Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.

scientific article published on January 1994

Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1101/GAD.8.2.190
P698PubMed publication ID8299938
P5875ResearchGate publication ID14899237

P2093author name stringLiu X
Berk AJ
Yew PR
P433issue2
P921main subjectAdenoviridaeQ193447
P304page(s)190-202
P577publication date1994-01-01
P1433published inGenes & DevelopmentQ1524533
P1476titleAdenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.
P478volume8

Reverse relations

cites work (P2860)
Q347642332-aminopurine enhances the oncolytic activity of an E1b-deleted adenovirus in hepatocellular carcinoma cells
Q40546338A conditionally replicating adenovirus for nasopharyngeal carcinoma gene therapy.
Q33827516A functional complex of adenovirus proteins E1B-55kDa and E4orf6 is necessary to modulate the expression level of p53 but not its transcriptional activity.
Q36808087A gene transfer vector-cell line system for complete functional complementation of adenovirus early regions E1 and E4.
Q38353922A hydrophobic region within the adenovirus E1B 19 kDa protein is necessary for the transient inhibition of NF-kappaB activated by different stimuli.
Q39852886A novel domain in adenovirus L4-100K is required for stable binding and efficient inhibition of human granzyme B: possible interaction with a species-specific exosite
Q45876577A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function
Q93199947ATO (Arsenic Trioxide) Effects on Promyelocytic Leukemia Nuclear Bodies Reveals Antiviral Intervention Capacity
Q40169121Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes
Q34895124Adenoviral inhibitors of apoptotic cell death
Q40628992Adenovirus 2 E1B-55K protein relieves p53-mediated transcriptional repression of the survivin and MAP4 promoters
Q39575238Adenovirus E1B 19,000-molecular-weight protein activates c-Jun N-terminal kinase and c-Jun-mediated transcription
Q64382715Adenovirus E1B 19-kDa death suppressor protein interacts with Bax but not with Bad
Q24297809Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx
Q33964757Adenovirus E1B 55-kilodalton oncoprotein inhibits p53 acetylation by PCAF.
Q34301861Adenovirus E1B 55-kilodalton protein is required for both regulation of mRNA export and efficient entry into the late phase of infection in normal human fibroblasts
Q37391112Adenovirus E1B 55-kilodalton protein: multiple roles in viral infection and cell transformation
Q24523301Adenovirus E1B 55K represses p53 activation in vitro.
Q39421013Adenovirus E4orf3 targets transcriptional intermediary factor 1γ for proteasome-dependent degradation during infection
Q37983134Adenovirus degradation of cellular proteins.
Q39612520Adenovirus exploits the cellular aggresome response to accelerate inactivation of the MRN complex
Q34573981Adenovirus infection of primary malignant lymphoid cells
Q35488742Adenovirus replaces mitotic checkpoint controls
Q38893456Adenovirus type 12 E1B 55-kilodalton oncoprotein promotes p53-mediated apoptotic response of ovarian cancer to cisplatin
Q35891411Adenovirus type 12 early region 1B 54K protein significantly extends the life span of normal mammalian cells in culture
Q39578554Adenovirus type 12-induced fragility of the human RNU2 locus requires p53 function.
Q41786916Adenovirus type 5 early region 1B 156R protein promotes cell transformation independently of repression of p53-stimulated transcription
Q28574947Adenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cells
Q35868343Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis
Q35850341Adenovirus type 5 exerts genome-wide control over cellular programs governing proliferation, quiescence, and survival
Q36759991Aggresome formation by the adenoviral protein E1B55K is not conserved among adenovirus species and is not required for efficient degradation of nuclear substrates
Q39906835An avian cell line designed for production of highly attenuated viruses
Q39960855An early function of the adenoviral E1B 55 kDa protein is required for the nuclear relocalization of the cellular p53 protein in adenovirus-infected normal human cells
Q39602482Analyses of single-amino-acid substitution mutants of adenovirus type 5 E1B-55K protein
Q33641023Analysis of synthesis, stability, phosphorylation, and interacting polypeptides of the 34-kilodalton product of open reading frame 6 of the early region 4 protein of human adenovirus type 5
Q24538586Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery
Q39549322Baculovirus p33 binds human p53 and enhances p53-mediated apoptosis.
Q37574153Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53.
Q39835775Cell lines from the Egyptian fruit bat are permissive for modified vaccinia Ankara
Q35847043Cell type-specific inhibition of p53-mediated apoptosis by mdm2.
Q30860353Cell-specific modulation of papovavirus replication by tumor suppressor protein p53
Q34225918Clinical research results with dl1520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: what have we learned?
Q45861487Conditionally replicating viruses in cancer therapy
Q40902810Consequences of disruption of the interaction between p53 and the larger adenovirus early region 1B protein in adenovirus E1 transformed human cells
Q36484050Control of mRNA export by adenovirus E4orf6 and E1B55K proteins during productive infection requires E4orf6 ubiquitin ligase activity
Q37632435Converting cancer genes into killer genes
Q39445508Corepressor required for adenovirus E1B 55,000-molecular-weight protein repression of basal transcription
Q53270092Cross-talk between phosphorylation and SUMOylation regulates transforming activities of an adenoviral oncoprotein.
Q40972382Definition of a major p53 binding site on Ad2E1B58K protein and a possible nuclear localization signal on the Ad12E1B54K protein
Q29041391Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex
Q35941628Deregulation of the cell cycle by the Epstein-Barr virus
Q64382573Detection of group C adenovirus DNA in small-cell lung cancer with the nested polymerase chain reaction
Q35835238Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation
Q36551539Direct transcriptional repression by pRB and its reversal by specific cyclins
Q39446048Distinct regulation of p53 and p73 activity by adenovirus E1A, E1B, and E4orf6 proteins
Q39963290Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates
Q104607567Double-edged Role of PML Nuclear Bodies during Human Adenovirus Infection
Q38317803E1B 55-kilodalton oncoproteins of adenovirus types 5 and 12 inactivate and relocalize p53, but not p51 or p73, and cooperate with E4orf6 proteins to destabilize p53.
Q24312647E1B 55-kilodalton-associated protein: a cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs
Q40481068Effects of febrile temperature on adenoviral infection and replication: implications for viral therapy of cancer.
Q35853884Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit
Q35852705Efficient nuclear localization and immortalizing ability, two functions dependent on the adenovirus type 5 (Ad5) E1A second exon, are necessary for cotransformation with Ad5 E1B but not with T24ras
Q39685569Evidence that replication of the antitumor adenovirus ONYX-015 is not controlled by the p53 and p14(ARF) tumor suppressor genes.
Q34529776Export of adenoviral late mRNA from the nucleus requires the Nxf1/Tap export receptor
Q41447210Fluctuating expression of microRNAs in adenovirus infected cells
Q45744096Functional impairment of p73 and p51, the p53-related proteins, by the human T-cell leukemia virus type 1 Tax oncoprotein
Q24290998Functional inactivation of p73, a homolog of p53 tumor suppressor protein, by human papillomavirus E6 proteins
Q33781719Genomic and bioinformatics analysis of HAdV-4, a human adenovirus causing acute respiratory disease: implications for gene therapy and vaccine vector development
Q45880712Genomic and bioinformatics analysis of HAdV-7, a human adenovirus of species B1 that causes acute respiratory disease: implications for vector development in human gene therapy
Q24554388HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor
Q38326994High-affinity Rb binding, p53 inhibition, subcellular localization, and transformation by wild-type or tumor-derived shortened Merkel cell polyomavirus large T antigens.
Q64377201How adenovirus strives to control cellular gene expression
Q24336890Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain
Q35873729Human cytomegalovirus mtrII oncoprotein binds to p53 and down-regulates p53-activated transcription
Q33835387Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complex
Q41034641Identification of transcriptional activation and repression domains in human CCAAT/enhancer-binding protein epsilon
Q35111076Impact of the adenoviral E4 Orf3 protein on the activity and posttranslational modification of p53.
Q33810466Induction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Balpha subunit of protein phosphatase 2A.
Q33825089Induction of transformation and p53-dependent apoptosis by adenovirus type 5 E4orf6/7 cDNA.
Q35140413Inhibition of p53 by adenovirus type 12 E1B-55K deregulates cell cycle control and sensitizes tumor cells to genotoxic agents
Q43831424Inhibition of the putative tumor suppressor gene TIMP-3 by tumor-derived p53 mutants and wild type p53.
Q33292209Interaction between the HPV-16 E2 transcriptional activator and p53.
Q36434260KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO Modification
Q37727809Krüppel-associated box-mediated repression of RNA polymerase II promoters is influenced by the arrangement of basal promoter elements
Q48067606Mammary tumors induced by human adenovirus type 9: a role for the viral early region 4 gene
Q28140555Marek's disease herpesvirus transforming protein MEQ: a c-Jun analogue with an alternative life style
Q35572466Mdm2: A regulator of cell growth and death
Q53656970Modulation of host cell gene expression during onset of the late phase of an adenovirus infection is focused on growth inhibition and cell architecture.
Q41290133Molecular and clinical aspects of apoptosis
Q28577102Molecular cloning of a novel transcriptional repressor protein of the rat type 1 vasoactive intestinal peptide receptor gene
Q28141883NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres
Q24530146Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain
Q33957704New insights into the mechanism of inhibition of p53 by simian virus 40 large T antigen
Q40353337Normal human cell proteins that interact with the adenovirus type 5 E1B 55kDa protein
Q33887076Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence
Q34115253ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus
Q37247046Oncogenic potential of the adenovirus E4orf6 protein
Q34571752Oncolytic biotherapy: a novel therapeutic plafform
Q34452020Oncolytic virotherapy for cancer with the adenovirus dl1520 (Onyx-015): results of phase I and II trials
Q34074708Oncolytic viruses as novel anticancer agents: turning one scourge against another
Q35902523Oncolytic viruses for the treatment of cancer: current strategies and clinical trials.
Q38020107Oncolytic viruses in the treatment of cancer: a review of current strategies
Q41792379PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.
Q36759358Poly(β-amino ester) nanoparticle delivery of TP53 has activity against small cell lung cancer in vitro and in vivo
Q74643391Protein kinase CK2 interacts with a multi-protein binding domain of p53
Q34519693RBP1 family proteins exhibit SUMOylation-dependent transcriptional repression and induce cell growth inhibition reminiscent of senescence
Q33861763RBP1 induces growth arrest by repression of E2F-dependent transcription
Q24554426RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins
Q34469114Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus
Q24678703Regulation of apoptosis by viral gene products
Q35883364Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells.
Q35882839Regulation of p53-dependent apoptosis, transcriptional repression, and cell transformation by phosphorylation of the 55-kilodalton E1B protein of human adenovirus type 5.
Q24337326Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7
Q24655012Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene
Q35755347Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein
Q39582723Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells.
Q39792211Replication of damaged DNA in vitro is blocked by p53.
Q34293607Replication-selective oncolytic adenoviruses: virotherapy aimed at genetic targets in cancer
Q24336020Repression of p53-mediated transcription by MDM2: a dual mechanism
Q40185681Repression of p53-mediated transcription by adenovirus E1B 55-kDa does not require corepressor mSin3A and histone deacetylases
Q40410984Repression of transcriptional activity at a distance by the evolutionarily conserved KRAB domain present in a subfamily of zinc finger proteins.
Q36556040Reversal of in vitro p53 squelching by both TFIIB and TFIID
Q28513708Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
Q39174506Role of E1B55K in E4orf6/E1B55K E3 ligase complexes formed by different human adenovirus serotypes
Q36039006Role of the RNA recognition motif of the E1B 55 kDa protein in the adenovirus type 5 infectious cycle
Q33649728Roles for the E4 orf6, orf3, and E1B 55-kilodalton proteins in cell cycle-independent adenovirus replication
Q24338995SUMO modification of E1B-55K oncoprotein regulates isoform-specific binding to the tumour suppressor protein PML
Q33944482SUMO-1 modification required for transformation by adenovirus type 5 early region 1B 55-kDa oncoprotein
Q46061653Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents
Q24290549Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1
Q34227735Sequestration of p53 in the cytoplasm by adenovirus type 12 E1B 55-kilodalton oncoprotein is required for inhibition of p53-mediated apoptosis
Q39619768Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection
Q40947307Sp100A is a tumor suppressor that activates p53-dependent transcription and counteracts E1A/E1B-55K-mediated transformation
Q38349921Strategic Attack on Host Cell Gene Expression during Adenovirus Infection
Q39878070Structural analysis of the adenovirus type 5 E1B 55-kilodalton-E4orf6 protein complex
Q53891195Structure of the adenovirus E4 Orf6 protein predicted by fold recognition and comparative protein modeling.
Q38811135The Dual Nature of Nek9 in Adenovirus Replication
Q40700516The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Can Mimic E1A Effects on E2F.
Q42055738The N terminus of p53 regulates its dissociation from DNA.
Q42557316The WTX tumor suppressor enhances p53 acetylation by CBP/p300
Q37145192The adenoviral E1B 55-kilodalton protein controls expression of immune response genes but not p53-dependent transcription
Q35991794The adenovirus E4orf6 protein can promote E1A/E1B-induced focus formation by interfering with p53 tumor suppressor function
Q40976806The adenovirus E4orf6 protein contributes to malignant transformation by antagonizing E1A-induced accumulation of the tumor suppressor protein p53.
Q30888959The adenovirus-2 E1B-55K protein interacts with a mSin3A/histone deacetylase 1 complex
Q64379637The cytotoxic effect of E1B 55-kDa mutant adenovirus on human hepatocellular carcinoma cell lines
Q38354882The dual effect of adenovirus type 5 E1A 13S protein on NF-kappaB activation is antagonized by E1B 19K.
Q35875344The early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycle
Q33783779The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis
Q34388476The human adenovirus type 5 E1B 55 kDa protein obstructs inhibition of viral replication by type I interferon in normal human cells
Q64082124The human adenovirus type 5 E1B 55kDa protein interacts with RNA promoting timely DNA replication and viral late mRNA metabolism
Q36556883The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activities
Q28282671The papillomavirus E6 proteins
Q33599759The regulation of apoptosis by microbial pathogens.
Q34579032The repression domain of the E1B 55-kilodalton protein participates in countering interferon-induced inhibition of adenovirus replication
Q44949640The transcriptome of the adenovirus infected cell
Q35826320Timely synthesis of the adenovirus type 5 E1B 55-kilodalton protein is required for efficient genome replication in normal human cells
Q33838380Tissue-specific, tumor-selective, replication-competent adenovirus vector for cancer gene therapy
Q40856128Transcription by RNA polymerase II in DNA-PK deficient scid mouse cells
Q28302177Transcriptional activity of the paired-like homeodomain proteins CHX10 and VSX1
Q45864999Tumour regression in a ligand inducible manner mediated by a chimeric tumour suppressor derived from p53.
Q39659874Tumour suppressor p53 down-regulates the expression of the human hepatocyte nuclear factor 4alpha (HNF4alpha) gene
Q39585092Two distinct activities contribute to the oncogenic potential of the adenovirus type 5 E4orf6 protein
Q41510729Viral inhibitors of apoptosis
Q41515308Virus-induced apoptosis
Q72234473Viruses and apoptosis
Q28512737p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition
Q28565821p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen
Q24550965p53 Stimulates TFIID-TFIIA-promoter complex assembly, and p53-T antigen complex inhibits TATA binding protein-TATA interaction
Q40902865p53 and tumour viruses: catching the guardian off-guard
Q40720232p53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop
Q33785919p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection
Q33814900p53-Independent and -dependent requirements for E1B-55K in adenovirus type 5 replication
Q33868917p53-mediated repression of alpha-fetoprotein gene expression by specific DNA binding
Q40564007p53: a cellular Achilles' heel revealed.
Q29618407p53: puzzle and paradigm

Search more.