Cyclic diGMP regulates production of sortase substrates of Clostridium difficile and their surface exposure through ZmpI protease-mediated cleavage

scientific article published on 17 August 2015

Cyclic diGMP regulates production of sortase substrates of Clostridium difficile and their surface exposure through ZmpI protease-mediated cleavage is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M115.665091
P932PMC publication ID4591827
P698PubMed publication ID26283789

P50authorJyoti ChoudharyQ56421088
Johann PeltierQ59701542
Neil F FairweatherQ63860208
Brendan W WrenQ65559586
P2093author name stringLu Yu
Volkhard Kaever
Lisa F Dawson
Edward C Couchman
Helen A Shaw
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Structural Basis for c-di-GMP-Mediated Inside-Out Signaling Controlling Periplasmic ProteolysisQ27666910
Structure-Based Modification of a Clostridium difficile-Targeting Endolysin Affects Activity and Host RangeQ27671293
Community-associated Clostridium difficile infection and antibiotics: a meta-analysisQ28289675
Principles of c-di-GMP signalling in bacteriaQ29615333
Regulated shift from helical to polar localization of Listeria monocytogenes cell wall-anchored proteins.Q30503927
Anchor structure of staphylococcal surface proteins. V. Anchor structure of the sortase B substrate IsdC.Q31148240
An embarrassment of sortases - a richness of substrates?Q32142224
A mariner-based transposon system for in vivo random mutagenesis of Clostridium difficileQ33519869
A c-di-GMP effector system controls cell adhesion by inside-out signaling and surface protein cleavageQ33815510
Autolysins of Bacillus subtilis: multiple enzymes with multiple functionsQ33857357
Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wallQ33869464
c-di-GMP turn-over in Clostridium difficile is controlled by a plethora of diguanylate cyclases and phosphodiesterasesQ33869493
Cyclic di-GMP signaling regulates invasion by Ehrlichia chaffeensis of human monocytesQ34045696
An allosteric self-splicing ribozyme triggered by a bacterial second messengerQ34131029
Sortase B, a new class of sortase in Listeria monocytogenesQ34306775
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genomeQ34542433
New trends in Clostridium difficile virulence and pathogenesisQ34605658
Genome-wide identification of regulatory RNAs in the human pathogen Clostridium difficile.Q34722556
Recent insights into Clostridium difficile pathogenesisQ34975246
Identification of a novel zinc metalloprotease through a global analysis of Clostridium difficile extracellular proteinsQ35058561
Cyclic di-GMP riboswitch-regulated type IV pili contribute to aggregation of Clostridium difficileQ35074912
Structure and function of a Clostridium difficile sortase enzymeQ35210713
Clostridium difficile has a single sortase, SrtB, that can be inhibited by small-molecule inhibitorsQ35237266
Cyclic dimeric GMP signaling regulates intracellular aggregation, sessility, and growth of Ehrlichia chaffeensisQ35273288
Clostridium difficile has an original peptidoglycan structure with a high level of N-acetylglucosamine deacetylation and mainly 3-3 cross-linksQ35309863
Protein secretion and surface display in Gram-positive bacteriaQ35814726
Sortase enzymes in Gram-positive bacteriaQ36661916
Molecular characterization of a Clostridium difficile bacteriophage and its cloned biologically active endolysinQ36933726
The second messenger cyclic Di-GMP regulates Clostridium difficile toxin production by controlling expression of sigDQ37264144
Bacterial adhesins in host-microbe interactions.Q37520112
Community-acquired Clostridium difficile infection: an increasing public health threatQ37655456
Intramolecular isopeptide bonds: protein crosslinks built for stress?Q37807627
You've come a long way: c-di-GMP signalingQ37973939
Spatial positioning of cell wall-anchored virulence factors in Gram-positive bacteria.Q38058966
Mechanism for gene control by a natural allosteric group I ribozymeQ38331465
A novel secreted metalloprotease (CD2830) from Clostridium difficile cleaves specific proline sequences in LPXTG cell surface proteinsQ39380045
Clinical features of Clostridium difficile-associated infections and molecular characterization of strains: results of a retrospective study, 2000-2004.Q40458839
Cyclic diguanylate inversely regulates motility and aggregation in Clostridium difficileQ41762895
The Clostridium difficile spo0A gene is a persistence and transmission factorQ41817325
Clostridium difficile has two parallel and essential Sec secretion systemsQ41914077
Precise manipulation of the Clostridium difficile chromosome reveals a lack of association between the tcdC genotype and toxin production.Q42115469
Engineering of Bacillus subtilis strains to allow rapid characterization of heterologous diguanylate cyclases and phosphodiesterasesQ42920317
Multiple factors modulate biofilm formation by the anaerobic pathogen Clostridium difficileQ42958466
The effect of c-di-GMP (3'-5'-cyclic diguanylic acid) on the biofilm formation and adherence of Streptococcus mutansQ46137049
Clostridium difficile InfectionQ56286563
Clostridium difficilesortase recognizes a (S/P)PXTG sequence motif and can accommodate diaminopimelic acid as a substrate for transpeptidationQ59688002
Quantification of cyclic dinucleotides by reversed-phase LC-MS/MSQ86814851
P433issue40
P407language of work or nameEnglishQ1860
P921main subjectClostridium difficileQ310543
P304page(s)24453-24469
P577publication date2015-08-17
P1433published inJournal of Biological ChemistryQ867727
P1476titleCyclic diGMP regulates production of sortase substrates of Clostridium difficile and their surface exposure through ZmpI protease-mediated cleavage
P478volume290

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