Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages.

scientific article published on 26 April 2007

Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1050231512
P356DOI10.1038/SJ.JID.5700842
P698PubMed publication ID17460730
P5875ResearchGate publication ID6367943

P50authorUrs ChristenQ55292965
P2093author name stringJosef Pfeilschifter
Stefan Frank
Elke Müller
Dana Schiefelbein
Itamar Goren
Heiko Mühl
P2860cites workPositional cloning of the mouse obese gene and its human homologueQ22251285
Inflammation, stress, and diabetesQ24523336
Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repairQ24607167
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
Alternative activation of macrophagesQ27860939
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin ResistanceQ28131660
F4/80, a monoclonal antibody directed specifically against the mouse macrophageQ28281328
Global and societal implications of the diabetes epidemicQ29614551
Regulation of wound healing by growth factors and cytokinesQ29615242
The many faces of macrophage activationQ29617449
Effects of the obese gene product on body weight regulation in ob/ob miceQ29617935
Adipocytokines: mediators linking adipose tissue, inflammation and immunityQ29619393
C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitusQ29619398
CCR2 modulates inflammatory and metabolic effects of high-fat feedingQ29622869
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipaseQ34216687
Inflammatory cells during wound repair: the good, the bad and the uglyQ34456471
Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute woundsQ34478664
Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers. A phase III randomized placebo-controlled double-blind studyQ34747226
Severely impaired insulin signaling in chronic wounds of diabetic ob/ob mice: a potential role of tumor necrosis factor-alphaQ35088035
Wound healing and its impairment in the diabetic footQ36314100
Expression of the macrophage-specific antigen F4/80 during differentiation of mouse bone marrow cells in cultureQ36345628
Leptin and wound inflammation in diabetic ob/ob mice: differential regulation of neutrophil and macrophage influx and a potential role for the scab as a sink for inflammatory cells and mediatorsQ38348763
Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in miceQ39725584
Caspase activation and apoptosis induction by adalimumab: demonstration in vitro and in vivo in a chimeric mouse modelQ40336783
The function of nitric oxide in wound repair: inhibition of inducible nitric oxide-synthase severely impairs wound reepithelializationQ40912643
Nitric oxide triggers enhanced induction of vascular endothelial growth factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair.Q40920416
The membrane attack complex of complement induces caspase activation and apoptosisQ43900091
Long-term prognosis for diabetic patients with foot ulcers.Q51052851
Long-term costs for foot ulcers in diabetic patients in a multidisciplinary settingQ71722724
Immunohistochemical characterization of the cutaneous cellular infiltrate in different areas of chronic leg ulcersQ71880787
Diabetic foot ulcersQ73370844
New ulceration, new major amputation, and survival rates in diabetic subjects hospitalized for foot ulceration from 1990 to 1993: a 6.5-year follow-upQ73477706
Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repairQ74199089
Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathwayQ77061247
Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort studyQ77769452
Adalimumab induces apoptosis of human monocytes: a comparative study with infliximab and etanerceptQ81361610
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)2259-2267
P577publication date2007-04-26
P1433published inJournal of Investigative DermatologyQ3186921
P1476titleSystemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages
P478volume127