Thymidine phosphorylase influences [(18)F]fluorothymidine uptake in cancer cells and patients with non-small cell lung cancer

scientific article published on 22 February 2014

Thymidine phosphorylase influences [(18)F]fluorothymidine uptake in cancer cells and patients with non-small cell lung cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00259-014-2712-Z
P698PubMed publication ID24562648
P5875ResearchGate publication ID260375544

P2093author name stringSe Jin Jang
Dae Hyuk Moon
Jong Jin Lee
Seung Jin Lee
Eun Jung Lee
Jin-Sook Ryu
Seog Young Kim
Jeong Seok Yeo
Haeng Jung Lee
P2860cites workSelectivity of 18F-FLT and 18F-FDG for differentiating tumor from inflammation in a rodent model.Q44836743
Tumor 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) uptake by PET correlates with thymidine kinase 1 expression: static and kinetic analysis of (18)F-FLT PET studies in lung tumorsQ46104674
18F-FDG and 18F-FLT do not discriminate between reactive and metastatic lymph nodes in oral cancer.Q46119190
The uptake of 3'-deoxy-3'-[18F]fluorothymidine into L5178Y tumours in vivo is dependent on thymidine kinase 1 protein levelsQ46404885
Imaging proliferation in vivo with [F-18]FLT and positron emission tomography.Q54117465
Structural modifications at the 2'- and 3'-positions of some pyrimidine nucleosides as determinants of their interaction with the mouse erythrocyte nucleoside transporterQ70667382
Expression of thymidine phosphorylase as an indicator of poor prognosis for patients with transitional cell carcinoma of the bladderQ73504286
Hallmarks of Cancer: The Next GenerationQ22252312
Platelet-derived endothelial cell growth factor has thymidine phosphorylase activityQ28114917
Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidineQ28318354
Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosidesQ28621379
Thymidine Phosphorylase/β-tubulin III expressions predict the response in Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxelQ33903541
Human thymidine kinase 1. Regulation in normal and malignant cellsQ34296535
The 5'-nucleotidases as regulators of nucleotide and drug metabolismQ34427241
Etoposide increases equilibrative nucleoside transporter 1 activity and fluorothymidine uptake: screening of 60 cytotoxic agentsQ34509132
Different modes of transport for 3H-thymidine, 3H-FLT, and 3H-FMAU in proliferating and nonproliferating human tumor cellsQ36012091
PET imaging of cellular proliferationQ36031444
Thymidine phosphorylase (platelet-derived endothelial-cell growth factor) in cancer biology and treatmentQ36057816
Proliferative markers as prognostic and predictive tools in early breast cancer: where are we now?Q36175746
Targeting platelet-derived endothelial cell growth factor/thymidine phosphorylase for cancer therapyQ36850635
Imaging of cell proliferation: status and prospectsQ37181529
[(18)F]FLT: an imaging biomarker of tumour proliferation for assessment of tumour response to treatment.Q37972435
Correlation between Ki-67 immunohistochemistry and 18F-fluorothymidine uptake in patients with cancer: A systematic review and meta-analysis.Q38015605
Current molecular imaging positron emitting radiotracers in oncologyQ38217835
[(18)F]FLT-PET imaging does not always "light up" proliferating tumor cellsQ38435509
Induction of thymidine kinase 1 after 5-fluorouracil as a mechanism for 3'-deoxy-3'-[18F]fluorothymidine flare.Q38482480
[18F]Fluorothymidine positron emission tomography before and 7 days after gefitinib treatment predicts response in patients with advanced adenocarcinoma of the lungQ38497891
Radiolabeled uracil derivative as a novel SPECT probe for thymidine phosphorylase: suppressed accumulation into tumor cells by target gene knockdownQ39470802
Biodistribution and uptake of 3'-deoxy-3'-fluorothymidine in ENT1-knockout mice and in an ENT1-knockdown tumor modelQ39665962
Evaluation of 5'-deoxy-5'-[F-18]fluorothymidine as a tracer of intracellular thymidine phosphorylase activityQ40115491
Metabolism of 3'-deoxy-3'-[F-18]fluorothymidine in proliferating A549 cells: validations for positron emission tomographyQ40508408
Effect of p53 activation on cell growth, thymidine kinase-1 activity, and 3'-deoxy-3'fluorothymidine uptakeQ40565389
Monitoring tumor cell proliferation by targeting DNA synthetic processes with thymidine and thymidine analogs.Q40609681
Cytosolic high K(m) 5'-nucleotidase and 5'(3')-deoxyribonucleotidase in substrate cycles involved in nucleotide metabolismQ40842487
Thymidine concentrations in serum and urine of different animal species and manQ41346695
The role of human nucleoside transporters in uptake of 3'-deoxy-3'-fluorothymidineQ43650689
Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells.Q44128080
Suppression of metastasis by thymidine phosphorylase inhibitorQ44253163
P433issue7
P921main subjecttipiracilQ21098889
tipiracil hydrochlorideQ27162848
P1104number of pages9
P304page(s)1327-1335
P577publication date2014-02-22
P1433published inEuropean Journal of Nuclear Medicine and Molecular ImagingQ15708890
P1476titleThymidine phosphorylase influences [(18)F]fluorothymidine uptake in cancer cells and patients with non-small cell lung cancer
P478volume41

Reverse relations

cites work (P2860)
Q478779003'-Deoxy-3'-[(18)F]Fluorothymidine Uptake Is Related to Thymidine Phosphorylase Expression in Various Experimental Tumor Models
Q51169855Assessment of metabolism-dependent drug efficacy and toxicity on a multilayer organs-on-a-chip.
Q60957206Enhanced Anticancer Activity of 5'-DFUR-PCL-MPEG Polymeric Prodrug Micelles Encapsulating Chemotherapeutic Drugs
Q38312373Image-derived biomarkers and multimodal imaging strategies for lung cancer management
Q38427767Positron emission tomography imaging of human colon cancer xenografts in mice with [18F]fluorothymidine after TAS-102 treatment

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