Extended quantitative structure-activity relationships for 80 aromatic and heterocyclic amines: structural, electronic, and hydropathic factors affecting mutagenic potency

scientific article published on January 2001

Extended quantitative structure-activity relationships for 80 aromatic and heterocyclic amines: structural, electronic, and hydropathic factors affecting mutagenic potency is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/EM.10028
P698PubMed publication ID11774358

P2093author name stringKnize MG
Colvin ME
Hatch FT
P2860cites workA Computer Program for Classifying PlantsQ34006445
A microcomputer program for analyzing Ames test dataQ36599522
Validation of a novel molecular orbital approach (COMPACT) for the prospective safety evaluation of chemicals, by comparison with rodent carcinogenicity and Salmonella mutagenicity data evaluated by the U.S. NCI/NTPQ36695041
Quantitative structure-activity relationships of heterocyclic amine mutagens formed during the cooking of foodQ37633205
Quantitative structure-activity relationship of flavonoids for inhibition of heterocyclic amine mutagenicityQ38459334
Chemical and biological factors affecting mutagen potencyQ38462410
Quantitative structure-activity (QSAR) relationships of mutagenic aromatic and heterocyclic aminesQ38463978
Structural and quantum chemical factors affecting mutagenic potency of aminoimidazo-azaarenesQ38466140
Quantitative correlation of mutagenic and carcinogenic potencies for heterocyclic amines from cooked foods and additional aromatic aminesQ38470728
Quantitative structure-activity relationships: principles, and applications to mutagenicity and carcinogenicity.Q38715307
Relationships between structure and mutagenic activity of environmental chemicalsQ39598597
Structure-activity relationships (SARs) among mutagens and carcinogens: a reviewQ39731806
Review of mutagenicity of monocyclic aromatic amines: quantitative structure-activity relationshipsQ41560466
Quantitative structure-activity relationships of mutagenic aromatic and heteroaromatic azides and aminesQ43496671
A QSAR investigation of the role of hydrophobicity in regulating mutagenicity in the Ames test: 1. Mutagenicity of aromatic and heteroaromatic amines in Salmonella typhimurium TA98 and TA100.Q44104976
Relative stabilities of nitrenium ions derived from heterocyclic amine food carcinogens: relationship to mutagenicityQ45250063
The inhibition by flavonoids of 2-amino-3-methylimidazo[4,5-f]quinoline metabolic activation to a mutagen: a structure-activity relationship studyQ50133207
Quantitative structure-activity relationships and COMPACT analysis of a series of food mutagensQ50142600
Strategic approaches to drug design. I. An integrated software framework for molecular modellingQ50149089
Structure-activity relationships within various series of p-phenylenediamine derivativesQ50149475
QSAR models for both mutagenic potency and activity: application to nitroarenes and aromatic aminesQ50154407
Antimutagenic effects of flavoniods, chalcones and structurally related compounds on the activity of 2-amino-3-methylinidazo[4,5-ƒ]quinoline (IQ) and other heterocyclic amine mutagens from cooked foodQ50162779
Structural basis of the mutagenicity of heterocyclic amines formed during the cooking processesQ50168240
Structure-activity relationships of aromatic diamines in the Ames Salmonella typhimurium assay. Part IIQ50173801
Relative stabilities of nitrenium ions derived from polycyclic aromatic amines. Relationship to mutagenicityQ50181277
Structure-activity relationships of aromatic amines in the Ames Salmonella typhimurium assayQ50190974
Mutagenic nitrenes/nitrenium ions from azido-imidazoarenes and their structure-activity relationshipsQ50192916
Revised methods for the Salmonella mutagenicity testQ50211560
Quantitative structure-activity relationships of mutagenic and carcinogenic aromatic amines.Q53393808
Natural population analysisQ56228315
Molecular modelling of CYP1A subfamily members based on an alignment with CYP102: rationalization of CYP1A substrate specificity in terms of active site amino acid residuesQ71563292
Further evaluation of COMPACT, the molecular orbital approach for the prospective safety evaluation of chemicalsQ74330367
P433issue4
P304page(s)268-291
P577publication date2001-01-01
P1433published inEnvironmental and Molecular MutagenesisQ15724469
P1476titleExtended quantitative structure-activity relationships for 80 aromatic and heterocyclic amines: structural, electronic, and hydropathic factors affecting mutagenic potency
P478volume38

Reverse relations

cites work (P2860)
Q38445690A QSAR for the mutagenic potencies of twelve 2-amino-trimethylimidazopyridine isomers: structural, quantum chemical, and hydropathic factors
Q33360917Can we change our microbiome to prevent colorectal cancer development?
Q34231307Cancer-promoting and Inhibiting Effects of Dietary Compounds: Role of the Aryl Hydrocarbon Receptor (AhR)
Q34152011Comments on the history and importance of aromatic and heterocyclic amines in public health
Q39990800Current and future application of genetic toxicity assays: the role and value of in vitro mammalian assays
Q41647719Evaluation of aromatic amines with different purities and different solvent vehicles in the Ames test
Q40506281Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana).
Q46214668Increased risk of lung cancer associated with occupational exposure to benzidine and/or beta-naphthylamine
Q53516919Inhibition of lycopene cyclase results in accumulation of chlorophyll precursors.
Q50066705Mechanistic QSAR of aromatic amines: new models for discriminating between homocyclic mutagens and nonmutagens, and validation of models for carcinogens
Q28391158Metabolism and biomarkers of heterocyclic aromatic amines in molecular epidemiology studies: lessons learned from aromatic amines
Q35202159Modeling biophysical and biological properties from the characteristics of the molecular electron density, electron localization and delocalization matrices, and the electrostatic potential
Q33845886Physicochemical drug properties associated with in vivo toxicological outcomes: a review
Q38733659Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses
Q34293437Risk for lung cancer in workers exposed to benzidine and/or beta-naphthylamine: a protocol for systematic review and meta-analysis
Q28659936Time-Dependent Regulation of Apoptosis by AEN and BAX in Response to 2-Aminoanthracene Dietary Consumption
Q24815781Use of QSARs in international decision-making frameworks to predict health effects of chemical substances

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