Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease

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Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease is …
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scholarly articleQ13442814

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P356DOI10.1002/HEP.20400
P698PubMed publication ID15382116
P5875ResearchGate publication ID8333080

P2093author name stringZhigang Tian
Bin Gao
Feng Hong
Svetlana Radaeva
Hong-na Pan
Richard Veech
P2860cites workMassive liver growth in mice induced by systemic interleukin 6 administration.Q51835027
Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.Q52522262
Failure of regeneration of the steatotic rat liver: disruption at two different levels in the regeneration pathway.Q52537460
Lack of gp130 expression in hepatocytes promotes liver injury1 1K.L.S. and T.W. contributed equally to this workQ57339931
IL-6: a magic potion for liver transplantation?Q57547025
Intracerebroventricular interleukin-6 treatment decreases body fat in ratsQ59649473
Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regenerationQ62658884
Ischemic preconditioning protects the mouse liver by inhibition of apoptosis through a caspase-dependent pathwayQ73114530
Mechanisms of ischemic injury are different in the steatotic and normal rat liverQ73229693
Increased monocyte nuclear factor-kappaB activation and tumor necrosis factor production in alcoholic hepatitisQ73792877
Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodentQ73939856
A new and simple technique of total hepatic ischemia in the mouseQ74725233
Peroxisomal and mitochondrial fatty acid beta-oxidation in mice nullizygous for both peroxisome proliferator-activated receptor alpha and peroxisomal fatty acyl-CoA oxidase. Genotype correlation with fatty liver phenotypeQ77926979
Ischemia impairs liver regeneration after major tissue loss in rodents: protective effects of interleukin-6Q78045269
Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in miceQ24170238
Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fastingQ24563197
In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in ratsQ30960436
Cytokines in alcoholic liver diseaseQ33697078
Fatty liver in liver transplantation and surgeryQ34215124
Clinical features and natural history of nonalcoholic steatosis syndromesQ34215131
Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitisQ34436747
Update on nonalcoholic fatty liver diseaseQ34548921
Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS.Q34826141
AGA technical review on nonalcoholic fatty liver diseaseQ34982453
Non-alcoholic fatty liver disease: an overviewQ35009628
Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioningQ35028609
Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injuryQ35546843
STAT-3 overexpression and p21 up-regulation accompany impaired regeneration of fatty liversQ35747457
Interferon-alpha activates multiple STAT signals and down-regulates c-Met in primary human hepatocytesQ38290942
Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver diseaseQ38358419
Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed miceQ40641820
Seven hundred forty-seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resectionQ40757028
Ischemic preconditioning increases the tolerance of Fatty liver to hepatic ischemia-reperfusion injury in the rat.Q42114330
Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesityQ43031928
Tumor necrosis factor alpha, but not Fas, mediates hepatocellular apoptosis in the murine ischemic liverQ43534255
Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL.Q43604824
Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-x(L) proteinsQ43854595
Transgenic mice overexpressing human Bcl-2 are resistant to hepatic ischemia and reperfusionQ43878357
Low-dose TNF-alpha protects against hepatic ischemia-reperfusion injury in mice: implications for preconditioningQ44261195
Ischemic preconditioning protects the steatotic mouse liver against reperfusion injury: an ATP dependent mechanismQ44487614
Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in miceQ44493750
Interleukin 6/gp130-dependent pathways are protective during chronic liver diseasesQ44493772
Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E.Q44527604
Dual role of tumor necrosis factor-alpha in hepatic ischemia-reperfusion injury: studies in tumor necrosis factor-alpha gene knockout miceQ44759287
Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in miceQ44880254
Interleukin 6 is important for survival after partial hepatectomy in miceQ45233229
Interleukin-6 stimulates hepatic triglyceride secretion in ratsQ46353326
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectsteatosisQ1365091
fatty liver diseaseQ6058862
P304page(s)933-941
P577publication date2004-10-01
P1433published inHepatologyQ15724398
P1476titleInterleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease
P478volume40