Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A.

scientific article

Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A. is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1001103682
P356DOI10.1038/SJ.ONC.1208662
P698PubMed publication ID15870696
P5875ResearchGate publication ID7867175

P50authorFrank GannonQ28741357
Chin-Yo LinQ30347498
Vladimir BenesQ41125179
Raphaël MétivierQ42808659
P2093author name stringFrank Gannon
Edison T Liu
George Reid
Stefanie Denger
David Ibberson
Heike Brand
Tomi Ivacevic
P2860cites workDiscovery of estrogen receptor alpha target genes and response elements in breast tumor cellsQ21184176
RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancerQ24291637
Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cellsQ24672087
Molecular basis of agonism and antagonism in the oestrogen receptorQ27746278
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screeningQ28210511
Molecular determinants for the tissue specificity of SERMsQ28211516
MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatinQ28576622
Cofactor dynamics and sufficiency in estrogen receptor-regulated transcriptionQ29547846
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogenQ29616224
Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoterQ29616537
Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliabilityQ29617252
Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative GroupQ29619251
Estrogens and health in malesQ33951106
Estrogens and estrogen-like non-feminizing compounds. Their role in the prevention and treatment of Alzheimer's disease.Q34149018
Etiology of Human Breast Cancer: A Review2Q34213087
Polycystic ovarian syndrome in women with epilepsy: a reviewQ34345051
Endocrine-resistant breast cancer: Underlying mechanisms and strategies for overcoming resistanceQ35123575
A pure estrogen antagonist inhibits cyclin E-Cdk2 activity in MCF-7 breast cancer cells and induces accumulation of p130-E2F4 complexes characteristic of quiescenceQ38308285
The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylationQ40690782
Nucleosome positioning and transcription-associated chromatin alterations on the human estrogen-responsive pS2 promoterQ41072437
Early hormonal changes during valproate or carbamazepine treatment: a 3-month studyQ43705794
Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsyQ43705798
First results from the International Breast Cancer Intervention Study (IBIS-I): a randomised prevention trialQ44146948
Increase in postprandial serum insulin levels in epileptic patients with valproic acid therapyQ44172530
Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsyQ70513355
Randomised comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed childhood epilepsyQ71002444
Associated effects of sodium butyrate on histone acetylation and estrogen receptor in the human breast cancer cell line MCF-7Q71290239
Direct inhibition of the expression of cyclin D1 gene by sodium butyrateQ71857913
P433issue31
P407language of work or nameEnglishQ1860
P921main subjectestrogenQ277954
gene silencingQ1431332
P304page(s)4894-4907
P577publication date2005-07-01
P1433published inOncogeneQ1568657
P1476titleMultiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A.
P478volume24

Reverse relations

cites work (P2860)
Q37656483A chimeric SERM-histone deacetylase inhibitor approach to breast cancer therapy
Q37200466A rationally designed histone deacetylase inhibitor with distinct antitumor activity against ovarian cancer
Q58214157A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes
Q24294901A zinc finger HIT domain-containing protein, ZNHIT-1, interacts with orphan nuclear hormone receptor Rev-erbbeta and removes Rev-erbbeta-induced inhibition of apoCIII transcription
Q90239810Advances in Targeting the Epidermal Growth Factor Receptor Pathway by Synthetic Products and Its Regulation by Epigenetic Modulators As a Therapy for Glioblastoma
Q37612400Biochemical pathways that regulate acetyltransferase and deacetylase activity in mammalian cells
Q35840700Butyrate mediates decrease of histone acetylation centered on transcription start sites and down-regulation of associated genes
Q39616031CG0006, a novel histone deacetylase inhibitor, induces breast cancer cell death via histone-acetylation and chaperone-disrupting pathways independent of ER status
Q41511134Cohesin is required for expression of the estrogen receptor-alpha (ESR1) gene
Q35201384Combined histone deacetylase inhibition and tamoxifen induces apoptosis in tamoxifen-resistant breast cancer models, by reversing Bcl-2 overexpression
Q90390883Combining epigenetic drugs with other therapies for solid tumours - past lessons and future promise
Q33637251Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis
Q37797705DNA Demethylating Agents and Epigenetic Therapy of Cancer
Q37386851DNA demethylating agents synergize with oncolytic HSV1 against malignant gliomas
Q33962117DNA methylation of microRNA-375 in impaired glucose tolerance
Q36788512Development of histone deacetylase inhibitors for cancer treatment
Q36115426Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor α and β in vitro
Q34606452Dynamic interaction of HDAC1 with a glucocorticoid receptor-regulated gene is modulated by the activity state of the promoter
Q41129576E2-mediated cathepsin D (CTSD) activation involves looping of distal enhancer elements
Q26853549EGFR Amplification and Glioblastoma Stem-Like Cells
Q42012563Effects of trichostatin A on neuronal mu-opioid receptor gene expression
Q64974925Endocrine Resistance in Hormone Receptor Positive Breast Cancer-From Mechanism to Therapy.
Q28396626Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes
Q37830385Epigenetic aberrations during oncogenesis.
Q37962586Epigenetic modulation: a novel therapeutic target for overcoming hormonal therapy resistance
Q52687717Estrogen-dependent control and cell-to-cell variability of transcriptional bursting.
Q28744012Fatty acids derived from royal jelly are modulators of estrogen receptor functions
Q39126183Functional assessment of MeCP2 in Rett syndrome and cancers of breast, colon, and prostate
Q34495315HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter
Q36912547HDAC inhibitors induce transcriptional repression of high copy number genes in breast cancer through elongation blockade
Q24292915HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription
Q92504777HDACs control RUNX2 expression in cancer cells through redundant and cell context-dependent mechanisms
Q42364933Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53 Signaling Pathway Activation
Q48150376Histone Deacetylase Inhibitors Resensitize EGFR/EGFRvIII-Overexpressing, Erlotinib-Resistant Glioblastoma Cells to Tyrosine Kinase Inhibition.
Q34488424Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy.
Q39573190Histone deacetylase 6 regulates estrogen receptor alpha in uterine leiomyoma
Q34503302Histone deacetylase 9 activates gamma-globin gene expression in primary erythroid cells
Q37097022Histone deacetylase inhibitor PCI-24781 enhances chemotherapy-induced apoptosis in multidrug-resistant sarcoma cell lines
Q28582424Histone deacetylases facilitate sodium/calcium exchanger up-regulation in adult cardiomyocytes
Q34152949Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis
Q24645148Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides
Q33705246Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling
Q37336908LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMP
Q34417159Manipulating protein acetylation in breast cancer: a promising approach in combination with hormonal therapies?
Q38439266Mechanisms of aromatase inhibitor resistance.
Q33632070Minireview: The versatile roles of lysine deacetylases in steroid receptor signaling
Q37962015Modulation of gene expression in ovarian cancer by active and repressive histone marks
Q33852615Motif-guided sparse decomposition of gene expression data for regulatory module identification
Q28743986Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model
Q35079955Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer
Q38969133Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation.
Q34603086Research Resource: STR DNA profile and gene expression comparisons of human BG-1 cells and a BG-1/MCF-7 clonal variant
Q40252452SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1.
Q34942979SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells.
Q47927498Targeting triple negative breast cancer with histone deacetylase inhibitors
Q46309280The Role of Sirtuins in Antioxidant and Redox Signaling
Q24300197The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter
Q35067415The proteasome inhibitor bortezomib induces an inhibitory chromatin environment at a distal enhancer of the estrogen receptor-α gene
Q47136713The role and possible molecular mechanism of valproic acid in the growth of MCF-7 breast cancer cells.
Q33569444The short-chain fatty acid methoxyacetic acid disrupts endogenous estrogen receptor-alpha-mediated signaling
Q37454297Trans-regulation of histone deacetylase activities through acetylation
Q40005345Transient cyclical methylation of promoter DNA.
Q33889528Trichostatin A enhances acetylation as well as protein stability of ERalpha through induction of p300 protein
Q64903545Weight Gain During Treatment of Bipolar Disorder (BD)—Facts and Therapeutic Options.

Search more.