Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma

scientific article published on January 1999

Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1043306332
P356DOI10.1038/SJ.ONC.1202349
P698PubMed publication ID9989814
P5875ResearchGate publication ID13299279

P2093author name stringBryant D
Behrens C
Gazdar AF
Milchgrub S
Wistuba II
Minna JD
Hung J
P2860cites workThe FHIT gene 3p14.2 is abnormal in lung cancer.Q53455201
Multiple-mutation theory of carcinogenesis.Q53615521
Development of carcinoma of the lung as reflected in exfoliated cells.Q53719094
Simplified hot start PCRQ59061373
Detection of loss of heterozygosity at the human TP53 locus using a dinucleotide repeat polymorphismQ67544701
Sputum cytopathology: use and potential in monitoring the workplace environment by screening for biological effects of exposureQ69595094
Microsatellite instability in primary and metastatic lung carcinomasQ71010040
Genomic instability, mutators, and the development of cancer: is there a role for p53?Q71807913
Clonal genetic alterations in the lungs of current and former smokersQ73443322
The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancersQ24321912
Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesisQ24561466
'Touchdown' PCR to circumvent spurious priming during gene amplificationQ24630793
Complete genomic sequence of the human retinoblastoma susceptibility geneQ28236997
The clonal evolution of tumor cell populationsQ28271546
Allelotype of colorectal carcinomasQ34461209
Microsatellite alterations as clonal markers for the detection of human cancerQ35819311
Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reactionQ36080181
Molecular damage in the bronchial epithelium of current and former smokersQ37541079
Comparison of molecular changes in lung cancers in HIV-positive and HIV-indeterminate subjectsQ38471959
Allele-specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small-cell lung cancersQ38480210
Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinomaQ38481338
Loss of heterozygosity in normal tissue adjacent to breast carcinomas.Q45975916
At least one in seven cases of cancer is caused by smoking. Global estimates for 1985.Q50600385
Cancer statistics, 1997.Q50980276
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)643-650
P577publication date1999-01-01
P1433published inOncogeneQ1568657
P1476titleSequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma
P478volume18

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cites work (P2860)
Q35042319A novel differential diagnostic model for multiple primary lung cancer: Differentially-expressed gene analysis of multiple primary lung cancer and intrapulmonary metastasis
Q33877437Advances in sputum analysis for screening and early detection of lung cancer
Q35586846Allelic imbalance at chromosome 11 in head and neck squamous cell carcinoma in an Indian patient population
Q37355446Allelic losses on chromosome 3p are accumulated in relation to morphological changes of lung adenocarcinoma
Q53369650Analytical and statistical methods to evaluate microsatellite allelic imbalance in small amounts of DNA.
Q40765128Aneuploidy of chromosome 7 can be detected in invasive lung cancer and associated premalignant lesions of the lung by fluorescence in situ hybridisation
Q31909986Association of allelic loss at the FHIT locus and p53 alterations with tumour kinetics and chromosomal instability in non-small cell lung carcinomas (NSCLCs).
Q34031219C4.4A as a biomarker in pulmonary adenocarcinoma and squamous cell carcinoma
Q36195562CT Characteristic of Early Local Recurrence After Resection of the Squamous Cell Carcinoma: Comparison With CT Characteristics of Stump Deformity or Granulation Tissue at Stump Site
Q39926329Cell migration leads to spatially distinct but clonally related airway cancer precursors.
Q37175654Characterizing the molecular spatial and temporal field of injury in early-stage smoker non-small cell lung cancer patients after definitive surgery by expression profiling
Q36414871Chromosomal aneusomy in bronchial high-grade lesions is associated with invasive lung cancer
Q28360494Chromosome 3p allele loss in early invasive breast cancer: detailed mapping and association with clinicopathological features.
Q53494880Chromosome 9 instability and alterations of p16 gene in squamous cell carcinoma of the lung and in adjacent normal bronchi: FISH and immunohistochemical study.
Q57306273Circulating cell-free DNA: a potential biomarker in lung cancer
Q39647590Clld7, A Candidate Tumor Suppressor on Chromosome 13q14, Regulates Pathways of DNA Damage/Repair and Apoptosis
Q80529481Clonal divergence in lung cancer development is associated with allelic loss on chromosome 4
Q34810714Clonality of multifocal urothelial carcinomas: 10 years of molecular genetic studies
Q58572462Critical tumor-suppressor gene regions on chromosome 3P in major human epithelial malignancies: Allelotyping and quantitative real-time PCR
Q34984208Cytogenetics and molecular genetics of lung cancer
Q83174926Deletion mapping of chromosome 13q in head and neck squamous cell carcinoma in Indian patients: correlation with prognosis of the tumour
Q74486037Deletion of tumor suppressor genes in Chinese non-small cell lung cancer
Q53275538Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression.
Q31120595Differential analysis of two-dimension gel electrophoresis profiles from the normal-metaplasia-dysplasia-carcinoma tissue of human bronchial epithelium
Q79156005Differential deletions in 3p are associated with the development of head and neck squamous cell carcinoma in Indian patients
Q33919221Differential deletions of chromosome 3p are associated with the development of uterine cervical carcinoma in Indian patients
Q42485639EGFR/erB-1, HER2/erB-2, CK7, LP34, Ki67 and P53 expression in preneoplastic lesions of bronchial epithelium: an immunohistochemical and genetic study
Q36014004Epidermal growth factor receptor abnormalities in the pathogenesis and progression of lung adenocarcinomas
Q24291194Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression
Q30884723Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.
Q42810857Expression and alteration of ras and p53 proteins in patients with lung carcinoma accompanied by idiopathic pulmonary fibrosis
Q42492165Expression of C4.4A in precursor lesions of pulmonary adenocarcinoma and squamous cell carcinoma
Q33791329Expression of c-kit and p53 in non-small cell lung cancers
Q53394313Expression of early lung cancer detection marker: hnRNP-A2/B1 and its relation to microsatellite alteration in non-small cell lung cancer.
Q24625463Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo
Q34272221Field cancerization in non-small cell lung cancer: implications in disease pathogenesis
Q30721136Fluorescence versus white-light bronchoscopy for detection of preneoplastic lesions: a randomized study
Q34710709Focus on lung cancer
Q35747975Fragile histidine triad gene abnormalities in the pathogenesis of gallbladder carcinoma
Q74523064Frequent 3p allele loss and epigenetic inactivation of the RASSF1A tumour suppressor gene from region 3p21.3 in head and neck squamous cell carcinoma
Q24621422Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2)
Q74000663Genetic analysis of Raf1, Mdm2, c-Myc, Cdc25a and Cdc25b proto-oncogenes in 2',3'-dideoxycytidine- and 1,3-butadiene-induced lymphomas in B6C3F1 mice
Q73311455Genetic heterogeneity in lung and colorectal carcinoma as revealed by microsatellite analysis in plasma or tumor tissue DNA
Q48077597Genome-wide copy number changes and CD133 expression characterized distinct subset of colon polyps: differentiation between incidental polyps and cancer-associated polyps
Q33569956Genomic Landscape Established by Allelic Imbalance in the Cancerization Field of a Normal Appearing Airway
Q36043875Genomic evidence of pre-invasive clonal expansion, dispersal and progression in bronchial dysplasia
Q49560201Genomic variations in the counterpart normal controls of lung squamous cell carcinomas
Q33777454Genomics of squamous cell lung cancer
Q36645990High resolution chromosome 3p, 8p, 9q and 22q allelotyping analysis in the pathogenesis of gallbladder carcinoma
Q42489421Histological types and significance of bronchial epithelial dysplasia
Q53310756IV international conference on prevention and early detection of lung cancer, Reykjavik, Iceland, August 9-12, 2001.
Q24291619Identification of AXUD1, a novel human gene induced by AXIN1 and its reduced expression in human carcinomas of the lung, liver, colon and kidney
Q34936005Innovative molecular and imaging approaches for the detection of lung cancer and its precursor lesions
Q36980449Issues in the design and interpretation of chronic toxicity and carcinogenicity studies in rodents: approaches to dose selection.
Q90701810Lingular segmentectomy and left lower lobectomy via unique bronchial dissection
Q34680492Loss of 4q21.23-22.1 is a prognostic marker for disease free and overall survival in non-small cell lung cancer.
Q24299088Loss of PL6 protein expression in renal clear cell carcinomas and other VHL-deficient tumours
Q57240046Loss of chromosome arms 3p and 9p and inactivation ofP16INK4a in normal epithelium of patients with primary lung cancer
Q80148666Loss of heterozygosity and human telomerase reverse transcriptase (hTERT) expression in bronchial mucosa of heavy smokers
Q74129109Loss of heterozygosity in tumour-adjacent normal tissue of breast and bladder cancer
Q36622470Loss of heterozygosity is related to p53 mutations and smoking in lung cancer
Q38679289Lung Cancer Genomics in the Era of Accelerated Targeted Drug Development.
Q93062897Lung Cancer Staging and Associated Genetic and Epigenetic Events
Q33972805Lung cancer * 9: Molecular biology of lung cancer: clinical implications
Q35075591Lung cancer . 3: Fluorescence bronchoscopy: clinical dilemmas and research opportunities
Q26995495Lung cancer chemoprevention: current status and future prospects
Q35179464Lung cancer chemoprevention: moving from concept to a reality
Q34569420Lung cancer evolution to preinvasive management
Q24552865MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M
Q44588658Mapping of the candidate tumor suppressor genes' loci on human chromosome 3 in head and neck squamous cell carcinoma of an Indian patient population
Q43583310Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours.
Q34835468Methylation of the RASSF1A gene in human cancers
Q35836697Microsatellite analysis of pleural supernatants could increase sensitivity of pleural fluid cytology
Q79319023Microscopic analysis of chromium accumulation in the bronchi and lung of chromate workers
Q33891465Molecular and genetic aspects of lung cancer
Q34569440Molecular biology of lung cancer: clinical implications.
Q37511952Molecular changes in the bronchial epithelium of patients with small cell lung cancer
Q43955974Molecular follow-up of preneoplastic lesions in bronchial epithelium of former Chernobyl clean-up workers
Q33722441Molecular genetic characteristics of lung cancer--useful as real' tumor markers?
Q33793308Molecular pathogenesis of lung cancer
Q36155104Molecular pathology of non-small-cell lung cancer
Q36691733Molecular profiling of lung carcinoma: identifying clinically useful tumor markers for diagnosis and prognosis
Q64097509Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions
Q35542147Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications
Q33879000Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer
Q36157758Natural history of bronchial preinvasive lesions
Q64282336Neoplastic Pathogenesis Associated with Cigarette Carcinogens
Q38089079New biomarkers for lung cancer
Q35156742Novel candidate key drivers in the integrative network of genes, microRNAs, methylations, and copy number variations in squamous cell lung carcinoma.
Q53628984Nuclear morphometry as a biomarker for bronchial intraepithelial neoplasia: correlation with genetic damage and cancer development.
Q40671231Pathogenetic and biologic significance of TP14ARF alterations in nonsmall cell lung carcinoma
Q36446587Persistence of Bronchial Dysplasia Is Associated with Development of Invasive Squamous Cell Carcinoma
Q28482937Phase I clinical trial of systemically administered TUSC2(FUS1)-nanoparticles mediating functional gene transfer in humans
Q24807204Preneoplastic lesions of the lung
Q39541029Promoter hypermethylation of the CFTR gene and clinical/pathological features associated with non-small cell lung cancer.
Q73497850Prospects for lung-cancer screening
Q28395348Pulmonary adenocarcinoma: a renewed entity in 2011
Q34220494Pulmonary preinvasive neoplasia
Q38009322RASSF Signalling and DNA Damage: Monitoring the Integrity of the Genome?
Q33955907Retrovirus-induced ovine pulmonary adenocarcinoma, an animal model for lung cancer
Q44798575SOX2 Drives Bronchial Dysplasia in a Novel Organotypic Model of Early Human Squamous Lung Cancer.
Q36202378SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis.
Q33842487Smoking and lung cancer: the role of inflammation
Q34963435Smoking molecular damage in bronchial epithelium
Q81817041Somatic genetic changes accompanying lung tumor development
Q50977348Spectra of antinuclear antibodies in patients with squamous cell carcinoma of the lung and of the head and neck.
Q36030691Squamous Metaplasia Is Increased in the Bronchial Epithelium of Smokers with Chronic Obstructive Pulmonary Disease
Q38048579Squamous-cell carcinomas of the lung: emerging biology, controversies, and the promise of targeted therapy
Q37571960Stem cells and lung cancer: future therapeutic targets?
Q40592131Suprabasal p53 immunostaining in premalignant endobronchial lesions in combination with histology is associated with bronchial cancer.
Q24617128Surfactant protein DNA methylation: a new entrant in the field of lung cancer diagnostics? (Review)
Q64975920TRIM58/cg26157385 methylation is associated with eight prognostic genes in lung squamous cell carcinoma.
Q24816722Teen smoking, field cancerization, and a "critical period" hypothesis for lung cancer susceptibility
Q43655920The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas
Q31121564The Ras-association domain family (RASSF) members and their role in human tumourigenesis
Q35078733The TP53 gene, tobacco exposure, and lung cancer
Q34510214The association between atypical adenomatous hyperplasia and primary lung cancer
Q38296670The hypoxic tumor microenvironment: driving the tumorigenesis of non-small-cell lung cancer
Q24802445The molecular basis of lung cancer: molecular abnormalities and therapeutic implications
Q27010437The pivotal role of pathology in the management of lung cancer
Q35200467The use of quantitative proteomics towards biomarker discovery in lung squamous cell carcinoma
Q53394311Topographical analysis of p53 expression and DNA ploidy in early bronchial squamous cell carcinoma and preneoplastic lesions.
Q79347789Topographical distribution of allelic loss in individual lung adenocarcinomas with lymph node metastases
Q37696458Transcriptomic architecture of the adjacent airway field cancerization in non-small cell lung cancer
Q34997208Transformation of rodent fibroblasts by the jaagsiekte sheep retrovirus envelope is receptor independent and does not require the surface domain.
Q36245778Whole Transcriptome Analysis of Pre-invasive and Invasive Early Squamous Lung Carcinoma in Archival Laser Microdissected Samples

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