Regulation of antiviral T cell responses by type I interferons

scientific article published on 20 March 2015

Regulation of antiviral T cell responses by type I interferons is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1038/NRI3806
P698PubMed publication ID25790790

P50authorAnnette OxeniusQ87490341
Ulrich KalinkeQ47156951
P2093author name stringJosh Crouse
P2860cites workA variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virusQ24307721
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineagesQ24642180
Interferon-inducible antiviral effectorsQ27486790
Structural Linkage between Ligand Discrimination and Receptor Activation by Type I InterferonsQ27671836
Virus interference. I. The interferonQ28181608
IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activationQ28207915
IL-15Ralpha recycles and presents IL-15 In trans to neighboring cellsQ28214975
Mechanisms of type-I- and type-II-interferon-mediated signallingQ28247893
Modulation of human plasmacytoid DC function by IFN-lambda1 (IL-29)Q28258808
Interferons, interferon-like cytokines, and their receptorsQ28293630
Type I interferon is required to mount an adaptive response to immunostimulatory DNAQ28508204
Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profileQ28508595
Cutting Edge: The direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infectionQ28511064
Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cellsQ28754733
Follicular helper CD4 T cells (TFH)Q29615063
Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrualQ30422031
Type I interferon is a therapeutic target for virus-induced lethal vascular damageQ33415686
Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infectionQ33569835
Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infectionQ33665625
Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage populationQ33815694
Analysis of apoptosis of memory T cells and dendritic cells during the early stages of viral infection or exposure to toll-like receptor agonistsQ33826847
Attrition of bystander CD8 T cells during virus-induced T-cell and interferon responsesQ33842424
Interferon Induces Natural Killer Cell Blastogenesis In VivoQ72728247
Interferon alpha augments activation-induced T cell death by upregulation of Fas (CD95/APO-1) and Fas ligand expressionQ73092090
Low levels of interferon-alpha induce CD86 (B7.2) expression and accelerates dendritic cell maturation from human peripheral blood mononuclear cellsQ73189599
Interferon alpha/beta-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradoxQ73956048
Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cellsQ74587993
Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infectionQ74813303
Interferon-alpha and granulocyte-macrophage colony-stimulating factor differentiate peripheral blood monocytes into potent antigen-presenting cellsQ77303042
Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infectionQ78346749
Down-modulation of responses to type I IFN upon T cell activationQ78762532
Selective Depletion of Nonspecific T Cells During the Early Stage of Immune Responses to InfectionQ79125476
Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysisQ80092122
IL-12, but not IFN-alpha, promotes STAT4 activation and Th1 development in murine CD4+ T cells expressing a chimeric murine/human Stat2 geneQ81178259
Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiationQ81621807
Antigen amount dictates CD8+ T-cell exhaustion during chronic viral infection irrespective of the type of antigen presenting cellQ84267427
Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cellsQ42941989
IFN-α enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing.Q43047480
IFN-alpha 2b reduces IL-2 production and IL-2 receptor function in primary CD4+ T cellsQ44195895
IFN-α exerts opposing effects on activation-induced and IL-7-induced proliferation of T cells that may impair homeostatic maintenance of CD4+ T cell numbers in treated HIV infectionQ44219687
Cross-priming of CD8+ T cells stimulated by virus-induced type I interferonQ44860628
Cutting edge: role of STAT1, STAT3, and STAT5 in IFN-alpha beta responses in T lymphocytesQ45059138
Type I IFN substitutes for T cell help during viral infectionsQ45309998
Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansionQ45373249
CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansionQ45418190
Effects of IFN-α as a signal-3 cytokine on human naïve and antigen-experienced CD8(+) T cellsQ45865259
The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8(+) dendritic cellsQ46071205
Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.Q46315215
Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signalingQ46465385
Sustained IL-12 signaling is required for Th1 developmentQ47305582
Loss of interferon-induced Stat1 phosphorylation in activated T cellsQ47910671
Type-I IFN drives the differentiation of short-lived effector CD8+ T cells in vivo.Q50982101
Signal 3 requirement for memory CD8+ T-cell activation is determined by the infectious pathogen.Q50996907
Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses.Q51020416
Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo.Q51887589
Innate inflammatory signals induced by various pathogens differentially dictate the IFN-I dependence of CD8 T cells for clonal expansion and memory formation.Q51980899
IFN-induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections.Q51984009
Interferon-beta mediates stromal cell rescue of T cells from apoptosis.Q52034883
The role of Stat4 in species-specific regulation of Th cell development by type I IFNs.Q52181256
IFN-alpha2 induces leukocyte integrin redistribution, increased adhesion, and migration.Q53555608
Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus.Q53718320
IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasisQ54285337
Type I IFNs enhance the terminal differentiation of dendritic cellsQ57272608
Antiproliferative action of interferon-α requires components of T-cell-receptor signallingQ59077517
Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN-αQ59415968
Expression of CCR-7, MIP-3beta , and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activitiesQ60687739
IFN-alpha2a induces IP-10/CXCL10 and MIG/CXCL9 production in monocyte-derived dendritic cells and enhances their capacity to attract and stimulate CD8+ effector T cellsQ61268439
Type I interferons and IL-12: convergence and cross-regulation among mediators of cellular immunityQ61316881
Type I interferons produced by dendritic cells promote their phenotypic and functional activationQ61473768
Direct Stimulation of T Cells by Type I IFN Enhances the CD8+ T Cell Response during Cross-PrimingQ63952505
Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopeniaQ63952509
Effect of interferon and interferon inducers on the NK sensitivity of normal mouse thymocytesQ72620737
Stat1 and Stat2 but not Stat3 arbitrate contradictory growth signals elicited by alpha/beta interferon in T lymphocytes.Q33862973
Natural adjuvants: endogenous activators of dendritic cellsQ33878894
Absence of mouse 2B4 promotes NK cell-mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesisQ33882896
Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memoryQ33946269
T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cellsQ33952975
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cellsQ34003618
Regulation of TNF-related apoptosis-inducing ligand on primary CD4+ T cells by HIV-1: role of type I IFN-producing plasmacytoid dendritic cellsQ34014711
Plasmacytoid dendritic cells: recent progress and open questionsQ34162925
Out-of-sequence signal 3 as a mechanism for virus-induced immune suppression of CD8 T cell responsesQ34257444
Signal 3 cytokines as modulators of primary immune responses during infections: the interplay of type I IFN and IL-12 in CD8 T cell responses.Q34345332
Differential activity of type I interferon subtypes for dendritic cell differentiationQ34615006
Negative regulation of type I IFN expression by OASL1 permits chronic viral infection and CD8⁺ T-cell exhaustion.Q34845501
Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairmentQ34857689
Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infectionQ35018048
Plasmacytoid dendritic cells contribute to systemic but not local antiviral responses to HSV infectionsQ35034249
Virus-induced transient immune suppression and the inhibition of T cell proliferation by type I interferonQ35077019
Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2Q35311132
Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progressionQ35564886
IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functionsQ35596351
Modulation of STAT1 protein levels: a mechanism shaping CD8 T-cell responses in vivoQ35850004
Differential role of "Signal 3" inflammatory cytokines in regulating CD8 T cell expansion and differentiation in vivo.Q35927631
Interferon-alpha/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infectionQ35958851
Functional STAT3 deficiency compromises the generation of human T follicular helper cells.Q35970620
Emergence of distinct multiarmed immunoregulatory antigen-presenting cells during persistent viral infectionQ35987045
Dendritic cells prime natural killer cells by trans-presenting interleukin 15Q36157184
Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway.Q36191417
Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection.Q36228011
Stats: multifaceted regulators of transcriptionQ36351955
Type I interferons keep activated T cells aliveQ36367751
Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice.Q36368488
Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for functionQ36370831
Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector functionQ36370978
Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infectionQ36402851
Type 1 interferons and the virus-host relationship: a lesson in détente .Q36475884
Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion.Q36547702
Type I interferon production in HIV-infected patientsQ36569087
Complex modulation of cell type-specific signaling in response to type I interferonsQ36595836
Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infectionQ36611354
Cytokines of the γ(c) family control CD4+ T cell differentiation and functionQ36781465
Persistent LCMV infection is controlled by blockade of type I interferon signalingQ36808119
Cutting edge: IL-12 and type I IFN differentially program CD8 T cells for programmed death 1 re-expression levels and tumor controlQ37038661
Programming for CD8 T cell memory development requires IL-12 or type I IFNQ37110371
Expanding roles for CD4⁺ T cells in immunity to viruses.Q37150560
High antigen levels are the cause of T cell exhaustion during chronic viral infectionQ37208927
TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN productionQ37230321
Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvantQ37273249
Homeostasis of naive and memory T cellsQ37356053
Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gammaQ37432208
Resolution of immune activation defines nonpathogenic SIV infectionQ37432647
IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivoQ37483123
Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic programQ37666675
Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cellsQ37711709
Induction of type I IFNs by intracellular DNA-sensing pathwaysQ37997334
Cross-presentation by dendritic cellsQ38025870
Control of human viral infections by natural killer cellsQ38072477
Natural killer cells regulate diverse T cell responses.Q38100373
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acidsQ38230646
NK cells regulating T cell responses: mechanisms and outcomeQ38272441
Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virusQ39439883
IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunityQ39603416
Effector T-cell differentiation during viral and bacterial infections: Role of direct IL-12 signals for cell fate decision of CD8(+) T cellsQ39834545
CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organsQ40307375
CD8 T Cell Clonal Expansion and Development of Effector Function Require Prolonged Exposure to Antigen, Costimulation, and Signal 3 CytokineQ40618314
Activated, but not resting, T cells can be recognized and killed by syngeneic NK cellsQ40662596
Hypertrophy of infected Peyer's patches arises from global, interferon-receptor, and CD69-independent shutdown of lymphocyte egressQ40798515
Blockade of chronic type I interferon signaling to control persistent LCMV infectionQ41807293
Bystander chronic infection negatively impacts development of CD8(+) T cell memory.Q41809254
Type I interferon-mediated stimulation of T cells by CpG DNAQ41824775
Enhanced NK cell activity in mice injected with interferon and interferon inducersQ41935188
Virus-induced interferon alpha production by a dendritic cell subset in the absence of feedback signaling in vivoQ41996467
Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity.Q42211517
Type I interferons protect T cells against NK cell attack mediated by the activating receptor NCR1.Q42213627
Antigen cross-presentation by dendritic cell subsets: one general or all sergeants?Q42245307
Distinct requirements for IFNs and STAT1 in NK cell functionQ42494660
IFN-alpha is not sufficient to drive Th1 development due to lack of stable T-bet expressionQ42497613
Type I IFN drives a distinctive dendritic cell maturation phenotype that allows continued class II MHC synthesis and antigen processingQ42568916
P433issue4
P304page(s)231-242
P577publication date2015-03-20
P1433published inNature Reviews ImmunologyQ43355
P1476titleRegulation of antiviral T cell responses by type I interferons
P478volume15

Reverse relations

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