Regulation of extracellular Zn(2+) homeostasis in the hippocampus as a therapeutic target for Alzheimer's disease

scientific article published on 27 March 2015

Regulation of extracellular Zn(2+) homeostasis in the hippocampus as a therapeutic target for Alzheimer's disease is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1517/14728222.2015.1029454
P698PubMed publication ID25818846

P50authorGeorge PerryQ5543353
P2093author name stringAtsushi Takeda
Haruna Tamano
P2860cites workZnT-3, a putative transporter of zinc into synaptic vesiclesQ24336868
Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic miceQ24530682
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memoryQ24645499
Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptakeQ24656613
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivoQ28131779
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Tissue plasminogen activator alters intracellular sequestration of zinc through interaction with the transporter ZIP4Q33857787
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Transient increase in Zn2+ in hippocampal CA1 pyramidal neurons causes reversible memory deficitQ34098272
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The neurophysiology and pathology of brain zincQ35572191
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Mossy fiber Zn2+ spillover modulates heterosynaptic N-methyl-D-aspartate receptor activity in hippocampal CA3 circuits.Q41843219
Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptorsQ42738430
PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analysesQ43158585
Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomersQ43509033
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ZnT-1 expression in astroglial cells protects against zinc toxicity and slows the accumulation of intracellular zinc.Q45066353
A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses.Q46064935
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beta-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons.Q48463841
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Zinquin identifies subcellular compartmentalization of zinc in cortical neurons. Relation to the trafficking of zinc and the mitochondrial compartmentQ48596909
Zinc-positive boutons in the cerebral cortex of lizards show glutamate immunoreactivityQ48649595
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Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide.Q55066167
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)1051-1058
P577publication date2015-03-27
P1433published inExpert Opinion on Therapeutic TargetsQ5421214
P1476titleRegulation of extracellular Zn(2+) homeostasis in the hippocampus as a therapeutic target for Alzheimer's disease
P478volume19

Reverse relations

cites work (P2860)
Q51811133Modification of hippocampal excitability in brain slices pretreated with a low nanomolar concentration of Zn2+.
Q38777678Significance of Low Nanomolar Concentration of Zn2+ in Artificial Cerebrospinal Fluid

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