Pooled Analysis of CNS Response to Alectinib in Two Studies of Pretreated Patients With ALK-Positive Non-Small-Cell Lung Cancer

scientific article published on 31 October 2016

Pooled Analysis of CNS Response to Alectinib in Two Studies of Pretreated Patients With ALK-Positive Non-Small-Cell Lung Cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1200/JCO.2016.68.4639
P932PMC publication ID7845943
P698PubMed publication ID27863201

P50authorJames Chih-Hsin YangQ37840097
Denis Moro-SibilotQ57054866
P2093author name stringDong-Wan Kim
Michael Duruisseaux
Ramaswamy Govindan
Mark A Socinski
Tommaso De Pas
D Ross Camidge
Leena Gandhi
Lucio Crino
Luigi De Petris
Shirish M Gadgeel
Alice T Shaw
Ji-Youn Han
Sai-Hong Ignatius Ou
Eric Dansin
Ali Zeaiter
Sophie Golding
Walter Bordogna
Alberto Chiappori
Antje Tessmer
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Clinical benefit of continuing ALK inhibition with crizotinib beyond initial disease progression in patients with advanced ALK-positive NSCLC.Q27852806
Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study.Q27853059
First-line crizotinib versus chemotherapy in ALK-positive lung cancerQ27853101
Alectinib in ALK-positive, crizotinib-resistant, non-small-cell lung cancer: a single-group, multicentre, phase 2 trialQ27853299
Alectinib: a review of its use in advanced ALK-rearranged non-small cell lung cancerQ34449807
Alectinib salvages CNS relapses in ALK-positive lung cancer patients previously treated with crizotinib and ceritinibQ35007620
Alectinib induces a durable (>15 months) complete response in an ALK-positive non-small cell lung cancer patient who progressed on crizotinib with diffuse leptomeningeal carcinomatosisQ35057308
Characteristics of long-term survivors of brain metastases from lung cancerQ35078652
Drug delivery to the central nervous system: a reviewQ35205301
Clinical Experience With Crizotinib in Patients With Advanced ALK-Rearranged Non-Small-Cell Lung Cancer and Brain MetastasesQ35549714
Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 studyQ37606591
Molecular pathways: resistance to kinase inhibitors and implications for therapeutic strategiesQ38208748
FDA approval: ceritinib for the treatment of metastatic anaplastic lymphoma kinase-positive non-small cell lung cancer.Q38371186
Alectinib in Crizotinib-Refractory ALK-Rearranged Non-Small-Cell Lung Cancer: A Phase II Global Study.Q38645064
Antitumor activity of the selective ALK inhibitor alectinib in models of intracranial metastasesQ38957939
Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2).Q40548554
Clinical characteristics of brain metastases from lung cancer according to histological type: Pretreatment evaluation and survival following whole-brain radiotherapyQ41920066
Irradiation of brain metastases from lung cancer: A retrospective studyQ45241708
Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational studyQ50711312
CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib.Q54602410
P433issue34
P407language of work or nameEnglishQ1860
P921main subjectlung cancerQ47912
P304page(s)4079-4085
P577publication date2016-10-31
P1433published inJournal of Clinical OncologyQ400292
P1476titlePooled Analysis of CNS Response to Alectinib in Two Studies of Pretreated Patients With ALK-Positive Non-Small-Cell Lung Cancer
P478volume34

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