| scholarly article | Q13442814 |
| P50 | author | Robert V Farese | Q88209774 |
| P2093 | author name string | Michael Leitges | |
| Mini P Sajan | |||
| Sonali Nimal | |||
| Ursula Braun | |||
| Stephen Mastorides | |||
| Mary L Standaert | |||
| Usha Varanasi | |||
| Tina Pastoor | |||
| P2860 | cites work | FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression | Q46955933 |
| Enhanced insulin-stimulated activation of phosphatidylinositol 3-kinase in the liver of high-fat-fed rats. | Q54108239 | ||
| Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKCλ/ζ | Q57899436 | ||
| Tissue-specific differences in activation of atypical protein kinase C and protein kinase B in muscle, liver, and adipocytes of insulin receptor substrate-1 knockout mice | Q80346221 | ||
| Obesity, Inflammation, and Insulin Resistance | Q22250939 | ||
| Activation of IkappaB kinase beta by protein kinase C isoforms | Q24554525 | ||
| Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1 | Q28283323 | ||
| Regulation of protein kinase C zeta by PI 3-kinase and PDK-1 | Q28567633 | ||
| PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity | Q28582308 | ||
| Effects of knockout of the protein kinase C beta gene on glucose transport and glucose homeostasis | Q28587797 | ||
| Knockout of PKC alpha enhances insulin signaling through PI3K | Q28590618 | ||
| Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB | Q29619314 | ||
| Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation | Q34217097 | ||
| Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes | Q35879528 | ||
| Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic (ob/ob and Goto-Kakazaki) liver. Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high | Q38342711 | ||
| Insulin and PIP3 activate PKC-zeta by mechanisms that are both dependent and independent of phosphorylation of activation loop (T410) and autophosphorylation (T560) sites | Q39423459 | ||
| Restored insulin-sensitivity in IRS-1-deficient mice treated by adenovirus-mediated gene therapy | Q40437444 | ||
| Effects of adenoviral gene transfer of wild-type, constitutively active, and kinase-defective protein kinase C-lambda on insulin-stimulated glucose transport in L6 myotubes | Q40840829 | ||
| Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities | Q42507824 | ||
| Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt | Q42996869 | ||
| Rosiglitazone, insulin treatment, and fasting correct defective activation of protein kinase C-zeta/lambda by insulin in vastus lateralis muscles and adipocytes of diabetic rats | Q43543575 | ||
| Effects of insulin on diacylglycerol/protein kinase-C signalling and glucose transport in rat skeletal muscles in vivo and in vitro | Q44055008 | ||
| Defective activation of atypical protein kinase C zeta and lambda by insulin and phosphatidylinositol-3,4,5-(PO4)(3) in skeletal muscle of rats following high-fat feeding and streptozotocin-induced diabetes | Q44315354 | ||
| Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise | Q44527036 | ||
| Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction | Q44527038 | ||
| Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes | Q44564021 | ||
| Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1. | Q44909436 | ||
| P433 | issue | 6 | |
| P921 | main subject | obesity | Q12174 |
| P304 | page(s) | 1133-1145 | |
| P577 | publication date | 2009-02-06 | |
| P1433 | published in | Journal of Lipid Research | Q6295449 |
| P1476 | title | The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity | |
| P478 | volume | 50 |
| Q33655490 | AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC. |
| Q35796978 | Ablation of PI3K p110-α prevents high-fat diet-induced liver steatosis |
| Q33959753 | Akt-dependent phosphorylation of hepatic FoxO1 is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet-induced obesity |
| Q34776293 | Anthocyanin inhibits high glucose-induced hepatic mtGPAT1 activation and prevents fatty acid synthesis through PKCζ. |
| Q47651314 | Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzhei |
| Q30366716 | Atypical PKC: a target for treating insulin-resistant disorders of obesity, the metabolic syndrome and type 2 diabetes mellitus. |
| Q37482997 | Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses |
| Q27026092 | Atypical protein kinase C in cardiometabolic abnormalities |
| Q36077931 | BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans |
| Q38434576 | Challenge of large-scale motion for residual dipolar coupling based analysis of configuration: the case of fibrosterol sulfate A. |
| Q40186768 | Constitutive Activation of AKT2 in Humans Leads to Hypoglycemia Without Fatty Liver or Metabolic Dyslipidemia |
| Q37205686 | Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι |
| Q37426801 | Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been |
| Q90494043 | Expression of SREBP2 and cholesterol metabolism related genes in TCGA glioma cohorts |
| Q41292624 | Fibrosterol sulfates from the Philippine sponge Lissodendoryx (Acanthodoryx) fibrosa: sterol dimers that inhibit PKCzeta |
| Q24810354 | Free fatty acid-induced PP2A hyperactivity selectively impairs hepatic insulin action on glucose metabolism |
| Q38345800 | Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway |
| Q35667136 | Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus |
| Q34757485 | Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation |
| Q35231302 | Higher protein kinase C ζ in fatty rat liver and its effect on insulin actions in primary hepatocytes |
| Q42260200 | Impact of intravascular hemolysis in malaria on liver dysfunction: involvement of hepatic free heme overload, NF-κB activation, and neutrophil infiltration |
| Q37568253 | Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis |
| Q35186665 | Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance. |
| Q34460969 | Insulin signaling and insulin sensitizing in muscle and liver of obese monkeys: peroxisome proliferator-activated receptor gamma agonist improves defective activation of atypical protein kinase C. |
| Q36526711 | Insulin signalling in hepatocytes of humans with type 2 diabetes: excessive production and activity of protein kinase C-ι (PKC-ι) and dependent processes and reversal by PKC-ι inhibitors |
| Q37174783 | Metabolic functions of atypical protein kinase C: "good" and "bad" as defined by nutritional status |
| Q37680132 | Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression |
| Q35227185 | Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice |
| Q59799269 | PKCζ Phosphorylates SIRT6 to Mediate Fatty Acid β-Oxidation in Colon Cancer Cells |
| Q33821585 | PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes. |
| Q42040140 | Par-complex aPKC and Par3 cross-talk with innate immunity NF-κB pathway in epithelial cells |
| Q39735993 | Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin. |
| Q47692117 | SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology |
| Q35131032 | Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation |
| Q38099064 | The tail wagging the dog--regulation of lipid metabolism by protein kinase C. |
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