Role of anti-inflammatory cytokines IL-4 and IL-13 in systemic sclerosis

scientific article published on March 2015

Role of anti-inflammatory cytokines IL-4 and IL-13 in systemic sclerosis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1018428326
P356DOI10.1007/S00011-015-0806-0
P698PubMed publication ID25725697

P2093author name stringJing Wang
Bing Chen
Yu-Jie Wang
Bao-Zhu Li
Guo-Jun Yang
Jun-Wei Yan
Ya-Nan Wan
Xiao-Lei Huang
P2860cites workRole of IRS-2 in insulin and cytokine signallingQ24337494
The immune pathogenesis of scleroderma: context is everythingQ24633658
Let-7 microRNA-mediated regulation of IL-13 and allergic airway inflammationQ28238669
IL13RA2 gene polymorphisms are associated with systemic sclerosisQ28264135
IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosisQ28285105
Differentiation potential of CD14+ monocytes into myofibroblasts in patients with systemic sclerosisQ28731304
Alternative activation of macrophages: mechanism and functionsQ29614350
Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension.Q33649222
The molecular basis of T helper 1 and T helper 2 cell differentiationQ34106569
Epidemiology of systemic sclerosis: incidence, prevalence, survival, risk factors, malignancy, and environmental triggersQ34249091
Scleroderma: nomenclature, etiology, pathogenesis, prognosis, and treatments: facts and controversiesQ34353948
Interleukin-4 and interleukin-13: their similarities and discrepanciesQ34488885
The discovery, engineering and characterisation of a highly potent anti-human IL-13 fab fragment designed for administration by inhalation.Q34503422
Reduced interleukin-4 receptor α expression on CD8+ T cells correlates with higher quality anti-viral immunityQ34576972
M2 polarized macrophages and giant cells contribute to myofibrosis in neuromuscular sarcoidosisQ34756244
Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammationQ35083309
Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-beta in response to fibrogenic stimuliQ35103031
GATA-3 up-regulation in CD8+ T cells as a biomarker of immune dysfunction in systemic sclerosis, resulting in excessive interleukin-13 production.Q54367655
Evaluation of interleukin 13 polymorphisms in systemic sclerosis.Q54592869
Interleukin-10 Gene Promoter and NFKB1 Promoter Insertion/Deletion Polymorphisms in Systemic SclerosisQ57987460
Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosisQ62748342
Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptorQ71066464
Expression of interleukin-4 in scleroderma skin specimens and scleroderma fibroblast cultures. Potential role in fibrosisQ71182942
Regulation of interleukin-4 on collagen gene expression by systemic sclerosis fibroblasts in cultureQ71549624
Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosisQ73076887
Interleukin-13 stimulates the proliferation of lung myofibroblasts via a signal transducer and activator of transcription-6-dependent mechanism: a possible mechanism for the development of airway fibrosis in asthmaQ73106197
Interleukin-13 in systemic sclerosis: relationship to nailfold capillaroscopy abnormalitiesQ73378880
Serum levels of tumor necrosis factor and interleukin-13 are elevated in patients with localized sclerodermaQ73812940
The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine actionQ77401459
Interleukin 4 co-stimulates the PDGF-BB- and bFGF-mediated proliferation of mesangial cells and myofibroblastsQ78425901
Induction of macrophage insulin-like growth factor-I expression by the Th2 cytokines IL-4 and IL-13Q79074366
Presence of CD4+CD8+ double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic sclerosisQ81377104
Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patientsQ83097062
A pro-fibrotic role for interleukin-4 in cardiac pressure overloadQ83857166
Serum leptin, resistin and TNF-α levels in patients with systemic sclerosis: the role of adipokines in sclerodermaQ84811598
Combining gene expression microarray- and cluster analysis with sequence-based predictions to identify regulators of IL-13 in allergyQ84975677
HLA-G5 induces IL-4 secretion critical for successful pregnancy through differential expression of ILT2 receptor on decidual CD4⁺ T cells and macrophagesQ87346215
IL-13 receptors and signaling pathways: An evolving webQ35110741
The function role of GATA-3 in Th1 and Th2 differentiation.Q35208763
Treatment with imatinib results in reduced IL-4-producing T cells, but increased CD4(+) T cells in the broncho-alveolar lavage of patients with systemic sclerosisQ35566387
Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunityQ35624378
Systemic sclerosis: a prototypic multisystem fibrotic disorderQ35649427
Fibrotic disease and the T(H)1/T(H)2 paradigmQ35852270
Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targetsQ35952040
Biochemical and Genetic Evidence for a SAP-PKC-θ Interaction Contributing to IL-4 RegulationQ36174537
How are T(H)2-type immune responses initiated and amplified?Q36394985
IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophagesQ36501243
IL-13 receptor isoforms: breaking through the complexityQ36909673
Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivityQ36946566
IL-13-producing Th1 and Th17 cells characterize adaptive responses to both self and foreign antigensQ37262658
Untangling the complex web of IL-4- and IL-13-mediated signaling pathwaysQ37358425
Role of IL-13 in systemic sclerosisQ37932807
Cytokine modulation by endothelin-1 and possible therapeutic implications in systemic sclerosisQ37973213
Interleukin 6 in systemic sclerosis and potential implications for targeted therapyQ38002843
T cells in systemic sclerosis: a reappraisalQ38009282
Update on stem cell transplantation for systemic sclerosis: recent trial resultsQ38091659
Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis.Q38309766
The association of the cytoplasmic domains of interleukin 4 receptor alpha and interleukin 13 receptor alpha 2 regulates interleukin 4 signalingQ39093135
Coordinated regulation of IL-4 and IL-13 expression in human T cells: 3C analysis for DNA loopingQ39416033
SHIP represses Th2 skewing by inhibiting IL-4 production from basophilsQ39623829
Effect of IL-4 and IL-13 on collagen production in cultured LI90 human hepatic stellate cellsQ40444779
IL-4-induced macrophage-derived IGF-I protects myofibroblasts from apoptosis following growth factor withdrawalQ40524540
Anti-IL-4 treatment prevents dermal collagen deposition in the tight-skin mouse model of sclerodermaQ41005869
Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4Q41020866
Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1).Q42101278
Supernatants from culture of type I collagen-stimulated PBMC from patients with cutaneous systemic sclerosis versus localized scleroderma demonstrate suppression of MMP-1 by fibroblastsQ42180802
Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expressionQ43752975
IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independentQ44007756
Dual roles of IL-4 in lung injury and fibrosisQ44306912
Molecular mechanisms of interleukin-4-induced up-regulation of type I collagen gene expression in murine fibroblasts.Q44400944
Interleukin-4 and interleukin-13 signaling connections mapsQ44469051
Potential Action of IL-4 and IL-13 as Fibrogenic Factors on Lung Fibroblasts in vitroQ44644231
Equilibrium and kinetic analysis of human interleukin-13 and IL-13 receptor alpha-2 complex formationQ45354358
Interleukin-13 induces collagen type-1 expression through matrix metalloproteinase-2 and transforming growth factor-β1 in airway fibroblasts in asthma.Q46270782
Interleukin-17A+ cell counts are increased in systemic sclerosis skin and their number is inversely correlated with the extent of skin involvementQ46474228
Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathwayQ46484361
Monocyte chemoattractant protein 1 released from glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T cellsQ46872987
Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming.Q51556618
Platelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts.Q51704419
P433issue3-4
P304page(s)151-159
P577publication date2015-03-01
P1433published inInflammation ResearchQ1819367
P1476titleRole of anti-inflammatory cytokines IL-4 and IL-13 in systemic sclerosis
P478volume64

Reverse relations

cites work (P2860)
Q47133710Asperlin Inhibits LPS-Evoked Foam Cell Formation and Prevents Atherosclerosis in ApoE-/- Mice
Q90678059Cytokines and inflammation in adipogenesis: an updated review
Q90746626Hierarchical control of interleukin 13 (IL-13) signals in lung fibroblasts by STAT6 and SOX11
Q92000973IL-1 receptor blockade skews inflammation towards Th2 in a mouse model of systemic sclerosis
Q38829766Interleukin-9 and T helper type 9 cells in rheumatic diseases.
Q64889226M2 macrophage-mediated interleukin-4 signalling induces myofibroblast phenotype during the progression of benign prostatic hyperplasia.
Q38607431Macrophage polarization: the link between inflammation and related diseases
Q58796921NRF2 Activation Inhibits Both TGF-1- and IL-13-Mediated Periostin Expression in Fibroblasts: Benefit of Cinnamaldehyde for Antifibrotic Treatment
Q38622042Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis.
Q39233347Protein Tyrosine Phosphatases in Systemic Sclerosis: Potential Pathogenic Players and Therapeutic Targets.
Q50662045Quantification of Inflammatory Markers in Laryngotracheal Stenosis.
Q38869606Regulatory T Cells in Systemic Sclerosis: a Comprehensive Review
Q97420826The Role of Endogenous Eicosapentaenoic Acid and Docosahexaenoic Acid-Derived Resolvins in Systemic Sclerosis
Q64897993The Role of Monocytes and Macrophages in Autoimmune Diseases: A Comprehensive Review.
Q92040299p75 neurotrophin receptor regulates NGF-induced myofibroblast differentiation and collagen synthesis through MRTF-A

Search more.