Glucagon administration elicits blunted GH but exaggerated ACTH response in obesity

scientific article

Glucagon administration elicits blunted GH but exaggerated ACTH response in obesity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/BF03345499
P698PubMed publication ID12109628

P2093author name stringTassone F
Giordano R
Ghigo E
Grottoli S
Maccario M
Gauna C
Rossetto R
Maccagno B
P2860cites workDual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man.Q30449288
The Central Melanocortin System and Energy HomeostasisQ33687989
Regulation of growth hormone secretion by signals produced by the adipose tissue.Q33708529
Neuroendocrine regulation and actions of leptinQ33777677
Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptorQ33942714
Biologic activities of growth hormone secretagogues in humansQ34231668
Adrenal responsiveness to high, low and very low ACTH 1-24 doses in obesityQ38307987
GH response to GHRH combined with pyridostigmine or arginine in different conditions of low somatotrope secretion in adulthood: obesity and Cushing's syndrome in comparison with hypopituitarismQ38337944
Effects of acipimox, an antilipolytic drug, on the growth hormone (GH) response to GH-releasing hormone alone or combined with arginine in obesityQ38361307
Endocrine function in human obesityQ40259582
Antidiabetic sulfonylurea enhances secretagogue-induced adrenocorticotropin secretion and proopiomelanocortin gene expression in vitroQ40857936
Dose-response aspects in the clinical assessment of the hypothalamo-pituitary-adrenal axis, and the low-dose adrenocorticotropin testQ41079484
Glucagon stimulates GH secretion after intramuscular but not intravenous administration. Evidence against the assumption that glucagon per se has a GH-releasing activityQ42485626
Regulation of pituitary-adrenocortical activity by free fatty acids in vivo and in vitroQ42486778
Metabolic modulation of the growth hormone-releasing activity of hexarelin in man.Q42489063
Effects of insulin on rat anterior pituitary cells. Inhibition of growth hormone secretion and mRNA levelsQ42511038
In obesity the somatotrope response to either growth hormone-releasing hormone or arginine is inhibited by somatostatin or pirenzepine but not by glucoseQ42512966
Growth-hormone release by glucagonQ43726035
A preview of growth hormone stimulation tests in childrenQ44007797
Suppression of counterregulatory hormone response to hypoglycemia by insulin per se.Q44831762
Evidence for a direct pituitary inhibition by free fatty acids of in vivo growth hormone responses to growth hormone-releasing hormone in the rat.Q45127749
The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distributionQ48236785
Subcutaneous glucagon as a test of the ability of the pituitary to secrete GH and ACTH.Q48568565
A comparison of the insulin tolerance/glucagon test with the short ACTH stimulation test in the assessment of the hypothalamo-pituitary-adrenal axis in the early post-operative period after hypophysectomyQ48663250
Mechanisms of impaired growth hormone secretion in genetically obese Zucker rats: roles of growth hormone-releasing factor and somatostatinQ48854624
Glucagon Stimulation of Human Growth HormoneQ48906341
Hypothalamic-pituitary-adrenal axis activity and its relationship to the autonomic nervous system in women with visceral and subcutaneous obesity: effects of the corticotropin-releasing factor/arginine-vasopressin test and of stressQ49106251
Free insulin-like growth factors in human obesity.Q51585625
Effect of insulin on the hepatic production of insulin-like growth factor-binding protein-1 (IGFBP-1), IGFBP-3, and IGF-I in insulin-dependent diabetes.Q51594172
Hyperactivity of the hypothalamo-pituitary-adrenal axis in obesity: a study of ACTH, AVP, beta-lipotrophin and cortisol responses to insulin-induced hypoglycaemia.Q51599309
Hypoglycemia: a potent stimulus to secretion of growth hormone.Q51692790
Acute pharmacologic blockade of lipolysis normalizes nocturnal growth hormone levels and pulsatility in obese subjects.Q52369747
Impaired growth hormone secretion in obese subjects is partially reversed by acipimox-mediated plasma free fatty acid depression.Q52520837
ACTH and cortisol response to combined corticotropin releasing hormone-arginine vasopressin stimulation in obese males and its relationship to body weight, fat distribution and parameters of the metabolic syndromeQ57012723
Glucagon is an ACTH secretagogue as effective as hCRH after intramuscolar administration while it is ineffective when given intravenously in normal subjectsQ60674318
Intramuscular glucagon as a provocative stimulus for the assessment of pituitary function: growth hormone and cortisol responsesQ69075819
Long-term administration of acipimox potentiates growth hormone response to growth hormone-releasing hormone by decreasing serum free fatty acid in obesityQ71061272
Glucagon-induced growth hormone release in childrenQ71739579
About the effects of glucagon on growth hormone releaseQ71827899
The assessment of growth hormone status in normal young adult males using a variety of provocative agentsQ71931824
Repetitive GHRH administration fails to increase the response to GHRH in obese subjects. Evidence for a somatotrope defect in obesity?Q72864600
Low concentrations of insulin-like growth factor-I in abdominal obesityQ72958838
Interaction between glucagon and hexarelin, a peptidyl GH secretagogue, on somatotroph and corticotroph secretion in humansQ73191651
Comparisons among old and new provocative tests of GH secretion in 178 normal adultsQ73645023
Interaction between glucagon and human corticotropin-releasing hormone or vasopressin on ACTH and cortisol secretion in humansQ73931382
Neuroendocrine abnormalities in visceral obesityQ74345559
The GH/IGF-I axis in obesity: influence of neuro-endocrine and metabolic factorsQ74345576
Stimulatory effect of adrenocorticotropin on cortisol, aldosterone, and dehydroepiandrosterone secretion in normal humans: dose-response studyQ74352487
Altered neuroregulation of GH secretion in viscerally obese premenopausal womenQ77148837
Growth hormone in obesityQ77292368
Comparison of the diagnostic utility of the simplified and standard i.m. glucagon stimulation test (IMGST)Q77344437
Relationships between dehydroepiandrosterone-sulphate and anthropometric, metabolic and hormonal variables in a large cohort of obese womenQ78196746
Growth Hormone Response to Intramuscular GlucagonQ93756256
P433issue6
P921main subjectobesityQ12174
glucagonQ28163629
P304page(s)551-556
P577publication date2002-06-01
P1433published inJournal of Endocrinological InvestigationQ15766847
P1476titleGlucagon administration elicits blunted GH but exaggerated ACTH response in obesity
P478volume25

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cites work (P2860)
Q38346795Obese patients with obstructive sleep apnoea syndrome show a peculiar alteration of the corticotroph but not of the thyrotroph and lactotroph function
Q36395186Systemic and local ACTH produced during inflammatory states promotes osteochondrogenic mesenchymal cell differentiation contributing to the pathologic progression of calcified atherosclerosis

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