Leptin-receptor gene transfer into the arcuate nucleus of female Fatty zucker rats using recombinant adeno-associated viral vectors stimulates the hypothalamo-pituitary-gonadal axis

scientific article published on 03 March 2004

Leptin-receptor gene transfer into the arcuate nucleus of female Fatty zucker rats using recombinant adeno-associated viral vectors stimulates the hypothalamo-pituitary-gonadal axis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1095/BIOLREPROD.103.025858
P698PubMed publication ID14998906
P5875ResearchGate publication ID7333697

P2093author name stringErin Keen-Rhinehart
Satya P Kalra
Pushpa S Kalra
P2860cites workEvidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intakeQ28572571
Weight-reducing effects of the plasma protein encoded by the obese geneQ29617934
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Identification and expression cloning of a leptin receptor, OB-RQ29620255
Leptin and metabolic control of reproductionQ33946838
Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networksQ34301257
Leptin: the tale of an obesity geneQ34402454
Selective and rapid uptake of adeno-associated virus type 2 in brainQ34471578
Leptin and leptin receptor mRNA and protein expression in the murine fetus and placentaQ36612678
The role of neuropeptide Y in the antiobesity action of the obese gene productQ38290434
Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term studyQ38300310
Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamusQ38326475
Leptin indirectly affects estrous cycles by increasing metabolic fuel oxidationQ38334529
Localization of leptin receptor immunoreactivity in the lean and obese Zucker rat brainQ38336941
Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamusQ38340494
Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamusQ38352557
Identification of targets of leptin action in rat hypothalamusQ38353571
Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridizationQ38356905
Tetracycline-inducible expression systems with reduced basal activity in mammalian cellsQ39726914
Steroidal modulation of the regulatory neuropeptides: luteinizing hormone releasing hormone, neuropeptide Y and endogenous opioid peptidesQ39755198
Production and purification of recombinant adeno-associated virusQ40881531
Nutritional infertility: the role of the interconnected hypothalamic neuropeptide Y-galanin-opioid networkQ41199941
An opioid-neuropeptide-Y transmission line to luteinizing hormone (LH)-releasing hormone neurons: a role in the induction of LH surgeQ41241695
Food restriction neither improves nor exacerbates reproduction in obese female Zucker ratsQ41679058
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brainQ42280576
Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysisQ42456330
Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamusQ43693955
Circulating reproductive hormones and hypothalamic oestradiol and progestin receptors in infertile Zucker ratsQ44036398
Arcuate Nucleus-Specific Leptin Receptor Gene Therapy Attenuates the Obesity Phenotype of Koletsky (fak/fak) RatsQ44405123
Reproductive function in the genetically obese "fatty" rat.Q44571533
Recombinant adeno-associated virus purification using novel methods improves infectious titer and yieldQ45747699
Evidence for GnRH regulation by leptin: leptin administration prevents reduced pulsatile LH secretion during fastingQ47850731
Leptin receptor missense mutation in the fatty Zucker rat.Q48064469
Morphine or capsaicin administration alters the secretion of beta-endorphin into the hypophysial portal vasculature of the rat.Q48419373
Comparison of the effects of neuropeptide Y and adrenergic transmitters on LH release and food intake in male ratsQ48461516
Neuropeptide Y in the magnocellular hypothalamic neurons of obese Zucker ratsQ48478417
Immunohistochemical localization of leptin receptor in the rat brainQ48492951
Leptin and ciliary neurotropic factor (CNTF) inhibit fasting-induced suppression of luteinizing hormone release in rats: role of neuropeptide Y.Q48520543
Nitric oxide mediates leptin-induced luteinizing hormone-releasing hormone (LHRH) and LHRH and leptin-induced LH release from the pituitary glandQ48605080
Altered neuropeptide Y concentrations in specific hypothalamic regions of obese (fa/fa) Zucker rats. Possible relationship to obesity and neuroendocrine disturbancesQ48637062
Hypothalamic neuropeptide Y (NPY) in obese Zucker rats: implications in feeding and sexual behaviorsQ49064462
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)266-272
P577publication date2004-03-03
P1433published inBiology of ReproductionQ4915061
P1476titleLeptin-receptor gene transfer into the arcuate nucleus of female Fatty zucker rats using recombinant adeno-associated viral vectors stimulates the hypothalamo-pituitary-gonadal axis
P478volume71

Reverse relations

cites work (P2860)
Q35940430Neuroendocrinology of nutritional infertility
Q24669972Neuropeptide Y in normal eating and in genetic and dietary-induced obesity
Q36721398Selective leptin insensitivity and alterations in female-reproductive patterns linked to hyperleptinemia during infancy.
Q28301116The relationship between gut and adipose hormones, and reproduction
Q35728457To subjugate NPY is to improve the quality of life and live longer

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