The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation.

scientific article

The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1189/JLB.0908548
P698PubMed publication ID19564572
P5875ResearchGate publication ID26328590

P50authorUlf AnderssonQ37375023
Karin PalmbladQ58739051
P2093author name stringHeidi Wähämaa
Ann-Charlotte Aveberger
Hanna Schierbeck
Helena Erlandsson Harris
Therese Ostberg
Lars Ottosson
Lena Klevenvall
Hulda Sigridur Hreggvidsdottir
P2860cites workHMGB1: endogenous danger signalingQ24645232
Release of chromatin protein HMGB1 by necrotic cells triggers inflammationQ28131815
HMG-1 as a late mediator of endotoxin lethality in miceQ28139166
High mobility group box 1 protein interacts with multiple Toll-like receptorsQ28280114
Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferationQ28572865
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytesQ28574795
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapyQ29619961
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGEQ29620722
Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteinsQ33689010
Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shockQ35052743
Reversing established sepsis with antagonists of endogenous high-mobility group box 1.Q35122534
A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrinQ35752891
A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA.Q35990737
High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunityQ36990574
Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLEQ37019629
RAGE as a receptor of HMGB1 (Amphoterin): roles in health and diseaseQ37106503
HMGB1 develops enhanced proinflammatory activity by binding to cytokines.Q40016396
Pivotal advance: analysis of proinflammatory activity of highly purified eukaryotic recombinant HMGB1 (amphoterin).Q40230859
Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 proteinQ40609759
Inflammation-promoting activity of HMGB1 on human microvascular endothelial cellsQ40686939
Extracellular high-mobility group 1 protein is essential for murine erythroleukaemia cell differentiation.Q42984601
High mobility group 1 B-box mediates activation of human endotheliumQ45182292
Sulfoglycolipids bind to adhesive protein amphoterin (P30) in the nervous systemQ48545696
High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-alpha production in human monocytesQ50335841
High mobility group box chromosomal protein 1: A novel proinflammatory mediator in synovitisQ58876474
P433issue3
P921main subjectinflammationQ101991
P304page(s)655-662
P577publication date2009-06-29
P1433published inJournal of Leukocyte BiologyQ1524048
P1476titleThe alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation
P478volume86

Reverse relations

cites work (P2860)
Q387486732-O, 3-O Desulfated Heparin Blocks High Mobility Group Box 1 Release by Inhibition of p300 Acetyltransferase Activity.
Q45868008Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps.
Q51886367Activation of Toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development.
Q64092947Alarmin HMGB1 and Soluble RAGE as New Tools to Evaluate the Risk Stratification in Patients With the Antiphospholipid Syndrome
Q35515960Alarmin function of galectin-9 in murine respiratory tularemia
Q24324028An immunogenic peptide in the A-box of HMGB1 protein reverses apoptosis-induced tolerance through RAGE receptor
Q35076030Anti-HMGB1 monoclonal antibody ameliorates immunosuppression after peripheral tissue trauma: attenuated T-lymphocyte response and increased splenic CD11b (+) Gr-1 (+) myeloid-derived suppressor cells require HMGB1.
Q37382986Attenuation of myocardial injury by HMGB1 blockade during ischemia/reperfusion is toll-like receptor 2-dependent
Q92494685Biomarkers of Macrophage Activation and Immune Danger Signals Predict Clinical Outcomes in Alcoholic Hepatitis
Q35319588Biophysical effects in off-resonant gold nanoparticle mediated (GNOME) laser transfection of cell lines, primary- and stem cells using fs laser pulses
Q54091637Boxb mediate BALB/c mice corneal inflammation through a TLR4/MyD88-dependent signaling pathway in Aspergillus fumigatus keratitis.
Q35902972Cancer and innate immune system interactions: translational potentials for cancer immunotherapy
Q40641396Cell death and inflammation: the case for IL-1 family cytokines as the canonical DAMPs of the immune system
Q27008742Cell death in the pathogenesis of immune-mediated diseases: the role of HMGB1 and DAMP-PAMP complexes
Q30583559Cell migration to CXCL12 requires simultaneous IKKα and IKKβ-dependent NF-κB signaling
Q37638028Changes in protein expression after treatment with Ancylostoma caninum excretory/secretory products in a mouse model of colitis
Q36857361Characterization of the structural and protein recognition properties of hybrid PNA-DNA four-way junctions
Q33987148Chondrocyte innate immune myeloid differentiation factor 88-dependent signaling drives procatabolic effects of the endogenous Toll-like receptor 2/Toll-like receptor 4 ligands low molecular weight hyaluronan and high mobility group box chromosomal p
Q39761212Co-inhibitory molecules: Controlling the effectors or controlling the controllers?
Q38154796DAMPs activating innate and adaptive immune responses in COPD.
Q37535386DAMPs and inflammatory processes: the role of redox in the different outcomes
Q48269154Damage-associated molecular patterns and their role as initiators of inflammatory and auto-immune signals in systemic lupus erythematosus.
Q38173348Danger signals in the initiation of the inflammatory response after myocardial infarction
Q38055437Danger-associated molecular patterns (DAMPs) in acute lung injury
Q34805688Dipotassium Glycyrrhizate Inhibits HMGB1-Dependent Inflammation and Ameliorates Colitis in Mice
Q36089059Early interleukin 6 production by leukocytes during ischemic acute kidney injury is regulated by TLR4.
Q48093757Elevated Serum Level of HMGB1 in Patients with the Antiphospholipid Syndrome.
Q26828596Emerging role of HMGB1 in fibrotic diseases
Q37446034Emerging role of high-mobility group box 1 (HMGB1) in liver diseases
Q35541859Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice
Q35494888Enhanced HMGB1 expression may contribute to Th17 cells activation in rheumatoid arthritis.
Q39743331Expression of high-mobility group box 1 and of receptor for advanced glycation end products in chronic obstructive pulmonary disease
Q40084796Expression of the Receptor for Advanced Glycation End Products in Epicardial Fat: Link with Tissue Thickness and Local Insulin Resistance in Coronary Artery Disease
Q27334837Extracellular BCL2 proteins are danger-associated molecular patterns that reduce tissue damage in murine models of ischemia-reperfusion injury
Q28387701Extracellular HMGB1 regulates multi-walled carbon nanotube-induced inflammation in vivo
Q94544471Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?
Q27314507Extracellular administration of BCL2 protein reduces apoptosis and improves survival in a murine model of sepsis
Q27025545Extracellular high-mobility group box 1 protein (HMGB1) as a mediator of persistent pain
Q42239800Follicular dendritic cell makes environmental sense.
Q87926738Fragmented hyaluronan has no alarmin function assessed in arthritis synovial fibroblast and chondrocyte cultures
Q34635334Galectin-3 functions as an alarmin: pathogenic role for sepsis development in murine respiratory tularemia
Q86689305HMGB1 Binds to Lipoteichoic Acid and Enhances TNF-α and IL-6 Production through HMGB1-Mediated Transfer of Lipoteichoic Acid to CD14 and TLR2
Q37326998HMGB1 acts in synergy with lipopolysaccharide in activating rheumatoid synovial fibroblasts via p38 MAPK and NF-κB signaling pathways.
Q35193905HMGB1 and microparticles as mediators of the immune response to cell death
Q51641769HMGB1 binding to receptor for advanced glycation end products enhances inflammatory responses of human bronchial epithelial cells by activating p38 MAPK and ERK1/2.
Q43844401HMGB1 blockade attenuates experimental autoimmune myocarditis and suppresses Th17-cell expansion.
Q34622835HMGB1 in health and disease
Q35953553HMGB1 is a therapeutic target for sterile inflammation and infection
Q37622874HMGB1 localization during experimental periodontitis
Q52337005HMGB1/IL-1β complexes in plasma microvesicles modulate immune responses to burn injury.
Q47719384HMGB1/IL-1β complexes regulate neuroimmune responses in alcoholism
Q37980335HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease
Q42326311HMGB1: a smoking gun in lupus nephritis?
Q37825717Heat shock proteins and high mobility group box 1 protein lack cytokine function
Q36322388High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule
Q35557813High mobility group box 1 (HMGB1) and anti-HMGB1 antibodies and their relation to disease characteristics in systemic lupus erythematosus
Q34153150High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes
Q24604370High mobility group box protein 1 (HMGB1)-partner molecule complexes enhance cytokine production by signaling through the partner molecule receptor
Q39831106High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts.
Q35136716High mobility group protein B1 (HMGB1) in Asthma: comparison of patients with chronic obstructive pulmonary disease and healthy controls
Q35192858High systemic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome
Q48331221High-Mobility Group Box 1 Upregulates MUC5AC and MUC5B Expression in Primary Airway Epithelial Cells.
Q45863504High-mobility group box 1 (HMGB1) as a master regulator of innate immunity
Q38888020High-mobility group box 1 accelerates lipopolysaccharide-induced lung fibroblast proliferation in vitro: involvement of the NF-κB signaling pathway
Q36174486High-mobility group box 1 inhibits HCO(3)(-) absorption in medullary thick ascending limb through a basolateral receptor for advanced glycation end products pathway
Q35891564High-mobility group box 1 protein is implicated in advanced glycation end products-induced vascular endothelial growth factor A production in the rat retinal ganglion cell line RGC-5.
Q34203942High-mobility group box 1 represents a potential marker of disease activity and novel therapeutic target in systemic lupus erythematosus
Q41394835IL-1β/HMGB1 complexes promote The PGE2 biosynthesis pathway in synovial fibroblasts
Q35037009Immune dysregulation by the rheumatoid arthritis shared epitope
Q36032021Impact of HMGB1/TLR Ligand Complexes on HIV-1 Replication: Possible Role for Flagellin during HIV-1 Infection
Q35561332Increased HMGB1 expression and release by mononuclear cells following surgical/anesthesia trauma
Q41160207Inflammation and epilepsy: the foundations for a new therapeutic approach in epilepsy?
Q34043446Inhibitor of NF-kappa B kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis [corrected]
Q38313261Interaction of HMG proteins and H1 with hybrid PNA-DNA junctions
Q51017414Interleukin-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice
Q37943809Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis
Q50228683Involvement of HMGB1 mediated signalling pathway in diabetic retinopathy: evidence from type 2 diabetic rats and ARPE-19 cells under diabetic condition
Q38066361Ischaemia-reperfusion injury in liver transplantation--from bench to bedside
Q36562901Life after death: targeting high mobility group box 1 in emergent cancer therapies
Q55425512Ligation of free HMGB1 to TLR2 in the absence of ligand is negatively regulated by the C-terminal tail domain.
Q37363183Lipopolysaccharide Attenuates Induction of Proallergic Cytokines, Thymic Stromal Lymphopoietin, and Interleukin 33 in Respiratory Epithelial Cells Stimulated with PolyI:C and Human Parechovirus
Q37888774Liver ischemia and reperfusion injury: new insights into mechanisms of innate-adaptive immune-mediated tissue inflammation
Q38625302Local and systemic pathogenesis and consequences of regimen-induced inflammatory responses in patients with head and neck cancer receiving chemoradiation
Q34994835Mechanical ventilation enhances HMGB1 expression in an LPS-induced lung injury model
Q39095935Members of the receptor for advanced glycation end products axis as potential therapeutic targets in patients with lupus nephritis
Q27016054Microparticles as mediators and biomarkers of rheumatic disease
Q37363894Microparticles in the blood of patients with systemic lupus erythematosus (SLE): phenotypic characterization and clinical associations
Q38067757Modeling nuclear molecule release during in vitro cell death.
Q26830597Mucins and toll-like receptors: kith and kin in infection and cancer
Q42238295Mycoplasma superantigen initiates a TLR4-dependent Th17 cascade that enhances arthritis after blocking B7-1 in Mycoplasma arthritidis-infected mice
Q26746478NK Cells, Tumor Cell Transition, and Tumor Progression in Solid Malignancies: New Hints for NK-Based Immunotherapy?
Q40111437Necroptosis in the periodontal homeostasis: Signals emanating from dying cells.
Q52373347Neuroinflammation in Response to Intracerebral Injections of Different HMGB1 Redox Isoforms.
Q36711791Oxidized extracellular DNA as a stress signal in human cells
Q58326494Partially-desulfated heparin improves survival inPseudomonaspneumonia by enhancing bacterial clearance and ameliorating lung injury
Q38965371Porcine reproductive and respiratory syndrome virus infection triggers HMGB1 release to promote inflammatory cytokine production
Q39674959Preconditioning With High Mobility Group Box 1 (HMGB1) Induces Lipoteichoic Acid (LTA) Tolerance
Q34315899Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes
Q37246964Proteolytic inactivation of nuclear alarmin high-mobility group box 1 by complement protease C1s during apoptosis
Q50956450Proteomic analysis of human epithelial lining fluid by microfluidics-based nanoLC-MS/MS: a feasibility study
Q38188456Recent developments in the role of high-mobility group box 1 in systemic lupus erythematosus
Q35044718Red blood cells induce necroptosis of lung endothelial cells and increase susceptibility to lung inflammation.
Q35885013Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1)
Q36605862Reduced soluble RAGE is associated with disease severity of axonal Guillain-Barré syndrome
Q36513532Regulation of Kir4.1 expression in astrocytes and astrocytic tumors: a role for interleukin-1 β
Q49333290Saquinavir Ameliorates Liver Warm Ischemia-Reperfusion-Induced Lung Injury via HMGB-1- and P38/JNK-Mediated TLR-4-Dependent Signaling Pathways
Q34390999Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosis.
Q40239891Synergistic effect of high-mobility group box-1 and lipopolysaccharide on cytokine induction in bovine peripheral blood mononuclear cells
Q42650240Synovial fibroblasts in 2017.
Q34667534TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant
Q35085962TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis
Q38781354TLRs, future potential therapeutic targets for RA.
Q27009518Targeting inflammation as a therapeutic strategy for drug-resistant epilepsies: an update of new immune-modulating approaches
Q34769562The C-terminal acidic tail is responsible for the inhibitory effects of HMGB1 on efferocytosis.
Q36321838The HMGB1 signaling pathway activates the inflammatory response in Schwann cells.
Q33745462The HMGB1-RAGE axis mediates traumatic brain injury-induced pulmonary dysfunction in lung transplantation
Q35056726The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis
Q30505780The IKKα-dependent NF-κB p52/RelB noncanonical pathway is essential to sustain a CXCL12 autocrine loop in cells migrating in response to HMGB1.
Q64096078The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation
Q38131032The alarmin functions of high-mobility group box-1 and IL-33 in the pathogenesis of systemic lupus erythematosus.
Q51274805The damage-associated molecular pattern HMGB1 is elevated in human alcoholic hepatitis, but does not seem to be a primary driver of inflammation.
Q38979165The danger from within: alarmins in arthritis
Q38555406The danger model: questioning an unconvincing theory
Q33851482The danger signal S100B integrates pathogen- and danger-sensing pathways to restrain inflammation
Q42381172The danger-associated molecular pattern HMGB1 mediates the neuroinflammatory effects of methamphetamine.
Q38195181The expression of HMGB1 on microparticles released during cell activation and cell death in vitro and in vivo
Q43072756The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death
Q38013050The impact of infection and tissue damage in solid-organ transplantation
Q38150096The interplay between pathogen-associated and danger-associated molecular patterns: an inflammatory code in cancer?
Q38116712The multifunctional alarmin HMGB1 with roles in the pathophysiology of sepsis and cancer
Q37047827The origin and properties of extracellular DNA: from PAMP to DAMP.
Q34128646The oxidative stress product carboxyethylpyrrole potentiates TLR2/TLR1 inflammatory signaling in macrophages
Q37712484The prelude on novel receptor and ligand targets involved in the treatment of diabetes mellitus.
Q39118808The role of neuroimmune signaling in alcoholism
Q27010599The translocation of nuclear molecules during inflammation and cell death
Q47147432Toll-Like Receptor 4 Signalling and Its Impact on Platelet Function, Thrombosis, and Haemostasis.
Q35550677Toll-like receptor 4 activation in cancer progression and therapy
Q36145679Toll-like receptor 4 signaling: A common pathway for interactions between prooxidants and extracellular disulfide high mobility group box 1 (HMGB1) protein-coupled activation
Q33645274Toll-like receptor signaling and stages of addiction
Q37954396Toll-like receptors and diabetes: a therapeutic perspective
Q37091891Toll-like receptors in atherosclerosis
Q27028225Vitreous mediators in retinal hypoxic diseases
Q38556787rhHMGB1 drives osteoblast migration in a TLR2/TLR4- and NF-κB-dependent manner

Search more.