Lovastatin inhibits bone marrow-derived dendritic cell maturation and upregulates proinflammatory cytokine production

scientific article

Lovastatin inhibits bone marrow-derived dendritic cell maturation and upregulates proinflammatory cytokine production is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0008-8749(03)00148-5
P698PubMed publication ID12914758

P2093author name stringGabriel Fernandes
Dongxu Sun
P2860cites workReduction of platelet activity markers in type II hypercholesterolemic patients by a HMG-CoA-reductase inhibitorQ73068639
Statins as a newly recognized type of immunomodulatorQ73252634
Hydroxymethylglutaryl-coenzyme A reductase inhibition stimulates caspase-1 activity and Th1-cytokine release in peripheral blood mononuclear cellsQ73409194
Cytokine modulation of LDL oxidation by activated human monocytesQ73832892
The PI3 kinase, p38 SAP kinase, and NF-kappaB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cellsQ74055104
Simvastatin-induced lupus erythematosusQ77318332
Maintenance of NF-kappaB activation in T-lymphocytes and a naive T-cell population in autoimmune-prone (NZB/NZW)F(1) mice by feeding a food-restricted diet enriched with n-3 fatty acidsQ77605810
Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cellsQ24533532
Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial productsQ24678867
Atherosclerosis — An Inflammatory DiseaseQ26776972
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
Dendritic cells and the control of immunityQ27860918
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alphaQ28251443
Expression of relB is required for the development of thymic medulla and dendritic cellsQ28594949
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)Q29547825
The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigatorsQ29547887
An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrowQ29615498
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study GroupQ29619842
Current perspectives on statinsQ33818381
Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel familyQ34317095
Cell cycle-specific effects of lovastatinQ34532393
Simvastatin initiated early after heart transplantation: 8-year prospective experienceQ34648179
Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.Q36367475
Lipopolysaccharide-induced NF-kappa B activation in mouse 70Z/3 pre-B lymphocytes is inhibited by mevinolin and 5'-methylthioadenosine: roles of protein isoprenylation and carboxyl methylation reactionsQ36807858
Immune response in the mutant diabetic C57BL/Ks-dt+ mouse. Discrepancies between in vitro and in vivo immunological assaysQ37050313
Origin, maturation and antigen presenting function of dendritic cells.Q40906220
Identifying strategies for immune interventionQ40907476
Lipid lowering and plaque regression. New insights into prevention of plaque disruption and clinical events in coronary diseaseQ40913054
Stimulation of bone formation in vitro and in rodents by statinsQ40914337
Inhibition of the mevalonate pathway: benefits beyond cholesterol reduction?Q40933208
Role of the mevalonate pathway of isoprenoid synthesis in IL-8 generation by activated monocytic cells.Q41462781
Cholesterol lowering with statin drugs, risk of stroke, and total mortality. An overview of randomized trialsQ41535803
Dendritic cell survival and maturation are regulated by different signaling pathways.Q42971737
Lipid modulation in insulin-dependent diabetes mellitus: effect on microvascular outcomesQ43612181
Lovastatin treatment decreases mononuclear cell infiltration into the CNS of Lewis rats with experimental allergic encephalomyelitisQ43760330
Ten-year mortality from cardiovascular disease in relation to cholesterol level among men with and without preexisting cardiovascular diseaseQ43929837
Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients.Q44063984
Lovastatin-stimulated superinduction of E-selectin, ICAM-1 and VCAM-1 in TNF-alpha activated human vascular endothelial cellsQ44064882
Effect of pravastatin on outcomes after cardiac transplantation.Q46203599
LPS-induced cytokine production and expression of LPS-receptors by peripheral blood mononuclear cells of patients with familial hypercholesterolemia and the effect of HMG-CoA reductase inhibitorsQ47702936
Differential nuclear localization of p50, p52, and RelB proteins in human accessory cells of the immune response in situ.Q50335866
Simvastatin inhibits the monocyte expression of proinflammatory cytokines in patients with hypercholesterolemiaQ58421218
Lovastatin-induced lupus erythematosusQ67945132
Lupuslike syndrome associated with simvastatinQ68025899
Lovastatin inhibits lipopolysaccharide-induced NF-kappaB activation in human mesangial cellsQ71164059
Effects of an HMG-CoA reductase inhibitor on cytokine production by human monocytes/macrophagesQ71744118
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectdendritic cellQ506253
P1104number of pages11
P304page(s)52-62
P577publication date2003-05-01
P1433published inCellular ImmunologyQ2597167
P1476titleLovastatin inhibits bone marrow-derived dendritic cell maturation and upregulates proinflammatory cytokine production
P478volume223

Reverse relations

cites work (P2860)
Q46972979Cytokine secretion via cholesterol-rich lipid raft-associated SNAREs at the phagocytic cup.
Q37942858Dendritic cells in human atherosclerosis: from circulation to atherosclerotic plaques
Q36300489Discovery of BVDU as a promising Drug for autoimmune diseases Therapy by Dendritic-cell-based functional screening
Q43194456GGTI-2133, an inhibitor of geranylgeranyltransferase, inhibits infiltration of inflammatory cells into airways in mouse experimental asthma
Q39643965IL-2 Costimulation Enables Statin-Mediated Activation of Human NK Cells, Preferentially through a Mechanism Involving CD56+ Dendritic Cells
Q46024300Lovastatin inhibits antigen-induced airway eosinophilia without affecting the production of inflammatory mediators in mice.
Q37902800Metabolism, LXR/LXR ligands, and tumor immune escape.
Q33612663Modulators affecting the immune dialogue between human immune and colon cancer cells
Q40101041On the factors modulating the effect of statins on malignant cell proliferation
Q57363558Pleiotropic Effects of Statins
Q57300013Prophylactic Treatment With Simvastatin Modulates the Immune Response and Increases Animal Survival Following Lethal Sepsis Infection
Q34650855Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells
Q24603957Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism
Q37639928Statins for community-acquired pneumonia: current state of the science.
Q44336248Statins inhibit iNOS-mediated microbicidal potential of activated monocyte-derived dendritic cells by an IFN-β-dependent mechanism
Q37165311Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response
Q46758935The effects of atorvastatin on gluten-induced intestinal T cell responses in coeliac disease
Q33610240Therapeutic potential of statins in multiple sclerosis: immune modulation, neuroprotection and neurorepair
Q37470209Update on statin-mediated anti-inflammatory activities in atherosclerosis

Search more.