The mRNA-binding protein YB-1 (p50) prevents association of the eukaryotic initiation factor eIF4G with mRNA and inhibits protein synthesis at the initiation stage

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The mRNA-binding protein YB-1 (p50) prevents association of the eukaryotic initiation factor eIF4G with mRNA and inhibits protein synthesis at the initiation stage is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M209145200
P698PubMed publication ID12582179

P2093author name stringElizaveta A Kovrigina
Konstantin G Chernov
Lev P Ovchinnikov
Maria P Ivshina
John W B Hershey
Adri A M Thomas
Valentina M Evdokimova
Maxim P Nekrasov
P2860cites workA newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translationQ22008560
Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-CelluloseQ24563043
RNP-1, an RNA-binding motif is conserved in the DNA-binding cold shock domainQ24609196
Universal nucleic acid-binding domain revealed by crystal structure of the B. subtilis major cold-shock proteinQ27731707
Nuclear translocation of the Y-box binding protein by ultraviolet irradiationQ28257567
Circularization of mRNA by eukaryotic translation initiation factorsQ28279463
A novel growth-inducible gene that encodes a protein with a conserved cold-shock domainQ28578728
Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entryQ29614570
Interrelationships of the pathways of mRNA decay and translation in eukaryotic cellsQ29620524
Structural and functional properties of the evolutionarily ancient Y-box family of nucleic acid binding proteinsQ30194436
Translational regulation by Y-box transcription factor: involvement of the major mRNA-associated protein, p50.Q33601665
The major mRNA-associated protein YB-1 is a potent 5' cap-dependent mRNA stabilizerQ34092756
Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome and the proteomeQ34287436
Multifunctional regulatory proteins that control gene expression in both the nucleus and the cytoplasmQ34356102
Overexpression in COS cells of p50, the major core protein associated with mRNA, results in translation inhibitionQ34631334
Cloning and characterization of chicken YB-1: regulation of expression in the liverQ36690477
The major protein of messenger ribonucleoprotein particles in somatic cells is a member of the Y-box binding transcription factor familyQ36715573
Tales of poly(A): a reviewQ37600123
Cytoplasmic mRNP proteins affect mRNA translationQ37937376
Positive and negative effects of the major mammalian messenger ribonucleoprotein p50 on binding of 40 S ribosomal subunits to the initiation codon of beta-globin mRNA.Q38291862
Specificity of mammalian Y-box binding protein p50 in interaction with ss and ds DNA analyzed with generic oligonucleotide microchipQ38361248
Poly(A), poly(A) binding protein and the regulation of mRNA stabilityQ38735718
The RNA binding protein YB-1 binds A/C-rich exon enhancers and stimulates splicing of the CD44 alternative exon v4.Q39645521
Hyperthermia-induced nuclear translocation of transcription factor YB-1 leads to enhanced expression of multidrug resistance-related ABC transportersQ40602504
YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoterQ40757502
Specific poly-A-binding protein of 76,000 molecular weight in polyribosomes is not present on poly A of free cytoplasmic mRNP.Q45030720
Gene regulation by Y-box proteins: coupling control of transcription and translation.Q47686955
A translation regulatory particle containing the Xenopus oocyte Y box protein mRNP3+4.Q48959291
Protein tightly bound to globin mRNAQ49487931
Translational repression dependent on the interaction of the Xenopus Y-box protein FRGY2 with mRNA. Role of the cold shock domain, tail domain, and selective RNA sequence recognition.Q50759756
Free poly(A) stimulates capped mRNA translation in vitro through the eIF4G-poly(A)-binding protein interaction.Q54541290
Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expressionQ56029438
A model of translational control involving mRNA-associated proteins in chick embryonic musclesQ67018726
Role of cytoplasmic mRNP proteins in translationQ68222202
Translational active mRNPs from rabbit reticulocytes are qualitatively different from free mRNA in their translatability in cell-free systemQ69384792
Regulation of protein synthesis in mammalian cells. II. Inhibition of protein synthesis at the level of initiation during mitosisQ71723650
Enhanced coexpression of YB-1 and DNA topoisomerase II alpha genes in human colorectal carcinomasQ73270622
The major core protein of messenger ribonucleoprotein particles (p50) promotes initiation of protein biosynthesis in vitroQ74129012
Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 geneQ74299207
The major messenger ribonucleoprotein particle protein p50 (YB-1) promotes nucleic acid strand annealingQ74591165
P433issue16
P407language of work or nameEnglishQ1860
P304page(s)13936-13943
P577publication date2003-02-11
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe mRNA-binding protein YB-1 (p50) prevents association of the eukaryotic initiation factor eIF4G with mRNA and inhibits protein synthesis at the initiation stage
P478volume278

Reverse relations

cites work (P2860)
Q33701542A conserved stem loop motif in the 5'untranslated region regulates transforming growth factor-β(1) translation
Q50651439A novel Ded1-like RNA helicase interacts with the Y-box protein ctYB-1 in nuclear mRNP particles and in polysomes.
Q34168533A novel cold-regulated cold shock domain containing protein from scallop Chlamys farreri with nucleic acid-binding activity
Q28586407Absence of the DNA-/RNA-binding protein MSY2 results in male and female infertility
Q34233421Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species
Q21128790An essential role for maternal control of Nodal signaling
Q35750105An essential role for protein synthesis in oncogenic cellular transformation
Q34209434Angiogenin-induced tRNA fragments inhibit translation initiation
Q34590679Antiviral protein APOBEC3G localizes to ribonucleoprotein complexes found in P bodies and stress granules
Q46192284Arabidopsis COLD SHOCK DOMAIN PROTEIN 2 is a negative regulator of cold acclimation
Q37119318Arabidopsis cold shock domain proteins: relationships to floral and silique development
Q34075898Cell type-dependent gene regulation by Staufen2 in conjunction with Upf1.
Q40594045Characterization of the 5'-untranslated region of YB-1 mRNA and autoregulation of translation by YB-1 protein
Q51996884Circadian changes in granulocyte-macrophage colony-stimulating factor message in circulating eosinophils.
Q37358130Cold shock domain protein 3 regulates freezing tolerance in Arabidopsis thaliana.
Q34863597Control of the papillomavirus early-to-late switch by differentially expressed SRp20
Q34734843Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q.
Q49749406Current Research on Non-Coding Ribonucleic Acid (RNA).
Q42180895Expression of YB-1 enhances production of murine leukemia virus vectors by stabilizing genomic viral RNA.
Q30352429Extracellular Signal-regulated Kinase (ERK)-dependent Phosphorylation of Y-Box-binding Protein 1 (YB-1) Enhances Gene Expression in Granulosa Cells in Response to Follicle-stimulating Hormone (FSH)
Q28247567From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome
Q37077846General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation
Q39291698Human immunodeficiency virus type 1 Gag polyprotein modulates its own translation
Q34007902Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs
Q92444971Inhibition of Transcription Induces Phosphorylation of YB-1 at Ser102 and Its Accumulation in the Nucleus
Q33707662Inhibition of protein synthesis by Y box-binding protein 1 blocks oncogenic cell transformation
Q40337169Interplay between Y-box-binding protein 1 (YB-1) and poly(A) binding protein (PABP) in specific regulation of YB-1 mRNA translation
Q50077149Investigation of function and regulation of the YB-1 cellular factor in HIV replication
Q28575300Isolation and characterization of brain Y-box protein: developmentally regulated expression, polyribosomal association and dendritic localization
Q36778676Mechanisms of translational deregulation in human tumors and therapeutic intervention strategies.
Q28578347Molecular composition of staufen2-containing ribonucleoproteins in embryonic rat brain
Q36337966Oncogenic PI3K deregulates transcription and translation
Q35752843Probing the mRNA processing body using protein macroarrays and "autoantigenomics".
Q45828435Protein arginine methylation modulates light-harvesting antenna translation in Chlamydomonas reinhardtii.
Q39069088RSK-mediated nuclear accumulation of the cold-shock Y-box protein-1 controls proliferation of T cells and T-ALL blasts
Q34098728Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2.
Q57649480Ribonucleoprotein Y-box-binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA
Q40249945Structural organization of mRNA complexes with major core mRNP protein YB-1.
Q30155919Structure-functional analyses of CRHSP-24 plasticity and dynamics in oxidative stress response
Q27015900Surmounting chemoresistance by targeting the Y-box binding protein-1
Q35683925The Cold Shock Domain of YB-1 Segregates RNA from DNA by Non-Bonded Interactions
Q24794247The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation
Q52718552The Long Non-coding RNA lnc-31 Interacts with Rock1 mRNA and Mediates Its YB-1-Dependent Translation.
Q57135008The Role of YB1 in Renal Cell Carcinoma Cell Adhesion
Q40176953The increased expression of Y box-binding protein 1 in melanoma stimulates proliferation and tumor invasion, antagonizes apoptosis and enhances chemoresistance.
Q50736835Transglutaminase-2 mediates calcium-regulated crosslinking of the Y-box 1 (YB-1) translation-regulatory protein in TGFβ1-activated myofibroblasts.
Q40695879Translation of non-capped mRNAs in a eukaryotic cell-free system: acceleration of initiation rate in the course of polysome formation.
Q40183466Two splicing isoforms of the Y-box protein ctYB-1 appear on the same mRNA molecule
Q36350264Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway
Q36197071Y-box binding protein 1 and RNase UK114 mediate monocyte chemoattractant protein 1 mRNA stability in vascular smooth muscle cells
Q55509913Y-box protein-associated acidic protein (YBAP1/C1QBP) affects the localization and cytoplasmic functions of YB-1.
Q57176499Y-box-binding protein 1 supports the early and late steps of HIV replication
Q42709944YB-1 autoregulates translation of its own mRNA at or prior to the step of 40S ribosomal subunit joining
Q44879094YB-1 is important for an early stage embryonic development: neural tube formation and cell proliferation
Q33369541YB-1 promotes microtubule assembly in vitro through interaction with tubulin and microtubules
Q38161834YB-1 protein: functions and regulation
Q37210975YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression
Q34534047YB-1 synthesis is regulated by mTOR signaling pathway
Q64226560YB-1, an abundant core mRNA-binding protein, has the capacity to form an RNA nucleoprotein filament: a structural analysis
Q36228025mRNA and DNA selection via protein multimerization: YB-1 as a case study.
Q90175404tRNA cleavage: a new insight
Q26824181tRNA fragments in human health and disease
Q33737299tRNAs as regulators of biological processes

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