The lectin chaperone calnexin utilizes polypeptide-based interactions to associate with many of its substrates in vivo

scientific article published on 03 May 2001

The lectin chaperone calnexin utilizes polypeptide-based interactions to associate with many of its substrates in vivo is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M100270200
P698PubMed publication ID11337494

P2093author name stringWilliams DB
Danilczyk UG
P2860cites workCalreticulin functions in vitro as a molecular chaperone for both glycosylated and non-glycosylated proteinsQ22010871
Interactions between newly synthesized glycoproteins, calnexin and a network of resident chaperones in the endoplasmic reticulumQ24681574
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Interaction of MHC class I molecules with the transporter associated with antigen processingQ28254129
Retention of unassembled components of integral membrane proteins by calnexinQ28258174
Role of N-linked oligosaccharide recognition, glucose trimming, and calnexin in glycoprotein folding and quality controlQ28259305
Calreticulin interacts with newly synthesized human immunodeficiency virus type 1 envelope glycoprotein, suggesting a chaperone function similar to that of calnexinQ28272645
Calnexin associates exclusively with individual CD3 delta and T cell antigen receptor (TCR) alpha proteins containing incompletely trimmed glycans that are not assembled into multisubunit TCR complexesQ28277778
Functional relationship between calreticulin, calnexin, and the endoplasmic reticulum luminal domain of calnexinQ28609675
The molecular chaperone calnexin binds Glc1Man9GlcNAc2 oligosaccharide as an initial step in recognizing unfolded glycoproteinsQ28609741
Calreticulin functions as a molecular chaperone in the biosynthesis of myeloperoxidaseQ28610241
Polypeptide binding properties of the chaperone calreticulin.Q30870135
Glycoprotein folding in the endoplasmic reticulum: a tale of three chaperones?Q33957095
Transient, lectin-like association of calreticulin with folding intermediates of cellular and viral glycoproteinsQ34451461
Calnexin and BiP act as sequential molecular chaperones during thyroglobulin folding in the endoplasmic reticulumQ36235150
Calreticulin, a peptide-binding chaperone of the endoplasmic reticulum, elicits tumor- and peptide-specific immunityQ36367825
Trypanosoma cruzi calreticulin is a lectin that binds monoglucosylated oligosaccharides but not protein moieties of glycoproteinsQ36859692
Calnexin Fails to Associate with Substrate Proteins in Glucosidase-deficient Cell LinesQ38289520
Glucose trimming and reglucosylation determine glycoprotein association with calnexin in the endoplasmic reticulumQ38295642
Calnexin recognizes carbohydrate and protein determinants of class I major histocompatibility complex moleculesQ38298548
Kinetics and the mechanism of interaction of the endoplasmic reticulum chaperone, calreticulin, with monoglucosylated (Glc1Man9GlcNAc2) substrateQ38312075
Calnexin discriminates between protein conformational states and functions as a molecular chaperone in vitroQ38319586
Calnexin interaction with N-glycosylation mutants of a polytopic membrane glycoprotein, the human erythrocyte anion exchanger 1 (band 3).Q38323896
Trimming and readdition of glucose to N-linked oligosaccharides determines calnexin association of a substrate glycoprotein in living cellsQ38327415
Promotion of tyrosinase folding in COS 7 cells by calnexinQ38329691
Inhibition of glucose trimming with castanospermine reduces calnexin association and promotes proteasome degradation of the alpha-subunit of the nicotinic acetylcholine receptorQ38336100
Differential interaction of coagulation factor VIII and factor V with protein chaperones calnexin and calreticulinQ38337996
Promotion of transferrin folding by cyclic interactions with calnexin and calreticulinQ38342876
Conformation-independent binding of monoglucosylated ribonuclease B to calnexinQ38349363
Glycan-dependent and -independent association of vesicular stomatitis virus G protein with calnexinQ38356606
Definition of the lectin-like properties of the molecular chaperone, calreticulin, and demonstration of its copurification with endomannosidase from rat liver GolgiQ38357852
Fractionation and structural assessment of oligosaccharides and glycopeptides by use of immobilized lectinsQ39664923
Identification of novel peptide binding proteins in the endoplasmic reticulum: ERp72, calnexin, and grp170.Q40936525
The transient association of ERp57 with N-glycosylated proteins is regulated by glucose trimmingQ41007404
Calnexin-dependent enhancement of nicotinic acetylcholine receptor assembly and surface expressionQ41079853
Unique expression of major histocompatibility complex class I proteins in the absence of glucose trimming and calnexin associationQ41267459
P-glycoprotein. Associations between domains and between domains and molecular chaperonesQ41295494
Regulation of MHC class I transport by the molecular chaperone, calnexin (p88, IP90).Q41493842
Association of folding intermediates of glycoproteins with calnexin during protein maturationQ41533203
Nucleotide sequence of a Drosophila melanogaster cDNA encoding a calnexin homologue.Q47070474
Nucleotide sequence of aDrosophila melanogastergene encoding a calreticulin homologueQ48194150
Enhanced Catalysis of Ribonuclease B Folding by the Interaction of Calnexin or Calreticulin with ERp57Q58450782
Glycoproteins form mixed disulphides with oxidoreductases during folding in living cellsQ59098658
P433issue27
P407language of work or nameEnglishQ1860
P921main subjectmolecular chaperonesQ422496
P304page(s)25532-25540
P577publication date2001-05-03
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe lectin chaperone calnexin utilizes polypeptide-based interactions to associate with many of its substrates in vivo
P478volume276

Reverse relations

cites work (P2860)
Q40372971A Novel Potential Signal Peptide Sequence and Overexpression of ER-Resident Chaperones Enhance Heterologous Protein Secretion in Thermotolerant Methylotrophic Yeast Ogataea thermomethanolica
Q35046950Accessory proteins and the assembly of human class I MHC molecules: a molecular and structural perspective
Q28265597Assembly of MHC class I molecules within the endoplasmic reticulum
Q40697127Association of the thyrotropin receptor with calnexin, calreticulin and BiP. Efects on the maturation of the receptor.
Q33292065Calnexin Delta 185-520 partially reverses the misprocessing of the Delta F508 cystic fibrosis transmembrane conductance regulator.
Q40502090Calreticulin promotes folding of functional human leukocyte antigen class I molecules in vitro
Q41965156Cell viability and secretion of active proteins in Schizosaccharomyces pombe do not require the chaperone function of calnexin.
Q100428060Characterization of five novel vasopressin V2 receptor mutants causing nephrogenic diabetes insipidus reveals a role of tolvaptan for M272R-V2R mutation
Q38291721Contributions of the Lectin and Polypeptide Binding Sites of Calreticulin to Its Chaperone Functions in Vitro and in Cells
Q35874618Cyclophilin C Participates in the US2-Mediated Degradation of Major Histocompatibility Complex Class I Molecules
Q40152161D1 and D2 dopamine receptor expression is regulated by direct interaction with the chaperone protein calnexin
Q35797496Delta F508 CFTR pool in the endoplasmic reticulum is increased by calnexin overexpression.
Q37149513ERp57 does not require interactions with calnexin and calreticulin to promote assembly of class I histocompatibility molecules, and it enhances peptide loading independently of its redox activity
Q36627304Endoplasmic reticulum chaperones stabilize nicotinic receptor subunits and regulate receptor assembly
Q64244254Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis
Q39675696Functional relationship between protein disulfide isomerase family members during the oxidative folding of human secretory proteins
Q40299278Functions of ERp57 in the folding and assembly of major histocompatibility complex class I molecules
Q24646392Getting in and out from calnexin/calreticulin cycles
Q40493568Glycan-independent role of calnexin in the intracellular retention of Charcot-Marie-tooth 1A Gas3/PMP22 mutants
Q34355599HIV-1 protein Nef inhibits activity of ATP-binding cassette transporter A1 by targeting endoplasmic reticulum chaperone calnexin
Q40703743Identification of specific glycoforms of major histocompatibility complex class I heavy chains suggests that class I peptide loading is an adaptation of the quality control pathway involving calreticulin and ERp57.
Q38328572In vitro and in vivo assays to assess the functions of calnexin and calreticulin in ER protein folding and quality control
Q38300233Increase of calnexin gene dosage boosts the secretion of heterologous proteins by Hansenula polymorpha
Q38346469Lectin-deficient calnexin is capable of binding class I histocompatibility molecules in vivo and preventing their degradation
Q36678050Lectin-deficient calreticulin retains full functionality as a chaperone for class I histocompatibility molecules.
Q39756850Lectin-mediated retention of p62 facilitates p62-E1 heterodimerization in endoplasmic reticulum of Semliki Forest virus-infected cells
Q28203094Localization of the lectin, ERp57 binding, and polypeptide binding sites of calnexin and calreticulin
Q24322887Major histocompatibility complex class I molecules expressed with monoglucosylated N-linked glycans bind calreticulin independently of their assembly status
Q38347777Maturation of hepatic lipase. Formation of functional enzyme in the endoplasmic reticulum is the rate-limiting step in its secretion
Q37133168Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death
Q44822080Missense mutations in ABCG5 and ABCG8 disrupt heterodimerization and trafficking
Q33240021Monitoring chaperone engagement of substrates in the endoplasmic reticulum of live cells
Q44246896Multiple mechanism-mediated retention of a defective brassinosteroid receptor in the endoplasmic reticulum of Arabidopsis
Q40740036Mutant MHC class I molecules define interactions between components of the peptide-loading complex
Q28085581N-Glycan-based ER Molecular Chaperone and Protein Quality Control System: The Calnexin Binding Cycle
Q36638528N-linked glycosylation is required for nicotinic receptor assembly but not for subunit associations with calnexin
Q26827318N-linked sugar-regulated protein folding and quality control in the ER
Q40743401Overexpression of calreticulin modulates protein kinase B/Akt signaling to promote apoptosis during cardiac differentiation of cardiomyoblast H9c2 cells
Q35825535Peptide-based interactions with calnexin target misassembled membrane proteins into endoplasmic reticulum-derived multilamellar bodies
Q40273382Productive folding of tyrosinase ectodomain is controlled by the transmembrane anchor
Q38018918Protein secretion and the endoplasmic reticulum.
Q29619929Quality control in the endoplasmic reticulum
Q38297618Relationship between calnexin and BiP in suppressing aggregation and promoting refolding of protein and glycoprotein substrates
Q35107713Role of calnexin in the glycan-independent quality control of proteolipid protein
Q37354240Specific ER quality control components required for biogenesis of the plant innate immune receptor EFR.
Q38328302Surface calreticulin mediates muramyl dipeptide-induced apoptosis in RK13 cells
Q46593938Synthesis of Glc1Man9-Glycoprotein Probes by a Misfolding/Enzymatic Glucosylation/Misfolding Sequence
Q35922740Tapasin and other chaperones: models of the MHC class I loading complex.
Q35973101The interplay between folding-facilitating mechanisms in Trypanosoma cruzi endoplasmic reticulum.
Q38212658The many functions of the endoplasmic reticulum chaperones and folding enzymes
Q38344871The primary substrate binding site in the b' domain of ERp57 is adapted for endoplasmic reticulum lectin association
Q45351252rCNT2 extracellular cysteines, Cys(615) and Cys(649), are important for maturation and sorting to the plasma membrane.

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