Defects in the leptin axis reduce abundance of the ABCG5-ABCG8 sterol transporter in liver

scientific article published on 07 June 2007

Defects in the leptin axis reduce abundance of the ABCG5-ABCG8 sterol transporter in liver is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M702236200
P8608Fatcat IDrelease_7wcj7tqtjzeejjn2orws6vftuq
P698PubMed publication ID17561514

P2093author name stringNadezhda S Sabeva
Gregory A Graf
Eric J Rouse
P2860cites workAccumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transportersQ24290568
ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol ExcretionQ24294961
Purification and ATP hydrolysis of the putative cholesterol transporters ABCG5 and ABCG8Q24299169
A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterolQ24806562
Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretionQ28299283
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile saltsQ28584816
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
Defects in processing and trafficking of the cystic fibrosis transmembrane conductance regulatorQ33865171
The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.Q34388548
Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretionQ34415865
A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I.Q34827947
Sterol transfer by ABCG5 and ABCG8: in vitro assay and reconstitutionQ35924415
Rescue of folding defects in ABC transporters using pharmacological chaperonesQ36476116
Cholesterol gallstone susceptibility loci: a mouse map, candidate gene evaluation, and guide to human LITH genesQ36646394
Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis riskQ38287568
Decreased gallbladder response in leptin-deficient obese miceQ38289060
Restoration of gallstone susceptibility by leptin in C57BL/6J ob/ob miceQ38356034
Specific rescue of cystic fibrosis transmembrane conductance regulator processing mutants using pharmacological chaperonesQ40290143
Rescue of DeltaF508 and other misprocessed CFTR mutants by a novel quinazoline compoundQ40367010
Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activationQ40708272
Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.Q40743941
A principal role for the proteasome in endoplasmic reticulum-associated degradation of misfolded intracellular cystic fibrosis transmembrane conductance regulatorQ40754491
Unsaturated fatty acids inhibit cholesterol efflux from macrophages by increasing degradation of ATP-binding cassette transporter A1.Q40763682
Pathogenesis and treatment of gallstonesQ40869509
Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosisQ41714520
QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strainsQ42685371
Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1cQ43848640
Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8.Q44324697
Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in miceQ44451361
Leptin-resistant obese mice have paradoxically low biliary cholesterol saturationQ44567960
FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in miceQ44569556
Cholesterol-lowering action of psyllium mucilloid in the hamster: sites and possible mechanisms of actionQ44599104
Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor.Q44709473
Missense mutations in ABCG5 and ABCG8 disrupt heterodimerization and traffickingQ44822080
Leptin-resistant obese mice do not form biliary crystals on a high cholesterol dietQ45157366
Diosgenin-induced biliary cholesterol secretion in mice requires Abcg8.Q45201682
Association of a lithogenic Abcg5/Abcg8 allele on Chromosome 17 (Lith9) with cholesterol gallstone formation in PERA/EiJ miceQ46694044
Hepatic expression of ABC transporters G5 and G8 does not correlate with biliary cholesterol secretion in liver transplant patients.Q46775420
Factors associated with gallstone disease in the MICOL experience. Multicenter Italian Study on Epidemiology of CholelithiasisQ50154817
The epidemiology of gallbladder disease: Observations in the Framingham studyQ50157695
Calreticulin facilitates the cell surface expression of ABCG5/G8.Q51806400
P433issue31
P407language of work or nameEnglishQ1860
P304page(s)22397-22405
P577publication date2007-06-07
P1433published inJournal of Biological ChemistryQ867727
P1476titleDefects in the leptin axis reduce abundance of the ABCG5-ABCG8 sterol transporter in liver
P478volume282

Reverse relations

cites work (P2860)
Q37463266ABCD2 is abundant in adipose tissue and opposes the accumulation of dietary erucic acid (C22:1) in fat
Q57115936ABCG5 and ABCG8: more than a defense against xenosterols
Q33994721ABCG5/ABCG8-independent biliary cholesterol excretion in lactating rats
Q33894773Acceleration of biliary cholesterol secretion restores glycemic control and alleviates hypertriglyceridemia in obese db/db mice
Q37070854Effect of peripheral circadian dysfunction on metabolic disease in response to a diabetogenic diet
Q36173755GRP78 rescues the ABCG5 ABCG8 sterol transporter in db/db mice
Q38317453Genetically obese mice do not show increased gut permeability or faecal bile acid hydrophobicity.
Q37603238Hepatic Mttp deletion reverses gallstone susceptibility in L-Fabp knockout mice.
Q36989788Inside job: ligand-receptor pharmacology beneath the plasma membrane
Q38742329LXR-dependent regulation of macrophage-specific reverse cholesterol transport is impaired in a model of genetic diabesity.
Q34786054Phytosterols differentially influence ABC transporter expression, cholesterol efflux and inflammatory cytokine secretion in macrophage foam cells
Q35838266Protein mediators of sterol transport across intestinal brush border membrane
Q33897816The ABCG5 ABCG8 sterol transporter and phytosterols: implications for cardiometabolic disease
Q36217307The ABCG5 ABCG8 sterol transporter opposes the development of fatty liver disease and loss of glycemic control independently of phytosterol accumulation
Q36610558The Impairment of Macrophage-to-Feces Reverse Cholesterol Transport during Inflammation Does Not Depend on Serum Amyloid A.
Q35958430The absence of ABCD2 sensitizes mice to disruptions in lipid metabolism by dietary erucic acid
Q35217035The combination of ezetimibe and ursodiol promotes fecal sterol excretion and reveals a G5G8-independent pathway for cholesterol elimination

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