The R7 subfamily of RGS proteins assists tachyphylaxis and acute tolerance at mu-opioid receptors

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The R7 subfamily of RGS proteins assists tachyphylaxis and acute tolerance at mu-opioid receptors is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1020142471
P356DOI10.1038/SJ.NPP.1300263
P698PubMed publication ID12902995

P2093author name stringJavier Garzón
Pilar Sánchez-Blázquez
Almudena López-Fando
P2860cites workA G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to G β5 subunitsQ22004020
RGS-PX1, a GAP for Gα s and Sorting Nexin in Vesicular TraffickingQ24291954
Interaction between RGS7 and polycystinQ24653605
Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathwaysQ28116135
RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currentsQ28139736
RGS7 is palmitoylated and exists as biochemically distinct formsQ28141269
GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteinsQ28145018
RGS9 proteins facilitate acute tolerance to mu-opioid effectsQ28201477
Regulators of G-Protein Signaling (RGS) Proteins: Region-Specific Expression of Nine Subtypes in Rat BrainQ28250219
A novel form of the G protein β Subunit Gβ5 is specifically expressed in the vertebrate retinaQ28296250
Distribution of heterotrimeric G-protein β and γ subunits in the rat brainQ28580574
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathwaysQ28616373
Cellular regulation of RGS proteins: modulators and integrators of G protein signalingQ28646133
LIGAND: A versatile computerized approach for characterization of ligand-binding systemsQ29547346
Myr+-Gi2 alpha and Go alpha subunits restore the efficacy of opioids, clonidine and neurotensin giving rise to antinociception in G-protein knock-down mice.Q30828627
Copurification of brain G-protein beta5 with RGS6 and RGS7.Q30834724
Emerging roles for RGS proteins in cell signallingQ33720599
Regulators of G-protein signaling in receptor complexesQ34204762
Ggamma-like (GGL) domains: new frontiers in G-protein signaling and beta-propeller scaffolding.Q34237416
Oligomerization of opioid receptors: generation of novel signaling unitsQ34489911
In vivo modulation of G proteins and opioid receptor function by antisense oligodeoxynucleotides.Q38318349
Differential expression of the G protein beta(5) gene: analysis of mouse brain, peripheral tissues, and cultured cell linesQ40873819
Administration of myr(+)-G(i2)alpha subunits prevents acute tolerance (tachyphylaxis) to mu-opioid effects in mice.Q43543026
Single-dose tolerance to antinociception, and physical dependence on beta-endorphin in miceQ43846737
Glycosylated phosducin-like protein long regulates opioid receptor function in mouse brainQ43996585
Genetic dissociation of opiate tolerance and physical dependence in delta-opioid receptor-1 and preproenkephalin knock-out mice.Q44251953
Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout miceQ44330314
Mu and delta opioid synergy between the periaqueductal gray and the rostro-ventral medullaQ44336043
The GBeta5 subunit that associates with the R7 subfamily of RGS proteins regulates mu-opioid effects.Q44341937
An antisense oligodeoxynucleotide to the delta opioid receptor (DOR-1) inhibits morphine tolerance and acute dependence in miceQ44343549
Comparison of the antinociceptive action of mu and delta opioid receptor ligands in the periaqueductal gray matter, medial and paramedial ventral medulla in the rat as studied by the microinjection techniqueQ44344375
Influence of Gz and Gi2 transducer proteins in the affinity of opioid agonists to mu receptors.Q44350218
Systematic examination in the rat of brain sites sensitive to the direct application of morphine: observation of differential effects within the periaqueductal grayQ48363900
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectopioidQ427523
tachyphylaxisQ2464757
P304page(s)1983-1990
P577publication date2003-11-01
P1433published inNeuropsychopharmacologyQ2261280
P1476titleThe R7 subfamily of RGS proteins assists tachyphylaxis and acute tolerance at mu-opioid receptors
P478volume28

Reverse relations

cites work (P2860)
Q37192031Changes in striatal signaling induce remodeling of RGS complexes containing Gbeta5 and R7BP subunits
Q37088994Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein
Q34162653Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent
Q35205782Effect of KEPI (Ppp1r14c) deletion on morphine analgesia and tolerance in mice of different genetic backgrounds: when a knockout is near a relevant quantitative trait locus
Q28245135Effector antagonism by the regulators of G protein signalling (RGS) proteins causes desensitization of mu-opioid receptors in the CNS
Q47094717Essentiality of Regulator of G Protein Signaling 6 and Oxidized Ca2+/Calmodulin-Dependent Protein Kinase II in Notch Signaling and Cardiovascular Development.
Q44938371Expression of neural RGS-R7 and Gbeta5 Proteins in Response to Acute and Chronic Morphine.
Q33704021Genome-wide association study and follow-up analysis of adiposity traits in Hispanic Americans: the IRAS Family Study
Q35652043How regulators of G protein signaling achieve selective regulation
Q89804175Interruption of continuous opioid exposure exacerbates drug-evoked adaptations in the mesolimbic dopamine system
Q37132059Macromolecular Composition Dictates Receptor and G Protein Selectivity of Regulator of G Protein Signaling (RGS) 7 and 9-2 Protein Complexes in Living Cells
Q33717610Membrane anchor R9AP potentiates GTPase-accelerating protein activity of RGS11 x Gbeta5 complex and accelerates inactivation of the mGluR6-G(o) signaling
Q36573196Modulation of μ-Opioid Receptor Signaling by RGS19 in SH-SY5Y Cells
Q38085387Opioid receptor interacting proteins and the control of opioid signaling.
Q35906057RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives
Q36931962RGS6 Variants Are Associated With Dietary Fat Intake in Hispanics: The IRAS Family Study
Q37600399RGS6 as a Novel Therapeutic Target in CNS Diseases and Cancer.
Q38344148RGSZ1 and GAIP regulate mu- but not delta-opioid receptors in mouse CNS: role in tachyphylaxis and acute tolerance
Q35129073Regulator of G protein signaling 6 is a critical mediator of both reward-related behavioral and pathological responses to alcohol
Q37228167Regulator of G protein signaling proteins differentially modulate signaling of mu and delta opioid receptors
Q37702376Regulator of G protein-signaling proteins and addictive drugs
Q89619696Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Management
Q38420812Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum
Q57284888Regulators of G-Protein Signaling (RGS) Proteins Promote Receptor Coupling to G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels
Q36502948Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity
Q42269176Sensitivity to μ‐opioid receptor‐mediated anti‐nociception is determined by cross‐regulation between μ‐ and δ‐opioid receptors at supraspinal level
Q36087249Subcellular localization of regulator of G protein signaling RGS7 complex in neurons and transfected cells.
Q33374783Targeting of RGS7/Gbeta5 to the dendritic tips of ON-bipolar cells is independent of its association with membrane anchor R7BP.
Q24643521The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling
Q34411115The RGSZ2 protein exists in a complex with mu-opioid receptors and regulates the desensitizing capacity of Gz proteins.
Q53585529The expression patterns of RGS transcripts in platelets
Q26991859μ-Opioid receptors and regulators of G protein signaling (RGS) proteins: From a symposium on new concepts in mu-opioid pharmacology

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