Shielding of the A1 domain by the D'D3 domains of von Willebrand factor modulates its interaction with platelet glycoprotein Ib-IX-V.

scientific article

Shielding of the A1 domain by the D'D3 domains of von Willebrand factor modulates its interaction with platelet glycoprotein Ib-IX-V. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M513314200
P698PubMed publication ID16373331

P50authorHans DeckmynQ37829138
P2093author name stringKaren Vanhoorelbeke
Peter J Lenting
Inge Pareyn
Nele Vandeputte
Hans Ulrichts
Miklós Udvardy
P2860cites workIdentification of the regulatory elements of the human von Willebrand factor for binding to platelet GPIb. Importance of structural integrity of the regions flanked by the CYS1272-CYS1458 disulfide bondQ24293697
Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domainQ24304907
Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutationsQ24319306
Crystal structure of the von Willebrand Factor A1 domain and implications for the binding of platelet glycoprotein IbQ27749469
A consensus tetrapeptide selected by phage display adopts the conformation of a dominant discontinuous epitope of a monoclonal anti-VWF antibody that inhibits the von Willebrand factor-collagen interactionQ30961540
Type 2 von Willebrand disease causing defective von Willebrand factor-dependent platelet functionQ34423491
Platelets in atherothrombosisQ34986345
A definitive set of oligonucleotide primers for amplifying human V regionsQ36896019
Expression of the mouse dihydrofolate reductase complementary deoxyribonucleic acid in simian virus 40 vectorsQ36957553
A monomeric von Willebrand factor fragment, Leu-504--Lys-728, inhibits von Willebrand factor interaction with glycoprotein Ib-IX [corrected]Q37168874
Effect of deletion of the A1 domain of von Willebrand factor on its binding to heparin, collagen and platelets in the presence of ristocetinQ38336125
A monoclonal antibody recognizes a von Willebrand factor domain within the amino-terminal portion of the subunit that modulates the function of the glycoprotein IB- and IIB/IIIA-binding domainsQ40512752
An experimental model to study the in vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation.Q40616991
Identification of amino acid residues essential for von Willebrand factor binding to platelet glycoprotein Ib. Charged-to-alanine scanning mutagenesis of the A1 domain of human von Willebrand factorQ41336486
Ristocetin-dependent, but not botrocetin-dependent, binding of von Willebrand factor to the platelet glycoprotein Ib-IX-V complex correlates with shear-dependent interactionsQ43513939
Isolation and chemical characterization of two structurally and functionally distinct forms of botrocetin, the platelet coagglutinin isolated from the venom of Bothrops jararacaQ43916499
von Willebrand factor but not alpha-thrombin binding to platelet glycoprotein Ibalpha is influenced by the HPA-2 polymorphismQ44459167
Functional modulation of the isolated glycoprotein Ib binding domain of von Willebrand factor expressed in Escherichia coliQ44699205
A monoclonal antibody directed against human von Willebrand factor induces type 2B-like alterationsQ45033734
Impact of O-linked glycosylation of the VWF-A1-domain flanking regions on platelet interactionQ45192183
Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow.Q45967882
The von Willebrand factor self-association is modulated by a multiple domain interactionQ58481460
Shear-dependent morphology of von Willebrand factor bound to immobilized collagenQ58481474
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)4699-4707
P577publication date2005-12-22
P1433published inJournal of Biological ChemistryQ867727
P1476titleShielding of the A1 domain by the D'D3 domains of von Willebrand factor modulates its interaction with platelet glycoprotein Ib-IX-V.
P478volume281

Reverse relations

cites work (P2860)
Q5233062214-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling.
Q27658166A Structural Explanation for the Antithrombotic Activity of ARC1172, a DNA Aptamer that Binds von Willebrand Factor Domain A1
Q39159765A biophysical view on von Willebrand factor activation.
Q34351167A common variant in the Von Willebrand factor gene is associated with multiple functional consequences.
Q48152338A discontinuous autoinhibitory module masks the A1 domain of von Willebrand factor.
Q39665373A mechanically stabilized receptor-ligand flex-bond important in the vasculature.
Q37168411A mechanism for localized dynamics-driven affinity regulation of the binding of von Willebrand factor to platelet glycoprotein Ibα.
Q34448727An integrated fragment based screening approach for the discovery of small molecule modulators of the VWF-GPIbα interaction.
Q34170382Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and α2β1-mediated collagen binding in thrombus formation
Q52672840Autoregulation of von Willebrand factor function by a disulfide bond switch.
Q37903936Biology and physics of von Willebrand factor concatamers
Q37293577Catch-bond mechanism of force-enhanced adhesion: counterintuitive, elusive, but ... widespread?
Q34016608Cleavage of von Willebrand factor by granzyme M destroys its factor VIII binding capacity
Q90572410Delimiting the autoinhibitory module of von Willebrand factor
Q34003816Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibalpha and platelet activation under shear stress
Q91856606Electrostatic Steering Enables Flow-Activated Von Willebrand Factor to Bind Platelet Glycoprotein, Revealed by Single-Molecule Stretching and Imaging
Q53394850Examining platelet adhesion via Stokes flow simulations and microfluidic experiments.
Q34684020Exploiting the kinetic interplay between GPIbα-VWF binding interfaces to regulate hemostasis and thrombosis
Q41490553Flow-induced elongation of von Willebrand factor precedes tension-dependent activation
Q37279293Fluid shear induces conformation change in human blood protein von Willebrand factor in solution.
Q40382861Force-sensitive autoinhibition of the von Willebrand factor is mediated by interdomain interactions
Q30353471Functional display of platelet-binding VWF fragments on filamentous bacteriophage
Q34122627Identification of a small molecule that modulates platelet glycoprotein Ib-von Willebrand factor interaction
Q34278082In vivo analysis of the role of O-glycosylations of von Willebrand factor.
Q56883323Interaction of the cysteine-rich domain of snake venom metalloproteinases with the A1 domain of von Willebrand factor promotes site-specific proteolysis of von Willebrand factor and inhibition of von Willebrand factor-mediated platelet aggregation
Q52579774Interdomain interaction in the FimH adhesin of Escherichia coli regulates the affinity to mannose.
Q39905838Internal tension in a collapsed polymer under shear flow and the connection to enzymatic cleavage of von Willebrand factor
Q35922561N-terminal flanking region of A1 domain in von Willebrand factor stabilizes structure of A1A2A3 complex and modulates platelet activation under shear stress.
Q98156926Noncanonical type 2B von Willebrand disease associated with mutations in the VWF D'D3 and D4 domains
Q33624852Pannexin- and Connexin-Mediated Intercellular Communication in Platelet Function.
Q45865145Plasma levels of active Von Willebrand factor are increased in patients with first ST-segment elevation myocardial infarction: a multicenter and multiethnic study.
Q30620128Platelet GpIba binding to von Willebrand Factor under fluid shear:contributions of the D′D3-domain, A1-domain flanking peptide and O-linked glycans
Q37824742Platelet adhesion to collagen
Q30483148Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF.
Q38303337Purified A2 domain of von Willebrand factor binds to the active conformation of von Willebrand factor and blocks the interaction with platelet glycoprotein Ibalpha
Q47625174Receptor-mediated cell mechanosensing.
Q38645643Role of fluid shear stress in regulating VWF structure, function and related blood disorders
Q37540219Rolling cell adhesion
Q34206072Shear-stabilized rolling behavior of E. coli examined with simulations.
Q90516261Structure of von Willebrand factor A1 on polystyrene determined from experimental and calculated sum frequency generation spectra
Q37289199The N-terminal flanking region of the A1 domain regulates the force-dependent binding of von Willebrand factor to platelet glycoprotein Ibα.
Q53073825The O-linked glycans of human von Willebrand factor modulate its interaction with ADAMTS-13.
Q30557410The linker between the D3 and A1 domains of vWF suppresses A1-GPIbα catch bonds by site-specific binding to the A1 domain.
Q47239922The physical spacing between the von willebrand factor d'd3- and a1- domains regulates platelet adhesion in vitro and in vivo
Q26852187The unfolded von Willebrand factor response in bloodstream: the self-association perspective
Q33775630Visualization of allostery in P-selectin lectin domain using MD simulations
Q27303207Von Willebrand factor-A1 domain binds platelet glycoprotein Ibα in multiple states with distinctive force-dependent dissociation kinetics
Q36010217von Willebrand factor (VWF) propeptide binding to VWF D'D3 domain attenuates platelet activation and adhesion
Q34310946von Willebrand factor self-association on platelet GpIbalpha under hydrodynamic shear: effect on shear-induced platelet activation
Q34106824von Willebrand factor, Jedi knight of the bloodstream
Q37903943von Willebrand factor: the complex molecular genetics of a multidomain and multifunctional protein

Search more.