Dapagliflozin: a new sodium-glucose cotransporter 2 inhibitor for treatment of type 2 diabetes

scientific article

Dapagliflozin: a new sodium-glucose cotransporter 2 inhibitor for treatment of type 2 diabetes is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.2146/AJHP140168
P698PubMed publication ID25694411

P2093author name stringEva M Vivian
P2860cites workMedical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of DiabetesQ24642503
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The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucoseQ34121476
Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trialQ34153496
The influence of kidney function on dapagliflozin exposure, metabolism and pharmacodynamics in healthy subjects and in patients with type 2 diabetes mellitusQ34315521
Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalenceQ34321390
Increased risk of common infections in patients with type 1 and type 2 diabetes mellitusQ47766554
Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: efficacy and safety over 2 yearsQ47871792
Urinary tract infections in patients with diabetes treated with dapagliflozinQ48016891
Dapagliflozin is effective as add-on therapy to sitagliptin with or without metformin: a 24-week, multicenter, randomized, double-blind, placebo-controlled study.Q51332473
Dapagliflozin has no effect on markers of bone formation and resorption or bone mineral density in patients with inadequately controlled type 2 diabetes mellitus on metformin.Q51335341
Long-term efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin: a randomized trial.Q51359456
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Lack of pharmacokinetic interaction between dapagliflozin, a novel sodium-glucose transporter 2 inhibitor, and metformin, pioglitazone, glimepiride or sitagliptin in healthy subjectsQ82651893
Lack of pharmacokinetic interactions between dapagliflozin and simvastatin, valsartan, warfarin, or digoxinQ83310339
Effect of a high-fat meal on the pharmacokinetics of dapagliflozin, a selective SGLT2 inhibitor, in healthy subjectsQ83703955
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Dapagliflozin added to usual care in individuals with type 2 diabetes mellitus with preexisting cardiovascular disease: a 24-week, multicenter, randomized, double-blind, placebo-controlled study with a 28-week extensionQ88008831
SGLT2 mediates glucose reabsorption in the early proximal tubule.Q34457264
Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose levelQ34575066
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Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year studyQ34720231
Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family membersQ35111563
Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trialQ35179843
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Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapyQ36047253
LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial.Q36105649
Targeting the kidney and glucose excretion with dapagliflozin: preclinical and clinical evidence for SGLT2 inhibition as a new option for treatment of type 2 diabetes mellitusQ36175431
The prevalence of meeting A1C, blood pressure, and LDL goals among people with diabetes, 1988-2010.Q37022665
Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetesQ37139427
Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetesQ37193454
Association between serum uric acid and development of type 2 diabetes.Q37319097
A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: applicability of a novel insulin-independent treatmentQ37319128
Renal sodium-glucose transport: role in diabetes mellitus and potential clinical implicationsQ37439364
Does short-term virologic failure translate to clinical events in antiretroviral-naïve patients initiating antiretroviral therapy in clinical practice?Q37475726
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetesQ37532095
Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic controlQ37679893
Inhibition of SGLT2: a novel strategy for treatment of type 2 diabetes mellitusQ37846528
Glucose handling by the kidneyQ37848041
Insulin treatment for type 2 diabetes: when to start, which to use.Q37871231
SGLT inhibitors in management of diabetesQ38195440
Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic ratsQ39999985
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Learning from glycosuriaQ42641850
The novel sodium glucose transporter 2 inhibitor dapagliflozin sustains pancreatic function and preserves islet morphology in obese, diabetic ratsQ42873604
Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trialQ42977455
In vitro characterization and pharmacokinetics of dapagliflozin (BMS-512148), a potent sodium-glucose cotransporter type II inhibitor, in animals and humansQ43227334
Efficacy and safety of ipragliflozin in patients with type 2 diabetes inadequately controlled on metformin: a dose-finding study.Q43755014
Efficacy and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, as add-on to metformin in type 2 diabetes with mild hyperglycaemiaQ45442620
Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitusQ46171591
Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjectsQ46171594
Vulvovaginitis and balanitis in patients with diabetes treated with dapagliflozinQ46401612
Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent modelsQ46516165
Dapagliflozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trialQ46595958
P433issue5
P921main subjectdapagliflozinQ409898
glycobiologyQ899224
type 2 diabetesQ3025883
P304page(s)361-372
P577publication date2015-03-01
P1433published inAmerican Journal of Health-System PharmacyQ15754037
P1476titleDapagliflozin: a new sodium-glucose cotransporter 2 inhibitor for treatment of type 2 diabetes
P478volume72

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cites work (P2860)
Q64069337Assessment of Dapagliflozin Effectiveness as Add-on Therapy for the Treatment of Type 2 Diabetes Mellitus in a Qatari Population
Q36180337Cost-Effectiveness of Dapagliflozin versus Acarbose as a Monotherapy in Type 2 Diabetes in China
Q39451601Cost-effectiveness analysis of dapagliflozin versus glimepiride as monotherapy in a Chinese population with type 2 diabetes mellitus
Q49963693Dapagliflozin Reduces Fat Mass without Affecting Muscle Mass in Type 2 Diabetes
Q38651175Diabetes drugs and the incidence of solid cancers: a survey of the current evidence.
Q37227410Renal threshold for glucose reabsorption predicts diabetes improvement by sodium-glucose cotransporter 2 inhibitor therapy

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