Localization of the binding site for the human high-affinity Fc receptor on IgG.

scientific article published on April 1988

Localization of the binding site for the human high-affinity Fc receptor on IgG. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1011495304
P356DOI10.1038/332563A0
P698PubMed publication ID2965792
P5875ResearchGate publication ID20190053

P2093author name stringPartridge LJ
Winter G
Burton DR
Duncan AR
Woof JM
P2860cites workCrystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolutionQ27729251
Production of target-specific effector cells using hetero-cross-linked aggregates containing anti-target cell and anti-Fc gamma receptor antibodiesQ34251290
Expression of biological effector functions by immunoglobulin G molecules lacking the hinge regionQ35311738
The binding of human immunoglobulin G1 monomer and small, covalently cross-linked polymers of immunoglobulin G1 to human peripheral blood monocytes and polymorphonuclear leukocytesQ37013549
Effector functions of a monoclonal aglycosylated mouse IgG2a: binding and activation of complement component C1 and interaction with human monocyte Fc receptorQ38352603
Human IgG1 and its Fc fragment bind with different affinities to the Fc receptors on the human U937, HL-60 and ML-1 cell linesQ38520523
Immunoglobulin G: functional sitesQ39820837
Improved oligonucleotide site-directed mutagenesis using M13 vectors.Q40470764
Variations in the S-S bridges of immunoglobins G: interchain disulfide bridges of gamma G3 myeloma proteinsQ44363905
Localisation of the monocyte-binding region on human immunoglobulin G.Q46578458
Variability of Interchain Binding of Immunoglobulins: Interchain Bridges of Mouse IgG1Q57698518
Disulphide Bridges of Immunoglobin G1 Heavy ChainsQ59062458
EndocytosisQ66883082
An IgG2a-producing variant of an IgG2b-producing mouse myeloma cell line. Structural studies on the Fc region of parent and variant heavy chainsQ67402400
The use of anti-IgG monoclonal antibodies in mapping the monocyte receptor site on IgGQ68986422
Is IgM-like dislocation a common feature of antibody function?Q85699516
Human leukocyte IgG Fc receptorsQ85700442
The monocyte binding domain(S) on human immunoglobulin GQ93853544
P433issue6164
P407language of work or nameEnglishQ1860
P304page(s)563-564
P577publication date1988-04-01
P1433published inNatureQ180445
P1476titleLocalization of the binding site for the human high-affinity Fc receptor on IgG.
P478volume332

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cites work (P2860)
Q33953159A conformational change in the Fc precludes the binding of two Fcgamma receptor molecules to one IgG.
Q53645990A mutant human IgG molecule with only one C1q binding site can activate complement and induce lysis of target cells.
Q40152593A novel Fc gamma receptor ligand augments humoral responses by targeting antigen to Fc gamma receptors
Q33572691A vaccine of L2 epitope repeats fused with a modified IgG1 Fc induced cross-neutralizing antibodies and protective immunity against divergent human papillomavirus types
Q71012001Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice
Q47864888Activation of complement by human IgG1 and human IgG3 antibodies against the human leucocyte antigen CD52.
Q45128845Activation of effector functions by immune complexes of mouse IgG2a with isotype-specific autoantibodies
Q28079016Advances in Therapeutic Fc Engineering - Modulation of IgG-Associated Effector Functions and Serum Half-life
Q42835972Aglycosylation of human IgG1 and IgG3 monoclonal antibodies can eliminate recognition by human cells expressing Fc gamma RI and/or Fc gamma RII receptors
Q27685255An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations
Q37505420Antibody engineering to develop new antirheumatic therapies
Q40912749Antibody engineering using Escherichia coli as host
Q36694805Biologic therapies in rheumatology: lessons learned, future directions
Q78177133Boosting therapeutic potency of antibodies by taming Fc domain functions.
Q35180027Building Antibodies from their Genes
Q70667222Building antibodies from their genes
Q33938158C1q receptors.
Q37597698Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn.
Q47959086Characterization of the three immunoglobulin G subclasses of macaques
Q37733224Cleavage of IgGs by proteases associated with invasive diseases: an evasion tactic against host immunity?
Q48093407Cloning and sequence analysis of kappa and gamma cynomolgus monkey immunoglobulin cDNAs
Q33653661Comparison of intact antibody structures and the implications for effector function.
Q48048096Complement recruitment using bispecific diabodies
Q81543208Construction and characterization of a humanized anti-human CD3 monoclonal antibody 12F6 with effective immunoregulation functions
Q27766423Crystal structure of the human high-affinity IgE receptor
Q46215386Designing CD4 immunoadhesins for AIDS therapy
Q92940332DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing
Q46879419Effect of glycosylation on antibody function: implications for genetic engineering
Q33870167Effector function activities of a panel of mutants of a broadly neutralizing antibody against human immunodeficiency virus type 1
Q34424958Engineered antibody Fc variants with enhanced effector function
Q39103601Engineered protease-resistant antibodies with selectable cell-killing functions
Q67470988Engineering Antibodies for Therapy
Q36846507Engineering of Fc(1) and Fc(3) from human immunoglobulin G to analyse subclass specificity for staphylococcal protein A.
Q47820029Engineering therapeutic monoclonal antibodies
Q42115042Enhancement of complement activation and cytolysis of human IgG3 by deletion of hinge exons
Q45272924Evaluation of Heavy-Chain C-Terminal Deletion on Product Quality and Pharmacokinetics of Monoclonal Antibodies
Q45741159Expression of Fc(gamma)r1 (CD64) on polymorphonuclear leucocytes during progression to acquired immunodeficiency syndrome in perinatally human immunodeficiency virus-infected children
Q38317018Expression of glucosamine trisaccharides on the rat uterine surface is altered by clomiphene citrate.
Q55421471Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Q54943207Fc engineering of anti-Nectin-2 antibody improved thrombocytopenic adverse event in monkey.
Q36954763Fc-gamma receptors: mediators, targets and markers of disease
Q34565354Function and heterogeneity of human Fc receptors for immunoglobulin G.
Q51730495Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing.
Q82413093HIV-1 and influenza antigens synthetically linked to IgG2a Fc elicit superior humoral responses compared to unmodified antigens in mice
Q90212766Harnessing the immune system via FcγR function in immune therapy: A pathway to next-gen mAbs
Q46117208High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.
Q37558460High-affinity binding sites for related fibroblast growth factor ligands reside within different receptor immunoglobulin-like domains
Q54136124Highly efficient neutralization of HIV with recombinant CD4-immunoglobulin molecules.
Q41022012Human Fc receptors for IgG.
Q59243333Human IgG isotype-specific amino acid residues affecting complement-mediated cell lysis and phagocytosis
Q26779758Human IgG4: a structural perspective
Q35695770Human antibody effector function
Q28252414Human antibody-Fc receptor interactions illuminated by crystal structures
Q52184933Humanized antibodies as potential therapeutic drugs.
Q40840186Humanized antibodies: enhancing therapeutic utility through antibody engineering
Q41117025Humanized porcine VCAM-specific monoclonal antibodies with chimeric IgG2/G4 constant regions block human leukocyte binding to porcine endothelial cells
Q90386023Identification and characterization of an IgG sequence variant with an 11 kDa heavy chain C-terminal extension using a combination of mass spectrometry and high-throughput sequencing analysis
Q28141479Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human fcalpha receptor (FcalphaR) CD89
Q37605135Identification of the Fc gamma receptor class I binding site in human IgG through the use of recombinant IgG1/IgG2 hybrid and point-mutated antibodies
Q54638658Identifying amino acid residues that influence plasma clearance of murine IgG1 fragments by site-directed mutagenesis.
Q47593242IgG Fc engineering to modulate antibody effector functions
Q40908616IgG binding sites on human Fc gamma receptors
Q33636882Improved biodistribution, tumor targeting, and reduced immunogenicity in mice with a gamma 4 variant of Campath-1H.
Q38344654Increasing the serum persistence of an IgG fragment by random mutagenesis.
Q34773410Inhibition of VEGF-dependent multistage carcinogenesis by soluble EphA receptors
Q73486532Inhibition of contact sensitivity in human CD4+ transgenic mice by human CD4-specific monoclonal antibodies: CD4+ T-cell depletion is not required
Q37027146Isotype selection in antibody engineering
Q30835165Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity
Q72715944Localization of the site of the murine IgG1 molecule that is involved in binding to the murine intestinal Fc receptor
Q30766668Loss of splice consensus signal is responsible for the removal of the entire C(H)1 domain of the functional camel IGG2A heavy-chain antibodies
Q37578785Low-affinity Fcgamma receptors, autoimmunity and infection
Q37624015Man-made antibodies
Q64066666Mind the Gap: How Interspecies Variability in IgG and Its Receptors May Complicate Comparisons of Human and Non-human Primate Effector Function
Q36585819Molecular and cellular basis for pathogenicity of autoantibodies: lessons from murine monoclonal autoantibodies
Q40602173Molecular basis of Fc receptor function
Q35110825Monoclonal antibody-mediated protection and neutralization of motility in experimental Proteus mirabilis infection
Q40454744Mutations within a human IgG2 antibody form distinct and homogeneous disulfide isomers but do not affect Fc gamma receptor or C1q binding.
Q35774772One disulfide bond in front of the second heavy chain constant region is necessary and sufficient for effector functions of human IgG3 without a genetic hinge
Q34147273Overview on the use of therapeutic antibodies in drug discovery
Q28202471PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Q34674773PEGylated antibodies and antibody fragments for improved therapy: a review
Q36452621Potent antibody therapeutics by design
Q90390474R409K mutation prevents acid-induced aggregation of human IgG4
Q36370858Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung
Q40933834Recombinant human IgG molecules lacking Fcgamma receptor I binding and monocyte triggering activities
Q38957490Regulation of antibody effector functions through IgG Fc N-glycosylation
Q36116253Regulation of antibody production mediated by Fc gamma receptors, IgG binding factors, and IgG Fc-binding autoantibodies
Q33672201Secretion of functional antibody and Fab fragment from yeast cells
Q53316915Section 1C: Assessment of the functional activity and IgG Fc receptor utilisation of 64 IgG Rh monoclonal antibodies. Coordinator's report.
Q30831891Solid-phase synthesis and cyclization of a large branched peptide from IgG Fc with affinity for Fc gammaRI.
Q37734089Stability of IgG isotypes in serum
Q57212988Streptococcal IgA-binding Proteins Bind in the Cα2-Cα3 Interdomain Region and Inhibit Binding of IgA to Human CD89
Q38615376Structural analysis of Fc/FcγR complexes: a blueprint for antibody design.
Q50520171Structural analysis of effector functions related motifs, complement activation and hemagglutinating activities in Lama glama heavy chain antibodies.
Q40388373Structural basis for binding of human IgG1 to its high-affinity human receptor FcγRI.
Q36624176Structural characterization of GASDALIE Fc bound to the activating Fc receptor FcγRIIIa
Q36362075Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation
Q61651725Structural motifs involved in human IgG antibody effector functions
Q41823952Structural requirements for the interaction of human IgM and IgA with the human Fcalpha/mu receptor
Q27625567Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha
Q74419758TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS
Q33758483Targeting FcRn for therapy: from live cell imaging to in vivo studies in mice.
Q37334251Targeting the neonatal fc receptor for antigen delivery using engineered fc fragments.
Q27625570The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex
Q33292180The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans
Q39920154The FGL2-FcgammaRIIB pathway: a novel mechanism leading to immunosuppression
Q38239283The FcγR of humans and non-human primates and their interaction with IgG: implications for induction of inflammation, resistance to infection and the use of therapeutic monoclonal antibodies
Q41227547The IgG binding site of human FcgammaRIIIB receptor involves CC' and FG loops of the membrane-proximal domain
Q59360845The Potential Role of Fc-Receptor Functions in the Development of a Universal Influenza Vaccine
Q46276474The antibody loci of the domestic goat (Capra hircus).
Q37586901The antitumor activity of the human FOLR1-specific monoclonal antibody, farletuzumab, in an ovarian cancer mouse model is mediated by antibody-dependent cellular cytotoxicity.
Q34453640The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fcα receptor interactions
Q37097432The high affinity receptor for IgE on mast cells
Q38615370The high-affinity receptor for IgG, FcγRI, of humans and non-human primates.
Q40998108The influence of the hinge region length in binding of human IgG to human Fcgamma receptors
Q67899868The nature and importance of the inter-ɛ chain disulfide bonds in human IgE
Q33581541The second century of the antibody. Molecular perspectives in regulation, pathophysiology, and therapeutic applications
Q38323488The stalk domain and the glycosylation status of the activating natural killer cell receptor NKp30 are important for ligand binding
Q33609768The structural basis of human IgE-Fc receptor interactions
Q54217589Therapeutic Administration of Broadly Neutralizing FI6 Antibody Reveals Lack of Interaction Between Human IgG1 and Pig Fc Receptors.
Q27732153Three-dimensional structure of a human immunoglobulin with a hinge deletion
Q34506062Transferrin-antibody fusion proteins are effective in brain targeting
Q37379755Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge
Q72265732[Recombinant immunoglobulins]

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