The interleukin-6 (IL-6) partial antagonist (Q159E,T162P)IL-6 interacts with the IL-6 receptor and gp130 but fails to induce a stable hexameric receptor complex

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The interleukin-6 (IL-6) partial antagonist (Q159E,T162P)IL-6 interacts with the IL-6 receptor and gp130 but fails to induce a stable hexameric receptor complex is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.271.10.5464
P698PubMed publication ID8621403
P5875ResearchGate publication ID14579962

P2093author name stringNice EC
Simpson RJ
Hammacher A
P2860cites workExpression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophyQ24314279
LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptorQ24315815
Molecular cloning and expression of an IL-6 signal transducer, gp130Q24328945
THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONSQ26778400
Cytokine signal transductionQ28258951
IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinaseQ28270103
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130Q28279735
Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptorQ28291157
Role of the C-terminus in the activity, conformation, and stability of interleukin-6.Q36278189
Structure-function analysis of human IL-6: identification of two distinct regions that are important for receptor bindingQ36278588
Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonanceQ36325295
Analysis of macromolecular interactions using immobilized ligands.Q36329769
Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approachQ36686508
Development of an interleukin (IL) 6 receptor antagonist that inhibits IL-6-dependent growth of human myeloma cells.Q38301871
Purification and characterization of soluble human IL-6 receptor expressed in CHO cellsQ41718829
Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130Q44527646
Determination of relative binding affinity of influenza virus N9 sialidases with the Fab fragment of monoclonal antibody NC41 using biosensor technologyQ45777882
Use of a biosensor with surface plasmon resonance detection for the determination of binding constants: measurement of interleukin-6 binding to the soluble interleukin-6 receptor.Q51606661
Analysis of the interaction between human interleukin-5 and the soluble domain of its receptor using a surface plasmon resonance biosensor.Q51607082
Interpreting complex binding kinetics from optical biosensors: a comparison of analysis by linearization, the integrated rate equation, and numerical integration.Q52342588
Determination of rate and equilibrium binding constants for macromolecular interactions using surface plasmon resonance: use of nonlinear least squares analysis methods.Q52392958
Purification and characterization of a recombinant murine interleukin-6. Isolation of N- and C-terminally truncated formsQ58039553
Biospecific interaction analysis using surface plasmon resonance detection applied to kinetic, binding site and concentration analysisQ58547252
Surface plasmon resonance based methods for measuring the kinetics and binding affinities of biomolecular interactionsQ72273975
Synergies between micropreparative high-performance liquid chromatography and an instrumental optical biosensorQ72342872
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectinterleukinsQ194908
P304page(s)5464-5473
P577publication date1996-03-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe interleukin-6 (IL-6) partial antagonist (Q159E,T162P)IL-6 interacts with the IL-6 receptor and gp130 but fails to induce a stable hexameric receptor complex
P478volume271

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cites work (P2860)
Q36145307A mathematical model for selective differentiation of neural progenitor cells on micropatterned polymer substrates
Q47888849A model of mitochondrial Ca(2+)-induced Ca2+ release simulating the Ca2+ oscillations and spikes generated by mitochondria
Q36280921Characterization of the recombinant extracellular domain of the neurotrophin receptor TrkA and its interaction with nerve growth factor (NGF)
Q33819690Human herpesvirus 8 interleukin-6 (vIL-6) signals through gp130 but has structural and receptor-binding properties distinct from those of human IL-6.
Q54578832Identification of residues in the putative 5th helical region of human interleukin-6, important for activation of the IL-6 signal transducer, gp130.
Q54582911Influence of interleukin-6 (IL-6) dimerization on formation of the high affinity hexameric IL-6.receptor complex.
Q33666427Instrumental biosensors: new perspectives for the analysis of biomolecular interactions
Q24532254Interaction of the alpha subunit of Na,K-ATPase with cofilin
Q36280356Interleukin-6: structure-function relationships.
Q52914159The N-terminus of gp130 is critical for the formation of the high-affinity interleukin-6 receptor complex.
Q38334177The immunoglobulin-like module of gp130 is required for signaling by interleukin-6, but not by leukemia inhibitory factor

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