Intranasal delivery of bone marrow-derived mesenchymal stem cells, macrophages, and microglia to the brain in mouse models of Alzheimer's and Parkinson's disease

scientific article published on 09 October 2014

Intranasal delivery of bone marrow-derived mesenchymal stem cells, macrophages, and microglia to the brain in mouse models of Alzheimer's and Parkinson's disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3727/096368914X684970
P698PubMed publication ID25302802
P5875ResearchGate publication ID267749457

P50authorAlexandra StolzingQ42314826
Ana NovakovicQ84393539
P2093author name stringMatthias Schwab
Richard Schäfer
Christoph H Gleiter
William H Frey
Sandra Beer-Hammer
Tilo Biedermann
Georg Siegel
Barbara Proksch
Lusine Danielyan
Marine Buadze
Ali Lourhmati
Claire Fabian
Philipp Kahle
P2860cites workMisfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathiesQ24554351
Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcuminQ24682639
Expression of constitutively active erythropoietin receptor in pyramidal neurons of cortex and hippocampus boosts higher cognitive functions in miceQ30475059
Microglia differentiation using a culture system for the expansion of mice non-adherent bone marrow stem cellsQ31053844
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Mesenchymal stem cells in a transgenic mouse model of multiple system atrophy: immunomodulation and neuroprotectionQ33916838
Intranasal delivery of cells to the brain.Q34016739
Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recoveryQ34351483
Delayed intranasal delivery of hypoxic-preconditioned bone marrow mesenchymal stem cells enhanced cell homing and therapeutic benefits after ischemic stroke in miceQ34432396
Mesenchymal stem cells for the treatment of neurodegenerative disease.Q34473474
Intranasal mesenchymal stem cell treatment for neonatal brain damage: long-term cognitive and sensorimotor improvementQ34542001
Hypoxia promotes dopaminergic differentiation of mesenchymal stem cells and shows benefits for transplantation in a rat model of Parkinson's diseaseQ34559310
Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal strokeQ34673506
Nasal administration of opioids for pain management in adultsQ34760508
Age-dependent astroglial vulnerability to hypoxia and glutamate: the role for erythropoietinQ35017110
Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse modelQ35747138
CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery.Q36112863
Neuroprotection in multiple sclerosisQ36368890
Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microgliaQ36487090
Erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of Alzheimer's diseaseQ36529533
Microglial activation and antioxidant responses induced by the Parkinson's disease protein α-synucleinQ36640417
Biodistribution of neural stem cells after intravascular therapy for hypoxic-ischemiaQ36797965
Intranasal delivery of neural stem/progenitor cells: a noninvasive passage to target intracerebral gliomaQ36861449
Effects of intravenous administration of allogenic bone marrow- and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic strokeQ36997873
Selective targeting of perivascular macrophages for clearance of beta-amyloid in cerebral amyloid angiopathy.Q37079075
Intranasal treatment of central nervous system dysfunction in humansQ37142166
Cellular immune response to intrastriatally implanted allogeneic bone marrow stromal cells in a rat model of Parkinson's diseaseQ37236894
Intranasal delivery to the central nervous system: mechanisms and experimental considerationsQ37624592
Involvement of immune response in the pathogenesis of amyotrophic lateral sclerosis: a therapeutic opportunity?Q37734499
Mesenchymal stem cells: Mechanisms of immunomodulation and homingQ37762880
Intranasal delivery of biologics to the central nervous systemQ37961386
Improvement of cognitive functions in chronic schizophrenic patients by recombinant human erythropoietinQ38403090
Intranasal delivery of mesenchymal stem cells significantly extends survival of irradiated mice with experimental brain tumorsQ38648551
Transplantation of a novel human cord blood-derived neural-like stem cell line in a rat model of cortical infarct.Q40111708
Disparate host response and donor survival after the transplantation of mesenchymal or neuroectodermal cells to the intact rodent brainQ40142380
Similar protective effects of BQ-123 and erythropoietin on survival of neural cells and generation of neurons upon hypoxic injuryQ40344679
Macrophages and inflammation in the central nervous systemQ40489629
The time course of loss of dopaminergic neurons and the gliotic reaction surrounding grafts of embryonic mesencephalon to the striatumQ41106061
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer diseaseQ41753192
Intra-arterial delivery is not superior to intravenous delivery of autologous bone marrow mononuclear cells in acute ischemic stroke.Q42152041
Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP miceQ42243192
Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy.Q42380907
AAV9-mediated erythropoietin gene delivery into the brain protects nigral dopaminergic neurons in a rat model of Parkinson's diseaseQ43281704
Leukocyte infiltration and glial reactions in xenografts of mouse brain tissue undergoing rejection in the adult rat brain. A light and electron microscopical immunocytochemical studyQ43641321
Intranasal formulation of erythropoietin (EPO) showed potent protective activity against amyloid toxicity in the Aβ₂₅₋₃₅ non-transgenic mouse model of Alzheimer's diseaseQ44363046
Systemically administered human bone marrow-derived mesenchymal stem home into peripheral organs but do not induce neuroprotective effects in the MCAo-mouse model for cerebral ischemia.Q45364855
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer diseaseQ45883058
Survival, neuron-like differentiation and functionality of mesenchymal stem cells in neurotoxic environment: the critical role of erythropoietin.Q45927294
Continuous intraventricular infusion of erythropoietin exerts neuroprotective/rescue effects upon Parkinson's disease model of rats with enhanced neurogenesisQ46187074
The SPECT imaging shows the accumulation of neural progenitor cells into internal organs after systemic administration in middle cerebral artery occlusion ratsQ46524695
Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's diseaseQ46942969
The blockade of endothelin A receptor protects astrocytes against hypoxic injury: common effects of BQ-123 anderythropoietin on the rejuvenation of the astrocyte populationQ47767135
Nasal administration of stem cells: a promising novel route to treat neonatal ischemic brain damage.Q48122882
Brain erythropoietin receptor expression in Alzheimer disease and mild cognitive impairmentQ48176932
Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like diseaseQ48247414
Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodiesQ48401512
Marrow stromal cells transplanted to the adult brain are rejected by an inflammatory response and transfer donor labels to host neurons and gliaQ48460765
Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.Q48468481
Immune blood biomarkers of Alzheimer disease patientsQ48684327
Erythropoietin improves memory function with reducing endothelial dysfunction and amyloid-beta burden in Alzheimer's disease modelsQ48833407
Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson disease.Q50527409
LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide.Q51817662
Erythropoietin promotes neuronal replacement through revascularization and neurogenesis after neonatal hypoxia/ischemia in rats.Q53534081
P921main subjectAlzheimer's diseaseQ11081
microgliaQ1622829
mesenchymal stem cellQ1922379
P304page(s)S123-39
P577publication date2014-10-09
P1433published inCell TransplantationQ15761863
P1476titleIntranasal delivery of bone marrow-derived mesenchymal stem cells, macrophages, and microglia to the brain in mouse models of Alzheimer's and Parkinson's disease
P478volume23 Suppl 1

Reverse relations

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