Two new p73 splice variants, gamma and delta, with different transcriptional activity.

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Two new p73 splice variants, gamma and delta, with different transcriptional activity. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.188.9.1763
P8608Fatcat IDrelease_ths5ylqm65bczn3joxpxb2azte
P932PMC publication ID2212516
P698PubMed publication ID9802988
P5875ResearchGate publication ID13483509

P50authorAntonio CostanzoQ38319077
Alessandro TerrinoniQ42836714
Vincenzo De LaurenziQ46755072
Massimo LevreroQ67592879
P2093author name stringG Melino
M Falco
M Annicchiarico-Petruzzelli
D Barcaroli
P2860cites workAnatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteinsQ24311703
Synergistic activation of transcription by CBP and p53Q24311979
Binding and modulation of p53 by p300/CBP coactivatorsQ24312018
p53, the cellular gatekeeper for growth and divisionQ27860990
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Recruitment of p300/CBP in p53-dependent signal pathwaysQ28243213
Mutations in the p53 gene occur in diverse human tumour typesQ28249770
p53 mutations in human cancersQ28302973
Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene productQ28645822
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursQ29547697
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasiaQ29615437
Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancersQ29616471
p53: puzzle and paradigmQ29618407
p53: oncogene or anti-oncogene?Q34627381
The hepatitis B virus X gene induces p53-mediated programmed cell deathQ36303449
Chromosomal aberrations in human neuroblastomasQ41057218
Tumor necrosis factor (TNF) receptor 1 signaling downstream of TNF receptor-associated factor 2. Nuclear factor kappaB (NFkappaB)-inducing kinase requirement for activation of activating protein 1 and NFkappaB but not of c-Jun N-terminal kinase/streQ41087172
p73 is a simian [correction of human] p53-related protein that can induce apoptosisQ41091013
P53 associates with trk tyrosine kinaseQ41099207
Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motifQ41555610
Lonely no more: p53 finds its kin in a tumor suppressor havenQ41595266
Mutation, allelotyping, and transcription analyses of the p73 gene in prostatic carcinomaQ48030109
Transcriptional activation by p53 correlates with suppression of growth but not transformation.Q53468212
Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.Q53505779
Cytogenetic studies in primary and metastatic neuroendocrine merkel cell carcinomaQ58813595
Killer in search of a motive?Q58987146
Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancersQ74427906
Apoptosis and the cell cycle: the p53 connectionQ77315452
P433issue9
P407language of work or nameEnglishQ1860
P1104number of pages6
P304page(s)1763-1768
P577publication date1998-11-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleTwo new p73 splice variants, gamma and delta, with different transcriptional activity
P478volume188

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cites work (P2860)
Q36623189A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma
Q28118809A common polymorphism acts as an intragenic modifier of mutant p53 behaviour
Q36898974A gene signature-based approach identifies mTOR as a regulator of p73.
Q51660356A naturally occurring p73 mutation in a p73-p53 double-mutant lung cancer cell line encodes p73 alpha protein with a dominant-negative function.
Q40228726A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells
Q34218441A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity
Q39458140A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain
Q37216001Aberrant cytoplasmic expression of p63 and prostate cancer mortality
Q44495330Adenovirus-mediated transfer of p53-related genes induces apoptosis of human cancer cells
Q38247152Alterations of p63 and p73 in human cancers
Q30167715Amphiphysin IIb-1, a novel splicing variant of amphiphysin II, regulates p73beta function through protein-protein interactions
Q80601828Analysis of p73 expression pattern in acute myeloid leukemias: lack of DeltaN-p73 expression is a frequent feature of acute promyelocytic leukemia
Q39662010Analysis of the intracellular localization of p73 N-terminal protein isoforms TAp73 and ∆Np73 in medulloblastoma cell lines
Q36994773Analysis of the oligomeric state and transactivation potential of TAp73α.
Q38289031Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage
Q34277205Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter
Q33838181BUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD).
Q73898479Binding of the C-terminal sterile alpha motif (SAM) domain of human p73 to lipid membranes
Q24323081Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription
Q40014129C-terminal diversity within the p53 family accounts for differences in DNA binding and transcriptional activity
Q33551236C-terminal ubiquitination of p53 contributes to nuclear export
Q36907168Caspase-1 is a novel target of p63 in tumor suppression
Q34141459Cell cycle and cell fate in the nervous system.
Q35867909Characterization of critical domains within the tumor suppressor CASZ1 required for transcriptional regulation and growth suppression
Q73646221Characterization of p73 functional domains necessary for transactivation and growth suppression
Q24317558Cloning and characterization of human and mouse DDA3 genes
Q35604588Complex regulation of p73 isoforms after alteration of amyloid precursor polypeptide (APP) function and DNA damage in neurons
Q27657467Conformational stability and activity of p73 require a second helix in the tetramerization domain
Q28144708Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif
Q39565566Crosstalk between c-Jun and TAp73alpha/beta contributes to the apoptosis-survival balance
Q40658272Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73.
Q40729390DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest.
Q26775866DNA repair and aging: the impact of the p53 family
Q42163174DeltaN-p73alpha accumulates in human neuroblastic tumors
Q40581726DeltaNp73beta is active in transactivation and growth suppression.
Q73800193Different expression of P14ARF defines two groups of breast carcinomas in terms of TP73 expression and TP53 mutational status
Q79768076Differential expression of p73 isoforms in relation to drug resistance in childhood T-lineage acute lymphoblastic leukaemia
Q40474411Differential regulation of MDR1 transcription by the p53 family members. Role of the DNA binding domain.
Q73876731Differential regulation of p63 and p73 expression
Q38317198Dysregulated ΔNp63α negatively regulates the maspin promoter in keratinocytes via blocking endogenous p73 binding
Q38317803E1B 55-kilodalton oncoproteins of adenovirus types 5 and 12 inactivate and relocalize p53, but not p51 or p73, and cooperate with E4orf6 proteins to destabilize p53.
Q36643752E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia
Q28077156Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness
Q28074586Epstein-Barr Virus: Diseases Linked to Infection and Transformation
Q43583398Expression of homologues for p53 and p73 in the softshell clam (Mya arenaria), a naturally-occurring model for human cancer
Q42412666Expression of p53 isoforms in squamous cell carcinoma of the head and neck
Q73120645Expression of proopiomelanocortin, corticotropin-releasing hormone (CRH), and CRH receptor in melanoma cells, nevus cells, and normal human melanocytes
Q24310627FLASH is essential during early embryogenesis and cooperates with p73 to regulate histone gene transcription
Q40366104Family members p53 and p73 act together in chromatin modification and direct repression of alpha-fetoprotein transcription
Q34164614From p63 to p53 across p73.
Q30936349Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB.
Q24633799Functional association between Wwox tumor suppressor protein and p73, a p53 homolog
Q74108637Functional characterization of naturally occurring mutants (P405R and P425L) of p73alpha and p73beta found in neuroblastoma and lung cancer
Q45744096Functional impairment of p73 and p51, the p53-related proteins, by the human T-cell leukemia virus type 1 Tax oncoprotein
Q28910323Functional interplay between MDM2, p63/p73 and mutant p53
Q38099613Functions, divergence and clinical value of TAp73 isoforms in cancer.
Q34813092Genetic alterations in ovarian cancer cells that might account for sensitivity to chemotherapy in patients.
Q78484469Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites
Q35216158Hsp72 mediates TAp73α anti-apoptotic effects in small cell lung carcinoma cells
Q40015300HtrA2 enhances the apoptotic functions of p73 on bax.
Q36394792Human DMTF1β antagonizes DMTF1α regulation of the p14(ARF) tumor suppressor and promotes cellular proliferation.
Q43560180Human T-cell leukemia virus type I tax repression of p73beta is mediated through competition for the C/H1 domain of CBP.
Q53393697Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53.
Q38363282Identification of direct p73 target genes combining DNA microarray and chromatin immunoprecipitation analyses.
Q40455860Identification of protein kinase A catalytic subunit beta as a novel binding partner of p73 and regulation of p73 function.
Q44124982Inactivation of retinoblastoma (RB) tumor suppressor by oncogenic isoforms of the p53 family member p73.
Q79696856Increased proliferation of CD8+ T cells in SAP-deficient mice is associated with impaired activation-induced cell death
Q48308845Induction of apoptosis by the p53-related p73 and partial inhibition by the baculovirus-encoded p35 in neuronal cells
Q40880106Induction of neuronal differentiation by p73 in a neuroblastoma cell line
Q24531472Induction of p57(KIP2) expression by p73beta.
Q33725939Interactions of the p53 protein family in cellular stress response in gastrointestinal tumors
Q36604805Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors
Q34671614Iron chelators as therapeutic agents for the treatment of cancer.
Q35250114Lack of homozygously inactivated p73 in single-copy MYCN primary neuroblastomas and neuroblastoma cell lines
Q45038997Loss of heterozygosity, allele silencing and decreased expression of p73 gene in breast cancers: prevalence of alterations in inflammatory breast cancers
Q73835852Loss of p73 gene expression in lymphoid leukemia cell lines is associated with hypermethylation
Q58327595MDM2 and MDMX can interact differently with ARF and members of the p53 family
Q28141357Mdm2 binds p73 alpha without targeting degradation
Q45345758Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function
Q24804223Measuring a cell's response to stress: the p53 pathway
Q27728187Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization
Q42626865Molecular characterization of the first non-mammalian p73 cDNA.
Q47982598Molecular clock and gene function
Q57045501Molecular strategies in Metazoan genomic evolution
Q42813449Mouse DDA3 gene is a direct transcriptional target of p53 and p73.
Q34928405Multiple stress signals induce p73beta accumulation
Q35250103Mutation and expression of the p51 gene in human lung cancer
Q46273393Non-oncogenic roles of TAp73: from multiciliogenesis to metabolism
Q40690754Novel cell-specific and dominant negative anti-apoptotic roles of p73 in transformed leukemia cells
Q26781297Novel endogenous angiogenesis inhibitors and their therapeutic potential
Q34511214On the shoulders of giants: p63, p73 and the rise of p53.
Q42575797Oncogenes do not Fully Override Cell-intrinsic Traits: Pronounced Impact of the Cellular Programme
Q26749382Oncogenic Intra-p53 Family Member Interactions in Human Cancers
Q33290650Overexpressed TP73 induces apoptosis in medulloblastoma
Q52934103Overexpression of the p73 gene is a novel finding in high-risk B-cell chronic lymphocytic leukemia.
Q38882601Overexpression of the ∆Np73 isoform is associated with centrosome amplification in brain tumor cell lines
Q42513771Overproduced p73alpha activates a minimal promoter through a mechanism independent of its transcriptional activity
Q34185768P63 and P73: P53 mimics, menaces and more
Q36736367P73 and age-related diseases: is there any link with Parkinson Disease?
Q39999072P73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis
Q42509601P73 expression in basal layers of head and neck squamous epithelium: a role in differentiation and carcinogenesis in concert with p53 and p63?
Q40616826PCAF is a coactivator for p73-mediated transactivation
Q24559766PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73
Q58073315Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73
Q24301094Physical and functional interaction between HCV core protein and the different p73 isoforms
Q52169566Physical interaction between Wilms tumor 1 and p73 proteins modulates their functions.
Q34114100Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function
Q24529877Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression
Q24291023Physical interaction with Yes-associated protein enhances p73 transcriptional activity
Q38291171Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.
Q36288249Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma
Q39892741Protein kinase C-dependent phosphorylation regulates the cell cycle-inhibitory function of the p73 carboxy terminus transactivation domain
Q43771754Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis
Q35103149Regulation of Fertility by the p53 Family Members
Q35865249Regulation of p73 activity by post-translational modifications
Q40045967RelA/NF-kappaB recruitment on the bax gene promoter antagonizes p73-dependent apoptosis in costimulated T cells.
Q41920691Relative expression of TAp73 and ΔNp73 isoforms
Q38330053Relief of p53-mediated telomerase suppression by p73.
Q40848736Role for the p53 homologue p73 in E2F-1-induced apoptosis
Q33810088Role of p53 family members in apoptosis
Q34541091Role of p73 in malignancy: tumor suppressor or oncogene?
Q42483377Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin
Q38306110Role of the p53-homologue p73 in E2F1-induced apoptosis
Q52027067S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation.
Q38072351Senescence regulation by the p53 protein family
Q38343516Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73gamma in lung cancer
Q42526350Sp1-like sequences mediate human caspase-3 promoter activation by p73 and cisplatin
Q33787611Species-specific regulation of alternative splicing in the C-terminal region of the p53 tumor suppressor gene
Q36496801Specific isoforms of p73 control the induction of cell death induced by the viral proteins, E1A or apoptin
Q27646113Structural evolution of C-terminal domains in the p53 family
Q35947662TAp63γ enhances nucleotide excision repair through transcriptional regulation of DNA repair genes
Q37071124TAp73 enhances the pentose phosphate pathway and supports cell proliferation
Q34624156TAp73 induction by nitric oxide: regulation by checkpoint kinase 1 (CHK1) and protection against apoptosis
Q40213854TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones.
Q36919913TAp73 knockout shows genomic instability with infertility and tumor suppressor functions
Q38320453TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma.
Q39421785TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death
Q28579894TNF-alpha-mediated apoptosis in vascular smooth muscle cells requires p73
Q35078717TP53 family members and human cancers
Q33358710TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy
Q37100742Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling
Q39871640The BAG-1 cochaperone is a negative regulator of p73-dependent transcription
Q40446389The C-terminal sterile alpha motif and the extreme C terminus regulate the transcriptional activity of the alpha isoform of p73.
Q24311644The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73
Q24314498The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch
Q33593937The emerging p53 gene family
Q38289606The human p73 promoter: characterization and identification of functional E2F binding sites
Q36521923The p53 family in nervous system development and disease
Q33720564The p53 family: same response, different signals?
Q33807839The p53 gene family
Q34187832The p53 tumour suppressor protein
Q36422865The role of p73 in hematological malignancies
Q24746257The transcriptional repressor ZEB regulates p73 expression at the crossroad between proliferation and differentiation
Q77672293The two faces of p73
Q22010200The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
Q24293071The ubiquitin-protein ligase Itch regulates p73 stability
Q36979908Therapeutic prospects for p73 and p63: rising from the shadow of p53.
Q36556362Tissue-specific expression of p73 C-terminal isoforms in mice.
Q34100529Tracing the protectors path from the germ line to the genome
Q40810992Transactivation-deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53.
Q38325797Transactivation-dependent and -independent regulation of p73 stability
Q36673695Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63.
Q38300240Transcriptional activities of p73 splicing variants are regulated by inter-variant association.
Q55011897Transcriptional deregulation underlying the pathogenesis of small cell lung cancer.
Q28364211Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51
Q38290743Transcriptional inactivation of TP73 expression in oligodendroglial tumors
Q34334443Transcriptional regulation of the p73 gene by Nrf-2 and promoter CpG methylation in human breast cancer
Q38298822Tumor necrosis factor-alpha-induced caspase-1 gene expression. Role of p73.
Q40371709UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiquitination
Q35082705Ubiquitin and ubiquitin-like modifications of the p53 family
Q36399088Ubiquitin-dependent degradation of p73 is inhibited by PML.
Q57044029VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX
Q38304778ZNF143 interacts with p73 and is involved in cisplatin resistance through the transcriptional regulation of DNA repair genes
Q47807561c-Abl tyrosine kinase selectively regulates p73 nuclear matrix association
Q40527005c-Jun regulates the stability and activity of the p53 homologue, p73.
Q52044852deltaEF1 repressor controls selectively p53 family members during differentiation.
Q35641380microRNA-34a regulates neurite outgrowth, spinal morphology, and function
Q41685839p53 Family members p63 and p73 are SAM domain-containing proteins
Q36052576p53 basic C terminus regulates p53 functions through DNA binding modulation of subset of target genes
Q34405292p53 inactivation upregulates p73 expression through E2F-1 mediated transcription
Q40720232p53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop
Q44426545p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis
Q35635329p53 protein variants: structural and functional similarities with p63 and p73 isoforms
Q34515770p53, p63 and p73--solos, alliances and feuds among family members
Q89805472p53-Related Transcription Targets of TAp73 in Cancer Cells-Bona Fide or Distorted Reality?
Q74083357p53-dependent apoptosis is regulated by a C-terminally alternatively spliced form of murine p53
Q36846083p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo
Q36443527p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress.
Q31109129p53FamTaG: a database resource of human p53, p63 and p73 direct target genes combining in silico prediction and microarray data
Q36749787p63 and p73 in human cancer: defining the network
Q34080237p63 and p73, the ancestors of p53.
Q30595453p63 and p73: old members of a new family
Q35192806p63 is necessary for the activation of human papillomavirus late viral functions upon epithelial differentiation
Q36581663p63 the guardian of human reproduction
Q37983307p63/p73 in the control of cell cycle and cell death.
Q43652191p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes
Q55322510p73 Alternative Splicing: Exploring a Biological Role for the C-Terminal Isoforms.
Q40614201p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation
Q28206369p73 Interacts with c-Myc to regulate Y-box-binding protein-1 expression
Q28590574p73 and p63 protein stability: the way to regulate function?
Q28611414p73 as a pharmaceutical target for cancer therapy
Q43700522p73 cooperates with DNA damage agents to induce apoptosis in MCF7 cells in a p53-dependent manner
Q53625386p73 cooperates with Ras in the activation of MAP kinase signaling cascade.
Q52671036p73 coordinates with Δ133p53 to promote DNA double-strand break repair.
Q40774641p73 is a growth-regulated protein in vascular smooth muscle cells and is present at high levels in human atherosclerotic plaque
Q28364918p73 is over-expressed in vulval cancer principally as the Delta 2 isoform
Q52101616p73 is regulated by phosphorylation at the G2/M transition.
Q73787650p73 is transcriptionally regulated by DNA damage, p53, and p73
Q42575247p73 plays a role in erythroid differentiation through GATA1 induction.
Q40170381p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death
Q37163723p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene.
Q64951157p73 regulates epidermal wound healing and induced keratinocyte programming.
Q40896738p73 transcriptional activity increases upon cooperation between its spliced forms
Q36306728p73, a sophisticated p53 family member in the cancer world
Q34307362p73, the "assistant" guardian of the genome?
Q38731186p73-Binding Partners and Their Functional Significance
Q44872954p73-alpha is capable of inducing scotin and ER stress
Q28513003p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
Q34770297p73: Friend or foe in tumorigenesis
Q34709625p73: a multifunctional protein in neurobiology
Q34023178p73: structure and function
Q40709921pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation
Q60301981polymorphism and cancer susceptibility: evidence from 36 case-control studies
Q34510516ΔNp73 enhances promoter activity of TGF-β induced genes

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