review article | Q7318358 |
scholarly article | Q13442814 |
P2093 | author name string | Fritz Melchers | |
P2860 | cites work | Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering | Q24538653 |
RANK is essential for osteoclast and lymph node development | Q24598872 | ||
The pre-B cell receptor; selecting for or against autoreactivity | Q26864956 | ||
Frequencies of multiple IgL chain gene rearrangements in single normal or kappaL chain-deficient B lineage cells | Q73065676 | ||
Changes in the V(H) gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor | Q73767616 | ||
VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus | Q74261418 | ||
BAFF is a survival and maturation factor for mouse B cells | Q74456240 | ||
Autoantibodies as predictors of disease | Q77198401 | ||
The PI3K p110delta is required for down-regulation of RAG expression in immature B cells | Q79717937 | ||
Censoring of autoreactive B cell development by the pre-B cell receptor | Q81485516 | ||
C1q inhibits immune complex-induced interferon-alpha production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus pathogenesis | Q84596359 | ||
Positive and negative selection of natural autoreactive B cells | Q84823635 | ||
Innate lymphoid cells--a proposal for uniform nomenclature | Q29617431 | ||
A lineage of myeloid cells independent of Myb and hematopoietic stem cells | Q29620147 | ||
Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis | Q33194891 | ||
Silencing and nuclear repositioning of the lambda5 gene locus at the pre-B cell stage requires Aiolos and OBF-1. | Q33381545 | ||
S1P1 receptor directs the release of immature B cells from bone marrow into blood. | Q33839902 | ||
Revising B cell receptors | Q33935117 | ||
Repertoire selection by pre-B-cell receptors and B-cell receptors, and genetic control of B-cell development from immature to mature B cells | Q33996199 | ||
Fidelity and infidelity in commitment to B-lymphocyte lineage development | Q33996246 | ||
Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cells | Q34125345 | ||
The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. | Q34134909 | ||
Regulation of the HIF-1alpha level is essential for hematopoietic stem cells | Q34134916 | ||
Selection events operating at various stages in B cell development | Q34167959 | ||
Lymphoid development from stem cells and the common lymphocyte progenitors | Q34170617 | ||
B cell development pathways | Q34178187 | ||
Germinal center B cell maintenance and differentiation are controlled by distinct NF-κB transcription factor subunits | Q34230576 | ||
Hematopoiesis is severely altered in mice with an induced osteoblast deficiency | Q34290169 | ||
Ontogeny and genetics of the hemato/lymphopoietic system | Q34547199 | ||
Ontogeny of the hematopoietic system | Q34653344 | ||
The hare and the tortoise: an embryonic haematopoietic race. | Q34770415 | ||
Consequences of receptor editing at the lambda locus: multireactivity and light chain secretion | Q34983943 | ||
Three-dimensional imaging of whole midgestation murine embryos shows an intravascular localization for all hematopoietic clusters | Q35067369 | ||
Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding | Q35382148 | ||
A protective role for innate immunity in systemic lupus erythematosus | Q35906102 | ||
Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo. | Q35921230 | ||
Autoreactive B-1 B cells: constraints on natural autoantibody B cell antigen receptors | Q36174142 | ||
The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire | Q36184410 | ||
Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction. | Q36228717 | ||
Receptor editing: an approach by autoreactive B cells to escape tolerance | Q36361497 | ||
Receptor editing in self-reactive bone marrow B cells | Q36361578 | ||
Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice | Q36364066 | ||
Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components | Q36399113 | ||
Defective B cell tolerance checkpoints in systemic lupus erythematosus | Q36402748 | ||
ITAM-mediated tonic signalling through pre-BCR and BCR complexes | Q36430140 | ||
B cell tolerance--how to make it and how to break it. | Q36489065 | ||
Rules for the rearrangement events at the L chain gene loci of the mouse | Q36751802 | ||
B-cell self-tolerance in humans | Q36942517 | ||
Sites and stages of autoreactive B cell activation and regulation. | Q37058621 | ||
Mouse hematopoietic stem cells | Q37288860 | ||
Clonal analysis of hematopoietic stem-cell differentiation in vivo | Q37462816 | ||
Organization and maintenance of immunological memory by stroma niches | Q37564254 | ||
Organization of immunological memory by bone marrow stroma | Q37692177 | ||
Self-recognition and clonal selection: autoreactivity drives the generation of B cells | Q37991451 | ||
Sphingosine-1-phosphate: a master regulator of lymphocyte egress and immunity | Q38166250 | ||
Generation of memory B cells inside and outside germinal centers | Q38194532 | ||
The imperfect control of self-reactive germinal center B cells | Q38200841 | ||
Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen. | Q39246618 | ||
The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription. | Q39705131 | ||
Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions. | Q39866994 | ||
Genes required for B cell development | Q40271553 | ||
In-vitro analyses of mechanisms of B-cell development | Q40424900 | ||
Cooperating mechanisms of CXCR5 and CCR7 in development and organization of secondary lymphoid organs | Q40590092 | ||
Cutting edge: signaling and cell surface expression of a mu H chain in the absence of lambda 5: a paradigm revisited. | Q40633243 | ||
Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia | Q40645791 | ||
Immature multipotent hemopoietic progenitors lacking long-term bone marrow-reconstituting activity in the aorta-gonad-mesonephros region of murine day 10 fetuses | Q40826652 | ||
Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement | Q41278530 | ||
Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci | Q41522821 | ||
Germinal center reaction: antigen affinity and presentation explain it all. | Q41835569 | ||
The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis | Q41998237 | ||
Interaction of murine precursor B cell receptor with stroma cells is controlled by the unique tail of lambda 5 and stroma cell-associated heparan sulfate. | Q42046827 | ||
Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. | Q42064178 | ||
Residues that mediate DNA binding of autoimmune antibodies | Q42799912 | ||
The nonimmunoglobulin portion of lambda5 mediates cell-autonomous pre-B cell receptor signaling | Q43483568 | ||
Editors and editing of anti-DNA receptors. | Q43832072 | ||
Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells | Q45856689 | ||
Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging. | Q46048350 | ||
Autoreactivity and allelic inclusion in a B cell nuclear transfer mouse | Q46761763 | ||
Mutations affecting either generation or survival of cells influence the pool size of mature B cells | Q47263297 | ||
Cellular niches controlling B lymphocyte behavior within bone marrow during development. | Q47365661 | ||
Multiple organ-reactive monoclonal autoantibodies | Q48777324 | ||
Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis. | Q50749492 | ||
Thymic stromal lymphopoietin induces early human B-cell proliferation and differentiation. | Q51916152 | ||
The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. | Q52112319 | ||
B-cell progenitors and precursors change their microenvironment in fetal liver during early development. | Q52884003 | ||
The non-Ig parts of the VpreB and λ5 proteins of the surrogate light chain play opposite roles in the surface representation of the precursor B cell receptor. | Q52888393 | ||
Suboptimal B-cell antigen receptor signaling activity in vivo elicits germinal center counterselection mechanisms. | Q54310645 | ||
A critical role of λ5 protein in B cell development | Q57339983 | ||
The Biology of Hematopoietic Stem Cells | Q58043095 | ||
Intraembryonic, but Not Yolk Sac Hematopoietic Precursors, Isolated before Circulation, Provide Long-Term Multilineage Reconstitution | Q58478756 | ||
SnapShot: The Germinal Center Reaction | Q58859205 | ||
Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity. | Q64890383 | ||
Definitive hematopoiesis is autonomously initiated by the AGM region | Q71535827 | ||
Does immunological tolerance explain the waste in the B-lymphocyte immune system? Experiment and theory | Q71556149 | ||
P433 | issue | 6 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 2203-2210 | |
P577 | publication date | 2015-05-04 | |
P1433 | published in | Journal of Clinical Investigation | Q3186904 |
P1476 | title | Checkpoints that control B cell development | |
P478 | volume | 125 |
Q42318813 | A generalized quantitative antibody homeostasis model: regulation of B-cell development by BCR saturation and novel insights into bone marrow function |
Q64096310 | At the intersection of DNA damage and immune responses |
Q39108710 | B-cell responses to HIV infection |
Q49978385 | Condition-dependent generation of aquaporin-4 antibodies from circulating B cells in neuromyelitis optica |
Q38674507 | Control of B lymphocyte development and functions by the mTOR signaling pathways |
Q58568422 | Cytoplasmic FOXO1 identifies a novel disease-activity associated B cell phenotype in SLE |
Q64256054 | Developmental regulation of DNA cytosine methylation at the immunoglobulin heavy chain constant locus |
Q47754080 | Dynamics of the human antibody repertoire after B cell depletion in systemic sclerosis. |
Q42366321 | Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms |
Q89474052 | E3 Ubiquitin Ligase Fbw7 Regulates the Survival of Mature B Cells |
Q90725944 | Expression and Function of Tetraspanins and Their Interacting Partners in B Cells |
Q57479873 | From zero to sixty and back to zero again: the metabolic life of B cells |
Q64068002 | Functional Roles of the IgM Fc Receptor in the Immune System |
Q40293911 | Generation of precursor, immature, and mature murine B1-cell lines from c-myc/bcl-xL-overexpressing pre-BI cells |
Q48147801 | Genetic immunization with mouse thyrotrophin hormone receptor plasmid breaks self-tolerance for a murine model of autoimmune thyroid disease and Graves' orbitopathy |
Q46339660 | Geographic clonal tracking in macaques provides insights into HSPC migration and differentiation. |
Q54227935 | Gαi Signaling Promotes Marginal Zone B Cell Development by Enabling Transitional B Cell ADAM10 Expression. |
Q28078211 | Heterogeneity of B Cell Functions in Stroke-Related Risk, Prevention, Injury, and Repair |
Q37102520 | Highly sensitive and unbiased approach for elucidating antibody repertoires |
Q50462908 | Ig Light Chain Precedes Heavy Chain Gene Rearrangement during Development of B Cells in Swine. |
Q38928710 | Immune senescence: significance of the stromal microenvironment |
Q61807497 | Impaired Expression of Rearranged Immunoglobulin Genes and Premature p53 Activation Block B Cell Development in BMI1 Null Mice |
Q50322446 | In the Absence of Central pre-B Cell Receptor Selection, Peripheral Selection Attempts to Optimize the Antibody Repertoire by Enriching for CDR-H3 Y101. |
Q64898951 | Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation. |
Q64079621 | LAMTOR2 (p14) Controls B Cell Differentiation by Orchestrating Endosomal BCR Trafficking |
Q36165278 | Likelihood-Based Inference of B Cell Clonal Families. |
Q39313226 | Metabolic Regulation of the Immune Humoral Response |
Q52808559 | MiR221 promotes precursor B-cell retention in the bone marrow by amplifying the PI3K-signaling pathway in mice. |
Q89389483 | Molecular Regulation of Differentiation in Early B-Lymphocyte Development |
Q90401123 | N-Glycosylation Site Analysis of Citrullinated Antigen-Specific B-Cell Receptors Indicates Alternative Selection Pathways During Autoreactive B-Cell Development |
Q92184072 | N-methyl-D-aspartate receptor dysfunction by unmutated human antibodies against the NR1 subunit |
Q57281736 | NKL homeobox gene activities in B-cell development and lymphomas |
Q53601817 | Naïve Human Antibody Libraries for Infectious Diseases. |
Q57794432 | Phospholipid flippases enable precursor B cells to flee engulfment by macrophages |
Q49885201 | Potential Epigenetic Regulation in the Germinal Center Reaction of Lymphoid Tissues in HIV/SIV Infection |
Q52721228 | Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner. |
Q37621530 | Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodies |
Q58607258 | Protective Epitope Discovery and the Design of MUC1 Based Vaccine for Effective Tumor Protections in Immunotolerant Mice |
Q33360826 | Putting together the autoimmunity puzzle |
Q92438812 | Quantifying the Dynamics of Hematopoiesis by In Vivo IdU Pulse-Chase, Mass Cytometry, and Mathematical Modeling |
Q46254398 | Regulation of B cell fate, survival, and function by mitochondria and autophagy |
Q91795595 | Regulation of Selective B Cell Autophagy by the Pro-oxidant Adaptor p66SHC |
Q55201143 | Regulation of the Development and Function of B Cells by ZBTB Transcription Factors. |
Q64904663 | Reversing Autoimmunity Combination of Rituximab and Intravenous Immunoglobulin. |
Q33554385 | Sequential monitoring of lymphocyte subsets and of T-and-B cell neogenesis indexes to identify time-varying immunologic profiles in relation to graft-versus-host disease and relapse after allogeneic stem cell transplantation |
Q98164562 | Single-cell approaches to investigate B cells and antibodies in autoimmune neurological disorders |
Q61447859 | Sirtuins in B lymphocytes metabolism and function |
Q47817021 | Stabilizing an amyloidogenic λ6 light chain variable domain |
Q38839981 | Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signaling pathways. |
Q83230212 | TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections |
Q49951221 | Targeting B cell receptor signalling in cancer: preclinical and clinical advances |
Q50129712 | The B cell response to citrullinated antigens in the development of rheumatoid arthritis. |
Q96303544 | The essential functions of mitochondrial dynamics in immune cells |
Q38745626 | The microprocessor component, DGCR8, is essential for early B-cell development in mice |
Q92218356 | The prognostic significance of hematogones and CD34+ myeloblasts in bone marrow for adult B-cell lymphoblastic leukemia without minimal residual disease |
Q37100431 | Transcriptome Analysis of B Cell Immune Functions in Periodontitis: Mucosal Tissue Responses to the Oral Microbiome in Aging. |
Q39322967 | V(D)J Recombination Exploits DNA Damage Responses to Promote Immunity |
Q37649940 | VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen-binding sites |