Direct binding of neutral endopeptidase 24.11 to ezrin/radixin/moesin (ERM) proteins competes with the interaction of CD44 with ERM proteins

scientific article published on 02 January 2004

Direct binding of neutral endopeptidase 24.11 to ezrin/radixin/moesin (ERM) proteins competes with the interaction of CD44 with ERM proteins is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M212737200
P698PubMed publication ID14704146

P2093author name stringAkira Iwase
David M Nanus
Daniel Navarro
Ruoqian Shen
P2860cites workMolecular cloning of the common acute lymphoblastic leukemia antigen (CALLA) identifies a type II integral membrane proteinQ24294498
NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrinQ24315976
Ezrin is a cyclic AMP-dependent protein kinase anchoring proteinQ24532065
CD44 cell adhesion moleculesQ24568164
Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathwayQ24671083
Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2Q24676628
Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarizationQ24683747
Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domainQ27622801
Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocationQ28143472
Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphateQ28279749
The ezrin protein family: membrane-cytoskeleton interactions and disease associationsQ30428648
ERM proteins in cell adhesion and membrane dynamicsQ33632981
ERM proteins: from cellular architecture to cell signalingQ34079082
Methionine aminopeptidase 2 is a new target for the metastasis-associated protein, S100A4.Q34127108
High-frequency transformation method and library transducing vectors for cloning mammalian cDNAs by trans-complementation of Schizosaccharomyces pombeQ34236306
Subcellular localization of moesin in dynamic filopodia, retraction fibers, and other structures involved in substrate exploration, attachment, and cell-cell contactsQ34301673
The hyaluronan receptor, CD44.Q34598130
ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletonsQ36382880
Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family membersQ36534860
CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lungQ37632942
Replacement of threonine 558, a critical site of phosphorylation of moesin in vivo, with aspartate activates F-actin binding of moesin. Regulation by conformational changeQ38325656
Molecular analysis of CD26-mediated signal transduction in T cellsQ39091438
Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signalingQ40736037
Endopeptidase-24.11: putative substrates and possible rolesQ40773727
CD44 Expression in Benign and Neoplastic Human ProstatesQ40933277
Evaluation of the tetracycline-repressible transactivator system for inducible gene expression in human prostate cancer cell linesQ41079589
CD44 phosphorylation regulates melanoma cell and fibroblast migration on, but not attachment to, a hyaluronan substratum.Q41187983
CD44 in inflammation and metastasisQ41594954
Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinasesQ42809055
A requirement for the CD44 cytoplasmic domain for hyaluronan binding, pericellular matrix assembly, and receptor-mediated endocytosis in COS-7 cellsQ43855729
Expression of CD44 isoforms correlates with the metastatic potential of osteosarcoma.Q43891752
Enhanced expression of vimentin in motile prostate cell lines and in poorly differentiated and metastatic prostate carcinoma.Q44124766
Using Schizosaccharomyces pombe as a host for expression and purification of eukaryotic proteinsQ48041497
Inactivation of neurotensin by rat brain synaptic membranes. Cleavage at the Pro10-Tyr11 bond by endopeptidase 24.11 (enkephalinase) and a peptidase different from proline-endopeptidaseQ48608392
Regulated CD44 cleavage under the control of protein kinase C, calcium influx, and the Rho family of small G proteins.Q55476721
Decreased expression of CD44 in metastatic prostate cancerQ73032204
Human mast cells express the hyaluronic-acid-binding isoform of CD44 and adhere to hyaluronic acidQ73486985
Oncostatin M and transforming growth factor-beta 1 induce post-translational modification and hyaluronan binding to CD44 in lung-derived epithelial tumor cellsQ73634638
Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progressionQ74033290
Association of Na(+)-H(+) exchanger isoform NHE3 and dipeptidyl peptidase IV in the renal proximal tubuleQ74599385
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)11898-11905
P577publication date2004-01-02
P1433published inJournal of Biological ChemistryQ867727
P1476titleDirect binding of neutral endopeptidase 24.11 to ezrin/radixin/moesin (ERM) proteins competes with the interaction of CD44 with ERM proteins
P478volume279

Reverse relations

cites work (P2860)
Q39297022Adenoviral neutral endopeptidase gene delivery in combination with paclitaxel for the treatment of prostate cancer
Q34777829Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin
Q33721897Casein kinase 2 dependent phosphorylation of neprilysin regulates receptor tyrosine kinase signaling to Akt
Q30439052Characterization of a novel interaction between ELMO1 and ERM proteins
Q37855740Concise review: neutral endopeptidase (CD10): a multifaceted environment actor in stem cells, physiological mechanisms, and cancer
Q42001296Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail of adhesion molecule CD44.
Q42001090Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail of membrane-type 1 matrix metalloproteinase (MT1-MMP)
Q41834384Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tails of adhesion molecules CD43 and PSGL-1
Q28588034Ezrin-radixin-moesin (ERM)-binding phosphoprotein 50 organizes ERM proteins at the apical membrane of polarized epithelia
Q39297821Ezrin/radixin/moesin are required for the purinergic P2X7 receptor (P2X7R)-dependent processing of the amyloid precursor protein
Q24299220HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells
Q46557742Hyaluronan synthesis inhibitor supplements the inhibitory effects of zoledronic acid on bone metastasis of lung cancer
Q40148478Lentiviral vector neutral endopeptidase gene transfer suppresses prostate cancer tumor growth
Q37432747Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex
Q42714368Negative regulation of NEP expression by hypoxia
Q33897696Neprilysin impedes islet amyloid formation by inhibition of fibril formation rather than peptide degradation
Q40238484Neprilysin inhibits angiogenesis via proteolysis of fibroblast growth factor-2.
Q40284709Neuropeptide-stimulated cell migration in prostate cancer cells is mediated by RhoA kinase signaling and inhibited by neutral endopeptidase
Q53370854Neutral endopeptidase is a myristoylated protein.
Q37379796Possible involvement of CD10 in the development of endometriosis due to its inhibitory effects on CD44-dependent cell adhesion
Q40563114Prostate cancer invasion is influenced more by expression of a CD44 isoform including variant 9 than by Muc18.
Q42606516Rational redesign of neutral endopeptidase binding to merlin and moesin proteins.
Q36575175Role of neprilysin in airway inflammation induced by diesel exhaust emissions
Q27644609Structural basis for type II membrane protein binding by ERM proteins revealed by the radixin-neutral endopeptidase 24.11 (NEP) complex

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