Model of glycoprotein hormone receptor ligand binding and signaling

scientific article

Model of glycoprotein hormone receptor ligand binding and signaling is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M406948200
P698PubMed publication ID15304493
P5875ResearchGate publication ID8407627

P2093author name stringYongna Xing
Donghui Cao
John E Kerrigan
Michael P Bernard
Rebecca V Myers
William R Moyle
Win Lin
P2860cites workInsights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complexQ24290565
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structuresQ26778412
Crystal structure of a ternary complex between human chorionic gonadotropin (hCG) and two Fv fragments specific for the alpha and beta-subunitsQ27618716
Crystal structure of rhodopsin: A G protein-coupled receptorQ27625972
Structural basis for recognition of the intron branch site RNA by splicing factor 1Q27635949
A new zinc-protein coordination site in intracellular metal trafficking: solution structure of the Apo and Zn(II) forms of ZntA(46-118)Q27639912
Solution structure of the fourth metal-binding domain from the Menkes copper-transporting ATPaseQ27748799
VMD: visual molecular dynamicsQ27860554
Raster3D: photorealistic molecular graphicsQ27860557
Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeatsQ28257491
Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactionsQ28286455
Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor familyQ28569921
A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculationsQ29547632
Efficient preparation of glycoprotein hormones lacking an alpha-subunit oligosaccharideQ30901225
A molecular dissection of the glycoprotein hormone receptors.Q35683443
Use of monoclonal antibodies to subunits of human chorionic gonadotropin to examine the orientation of the hormone in its complex with receptorQ36289524
Conversion of human choriogonadotropin into a follitropin by protein engineeringQ37384438
Thyrotropin-luteinizing hormone/chorionic gonadotropin receptor extracellular domain chimeras as probes for thyrotropin receptor functionQ37388887
Equine chorionic gonadotropinQ37712183
Model of Human Chorionic Gonadotropin and Lutropin Receptor Interaction That Explains Signal Transduction of the Glycoprotein HormonesQ38292418
The Groove between the α- and β-Subunits of Hormones with Lutropin (LH) Activity Appears to Contact the LH Receptor, and Its Conformation Is Changed during Hormone BindingQ38292422
Hormone-binding properties and glycosylation pattern of a recombinant form of the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor expressed in mammalian cellsQ38302898
Posttranslational modifications of the lutropin receptor: mass spectrometric analysisQ38312116
Only a portion of the small seatbelt loop in human choriogonadotropin appears capable of contacting the lutropin receptorQ38337892
Use of protein knobs to characterize the position of conserved alpha-subunit regions in lutropin receptor complexesQ38337907
Glycoprotein hormone receptors: determinants in leucine-rich repeats responsible for ligand specificityQ39758878
Engineering the human thyrotropin receptor ectodomain from a non-secreted form to a secreted, highly immunoreactive glycoprotein that neutralizes autoantibodies in Graves' patients' seraQ40886828
Chimeric proteins can exceed the sum of their parts: implications for evolution and protein designQ41114221
Exoloop 3 of the luteinizing hormone/choriogonadotropin receptor. Lys583 is essential and irreplaceable for human choriogonadotropin (hCG)-dependent receptor activation but not for high affinity hCG bindingQ41213281
Requirement of cysteine residues in exons 1-6 of the extracellular domain of the luteinizing hormone receptor for gonadotropin bindingQ41217460
Differential Roles of Exoloop 1 of the Human Follicle-stimulating Hormone Receptor in Hormone Binding and Receptor ActivationQ41326584
Mapping of HCG-receptor complexes.Q41346965
Co-evolution of ligand-receptor pairsQ41480447
On the functional importance of thyrotropin receptor intramolecular cleavageQ41692363
Subunit structure of thyrotropin receptors expressed on the cell surfaceQ41703208
Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge regionQ41746302
Lutropins appear to contact two independent sites in the extracellular domain of their receptorsQ42231375
Structural requirements for mutational lutropin/choriogonadotropin receptor activationQ42526466
The role of Asp578 in maintaining the inactive conformation of the human lutropin/choriogonadotropin receptorQ42527594
A two-receptor model for salmon gonadotropins (GTH I and GTH II)Q43409132
Alternatively folded choriogonadotropin analogs. Implications for hormone folding and biological activityQ43760084
Evidence that the C terminus of the A subunit suppresses thyrotropin receptor constitutive activityQ44559272
Tight attachment of chitin-binding-domain-tagged proteins to surfaces coated with acetylated chitosanQ44820228
The thyrotropin (TSH) receptor: interaction with TSH and autoantibodiesQ46228305
Targeted restoration of cleavage in a noncleaving thyrotropin receptor demonstrates that cleavage is insufficient to enhance ligand-independent activityQ46538911
The duality of fish gonadotropin receptors: cloning and functional characterization of a second gonadotropin receptor cDNA expressed in the ovary and testis of amago salmon (Oncorhynchus rhodurus).Q47911752
Absence of exon 10 of the human luteinizing hormone (LH) receptor impairs LH, but not human chorionic gonadotropin actionQ47937885
Cloning and sequencing of porcine LH-hCG receptor cDNA: variants lacking transmembrane domainQ48290271
A new subclass of the luteinizing hormone/chorionic gonadotropin receptor lacking exon 10 messenger RNA in the New World monkey (Platyrrhini) lineageQ48379243
The surface of α-subunit loop 1 distant from the subunit interface is exposed in the hCG lutropin receptor complexQ57407098
The KH module has an αβ foldQ57591562
P433issue43
P407language of work or nameEnglishQ1860
P921main subjectligand bindingQ61659151
P304page(s)44442-44459
P577publication date2004-08-09
P1433published inJournal of Biological ChemistryQ867727
P1476titleModel of glycoprotein hormone receptor ligand binding and signaling
P478volume279

Reverse relations

cites work (P2860)
Q36632470A functional transmembrane complex: the luteinizing hormone receptor with bound ligand and G protein.
Q37244541A monoclonal antibody with thyrotropin (TSH) receptor inverse agonist and TSH antagonist activities binds to the receptor hinge region as well as to the leucine-rich domain
Q41555597Assembly and structural characterization of an authentic complex between human follicle stimulating hormone and a hormone-binding ectodomain of its receptor
Q54298996Cloning and expression analysis of follicle-stimulating hormone and luteinizing hormone receptor during the reproductive cycle in Korean rockfish (Sebastes schlegeli).
Q39912851Critical involvement of the hinge region of the follicle-stimulating hormone receptor in the activation of the receptor
Q35063176Defining structural and functional dimensions of the extracellular thyrotropin receptor region
Q35745199Demonstration of the Coexistence of Duplicated LH Receptors in Teleosts, and Their Origin in Ancestral Actinopterygians
Q48514174Effects of human pituitary FSH isoforms on mouse follicles in vitro
Q42855341Follitropin receptors contain cryptic ligand binding sites
Q34251314Functional differences of invariant and highly conserved residues in the extracellular domain of the glycoprotein hormone receptors
Q88372670Gonadotropin receptors of Labeo rohita: Cloning and characterization of full-length cDNAs and their expression analysis during annual reproductive cycle
Q36755364Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties
Q33232180Identification of sea lamprey GTHbeta-like cDNA and its evolutionary implications
Q34735557In silico study on binding specificity of gonadotropins and their receptors: design of a novel and selective peptidomimetic for human follicle stimulating hormone receptor.
Q36202068Models of glycoprotein hormone receptor interaction
Q40551660Molecular characterization and quantification of the follicle-stimulating hormone receptor in turbot (Scophthalmus maximus).
Q48735501Molecular characterization and quantification of the gonadotropin receptors FSH-R and LH-R from Atlantic cod (Gadus morhua).
Q48503148Molecular cloning and characterization of FSH and LH receptors in Atlantic salmon (Salmo salar L.).
Q44173680Molecular cloning of two gonadotropin receptors in mummichog Fundulus heteroclitus and their gene expression during follicular development and maturation
Q42668542Molecular cloning, characterization, and expression analysis of luteinizing hormone receptor gene in turbot (Scophthalmus maximus).
Q36202107Molecular pharmacology of gonadotropins
Q38337892Only a portion of the small seatbelt loop in human choriogonadotropin appears capable of contacting the lutropin receptor
Q37581152Perspectives on fish gonadotropins and their receptors.
Q34942963Relationship between Thyrotropin Receptor Hinge Region Proteolytic Posttranslational Modification and Receptor Physiological Function
Q38107901Structural and functional plasticity of the luteinizing hormone/choriogonadotrophin receptor
Q42131239Structure and activation of the TSH receptor transmembrane domain
Q27670753Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor
Q34384048The antibodies against the computationally designed mimic of the glycoprotein hormone receptor transmembrane domain provide insights into receptor activation and suppress the constitutively activated receptor mutants
Q37269160The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor
Q36629258The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction
Q33775572Thyrotropin (TSH) receptor residue E251 in the extracellular leucine-rich repeat domain is critical for linking TSH binding to receptor activation
Q38337907Use of protein knobs to characterize the position of conserved alpha-subunit regions in lutropin receptor complexes

Search more.