Intracellular signals of lung cancer cells as possible therapeutic targets

scientific article

Intracellular signals of lung cancer cells as possible therapeutic targets is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/CAS.12643
P932PMC publication ID4452148
P698PubMed publication ID25707772
P5875ResearchGate publication ID272844184

P50authorHiroo UenoQ117281898
P2093author name stringKeiki Kumano
Kiyomichi Tanaka
P2860cites workNotch signaling induces cell cycle arrest in small cell lung cancer cellsQ24291129
Notch signaling induces rapid degradation of achaete-scute homolog 1.Q24293622
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3BQ24564757
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary glandQ24669531
EGFR mutation and resistance of non-small-cell lung cancer to gefitinibQ27824829
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signalingQ27851406
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancerQ27851410
Alterations of the Notch pathway in lung cancer.Q27851544
EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors.Q27851590
Generalized lacZ expression with the ROSA26 Cre reporter strainQ27860837
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathwaysQ28274882
MicroRNA miR-199a* regulates the MET proto-oncogene and the downstream extracellular signal-regulated kinase 2 (ERK2)Q28278925
let-7 and miR-17-92: small-sized major players in lung cancer developmentQ28291431
Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epitheliumQ28588912
Identification of bronchioalveolar stem cells in normal lung and lung cancerQ29619267
Targeting specific regions of the Notch3 ligand-binding domain induces apoptosis and inhibits tumor growth in lung cancerQ33523430
Alveolar progenitor and stem cells in lung development, renewal and cancer.Q33579149
Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim.Q33618246
Cigarette smoke induces C/EBP-β-mediated activation of miR-31 in normal human respiratory epithelia and lung cancer cellsQ33737442
MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesisQ33815238
Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancerQ33863504
SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicityQ34022836
Bmi1 expression in long-term germ stem cellsQ34077114
SOX2 gene regulates the transcriptional network of oncogenes and affects tumorigenesis of human lung cancer cellsQ34277248
The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2.Q34342864
EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancerQ34421001
Interleukin 6, but not T helper 2 cytokines, promotes lung carcinogenesis.Q34679251
Epigenetic inactivation of Notch-Hes pathway in human B-cell acute lymphoblastic leukemia.Q34700660
DNA methylation markers and early recurrence in stage I lung cancerQ34761286
Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium.Q34876177
Lineage-negative progenitors mobilize to regenerate lung epithelium after major injuryQ35032592
Direct and indirect roles for β-catenin in facultative basal progenitor cell differentiationQ35850296
β-Catenin-SOX2 signaling regulates the fate of developing airway epitheliumQ35851532
Gene-promoter hypermethylation as a biomarker in lung cancerQ35877182
Calcitonin driven v-Ha-ras induces multilineage pulmonary epithelial hyperplasias and neoplasms.Q53420491
Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers.Q53529945
Opposing role of Notch1 and Notch2 in a KrasG12D-driven murine non-small cell lung cancer modelQ57847240
Disruption of tumor cell adhesion promotes angiogenic switch and progression to micrometastasis in RAF-driven murine lung cancerQ80783647
Synchronous alterations of Wnt and epidermal growth factor receptor signaling pathways through aberrant methylation and mutation in non small cell lung cancerQ81463886
Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomasQ36026392
Mouse models for human lung cancerQ36071893
miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma.Q36368456
Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesisQ36378496
High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancerQ36423456
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancerQ36568988
Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesisQ36638089
Epigenetic field for cancerizationQ36774336
Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibitionQ36905632
Multicolor lineage tracing methods and intestinal tumorsQ36973379
Constitutive expression of human keratin 14 gene in mouse lung induces premalignant lesions and squamous differentiationQ37090686
Insulin-like growth factor-I stimulates differentiation of ATII cells to ATI-like cells through activation of Wnt5aQ37094220
Multiple roles for Sox2 in the developing and adult mouse tracheaQ37186879
Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERKQ37269941
Conditional stabilization of beta-catenin expands the pool of lung stem cellsQ37412788
A rare population of CD24(+)ITGB4(+)Notch(hi) cells drives tumor propagation in NSCLC and requires Notch3 for self-renewalQ37582286
Multiple cells-of-origin of mutant K-Ras-induced mouse lung adenocarcinoma.Q37687546
NOTCH1 is required for regeneration of Clara cells during repair of airway injuryQ37734267
Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53Q38453169
Activated Notch1 induces lung adenomas in mice and cooperates with Myc in the generation of lung adenocarcinoma.Q38461863
The emerging role of SOX2 in cell proliferation and survival and its crosstalk with oncogenic signaling in lung cancer.Q39111034
Notch-1 contributes to epidermal growth factor receptor tyrosine kinase inhibitor acquired resistance in non-small cell lung cancer in vitro and in vivoQ39115106
Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma.Q39187994
The novel miR-7515 decreases the proliferation and migration of human lung cancer cells by targeting c-MetQ39255298
A functional role for tumor cell heterogeneity in a mouse model of small cell lung cancerQ39593316
Bcl-XL and STAT3 mediate malignant actions of gamma-irradiation in lung cancer cellsQ39724227
Wnt/beta-catenin signaling regulates cancer stem cells in lung cancer A549 cellsQ39751974
A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survivalQ39845869
Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations.Q39916367
Notch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice.Q40222473
Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells.Q40543122
p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration.Q41669667
Identification of stem cells that maintain and regenerate lingual keratinized epithelial cellsQ42436810
Coronary arteries form by developmental reprogramming of venous cellsQ42530831
E-cadherin controls bronchiolar progenitor cells and onset of preneoplastic lesions in miceQ42593450
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylationQ44364520
Constitutive activation of Notch3 inhibits terminal epithelial differentiation in lungs of transgenic miceQ47996286
Isolation of a putative progenitor subpopulation of alveolar epithelial type 2 cells.Q51658502
VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2.Q53025494
Cell of origin of small cell lung cancer: inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung.Q53241385
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 4.0 InternationalQ24082749
P433issue5
P921main subjectlung cancerQ47912
lung neoplasmQ15124212
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)489-496
P577publication date2015-03-20
2015-05-01
P1433published inCancer ScienceQ326125
P1476titleIntracellular signals of lung cancer cells as possible therapeutic targets
P478volume106

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cites work (P2860)
Q58565363Crizotinib presented with promising efficacy but for concomitant mutation in next-generation sequencing-identified ROS1-rearranged non-small-cell lung cancer
Q54978516Establishment of lung cancer patient-derived xenograft models and primary cell lines for lung cancer study.
Q52569816Knockdown of POLDIP2 suppresses tumor growth and invasion capacity and is linked to unfavorable transformation ability and metastatic feature in non-small cell lung cancer.
Q34530728Krüppel-Like Factor 4 Enhances Sensitivity of Cisplatin to Lung Cancer Cells and Inhibits Regulating Epithelial-to-Mesenchymal Transition
Q92631641MiR-1246 Promotes Metastasis and Invasion of A549 cells by Targeting GSK-3β‒Mediated Wnt/β-Catenin Pathway
Q51266036Multifunctional gold nanocomposites designed for targeted CT/MR/optical trimodal imaging of human non-small cell lung cancer cells.
Q37298676SMC4, which is essentially involved in lung development, is associated with lung adenocarcinoma progression
Q37720250Sox2 inhibits Wnt-β-catenin signaling and metastatic potency of cisplatin-resistant lung adenocarcinoma cells
Q49182439The clinical value of miR-193a-3p in non-small cell lung cancer and its potential molecular mechanism explored in silico using RNA-sequencing and microarray data

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