslipidaemia.Q34426322
Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitorsQ34463540
Place of pitavastatin in the statin armamentarium: promising evidence for a role in diabetes mellitusQ34999753
Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cellsQ35028546
Association between adiponectin concentrations and cardiovascular disease in diabetic patients: a systematic review and meta-analysisQ35040943
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trialsQ35065253
Novel CoQ10 antidiabetic mechanisms underlie its positive effect: modulation of insulin and adiponectine receptors, Tyrosine kinase, PI3K, glucose transporters, sRAGE and visfatin in insulin resistant/diabetic ratsQ35106778
Adipocytokines and insulin resistanceQ35649614
Coenzyme Q10 and diabetic endotheliopathy: oxidative stress and the 'recoupling hypothesis'.Q35837905
Obesity-associated improvements in metabolic profile through expansion of adipose tissueQ35945161
Adiponectin increases skeletal muscle mitochondrial biogenesis by suppressing mitogen-activated protein kinase phosphatase-1.Q35976593
Simvastatin (40 mg/day), adiponectin levels, and insulin sensitivity in subjects with the metabolic syndromeQ36148478
Effects of maximal atorvastatin and rosuvastatin treatment on markers of glucose homeostasis and inflammationQ36463044
Rosuvastatin does not affect fasting glucose, insulin resistance, or adiponectin in patients with mild to moderate hypertensionQ36837587
Coenzyme Q10: is there a clinical role and a case for measurement?Q36869671
Risk of incident diabetes among patients treated with statins: population based study.Q36871618
Bioenergetic and antioxidant properties of coenzyme Q10: recent developments.Q36959666
Adipokines and insulin resistanceQ36972589
Plasma coenzyme Q10 levels in type 2 diabetic patients with retinopathy.Q37256878
Differential metabolic effects of pravastatin and simvastatin in hypercholesterolemic patients.Q37362218
Statin therapy and risk of developing type 2 diabetes: a meta-analysisQ37364976
Cholesterol metabolism and pancreatic beta-cell functionQ37471308
Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysisQ37543864
Differing effect of statins on insulin sensitivity in non-diabetics: a systematic review and meta-analysisQ37632786
Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes.Q37649260
Role of mitochondria in beta-cell function and dysfunction.Q37706222
HDL and cardiovascular disease: atherogenic and atheroprotective mechanismsQ37838234
Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysisQ37884457
Pitavastatin: clinical effects from the LIVES StudyQ37966067
Molecular mechanisms of diabetes and atherosclerosis: role of adiponectinQ37974942
Statins are diabetogenic--myth or reality?Q38028072
Is statin-induced diabetes clinically relevant? A comprehensive review of the literatureQ38174285
The use of statins in people at risk of developing diabetes mellitus: evidence and guidance for clinical practice.Q38212766
Predictors of new-onset diabetes in patients treated with atorvastatin: results from 3 large randomized clinical trialsQ39765409
Neither plasma coenzyme Q10 concentration, nor its decline during pravastatin therapy, is linked to recurrent cardiovascular disease events: a prospective case-control study from the LIPID studyQ40382060
Adiponectin induces TNF-alpha and IL-6 in macrophages and promotes tolerance to itself and other pro-inflammatory stimuliQ40382523
Cytokines and diabetes: the final step? Involvement of TNF-alpha in both type I and II diabetes mellitusQ40590331
Lovastatin Disrupts Early Events in Insulin Signaling: A Potential Mechanism of Lovastatins Anti-Mitogenic ActivityQ41436012
Effects of pitavastatin on plasminogen activator inhibitor-1 in hyperlipidemic patientsQ41966657
Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4): implications in glycaemic controlQ42802278
Effects of atorvastatin and pravastatin on signal transduction related to glucose uptake in 3T3L1 adipocytesQ42813250
Inhibition of isoprenoid biosynthesis causes insulin resistance in 3T3-L1 adipocytesQ42823990
Coenzyme Q10 ameliorates the reduction in GLUT4 transporter expression induced by simvastatin in 3T3-L1 adipocytesQ42824589
Beneficial direct adipotropic actions of pitavastatin in vitro and their manifestations in obese miceQ42826744
Effect of pravastatin on the development of diabetes and adiponectin productionQ42829765
Rosuvastatin treatment is associated with an increase in insulin resistance in hyperlipidaemic patients with impaired fasting glucose.Q43289669
Statins and risk of new-onset diabetes mellitusQ43979349
Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humansQ44007232
Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes.Q44213808
Effect of atorvastatin versus rosuvastatin on levels of serum lipids, inflammatory markers and adiponectin in patients with hypercholesterolemiaQ46198283
Effects of antioxidants coenzyme Q10 and lipoic acid on interleukin-1 beta-mediated inhibition of glucose-stimulated insulin release from cultured mouse pancreatic isletsQ46416312
Additive beneficial effects of fenofibrate combined with atorvastatin in the treatment of combined hyperlipidemiaQ46489681
Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patientsQ46533533
Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration.Q46680003
Effects of pitavastatin on adiponectin in patients with hyperlipidemiaQ46708651
Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysisQ46810855
Statin therapy on glycaemic control in type 2 diabetes: a meta-analysis.Q50858431
Comparative effects of rosuvastatin and atorvastatin on glucose metabolism and adipokine levels in non-diabetic patients with dyslipidaemia: a prospective randomised open-label study.Q51373377
Effect of simvastatin and/or pioglitazone on insulin resistance, insulin secretion, adiponectin, and proinsulin levels in nondiabetic patients at cardiovascular risk--the PIOSTAT Study.Q51475159
Integrative physiology of human adipose tissueQ57321418
Adiponectin and Coronary Heart DiseaseQ57416324
Direct Effect of Cholesterol on Insulin Secretion: A Novel Mechanism for Pancreatic -Cell DysfunctionQ60642303
P433issue1
P921main subjectubidecarenoneQ321285
pathogenesisQ372016
P304page(s)472
P577publication date2015-01-01
P1433published inCurrent Atherosclerosis ReportsQ20821076
P1476titlePathogenesis and management of the diabetogenic effect of statins: a role for adiponectin and coenzyme Q10?
P478volume17

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cites work (P2860)
Q92154128Associations of statin use with glycaemic traits and incident type 2 diabetes
Q38881481Clinical benefits of pitavastatin: focus on patients with diabetes or at risk of developing diabetes
Q64245365Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview
Q38586781Drug-Induced Hyperglycaemia and Diabetes
Q59791848Effect of statins on fasting glucose in non-diabetic individuals: nationwide population-based health examination in Korea
Q91619205Effects of Pitavastatin on Insulin Sensitivity and Liver Fat: A Randomized Clinical Trial
Q39107221Pitavastatin: A Review in Hypercholesterolemia
Q51479885Rosuvastatin limits the activation of hepatic stellate cells in diet-induced obese mice.
Q26786008Statin use in prediabetic patients: rationale and results to date
Q38553529Targeting inflammation in metabolic syndrome.
Q38669513The diabetogenic action of statins - mechanisms and clinical implications
Q41151540The mixed benefit of low lipoprotein(a) in type 2 diabetes.

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