Expression of a mutant prohibitin from the aP2 gene promoter leads to obesity-linked tumor development in insulin resistance-dependent manner.

scientific article published on 11 January 2016

Expression of a mutant prohibitin from the aP2 gene promoter leads to obesity-linked tumor development in insulin resistance-dependent manner. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1007973129
P356DOI10.1038/ONC.2015.501
P8608Fatcat IDrelease_gg7444c7uvfxbbwxr7tzlctogy
P698PubMed publication ID26751773

P50authorB L Grégoire NyombaQ79378110
P2093author name stringS R Ande
S Mishra
K H Nguyen
G P Padilla-Meier
P2860cites workConcordance with World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines for cancer prevention and obesity-related cancer risk in the Framingham Offspring cohort (1991-2008)Q37336185
The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related proteinQ37635432
Adipose tissue-resident immune cells: key players in immunometabolism.Q38026316
Adaptive immunity in obesity and insulin resistanceQ38030832
SeXX matters in immunityQ38163200
Prohibitin overexpression in adipocytes induces mitochondrial biogenesis, leads to obesity development, and affects glucose homeostasis in a sex-specific manner.Q38306276
Insulin induced phosphorylation of prohibitin at tyrosine 114 recruits Shp1.Q38353489
Immunometabolism: an emerging frontierQ38876919
Lipid metabolism mediated by adipocyte lipid binding protein (ALBP/aP2) gene expression in human THP-1 macrophagesQ40346706
Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migrationQ40393756
ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC developmentQ42199386
A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitisQ42249964
Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cellsQ42460970
Prohibitin has an important role in adipocyte differentiationQ42802709
White adipose tissue cells are recruited by experimental tumors and promote cancer progression in mouse modelsQ42826900
Prohibitin interacts with phosphatidylinositol 3,4,5-triphosphate (PIP3) and modulates insulin signalingQ42832815
Heterogeneity in a mouse model of histiocytosis: transformation of Langerin+ dendritic cells, macrophages, and precursors.Q53301956
A postmigrational switch among skin-derived dendritic cells to a macrophage-like phenotype is predetermined by the intracutaneous cytokine balance.Q53619786
Obesity and cancerQ57748968
Mild caloric restriction up-regulates the expression of prohibitin: a proteome studyQ83265115
The scaffold protein prohibitin is required for antigen-stimulated signaling in mast cellsQ85721263
Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cellsQ24298483
Mechanisms and therapeutic advances in the management of endocrine-resistant breast cancerQ27001260
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studiesQ29614869
Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013Q29616834
Vi polysaccharide of Salmonella typhi targets the prohibitin family of molecules in intestinal epithelial cells and suppresses early inflammatory responsesQ30448411
Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases.Q34139220
Differential effects of metformin on breast cancer proliferation according to markers of insulin resistance and tumor subtype in a randomized presurgical trial.Q34334262
DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodelingQ34421187
Elevated GH/IGF-I promotes mammary tumors in high-fat, but not low-fat, fed miceQ34434910
Therapeutic action of ghrelin in a mouse model of colitis.Q34525422
The mitochondrial PHB complex: roles in mitochondrial respiratory complex assembly, ageing and degenerative diseaseQ34536917
Inflammation driven by tumour-specific Th1 cells protects against B-cell cancerQ34769124
Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation.Q34944118
Impact of obesity on development and progression of mammary tumors in preclinical models of breast cancerQ34975962
Role of inflammation and oxidative stress in post-menopausal oestrogen-dependent breast cancerQ34998410
Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegansQ35007074
Treatment with insulin analog X10 and IGF-1 increases growth of colon cancer allograftsQ35048673
Differences in IGF-axis protein expression and survival among multiethnic breast cancer patientsQ35236778
Obesity, adipocytokines, and insulin resistance in breast cancerQ35831676
Obesity and cancer risk: the role of the insulin-IGF axisQ36587115
Ghrelin, obesity and diabetesQ36950900
Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health spanQ37089841
MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity.Q37100064
Insulin receptor phosphorylation by endogenous insulin or the insulin analog AspB10 promotes mammary tumor growth independent of the IGF-I receptorQ37193406
P433issue34
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
insulin resistanceQ1053470
P304page(s)4459-4470
P577publication date2016-01-11
P1433published inOncogeneQ1568657
P1476titleExpression of a mutant prohibitin from the aP2 gene promoter leads to obesity-linked tumor development in insulin resistance-dependent manner
P478volume35

Reverse relations

cites work (P2860)
Q90310096A novel c-Kit/phospho-prohibitin axis enhances ovarian cancer stemness and chemoresistance via Notch3-PBX1 and β-catenin-ABCG2 signaling
Q50649721Characterization of mitochondrial prohibitin from Boleophthalmus pectinirostris and evaluation of its possible role in spermatogenesis.
Q58696754Gonadectomy in Mito-Ob mice revealed a sex-dimorphic relationship between prohibitin and sex steroids in adipose tissue biology and glucose homeostasis
Q60949486Obesity-Linked Cancers: Current Knowledge, Challenges and Limitations in Mechanistic Studies and Rodent Models
Q38288384Prohibitin - At the crossroads of obesity-linked diabetes and cancer.
Q47555171Prohibitin plays a critical role in Enterovirus 71 neuropathogenesis
Q33830554Prohibitin-induced obesity leads to anovulation and polycystic ovary in mice
Q36719439Prohibitin-induced, obesity-associated insulin resistance and accompanying low-grade inflammation causes NASH and HCC
Q89700562Prohibitin: a potential therapeutic target in tyrosine kinase signaling
Q64275992Prohibitin: a prime candidate for a pleiotropic effector that mediates sex differences in obesity, insulin resistance, and metabolic dysregulation
Q37037962Prohibitin: an unexpected role in sex dimorphic functions
Q38953433Tumour biology of obesity-related cancers: understanding the molecular concept for better diagnosis and treatment.
Q91868469Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways in Eight Groups of 34 Diseases Including 24 Inflammatory Organ Diseases and 10 Types of Tumors

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