Oxidative injury is a common consequence of BMPR2 mutations

scientific article published on January 2011

Oxidative injury is a common consequence of BMPR2 mutations is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4103/2045-8932.78107
P932PMC publication ID3167174
P698PubMed publication ID21904662
P5875ResearchGate publication ID51636267

P2093author name stringL Jackson Roberts
Ray L Mernaugh
Joshua P Fessel
James West
Jennifer A Johnson
Tom Blackwell
Anna R Hemnes
Linda Robinson
Eric Austin
Megha Talati
Candice Fike
Kirk L Lane
P2860cites workA proposed mitochondrial-metabolic mechanism for initiation and maintenance of pulmonary arterial hypertension in fawn-hooded rats: the Warburg model of pulmonary arterial hypertensionQ37702950
Cross talk between Smad, MAPK, and actin in the etiology of pulmonary arterial hypertensionQ37702964
Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injuryQ39710554
Phosphorylation of endothelial nitric-oxide synthase regulates superoxide generation from the enzymeQ42119587
Bringing down the ROS: a new therapeutic approach for PPHN.Q43164191
Oxidant stress but not thromboxane decreases with epoprostenol therapyQ43772005
Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: implications for familial pulmonary arterial hypertensionQ46626780
Quantification of F2-isoprostanes in biological fluids and tissues as a measure of oxidant stressQ46937052
BMPR2 mutations have short lifetime expectancy in primary pulmonary hypertensionQ47589236
Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH.Q51760564
Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertensionQ55670914
A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: applications in detecting the activity of phagocyte NADPH oxidase and other oxidasesQ73876065
Evidence that the E2-isoprostane, 15-E2t-isoprostane (8-iso-prostaglandin E2) is formed in vivoQ77150641
Gross BMPR2 gene rearrangements constitute a new cause for primary pulmonary hypertensionQ81541147
Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertensionQ24298704
Understanding the Warburg effect: the metabolic requirements of cell proliferationQ24604760
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancerQ24652941
Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1Q24675335
GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchiesQ24801173
Model-based analysis of oligonucleotide arrays: expression index computation and outlier detectionQ27860727
Stress Doppler echocardiography in relatives of patients with idiopathic and familial pulmonary arterial hypertension: results of a multicenter European analysis of pulmonary artery pressure response to exercise and hypoxiaQ28239012
Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent modelsQ30487260
The Gene Ontology in 2010: extensions and refinementsQ33600840
In vivo measurement of proximal pulmonary artery elastic modulus in the neonatal calf model of pulmonary hypertension: development and ex vivo validation.Q33783472
Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stressQ33949978
Detection of superoxide in vascular tissueQ34993923
Controlling cell fate by bone morphogenetic protein receptors.Q35600636
Alterations of cellular bioenergetics in pulmonary artery endothelial cellsQ35611704
Isoketals: highly reactive gamma-ketoaldehydes formed from the H2-isoprostane pathwayQ35705122
Insight into redox-regulated gene networks in vascular cellsQ35850434
Isofurans: novel products of lipid peroxidation that define the occurrence of oxidant injury in settings of elevated oxygen tensionQ36009394
NAD+-linked 15-hydroxyprostaglandin dehydrogenase: structure and biological functionsQ36419639
Pulmonary hypertension due to BMPR2 mutation: a new paradigm for tissue remodeling?Q36634716
Cross-talk between the bone morphogenetic protein pathway and other major signaling pathways results in tightly regulated cell-specific outcomesQ36830217
Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesionsQ36977330
Redox regulation of lung inflammation: role of NADPH oxidase and NF-kappaB signalling.Q36979666
Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancerQ37033660
Clinical review: The role of advanced glycation end products in progression and complications of diabetesQ37053328
Oxidative stress in vascular disease: causes, defense mechanisms and potential therapiesQ37156415
Structural implications of mitochondrial dynamicsQ37177420
Regulation of reactive oxygen species and genomic stability in hematopoietic stem cellsQ37216678
Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertensionQ37389602
Targeting the Warburg effect in hematological malignancies: from PET to therapyQ37545285
Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentialsQ37678455
Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen speciesQ37685389
P433issue1
P304page(s)72-83
P577publication date2011-01-01
P1433published inPulmonary circulationQ26842412
P1476titleOxidative injury is a common consequence of BMPR2 mutations
P478volume1

Reverse relations

cites work (P2860)
Q37104263A potential role for insulin resistance in experimental pulmonary hypertension
Q38078369A process-based review of mouse models of pulmonary hypertension
Q38448103Accumulation of isolevuglandin-modified protein in normal and fibrotic lung
Q36908852Antagonism of the thromboxane-prostanoid receptor is cardioprotective against right ventricular pressure overload
Q35142695BMP pathway regulation of and by macrophages
Q35376926BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension
Q26786834BMPR2 spruces up the endothelium in pulmonary hypertension
Q36185917Bone morphogenetic protein receptor type II deficiency and increased inflammatory cytokine production. A gateway to pulmonary arterial hypertension
Q57070238Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells
Q36110556Connectivity map analysis of nonsense-mediated decay-positive BMPR2-related hereditary pulmonary arterial hypertension provides insights into disease penetrance.
Q35850232Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension
Q33738642Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension
Q36352101Expression of mutant bone morphogenetic protein receptor II worsens pulmonary hypertension secondary to pulmonary fibrosis
Q37596437Hyperoxia synergizes with mutant bone morphogenic protein receptor 2 to cause metabolic stress, oxidant injury, and pulmonary hypertension.
Q34130859Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension.
Q35573948Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression.
Q35941642Increased Mutagen Sensitivity and DNA Damage in Pulmonary Arterial Hypertension
Q33806083Interaction between bone morphogenetic protein receptor type 2 and estrogenic compounds in pulmonary arterial hypertension
Q36108056Metabolomic analysis of bone morphogenetic protein receptor type 2 mutations in human pulmonary endothelium reveals widespread metabolic reprogramming
Q38262569Novel serum biomarkers in pulmonary arterial hypertension
Q38642429Oestrogen inhibition reverses pulmonary arterial hypertension and associated metabolic defects
Q50041340Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA.
Q35121379Physiologic and molecular consequences of endothelial Bmpr2 mutation
Q58998388Pulmonary Hypertension Is a Probable NO/ONOO− Cycle Disease: A Review
Q39419466Reactive Oxygen and Nitrogen Species in the Development of Pulmonary Hypertension
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Q35410950Rescuing the BMPR2 signaling axis in pulmonary arterial hypertension
Q28078566Role of oxidized lipids in pulmonary arterial hypertension
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