Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2.

scientific article published on July 1994

Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.14.7.4815
P932PMC publication ID358854
P698PubMed publication ID8007980
P5875ResearchGate publication ID15191225

P2093author name stringKortenjann M
Shaw PE
Thomae O
P2860cites workIsolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response elementQ24297374
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGFQ24304344
Synergism in ternary complex formation between the dimeric glycoprotein p67SRF, polypeptide p62TCF and the c-fos serum response elementQ24307673
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1Q24309607
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2Q24336357
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signalingQ24337017
Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response elementQ24337763
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transductionQ24338592
Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirusQ24595462
Raf-1 activates MAP kinase-kinaseQ28211351
Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitroQ28211916
Activation of the MAP kinase pathway by the protein kinase rafQ28212495
Protein kinase C alpha activates RAF-1 by direct phosphorylationQ28260100
A divergence in the MAP kinase regulatory network defined by MEK kinase and RafQ28263195
Raf-1 protein kinase is required for growth of induced NIH/3T3 cellsQ28265128
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signallingQ28268458
Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinaseQ28269621
Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzymeQ28275910
Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCFQ28283139
Analysis and prediction of the different types of beta-turn in proteinsQ28292391
Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitroQ28625928
Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factorQ29616395
Growth factor signaling by receptor tyrosine kinasesQ29618315
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogeneQ29618347
The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domainQ29620270
A vector for expressing GAL4(1-147) fusions in mammalian cellsQ29620516
Transcription activation by the adenovirus E1a proteinQ29620538
SH2 and SH3 domainsQ30194932
MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinaseQ30448366
Direct interaction of Ras and the amino-terminal region of Raf-1 in vitroQ33292215
Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascadeQ33937504
Isolation and characterization of SRF accessory proteins.Q34335354
Inducible binding of a factor to the c-fos regulatory regionQ34600591
Receptor tyrosine kinasesQ35225814
Mitogen-activated protein kinases: versatile transducers for cell signalingQ35231791
The mitogen-activated protein kinase activatorQ35659756
Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleusQ36232666
Mutation of the c-fos gene dyad symmetry element inhibits serum inducibility of transcription in vivo and the nuclear regulatory factor binding in vitroQ36837457
c-fos sequence necessary for basal expression and induction by epidermal growth factor, 12-O-tetradecanoyl phorbol-13-acetate and the calcium ionophoreQ36922259
Mitogen-activated protein kinase activation resulting from selective oncogene expression in NIH 3T3 and rat 1a cellsQ37146635
Phorbol ester stimulates a protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene productQ37183425
Negative charge at the casein kinase II phosphorylation site is important for transformation but not for Rb protein binding by the E7 protein of human papillomavirus type 16.Q37531695
Molecular themes in oncogenesisQ37625792
The SRE: a growth factor responsive transcriptional regulatorQ37844409
The structure and function of the fos proto-oncogene.Q38245943
Ternary complex formation over the c-fos serum response element: p62TCF exhibits dual component specificity with contacts to DNA and an extended structure in the DNA-binding domain of p67SRF.Q38326992
The SIF binding element confers sis/PDGF inducibility onto the c-fos promoterQ38338025
The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP.Q38347607
Fos and Jun: the AP-1 connectionQ39606540
Improved primer design for PCR-based, site-directed mutagenesisQ40420778
The assembly of signalling complexes by receptor tyrosine kinasesQ40853794
The MAP kinase cascade is essential for diverse signal transduction pathwaysQ40853991
A protein domain conserved between yeast MCM1 and human SRF directs ternary complex formationQ41083836
Proto-oncogene c-fos expression in growth regions of fetal bone and mesodermal web tissueQ41460489
Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylationQ41530867
Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoterQ41612990
Activation of mitogen-activated protein (MAP) kinase by a MAP kinase-kinaseQ41614456
ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSKQ41634356
Microtubule-associated-protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells. Identity with the mitogen-activated MAP kinase of fibroblastic cellsQ41714893
Phosphorylation of the C terminus of Fos protein is required for transcriptional transrepression of the c-fos promoterQ41716814
Transactivation of c-fos and beta-actin genes by raf as a step in early response to transmembrane signalsQ41740029
Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitroQ42510291
Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptorQ42796135
Multiple sequence elements in the c-fos promoter mediate induction by cAMP.Q42800062
Functional analysis of a growth factor-responsive transcription factor complexQ42810320
Induction of c-fos gene and protein by growth factors precedes activation of c-mycQ44887897
Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5' element and c-fos 3' sequencesQ48375058
Activation of the c-Raf protein kinase by protein kinase C phosphorylationQ52442555
Role of ion flux in the control of c-fos expressionQ57963317
Bone and haematopoietic defects in mice lacking c-fosQ58326969
Deregulated c-fos expression interferes with normal bone development in transgenic miceQ58327005
Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factorsQ58485006
Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and proteinQ59086707
Pleiotropic effects of a null mutation in the c-fos proto-oncogeneQ62555352
EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signalingQ69078300
The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoterQ69177591
SPXX, a frequent sequence motif in gene regulatory proteinsQ69209195
A sensitive method for detection of calmodulin-dependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamide gelQ69363944
Yeast (Saccharomyces cerevisiae) fructose-1,6-bisphosphatase. Properties of phospho and dephospho forms and of two mutants in which serine 11 has been changed by site-directed mutagenesisQ69824634
The immunosuppressant rapamycin induces inactivation of p70s6k through dephosphorylation of a novel set of sitesQ72865321
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)4815-4824
P577publication date1994-07-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleInhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2.
P478volume14

Reverse relations

cites work (P2860)
Q73413981A bombesin receptor subtype-3 peptide increases nuclear oncogene expression in a MEK-1 dependent manner in human lung cancer cells
Q47848122A cellular threshold for active ERK1/2 levels determines Raf/MEK/ERK-mediated growth arrest versus death responses
Q41716419Activation and signal transduction via mitogen-activated protein (MAP) kinases in T lymphocytes
Q74428408Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma
Q28272395Activation of ternary complex factor Elk-1 by stress-activated protein kinases
Q30442086Activation of the MKK/ERK pathway during somatic cell mitosis: direct interactions of active ERK with kinetochores and regulation of the mitotic 3F3/2 phosphoantigen.
Q35900365Activation of the serum response factor by p65/NF-kappaB
Q89820936Activator Protein-1 Transcriptional Activity Drives Soluble Micrograft-Mediated Cell Migration and Promotes the Matrix Remodeling Machinery
Q35202386Active ERK2 is sufficient to mediate growth arrest and differentiation signaling
Q30871375All-trans retinoic acid promotes neural lineage entry by pluripotent embryonic stem cells via multiple pathways
Q42515619Altered PYK2 phosphorylation by ANG II in hypertensive vascular smooth muscle
Q57888734CBP/p300 Integrates Raf/Rac-Signaling Pathways in the Transcriptional Induction of NF-ATc during T Cell Activation
Q35010869Calcium input potentiates the transforming growth factor (TGF)-beta1-dependent signaling to promote the export of inorganic pyrophosphate by articular chondrocyte
Q34087757Characterisation of somatostatin sst2 receptor splice variants
Q40022092Characterization of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) mitogen-activated protein kinase pathway
Q24568248Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET)
Q33887662Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins
Q34563136Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals
Q39674554Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.
Q41173912Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.
Q36338868Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway
Q41133919Cytoskeleton reorganization induces the urokinase-type plasminogen activator gene via the Ras/extracellular signal-regulated kinase (ERK) signaling pathway
Q40394722DNA bending in the ternary nucleoprotein complex at thec-fosprometer
Q42833754Dephosphorylation of cofilin is regulated through Ras and requires the combined activities of the Ras-effectors MEK and PI3K.
Q36560535Determinants of DNA-binding specificity of ETS-domain transcription factors
Q40772270Development of a homogeneous MAP kinase reporter gene screen for the identification of agonists and antagonists at the CXCR1 chemokine receptor
Q40789670Differential activation of c-fos promoter elements by serum, lysophosphatidic acid, G proteins and polypeptide growth factors.
Q43764421Differential expression of active, phosphorylation-dependent MAP kinases, MAPK/ERK, SAPK/JNK and p38, and specific transcription factor substrates following quinolinic acid excitotoxicity in the rat.
Q42829135Differential usage of signal transduction pathways defines two types of serum response factor target gene
Q40906065Dimer formation by ternary complex factor ELK-1.
Q38361280Dissociation of c-fos induction and mitogen-activated-protein kinase activation from the hepatocyte-growth-factor-induced motility response in human gastric carcinoma cells.
Q41159649Dual leucine zipper-bearing kinase (DLK) activates p46SAPK and p38mapk but not ERK2.
Q42806499ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry
Q41898385ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1
Q28578241ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation
Q54608590ERK2/p42 MAP kinase stimulates both autonomous and SRF-dependent DNA binding by Elk-1.
Q28140491ERK5 and ERK2 cooperate to regulate NF-kappaB and cell transformation
Q28578966Efficient trafficking of TGN38 from the endosome to the trans-Golgi network requires a free hydroxyl group at position 331 in the cytosolic domain
Q43070748Endogenous opioids: overview and current issues
Q33957925Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation
Q33836237Growth arrest signaling of the Raf/MEK/ERK pathway in cancer
Q42834940Growth hormone regulates ternary complex factors and serum response factor associated with the c-fos serum response element
Q37706260IL-17A weakens the antitumor immuity by inhibiting apoptosis of MDSCs in Lewis lung carcinoma bearing mice
Q28584101Immunolocalization of the mitogen-activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system
Q46646892Inhibition of MAP kinase blocks insulin-mediated DNA synthesis and transcriptional activation of c-fos by Elk-1 in vascular smooth muscle cells
Q40022357Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells
Q44028801Inhibitors of nitric oxide synthase attenuate nerve growth factor-mediated increases in choline acetyltransferase expression in PC12 cells
Q39695655Interaction of serum response factor (SRF) with the Elk-1 B box inhibits RhoA-actin signaling to SRF and potentiates transcriptional activation by Elk-1.
Q73357698Janus kinase 2-dependent activation of p38 mitogen-activated protein kinase by growth hormone. Resultant transcriptional activation of ATF-2 and CHOP, cytoskeletal re-organization and mitogenesis
Q38579800Journey to the surface of the cell: Fos regulation and the SRE
Q46298973Kaempferol induces cell death through ERK and Akt-dependent down-regulation of XIAP and survivin in human glioma cells
Q38308935Large isoform of hepatitis delta antigen activates serum response factor-associated transcription.
Q34072088Luteolin induces apoptotic cell death through AIF nuclear translocation mediated by activation of ERK and p38 in human breast cancer cell lines
Q40499329MAP kinase pathways. Straight and narrow or tortuous and intersecting?
Q36567534Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase
Q41489240Mitogen-activated protein kinase cascades and the signaling of hyperosmotic stress to immediate early genes
Q24561871Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif
Q39791081Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling
Q30453600Novel membrane-targeted ERK1 and ERK2 chimeras which act as dominant negative, isotype-specific mitogen-activated protein kinase inhibitors of Ras-Raf-mediated transcriptional activation of c-fos in NIH 3T3 cells
Q35131269OVA66 increases cell growth, invasion and survival via regulation of IGF-1R-MAPK signaling in human cancer cells
Q33853144Oxidative stress and gene regulation
Q40620283Oxidative stress-induced apoptosis is mediated by ERK1/2 phosphorylation
Q42805420PKC epsilon -mediated ERK1/2 activation involved in radiation-induced cell death in NIH3T3 cells
Q48524121PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway
Q28609161Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation
Q24650677Phosphorylation-dependent formation of a quaternary complex at the c-fos SRE
Q46937651Pim-1 kinase inhibits the activation of reporter gene expression in Elk-1 and c-Fos reporting systems but not the endogenous gene expression: an artifact of the reporter gene assay by transient co-transfection
Q40017118Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1.
Q24548297Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation
Q70911058Raf-1 provides a dominant but not exclusive signal for the induction of CD69 expression on T cells
Q34973413Ras-MAP kinase signaling pathways and control of cell proliferation: relevance to cancer therapy
Q28344727Regulation of Raf-1 activation and signalling by dephosphorylation
Q24316278Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins
Q34729913Regulation of alternative pre-mRNA splicing by the ERK MAP-kinase pathway
Q41013193Regulation of heregulin beta1-induced differentiation in a human breast carcinoma cell line by the extracellular-regulated kinase (ERK) pathway
Q24336720Regulation of human myoblast differentiation by PEBP4
Q24647062Regulation of the cfos serum response element by C/EBPbeta
Q29618477Regulation of transcription by MAP kinase cascades
Q40744450Rho regulates p21(CIP1), cyclin D1, and checkpoint control in mammary epithelial cells
Q38321462Role of distinct mitogen-activated protein kinase pathways and cooperation between Ets-2, ATF-2, and Jun family members in human urokinase-type plasminogen activator gene induction by interleukin-1 and tetradecanoyl phorbol acetate
Q42490017Roles of MAP kinases in the regulation of bone matrix gene expressions in human osteoblasts by oscillatory fluid flow
Q24605354Selective response of ternary complex factor Sap1a to different mitogen-activated protein kinase subgroups
Q40793882Serum-regulated transcription by serum response factor (SRF): a novel role for the DNA binding domain.
Q41750250Signal transduction through MAP kinase cascades
Q39576996Signaling from polyomavirus middle T and small T defines different roles for protein phosphatase 2A.
Q40015717Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling
Q77113231Specificity within the ets family of transcription factors
Q39954149Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A.
Q41105089Stimulation of interleukin-8 production by okadaic acid and vanadate in a human promyelocyte cell line, an HL-60 subline. Possible role of mitogen-activated protein kinase on the okadaic acid-induced NF-kappaB activation
Q28144497Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
Q24522480TFII-I enhances activation of the c-fos promoter through interactions with upstream elements
Q35131700Ternary complex factors: prime nuclear targets for mitogen-activated protein kinases
Q34066415The ETS-domain transcription factor family
Q38288925The ETS-domain transcription factors Elk-1 and SAP-1 exhibit differential DNA binding specificities.
Q33770637The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif.
Q39023984The Ras/Raf/MEK/ERK signaling pathway and its role in the occurrence and development of HCC.
Q28292490The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF
Q40939860The gene expression of the amiloride-sensitive epithelial sodium channel alpha-subunit is regulated by antagonistic effects between glucocorticoid hormone and ras pathways in salivary epithelial cells
Q35848449The hydroxyurea-induced small GTP-binding protein SAR modulates gamma-globin gene expression in human erythroid cells
Q42640864The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation
Q41078766The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.
Q40427848Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus
Q33763939Transcriptional networks and cellular senescence in human mammary fibroblasts
Q41469138Translocation of YopE and YopN into eukaryotic cells by Yersinia pestis yopN, tyeA, sycN, yscB and lcrG deletion mutants measured using a phosphorylatable peptide tag and phosphospecific antibodies
Q35076678Treatment of a human papillomavirus type 31b-positive cell line with benzo[a]pyrene increases viral titer through activation of the Erk1/2 signaling pathway
Q28379241Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia
Q42835325Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation
Q27936298Yeast RLM1 encodes a serum response factor-like protein that may function downstream of the Mpk1 (Slt2) mitogen-activated protein kinase pathway
Q36667357c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases

Search more.