A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase.

scientific article published on 09 June 2015

A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1039/C5MB00303B
P932PMC publication ID4573825
P698PubMed publication ID26055255

P50authorJeffrey D. RudolfQ41583636
Liao-Bin DongQ83176168
P2093author name stringBen Shen
Tingting Huang
P2860cites workAntidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetesQ24629052
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Gene disruption in Escherichia coli: TcR and KmR cassettes with the option of Flp-catalyzed excision of the antibiotic-resistance determinantQ29615039
PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosminQ30764407
Analysis of genes involved in 6-deoxyhexose biosynthesis and transfer in Saccharopolyspora erythraeaQ33181530
Genetic dissection of the polyoxin building block-carbamoylpolyoxamic acid biosynthesis revealing the "pathway redundancy" in metabolic networksQ33642672
Engineering of Streptomyces platensis MA7339 for overproduction of platencin and congeners.Q33793107
Strain prioritization for natural product discovery by a high-throughput real-time PCR method.Q34400070
Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners.Q34479743
Engineered Streptomyces platensis strains that overproduce antibiotics platensimycin and platencin.Q34928039
Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis.Q35170957
Gibberellin production by bacteria and its involvement in plant growth promotion and yield increaseQ35892253
Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexityQ37159840
Diversity, regulation, and evolution of the gibberellin biosynthetic pathway in fungi compared to plants and bacteriaQ37533370
Bacterial diterpene synthases: new opportunities for mechanistic enzymology and engineered biosynthesis.Q37996675
Isolation and structural elucidation of glucoside congeners of platencin from Streptomyces platensis SB12600.Q38455632
Platensimycin is a selective FabF inhibitor with potent antibiotic propertiesQ38468310
beta-oxidation of fatty acids in mitochondria, peroxisomes, and bacteria: a century of continued progressQ41018645
Assignment of the absolute configuration of alpha-chiral carboxylic acids by 1H NMR spectroscopyQ42626328
Isolation, structure and biological activities of platencin A(2)-A(4) from Streptomyces platensisQ43124757
Isolation, structure and biological activities of platensimycin B4 from Streptomyces platensisQ43243029
Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vectorQ44047474
Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad-Spectrum Antibiotic ActivityQ58854274
Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity StrategyQ58854282
Lycopalhine A, a novel sterically congested Lycopodium alkaloid with an unprecedented skeleton from Palhinhaea cernuaQ84703766
Chemical and chemotaxonomical studies on filices. XLIII. Chemical studies on the constituents of Lindsaea javanensis Bl., L. japonica (Bak.) Diels and Tapeinidium pinnatum (Cav.) C. Chr.Q105032988
Chemische und chemotaxonomische Untersuchungen von Filices. XXXIII. Chemische Untersuchungen der Inhaltsstoffe von Pteris longipes Don.Q111734643
P433issue10
P304page(s)2717-2726
P577publication date2015-10-01
P1433published inMolecular BioSystemsQ3319467
P1476titleA genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase
P478volume11

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cites work (P2860)
Q36408584A Facile Semi-Synthetic Approach towards Halogen-Substituted Aminobenzoic Acid Analogues of Platensimycin.
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Q35759276Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery
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Q90388774Leveraging a large microbial strain collection for natural product discovery
Q57178716Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme
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