The CD40L promoter contains nuclear factor of activated T cells-binding motifs which require AP-1 binding for activation of transcription

scientific article published in February 1996

The CD40L promoter contains nuclear factor of activated T cells-binding motifs which require AP-1 binding for activation of transcription is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.271.7.3763
P698PubMed publication ID8631992

P2093author name stringGeha RS
Tsitsikov EN
Tsytsykova AV
P2860cites workIsolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteinsQ24317724
Characterization of antigen receptor response elements within the interleukin-2 enhancerQ24632042
NF-AT-AP-1 and Rel-bZIP: hybrid vigor and binding under the influenceQ26810064
NF-AT components define a family of transcription factors targeted in T-cell activationQ28114991
A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cellsQ28187669
The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and JunQ28263918
The CD40 antigen and its ligandQ28286277
Isolation of the cyclosporin-sensitive T cell transcription factor NFATpQ28511815
The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formationQ28586300
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activationQ29620223
The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and deathQ29620519
Cyclosporin A inhibits CD40 ligand expression in T lymphocytesQ30449273
CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.Q35962812
Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 geneQ38295828
Cyclosporin-A sensitive induction of NF-AT in murine B cellsQ38307826
Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATcQ38317270
Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activationQ38342696
Molecular Pathology of X‐Linked Immunoglobulin Deficiency with Normal or Elevated IgM (HIGMX‐1)Q40391934
NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genesQ40693171
Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4.Q41465837
The Ca2+/calmodulin-activated, phosphoprotein phosphatase calcineurin is sufficient for positive transcriptional regulation of the mouse IL-4 geneQ41490905
Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor.Q46195210
Structure of the murine CD40 ligand geneQ48080746
Sequence-specific interactions of nuclear factors with the insulin gene enhancer.Q48366496
Nuclear factor of activated T cells contains Fos and Jun.Q54271859
NF-AT comes under controlQ59042515
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)3763-3770
P577publication date1996-02-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe CD40L promoter contains nuclear factor of activated T cells-binding motifs which require AP-1 binding for activation of transcription
P478volume271

Reverse relations

cites work (P2860)
Q40761786A T cell-specific enhancer of the human CD40 ligand gene
Q53458849A T-cell-specific CD154 transcriptional enhancer located just upstream of the promoter.
Q39627668A tissue-specific, activation-inducible, lentiviral vector regulated by human CD40L proximal promoter sequences
Q92150338AP-1 Transcription Factors as Regulators of Immune Responses in Cancer
Q36401891Association of the microsatellite in the 3' untranslated region of the CD154 gene with rheumatoid arthritis in females from a Spanish cohort: a case-control study.
Q44066637Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis
Q77711918B-cell activation and allosensitization after left ventricular assist device implantation is due to T-cell activation and CD40 ligand expression
Q35176320CD154 transcriptional regulation in primary human CD4 T cells
Q35996947CD30 induction of human immunodeficiency virus gene transcription is mediated by TRAF2
Q34082784CD40-mediated regulation of immune responses by TRAF-dependent and TRAF-independent signaling mechanisms.
Q46143177CD40L association with protection from severe malaria
Q28141639CD43-mediated signals induce DNA binding activity of AP-1, NF-AT, and NFkappa B transcription factors in human T lymphocytes
Q34488816Calcineurin/nuclear factor of activated T cells and MAPK signaling induce TNF-{alpha} gene expression in pancreatic islet endocrine cells
Q40425368Calcium-dependent activation of interleukin-21 gene expression in T cells
Q44138182Cyclic AMP differentially modulates CD40L expression on human naïve and memory CD4(+) T cells
Q30453097Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations
Q35941655Deregulated expression of CD40 ligand in HTLV-I infection: distinct mechanisms of downregulation in HTLV-I-transformed cell lines and ATL patients
Q34507144Early growth response-1 is required for CD154 transcription
Q43977294Endothelial cell and cAMP regulation of T-cell CD40 ligand: relevance of calcium/calmodulin-dependent kinase IV signalling
Q35854737Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus
Q51771134Estrogen does not regulate CD154 mRNA stability in systemic lupus erythematosus T cells.
Q33960009Estrogen receptor signaling and its relationship to cytokines in systemic lupus erythematosus
Q79378729FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice
Q40025338Functional analysis of a tripartite stability element within the CD40 ligand 3' untranslated region
Q28346560Glucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching
Q36160292Homodimerization of the human interleukin 4 receptor alpha chain induces Cepsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma chain
Q37634250Human neonatal naive CD4+ T cells have enhanced activation-dependent signaling regulated by the microRNA miR-181a
Q73980580Identification and characterization of two CD40-inducible enhancers in the mouse TRAF1 gene locus
Q35994774Immunotherapy targeting the CD40/CD154 costimulatory pathway for treatment of autoimmune disease
Q35794358Impaired NFAT and NFκB activation are involved in suppression of CD40 ligand expression by Δ(9)-tetrahydrocannabinol in human CD4(+) T cells
Q33797093In vivo post-transcriptional regulation of CD154 in mouse CD4+ T cells
Q58782579K1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4 effector memory T cell response to TCR stimulation
Q35076704Kinetic perspectives of T cell antigen receptor signaling. A two-tier model for T cell full activation
Q30428085Ligation of CD46 to CD40 inhibits CD40 signaling in B cells
Q35119907Major Peptide Autoepitopes for Nucleosome‐Centered T and B Cell Interaction in Human and Murine Lupus
Q33607430Molecular regulation of cytokine gene expression during the immune response
Q28365233Multiple cytokines sharing the common receptor gamma chain can induce CD154/CD40 ligand expression by human CD4+ T lymphocytes via a cyclosporin A-resistant pathway
Q31010956N-substituted benzamides inhibit nuclear factor-kappaB and nuclear factor of activated T cells activity while inducing activator protein 1 activity in T lymphocytes
Q28347536NF-kappaB is involved in the regulation of CD154 (CD40 ligand) expression in primary human T cells
Q39752406NF-κB Is Involved in Regulation of CD40 Ligand Expression onMycobacterium bovisBacillus Calmette-Guérin-Activated Human T Cells
Q52641496NFAT control of immune function: New Frontiers for an Abiding Trooper.
Q34063451Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription, increased nuclear factor of activated T cell activity, and glomerulonephritis.
Q92979258Protein kinase 2 (CK2) controls CD4+ T cell effector function in the pathogenesis of colitis
Q33957551Requirement for transcription factor NFAT in interleukin-2 expression
Q47707510Role of the cyclosporin-sensitive transcription factor NFAT1 in the allergic response
Q35998853T-helper cell intrinsic defects in lupus that break peripheral tolerance to nuclear autoantigens
Q34328138The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells
Q47998036The hyper-IgM (HIM) syndrome
Q34066446The role of NF-AT transcription factors in T cell activation and differentiation
Q41065666The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production

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