Ets Related Gene and Smad3 Proteins Collaborate to Activate Transforming Growth Factor-Beta Mediated Signaling Pathway in ETS Related Gene-Positive Prostate Cancer Cells

scientific article published on September 2014

Ets Related Gene and Smad3 Proteins Collaborate to Activate Transforming Growth Factor-Beta Mediated Signaling Pathway in ETS Related Gene-Positive Prostate Cancer Cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1166/JPSP.2014.1022
P932PMC publication ID4347898
P698PubMed publication ID25745638

P2093author name stringHuali Xu
E Shyam P Reddy
Veena N Rao
Chunshu Yang
Kunchala Rungsrisuriyachai
Jinbo Fang
Sharif Morsalin
Shubhalaxmi Kayarthodi
Brittany Mckenzie
Ujwala Gunnal
P2860cites workThe erg gene: a human gene related to the ets oncogeneQ24299030
The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domainsQ24319886
Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteinsQ24633428
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.Q27824849
Mechanisms of TGF-beta signaling from cell membrane to the nucleusQ27860785
Role of transforming growth factor-beta signaling in cancerQ28145449
Smad-dependent and Smad-independent pathways in TGF-beta family signallingQ28208250
erg, an ets-related gene, codes for sequence-specific transcriptional activatorsQ28238746
TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domainQ28241486
Characterization of the DNA binding and transcriptional activation domains of the erg proteinQ28270082
TGF-β family signaling in stem cellsQ28274611
TGFβ signalling in contextQ28275410
The human erg gene maps to chromosome 21, band q22: relationship to the 8; 21 translocation of acute myelogenous leukemiaQ28294400
erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translationQ28295357
Specificity and versatility in tgf-beta signaling through SmadsQ29616324
Delineation of TMPRSS2-ERG splice variants in prostate cancerQ33357287
Role of TMPRSS2-ERG gene fusion in negative regulation of PSMA expressionQ33952306
Use of a TGFβ type I receptor inhibitor in mouse skin carcinogenesis reveals a dual role for TGFβ signaling in tumor promotion and progressionQ34363852
Transforming growth factor-beta signal transduction in epithelial cells.Q34438032
A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers.Q34768457
Transforming growth factor-β and the hallmarks of cancerQ34789300
Oncogenic activation of ERG: A predominant mechanism in prostate cancerQ35685920
Phospho-specific Smad3 signaling: impact on breast oncogenesisQ36116217
A causal role for ERG in neoplastic transformation of prostate epithelium.Q36883091
The discovery of common recurrent transmembrane protease serine 2 (TMPRSS2)-erythroblastosis virus E26 transforming sequence (ETS) gene fusions in prostate cancer: significance and clinical implicationsQ37460610
Molecular Mechanism of Activation of Transforming Growth Factor Beta/Smads Signaling Pathway in Ets Related Gene-Positive Prostate CancersQ38301071
Anti-Epileptic Drug Targets Ewing SarcomaQ38301170
Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cellsQ38335697
Increased TGF-β1-mediated suppression of growth and motility in castrate-resistant prostate cancer cells is consistent with Smad2/3 signalingQ39415532
SMAD3 is essential for transforming growth factor-β1-induced urokinase type plasminogen activator expression and migration in transformed keratinocytesQ39498984
Mapping of TMPRSS2-ERG fusions in the context of multi-focal prostate cancerQ40038137
ETS gene fusions and prostate cancerQ42064904
Monoallelic expression of TMPRSS2/ERG in prostate cancer stem cellsQ44287808
Detection and clinical significance of gene rearrangements in Chinese patients with adult acute lymphoblastic leukemiaQ46091599
Promotion and maintenance of leukemia by ERG.Q53268059
P433issue3
P921main subjectcollaborationQ1145523
P304page(s)175-181
P577publication date2014-09-01
P1433published inJournal of pharmaceutical sciences and pharmacologyQ27726023
P1476titleEts Related Gene and Smad3 Proteins Collaborate to Activate Transforming Growth Factor-Beta Mediated Signaling Pathway in ETS Related Gene-Positive Prostate Cancer Cells
P478volume1

Reverse relations

cites work (P2860)
Q42375998Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis
Q41446090Molecular Mechanism of β-Catenin Signaling Pathway Inactivation in ETV1-Positive Prostate Cancers
Q50139666Novel EWSR1-SMAD3 Gene Fusions in a Group of Acral Fibroblastic Spindle Cell Neoplasms
Q64906050Relationship between ETS Transcription Factor ETV1 and TGF-β-regulated SMAD Proteins in Prostate Cancer.
Q52584365The role and gene expression profile of SOCS3 in colorectal carcinoma.
Q41478244Up-regulation of Biglycan is Associated with Poor Prognosis and PTEN Deletion in Patients with Prostate Cancer

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