Intrathecal injection of naked plasmid DNA provides long-term expression of secreted proteins

scientific article published on 21 October 2008

Intrathecal injection of naked plasmid DNA provides long-term expression of secreted proteins is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/MT.2008.230
P932PMC publication ID2834984
P698PubMed publication ID18941439
P5875ResearchGate publication ID23403269

P50authorLinda R. WatkinsQ4291013
Leslie LeinwandQ29447012
Erin D MilliganQ114776098
Raymond A ChavezQ125308078
P2093author name stringKirk W Johnson
Travis S Hughes
Stephen J Langer
P2860cites workControlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10Q24796221
Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic painQ28583865
Sequential injection of cationic liposome and plasmid DNA effectively transfects the lung with minimal inflammatory toxicityQ33337328
Reactivation of the previously silenced cytomegalovirus major immediate-early promoter in the mouse liver: involvement of NFkappaB.Q33781921
Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathologyQ34325791
Progress and problems with the use of viral vectors for gene therapyQ35120176
Gene therapy progress and prospects: episomally maintained self-replicating systems.Q35896163
Formation and intracellular trafficking of lipoplexes and polyplexesQ36053120
Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: implications for therapeutic application within the central nervous systemQ36310853
Gene therapy clinical trials worldwide to 2007--an update.Q36920192
Blood-brain barrier: structural components and function under physiologic and pathologic conditionsQ37015412
Optimization of cis-acting elements for gene expression from nonviral vectors in vivoQ38494103
Astrocytic expression of transgene in the rat brain mediated by baculovirus vectors containing an astrocyte-specific promoterQ40275505
Intrathecal gene delivery of glial cell line-derived neurotrophic factor ameliorated paraplegia in rats after spinal ischemia.Q40458634
Inclusion of the hepatic locus control region, an intron, and untranslated region increases and stabilizes hepatic factor IX gene expression in vivo but not in vitroQ40863120
Creation of a biologically active interleukin-5 monomerQ41228167
Interleukin 10 increases CCR5 expression and HIV infection in human monocytesQ41779916
CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable polycation PPE-EA: a comparison with polyethylenimine/DNA complexesQ42454485
Direct gene transfer into nonhuman primate myofibers in vivoQ43851694
Electroporation-mediated pain-killer gene therapy for mononeuropathic ratsQ44128320
Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasoundQ44288775
Gene transfer to dorsal root ganglia by intrathecal injection: effects on regeneration of peripheral nervesQ44485844
In vivo electroporation of proopiomelanocortin induces analgesia in a formalin-injection pain model in rats.Q44509520
Enhanced systemic transgene expression after nonviral salivary gland transfection using a novel endonuclease inhibitor/DNA formulationQ44661097
Regulated, electroporation-mediated delivery of pro-opiomelanocortin gene suppresses chronic constriction injury-induced neuropathic pain in ratsQ44872856
Expression of a transgene encoded on a non-viral episomal vector is not subject to epigenetic silencing by cytosine methylationQ45006939
Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment.Q45149314
Enhanced expression and stable transmission of transgenes flanked by inverted terminal repeats from adeno-associated virus in zebrafishQ45737752
Repeated intrathecal administration of plasmid DNA complexed with polyethylene glycol-grafted polyethylenimine led to prolonged transgene expression in the spinal cordQ45863310
Spinal gene transfer using ultrasound and microbubblesQ45864438
Long-term therapeutic levels of human alpha-1 antitrypsin in plasma after hydrodynamic injection of nonviral DNA.Q45864764
Efficient nonviral cutaneous transfectionQ45870241
Intrathecal injection of HVJ-E containing HGF gene to cerebrospinal fluid can prevent and ameliorate hearing impairment in ratsQ45870356
Intrathecal coelectrotransfer of a tetracycline-inducible, three-plasmid-based system to achieve tightly regulated antinociceptive gene therapy for mononeuropathic ratsQ45873486
IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis.Q45874893
Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotidesQ45877030
Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10.Q45883209
Interleukin-2 gene therapy of chronic neuropathic painQ45886670
Silencing of episomal transgene expression in liver by plasmid bacterial backbone DNA is independent of CpG methylationQ46423291
Immunostimulatory effects of plasmid DNA and synthetic oligodeoxynucleotidesQ61053510
Gene expression along the cerebral-spinal axis after regional gene deliveryQ73194818
Antigen levels and antibody titers after DNA vaccinationQ73421996
Efficient expression of naked dna delivered intraarterially to limb muscles of nonhuman primatesQ73595247
A prospective study of catheter-related complications of intrathecal drug delivery systemsQ73666270
Marked enhancement of direct respiratory tissue transfection by aurintricarboxylic acidQ78067379
Interleukin-2 gene has superior antinociceptive effects when delivered intrathecallyQ78069896
Pharmacokinetics and in vitro and in vivo anti-tumor response of an interleukin-2-human serum albumin fusion protein in miceQ81127466
Lentiviral gene delivery to CNS by spinal intrathecal administration to neonatal miceQ82152984
P433issue1
P304page(s)88-94
P577publication date2008-10-21
P1433published inMolecular TherapyQ15762400
P1476titleIntrathecal injection of naked plasmid DNA provides long-term expression of secreted proteins
P478volume17

Reverse relations

cites work (P2860)
Q37532600Analgesic tolerance of opioid agonists in mutant mu-opioid receptors expressed in sensory neurons following intrathecal plasmid gene delivery
Q38466189Characterization and heterologous expression of a new matrix attachment region binding protein from the unicellular green alga Dunaliella salina
Q45874115Effects of spinal non-viral interleukin-10 gene therapy formulated with d-mannose in neuropathic interleukin-10 deficient mice: Behavioral characterization, mRNA and protein analysis in pain relevant tissues.
Q45873482Gene therapy for neuropathic pain induced by spared nerve injury with naked plasmid encoding hepatocyte growth factor
Q48510107Gene transfer of a naked plasmid (pUDK-HGF) encoding human hepatocyte growth factor attenuates skin/muscle incision and retraction-induced chronic post-surgical pain in rats
Q36831409Immunogenicity of intrathecal plasmid gene delivery: cytokine release and effects on transgene expression
Q45868167Longevity of rAAV vector and plasmid DNA in blood after intramuscular injection in nonhuman primates: implications for gene doping
Q39077819Multiplex blood reporters for simultaneous monitoring of cellular processes.
Q37872790Non-viral episomal modification of cells using S/MAR elements
Q47961707Secreted Reporters for Monitoring Multiple Promoter Function
Q35294368Secreted blood reporters: insights and applications
Q26861391Spinal interleukin-10 therapy to treat peripheral neuropathic pain
Q52372286Target-specific delivery of doxorubicin to human glioblastoma cell line via ssDNA aptamer.
Q30447740Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound
Q28543965Targeted inhibitory effect of Lenti-SM22alpha-p27-EGFP recombinant lentiviral vectors on proliferation of vascular smooth muscle cells without compromising re-endothelialization in a rat carotid artery balloon injury model
Q64916242Viral Metagenomics on Cerebrospinal Fluid.

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