scholarly article | Q13442814 |
P356 | DOI | 10.1002/BIES.201500004 |
P698 | PubMed publication ID | 25773221 |
P50 | author | Arthur Konnerth | Q15452516 |
P2093 | author name string | Marc Aurel Busche | |
P2860 | cites work | Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease. | Q48920532 |
Age-associated alterations of hippocampal place cells are subregion specific. | Q51990282 | ||
Single unit activity in the rat hippocampus during a spatial memory task. | Q52133841 | ||
Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. | Q53274559 | ||
Neuron loss in APP transgenic mice | Q59060085 | ||
Dendritic organization of sensory input to cortical neurons in vivo | Q47804412 | ||
Dentate filter function is altered in a proepileptic fashion during aging | Q48158827 | ||
Detecting action potentials in neuronal populations with calcium imaging | Q48193991 | ||
Various dendritic abnormalities are associated with fibrillar amyloid deposits in Alzheimer's disease | Q48215020 | ||
Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer's disease. | Q48431425 | ||
Dynamics of ongoing activity: explanation of the large variability in evoked cortical responses. | Q48913548 | ||
Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice | Q22242267 | ||
A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline | Q22251083 | ||
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein | Q22251280 | ||
Clinical features of Alzheimer's disease | Q22252702 | ||
A default mode of brain function | Q24544311 | ||
Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease | Q24595802 | ||
Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model | Q24603560 | ||
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice | Q24604235 | ||
Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks | Q24622558 | ||
Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model | Q24624879 | ||
Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake | Q24656613 | ||
Brain imaging in Alzheimer disease | Q26996299 | ||
Neuropathological alterations in Alzheimer disease | Q27003314 | ||
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics | Q27860914 | ||
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1 | Q28118975 | ||
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models | Q28119018 | ||
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide | Q28131750 | ||
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome | Q45007178 | ||
Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68. | Q46011081 | ||
Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. | Q46018632 | ||
Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy. | Q46084355 | ||
Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition | Q46440079 | ||
APP homodimers transduce an amyloid-β-mediated increase in release probability at excitatory synapses | Q46616848 | ||
The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat | Q28250476 | ||
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice | Q28300764 | ||
Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease | Q28386524 | ||
Regulation of NMDA receptor trafficking by amyloid-beta | Q28506085 | ||
A specific amyloid-beta protein assembly in the brain impairs memory | Q28854597 | ||
Alzheimer's disease: the amyloid cascade hypothesis | Q29547160 | ||
Alzheimer's disease is a synaptic failure | Q29547670 | ||
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade | Q29614407 | ||
Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory | Q29614724 | ||
AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss | Q29614850 | ||
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics | Q29614972 | ||
APP processing and synaptic function | Q29615873 | ||
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model | Q29617937 | ||
Deep tissue two-photon microscopy | Q29619662 | ||
Clinical and biomarker changes in dominantly inherited Alzheimer's disease | Q29619940 | ||
Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers | Q29620245 | ||
Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele | Q29622928 | ||
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease | Q30080016 | ||
Laminar structure of spontaneous and sensory-evoked population activity in auditory cortex | Q30478700 | ||
Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques | Q30486499 | ||
Sparsification of neuronal activity in the visual cortex at eye-opening | Q30489932 | ||
Neurocognitive aging: prior memories hinder new hippocampal encoding | Q30491828 | ||
Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice | Q30497417 | ||
Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. | Q30513293 | ||
Seizures and epileptiform activity in the early stages of Alzheimer disease | Q30577633 | ||
Epilepsy and cognitive impairments in Alzheimer disease | Q33616746 | ||
Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment | Q33645744 | ||
Patterns of brain activation in people at risk for Alzheimer's disease. | Q33700984 | ||
Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease | Q33827267 | ||
Imaging input and output of neocortical networks in vivo | Q33947067 | ||
Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline | Q34002796 | ||
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo | Q34063772 | ||
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease | Q34157492 | ||
Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift | Q34160589 | ||
In vivo two-photon calcium imaging of neuronal networks | Q34201683 | ||
Neural compensation in older people with brain amyloid-β deposition | Q34253028 | ||
Neurobehavioral characterization of APP23 transgenic mice with the SHIRPA primary screen | Q34379479 | ||
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes | Q34452028 | ||
Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice | Q34541972 | ||
Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases | Q34621541 | ||
Brain states: top-down influences in sensory processing | Q34635087 | ||
Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration | Q34804911 | ||
Electrophysiology in the age of light | Q35008002 | ||
Neuronal activity regulates the regional vulnerability to amyloid-β deposition | Q35009626 | ||
Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models | Q35070000 | ||
Single-neuron dynamics in human focal epilepsy | Q35099268 | ||
Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD | Q35105340 | ||
Hippocampal hyperactivation in presymptomatic familial Alzheimer's disease | Q35218523 | ||
Communication in Neuronal Networks | Q35544856 | ||
Hippocampal hyperactivation associated with cortical thinning in Alzheimer's disease signature regions in non-demented elderly adults | Q35787932 | ||
The many faces of tau | Q35870359 | ||
Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease | Q35916637 | ||
Neuronal structure is altered by amyloid plaques | Q35939250 | ||
Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment | Q35957965 | ||
Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease | Q36001449 | ||
Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease | Q36279313 | ||
The molecular pathology of Alzheimer's disease | Q36490940 | ||
Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model | Q36676830 | ||
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology | Q36724967 | ||
Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline | Q37194883 | ||
Amyloid deposition is associated with impaired default network function in older persons without dementia | Q37335603 | ||
Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice | Q37373211 | ||
Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease | Q37633601 | ||
Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease | Q37764164 | ||
The genetics of Alzheimer disease: back to the future | Q37801081 | ||
Apolipoprotein E in Alzheimer's disease and other neurological disorders | Q37846932 | ||
Cortical state and attention | Q37914677 | ||
Imaging calcium in neurons | Q37992250 | ||
Imaging neuronal activity with genetically encoded calcium indicators | Q38015778 | ||
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. | Q39173722 | ||
Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice | Q41002869 | ||
Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses. | Q43236403 | ||
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils | Q43718666 | ||
Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease | Q44191043 | ||
P433 | issue | 6 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | Alzheimer's disease | Q11081 |
P304 | page(s) | 624-632 | |
P577 | publication date | 2015-03-14 | |
P1433 | published in | BioEssays | Q4914614 |
P1476 | title | Neuronal hyperactivity--A key defect in Alzheimer's disease? | |
P478 | volume | 37 |
Q92508449 | A vicious cycle of β amyloid-dependent neuronal hyperactivation |
Q36799532 | Abnormal Population Responses in the Somatosensory Cortex of Alzheimer's Disease Model Mice |
Q45838619 | Activation of G-protein-gated inwardly rectifying potassium (Kir3/GirK) channels rescues hippocampal functions in a mouse model of early amyloid-β pathology |
Q42370244 | Altering neuronal excitability to preserve network connectivity in a computational model of Alzheimer's disease |
Q90560189 | Amyloid Plaques of Alzheimer's Disease as Hotspots of Glutamatergic Activity |
Q38663691 | BACE inhibition-dependent repair of Alzheimer's pathophysiology |
Q40179990 | Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice |
Q55002622 | Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease. |
Q45021910 | Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models |
Q56967836 | Differentiation of Alzheimer's disease based on local and global parameters in personalized Virtual Brain models |
Q89494064 | Distinct Spontaneous Brain Activity Patterns in Different Biologically-Defined Alzheimer's Disease Cognitive Stage: A Preliminary Study |
Q30836664 | Early and progressive deficit of neuronal activity patterns in a model of local amyloid pathology in mouse prefrontal cortex |
Q92735463 | Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer's disease |
Q38837604 | Early synaptic dysfunction in Parkinson's disease: Insights from animal models. |
Q92255306 | Evidence of parietal hyperactivation in individuals with mild cognitive impairment who progressed to dementia: A longitudinal fMRI study |
Q97066870 | Exciting Complexity: The Role of Motor Circuit Elements in ALS Pathophysiology |
Q45353132 | Gamma rhythm low field magnetic stimulation alleviates neuropathologic changes and rescues memory and cognitive impairments in a mouse model of Alzheimer's disease |
Q48349276 | Heightened cortical excitability in aged rodents with memory impairment |
Q92131798 | Hippocampal Deficits in Amyloid-β-Related Rodent Models of Alzheimer's Disease |
Q98906760 | Hippocampal alterations in glutamatergic signaling during amyloid progression in AβPP/PS1 mice |
Q47443049 | Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP. |
Q64105245 | Impaired hippocampal-cortical coupling but preserved local synchrony during sleep in APP/PS1 mice modeling Alzheimer's disease |
Q92994454 | Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence |
Q50703202 | Is riluzole a new drug for Alzheimer's disease? |
Q92685469 | Longitudinal trajectory of Amyloid-related hippocampal subfield atrophy in nondemented elderly |
Q91786481 | Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis |
Q96033912 | Molecular, Structural, Functional, and Pharmacological Sites for Vesicular Glutamate Transporter Regulation |
Q92541099 | NGL-3 in the regulation of brain development, Akt/GSK3b signaling, long-term depression, and locomotive and cognitive behaviors |
Q91199030 | Neural oscillations during cognitive processes in an App knock-in mouse model of Alzheimer's disease pathology |
Q99634466 | Neuronal Selection Based on Relative Fitness Comparison Detects and Eliminates Amyloid-β-Induced Hyperactive Neurons in Drosophila |
Q37168959 | Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer's disease |
Q90265077 | New Approaches to Studying Silent Mesial Temporal Lobe Seizures in Alzheimer's Disease |
Q55498137 | Novel interaction between Alzheimer's disease-related protein presenilin 1 and glutamate transporter 1. |
Q38896981 | Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals |
Q90029497 | REST: An epigenetic regulator of neuronal stress responses in the young and ageing brain |
Q47928098 | Rescue of long-range circuit dysfunction in Alzheimer's disease models |
Q58723464 | Robust spatial memory maps encoded by networks with transient connections |
Q64121595 | Role of GirK Channels in Long-Term Potentiation of Synaptic Inhibition in an In Vivo Mouse Model of Early Amyloid- Pathology |
Q92188275 | Sevoflurane increases locomotion activity in mice |
Q42488460 | Spatial Memory Impairment is Associated with Intraneural Amyloid-β Immunoreactivity and Dysfunctional Arc Expression in the Hippocampal-CA3 Region of a Transgenic Mouse Model of Alzheimer's Disease. |
Q31122548 | Spatial learning and memory impairments are associated with increased neuronal activity in 5XFAD mouse as measured by manganese-enhanced magnetic resonance imaging |
Q38690658 | TRPA1 channels promote astrocytic Ca2+ hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptide. |
Q39339952 | Targeting Neural Hyperactivity as a Treatment to Stem Progression of Late-Onset Alzheimer's Disease |
Q62492915 | Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity |
Q36251986 | The Alzheimer's disease risk factor CD2AP maintains blood-brain barrier integrity |
Q42180603 | The Virtual Trial. |
Q39052041 | The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases |
Q38809233 | The vicious circle of hypometabolism in neurodegenerative diseases: Ways and mechanisms of metabolic correction |
Q61444271 | Through synapses to spatial memory maps via a topological model |
Q64990217 | What Happens with the Circuit in Alzheimer's Disease in Mice and Humans? |
Search more.